Organic Process Research & Development (ACS Publications)

A Versatile Lab to Pilot Scale Continuous Reaction System for Supercritical Fluid Processing
Ulrich Hintermair, Christoph Roosen, Markus Kaever, Horst Kronenberg, Ralf Thelen, Stefan Aey, Walter Leitner*, and Lasse Greiner*

Development of a Commercial Process for (S)-β-Phenylalanine(1)
J. Ian Grayson*, Jürgen Roos, and Steffen Osswald

Serendipitous Discovery of a Zidovudine Guanidine Complex: A Superior Process for the Production of Zidovudine
Bruno K Radatus

Route Selection and Process Development for a 5-Piperazinylquinaldine Derivative for the Treatment of Depression and Anxiety
Zadeo Cimarosti*, Nicola Giubellina, Paolo Stabile, Gilles Laval, Francesco Tinazzi, William Maton, Roberta Pachera, Paola Russo, Ramona Moretti, Sara Rossi, Jason W. B. Cooke, and Pieter Westerduin

Genotoxic Impurities: A Regulatory Toxicology Commentary on Recent Articles in Organic Process Research & Development
David J Snodin*

Prediction of Agglomerate Type during Scale-Up of a Batch Crystallization Using Computational Fluid Dynamics Models
Richard F. Falk*, Ivan Marziano, Terry Kougoulos, and Kevin P. Girard

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Removal of Acrolein from Active Pharmaceutical Ingredients Using Aldehyde Scavengers

Rustem Kecili, David Nivhede, Johan Billing, Mats Leeman, Börje Sellergren, and Ecevit Yilmaz

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): April 19, 2012 (Article)

DOI: 10.1021/op3000459

Abstract

Selective Hydrogenation of Alkenes under Ultramild Conditions

Valerica Pandarus, Genevieve Gingras, François Béland, Rosaria Ciriminna, and Mario Pagliaro

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): May 2, 2012 (Article)

DOI: 10.1021/op300079z

Abstract

Some Items of Interest to Process R&D Chemists and Engineers

Mark McLaughlin, Magnus Widegren, Soumendu Paul, Antonio Ramirez, Paul Richardson, Andrei Zlota, and Trevor Laird

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): May 11, 2012 (Highlights from the Literature)

DOI: 10.1021/op300090w

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Process Development of a Novel Azetidinyl Ketolide Antibiotic

Bryan Li, Thomas V. Magee, Richard A. Buzon, Daniel W. Widlicka, Dave R. Bill, Thomas Brandt, Xiaoping Cao, Michael Coutant, Haijian Dou, Karl Granskog, Mark E. Flanagan, Cheryl M. Hayward, Bin Li, Fengwei Liu, Wei Liu, Thuy-Trinh Nguyen, Jeffrey W. Raggon, Peter Rose, Joseph Rainville, Usa Datta Reilly, Yue Shen, Jianmin Sun, and Glenn E. Wilcox

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Publication Date (Web): April 30, 2012 (Article)

DOI: 10.1021/op300064b

Abstract

Isoindolone Formation via Intramolecular Diels–Alder Reaction

Matthew Ball, Alistair Boyd, Gwydion Churchill, Murray Cuthbert, Mark Drew, Mark Fielding, Gair Ford, Lianne Frodsham, Michael Golden, Kevin Leslie, Sarah Lyons, Ben McKeever-Abbas, Andrew Stark, and Paula Tomlin , Stephen Gottschling, Abraham Hajar, Ji-long Jiang, Josephine Lo, and Bob Suchozak

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Publication Date (Web): April 27, 2012 (Article)

DOI: 10.1021/op300002f

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Crystallisation and Polymorphism

Trevor Laird

Org. Process Res. Dev., 2012, 16 (4), pp 525–525

Publication Date (Web): March 20, 2012 (Editorial)

DOI: 10.1021/op3000702

Abstract

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Some Items of Interest to Process R&D Chemists and Engineers

Ian Wilson, Wenyi Zhao, Dongbo Zhao, Aman A. Desai, Rodrigo Octavio M. A. de Souza, Sylvain Guizzetti, and Trevor Laird

Org. Process Res. Dev., 2012, 16 (4), pp 526–534

Publication Date (Web): April 3, 2012 (Highlights from the Literature)

DOI: 10.1021/op300066h

Abstract

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Green Chemistry Articles of Interest to the Pharmaceutical Industry

L. Amarnath, Ian Andrews, Rakeshwar Bandichhor, Apurba Bhattacharya, Peter Dunn, John Hayler, William Hinkley, Nicole Holub, David Hughes, Luke Humphreys, Bernard Kaptein, Hare Krishnen, Kurt Lorenz, SujuMathew, G. Nagaraju, Thomas Rammeloo, Paul Richardson, Lijun Wang, Andrew Wells, Timothy White

Org. Process Res. Dev., 2012, 16 (4), pp 535–544

Publication Date (Web): April 10, 2012 (Green Chemistry Highlights)

DOI: 10.1021/op300068d

Abstract

Regulatory Highlights for August 2011–January 2012

Derek Robinson

Org. Process Res. Dev., 2012, 16 (4), pp 545–549

Publication Date (Web): February 27, 2012 (Regulatory Highlights)

DOI: 10.1021/op300032j

Abstract

Development of the Large-Scale Preparation of 2-(Methanesulfonyl)benzenesulfonyl Chloride

Harold Meckler and R. Jason Herr

Org. Process Res. Dev., 2012, 16 (4), pp 550–555

Publication Date (Web): March 5, 2012 (Article)

DOI: 10.1021/op2002744

Section:

Industrial Organic Chemicals, Leather, Fats, and Waxes

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Most Read articles are updated on a monthly basis and available as 1 month and 12 month lists. Below is a Top 5 excerpt from the 1 month list.

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Large-Scale Carbonyl Reductions in the Pharmaceutical Industry

Javier Magano and Joshua R. Dunetz

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 14, 2012 (Review)

DOI: 10.1021/op2003826

Abstract

Some Items of Interest to Process R&D Chemists and Engineers

Ian Wilson, Wenyi Zhao, Dongbo Zhao, Aman A. Desai, Rodrigo Octavio M. A. de Souza, Sylvain Guizzetti, and Trevor Laird

Org. Process Res. Dev., 2012, 16 (4), pp 526–534

Publication Date (Web): April 3, 2012 (Highlights from the Literature)

DOI: 10.1021/op300066h

Abstract

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OPRD’s First Large Scale Review

Jaan Pesti

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): April 9, 2012 (Editorial)

DOI: 10.1021/op3000866

Abstract

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Green Chemistry Articles of Interest to the Pharmaceutical Industry

Org. Process Res. Dev., 2012, 16 (4), pp 535–544

Publication Date (Web): April 10, 2012 (Green Chemistry Highlights)

DOI: 10.1021/op300068d

Abstract

Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor

Pintipa Grongsaard, Paul G. Bulger, Debra J. Wallace, Lushi Tan, Qinghao Chen, Sarah J. Dolman, Jason Nyrop, R. Scott Hoerrner, Mark Weisel, Juan Arredondo, Takahiro Itoh, Chengfu Xie, Xianghui Wen, Dalian Zhao, Daniel J. Muzzio, Ephraim M. Bassan, and C. Scott Shultz

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Publication Date (Web): March 23, 2012 (Article)

DOI: 10.1021/op300031r

Abstract | Supporting Info

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Most Cited articles are updated on a monthly basis and available as Last 3 Years and All Time lists. Citation data is made available by participants in CrossRef's Cited-by Linking service. Below is an excerpt from the Last 3 Years list. For a more comprehensive list of citations, users are encouraged to perform a search in SciFinder.

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