Organic Process Research & Development (ACS Publications)

Model-Based Solvent Selection during Conceptual Process Design of a New Drug Manufacturing Process

Intensification of the Capillary-Based Kolbe−Schmitt Synthesis from Resorcinol by Reactive Ionic Liquids, Microwave Heating, or a Combination Thereof

A Simple, Efficient, Green, Cost Effective and Chemoselective Process for the Esterification of Carboxylic Acids

Process Development for A Novel Pleuromutilin-Derived Antibiotic

Investigation on the Formation and Hydrolysis of N,N-Dimethylcarbamoyl Chloride (DMCC) in Vilsmeier Reactions Using GC/MS as the Analytical Detection Method

Renaissance of Traditional Organic Reactions under Microfluidic Conditions: A New Paradigm for Natural Products Synthesis

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Current Issue

Reports on practical chemistry for more easily reproducible results, particularly on large scale (kg). Reporting work in the broad field of process chemistry encompassing aspects of organic chemistry, catalysis, analytical chemistry, and chemical engineering.

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Just Accepted Manuscripts

Just Accepted manuscripts are peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing.

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Articles ASAP (As Soon As Publishable)

ASAP articles are edited and published online ahead of print.

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Process Development and Pilot-Scale Synthesis of New Cyclization Conditions of Substituted Phenylacetamides to Tetrahydroisoquinoline-2-ones Using Eaton’s Reagent

Luckner G. Ulysse, Qiang Yang, Mark D. McLaws, Daniel K. Keefe, Peter R. Guzzo and Brian P. Haney

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 17, 2009 (Communication to Editor)

DOI: 10.1021/op9002533

Abstract

Book Review: Dynamic Stereochemistry of Chiral Compounds - Principles and Applications

Trevor Laird

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 17, 2009 (Book Review)

DOI: 10.1021/op9002856

Abstract

The Development of a New Manufacturing Route to the Novel Anticonvulsant, SB-406725A

Matthew D. Walker, Benjamin I. Andrews, Andrew J. Burton, Luke D. Humphreys, Gary Kelly, Mark B. Schilling and Peter W. Scott

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 16, 2009 (Article)

DOI: 10.1021/op9002054

Abstract | Supporting Info

Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates

Debra Ainge, James E. M. Booker, Nicholas Pedge, Rhona Sinclair, Chris Sleigh, Marijan

tefinovi

, Luis-Manuel Vaz and Edward Way

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 10, 2009 (Article)

DOI: 10.1021/op900172t

Abstract | Supporting Info

Application of Quality by Design Principles to Support Development of a Control Strategy for the Control of Genotoxic Impurities in the Manufacturing Process of a Drug Substance

Zadeo Cimarosti, Fernando Bravo, Paul Stonestreet, Francesco Tinazzi, Orsola Vecchi and Giulio Camurri

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): November 6, 2009 (Article)

DOI: 10.1021/op900242x

Abstract

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Current Issue

The latest published issue of Organic Process Research & Development.

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Some Thoughts on Generic API Manufacture

Trevor Laird

Org. Process Res. Dev., 2009, 13 (6), p 1037

Publication Date (Web): October 30, 2009 (Editorial)

Abstract

Some Items of Interest to Process R&D Chemists and Engineers

Mark McLaughlin, Silvina Garc

a Rubio, Ulf Tilstam, Trevor Laird, Andrei Zlota

Org. Process Res. Dev., 2009, 13 (6), pp 1038–1045

Publication Date (Web): November 3, 2009 (Highlights from the Literature)

Abstract

A Review of U.S. Patents in the Field of Organic Process Development Published During June and July 2009

Keith Turner

Org. Process Res. Dev., 2009, 13 (6), pp 1046–1058

Publication Date (Web): October 28, 2009 (Highlights From Patents)

Abstract

An Efficient Laboratory Automation Concept for Process Chemistry

Christian Bernlind and Csaba Urbaniczky

Org. Process Res. Dev., 2009, 13 (6), pp 1059–1067

Publication Date (Web): September 23, 2009 (Concept Article)

Abstract

Removal of Heavy Metals from Organic Reaction Mixtures: Preparation and Application of Functionalized Resins

Damien Barbaras, J

rg Brozio, Ib Johannsen and Thomas Allmendinger

Org. Process Res. Dev., 2009, 13 (6), pp 1068–1079

Publication Date (Web): October 20, 2009 (Article)

Abstract | Supporting Info

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Most Read Articles

Most Read articles are updated on a monthly basis and available as 1 month and 12 month lists. Below is a Top 5 excerpt from the 1 month list.

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A Novel Crystallization Methodology To Ensure Isolation of the Most Stable Crystal Form

Aaron Cote, George Zhou and Mary Stanik

Org. Process Res. Dev., 2009, 13 (6), pp 1276–1283

Publication Date (Web): October 1, 2009 (Article)

Abstract

Some Items of Interest to Process R&D Chemists and Engineers

Mark McLaughlin, Matthew Pfeiffer, Andrei A. Zlota, Trevor Laird

Org. Process Res. Dev., 2009, 13 (5), pp 824–828

Publication Date (Web): August 31, 2009 (Highlights from the Literature)

DOI: 10.1021/op900215m

Abstract

Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End

Giuseppe Guercio, Sergio Bacchi, Alcide Perboni, Corinne Leroi, Francesco Tinazzi, Ilaria Bientinesi, Marie Hourdin, Michael Goodyear, Stefano Curti, Stefano Provera and Zadeo Cimarosti

Org. Process Res. Dev., 2009, 13 (6), pp 1100–1110

Publication Date (Web): October 2, 2009 (Article)

DOI: 10.1021/op9002032

Abstract | Supporting Info

Preparation of Saxagliptin, a Novel DPP-IV Inhibitor

Scott A. Savage, Gregory S. Jones, Sergei Kolotuchin, Shelly Ann Ramrattan, Truc Vu and Robert E. Waltermire

Org. Process Res. Dev., 2009, 13 (6), pp 1169–1176

Publication Date (Web): October 16, 2009 (Article)

Abstract

Polymorphism in Processes of Crystallization in Solution: A Practical Review

Denis Mangin, Francois Puel and Stephane Veesler

Org. Process Res. Dev., 2009, 13 (6), pp 1241–1253

Publication Date (Web): October 1, 2009 (Review)

Abstract

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Most Cited Articles

Most Cited articles are updated on a monthly basis and available as Last 3 Years and All Time lists. Citation data is made available by participants in CrossRef's Cited-by Linking service. Below is an excerpt from the Last 3 Years list (published across all volumes). For a more comprehensive list of citations, users are encouraged to perform a search in SciFinder.

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Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development

Sanjay R. Chemburkar, John Bauer, Kris Deming, Harry Spiwek, Ketan Patel, John Morris, Rodger Henry, Stephen Spanton, Walter Dziki, William Porter, John Quick, Phil Bauer, John Donaubauer, B. A. Narayanan, Mauro Soldani, Dave Riley, and Kathyrn McFarland

Org. Process Res. Dev., 2000, 4 (5), pp 413–417

Publication Date (Web): June 21, 2000 (Article)

DOI: 10.1021/op000023y

Abstract

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A Scalable Synthesis of Meso-Substituted Dipyrromethanes

Joydev K. Laha, Savithri Dhanalekshmi, Masahiko Taniguchi, Arounaguiry Ambroise, and Jonathan S. Lindsey

Org. Process Res. Dev., 2003, 7 (6), pp 799–812

Publication Date (Web): September 09, 2003 (Article)

DOI: 10.1021/op034083q

Abstract | Supporting Info

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Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Alle Bruggink, Eric C. Roos, and Erik de Vroom

Org. Process Res. Dev., 1998, 2 (2), pp 128–133

Publication Date (Web): February 28, 1998 (Review)

DOI: 10.1021/op9700643

Abstract

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Concepts of Nature in Organic Synthesis: Cascade Catalysis and Multistep Conversions in Concert

Alle Bruggink, Rob Schoevaart, and Tom Kieboom

Org. Process Res. Dev., 2003, 7 (5), pp 622–640

Publication Date (Web): August 16, 2003 (Review)

DOI: 10.1021/op0340311

Abstract | Supporting Info

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Seeding the Desired Polymorph: Background, Possibilities, Limitations, and Case Studies

Wolfgang Beckmann

Org. Process Res. Dev., 2000, 4 (5), pp 372–383

Publication Date (Web): August 26, 2000 (Review)

DOI: 10.1021/op0000778

Abstract

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OPR&D total citations increased to 2,062 in 2008

Beginning July 2009, ACS print journals will appear in a new two-up, condensed format.

OPR&D remembers Associate Editor Chris Schmid

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About the Journal

Just Accepted Manuscripts

Articles ASAP (As Soon As Publishable)

Process Development and Pilot-Scale Synthesis of New Cyclization Conditions of Substituted Phenylacetamides to Tetrahydroisoquinoline-2-ones Using Eaton’s Reagent

Book Review: Dynamic Stereochemistry of Chiral Compounds - Principles and Applications

The Development of a New Manufacturing Route to the Novel Anticonvulsant, SB-406725A

Development of a Multikilogram Synthesis of a Chiral Epoxide Precursor to a CCR1 Antagonist. Use of in Situ Monitoring for Informed Optimisation via Fragile Intermediates

Application of Quality by Design Principles to Support Development of a Control Strategy for the Control of Genotoxic Impurities in the Manufacturing Process of a Drug Substance

Current Issue

Some Thoughts on Generic API Manufacture

Some Items of Interest to Process R&D Chemists and Engineers

A Review of U.S. Patents in the Field of Organic Process Development Published During June and July 2009

An Efficient Laboratory Automation Concept for Process Chemistry

Removal of Heavy Metals from Organic Reaction Mixtures: Preparation and Application of Functionalized Resins

Most Read Articles

A Novel Crystallization Methodology To Ensure Isolation of the Most Stable Crystal Form

Some Items of Interest to Process R&D Chemists and Engineers

Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End

Preparation of Saxagliptin, a Novel DPP-IV Inhibitor

Polymorphism in Processes of Crystallization in Solution: A Practical Review

Most Cited Articles

Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development

A Scalable Synthesis of Meso-Substituted Dipyrromethanes

Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Concepts of Nature in Organic Synthesis: Cascade Catalysis and Multistep Conversions in Concert

Seeding the Desired Polymorph: Background, Possibilities, Limitations, and Case Studies

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Special Feature Sections

Announcements

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