Organic Process Research & Development (ACS Publications)

An Efficient Synthesis of a Cyclic Ether Key Intermediate for 9-Membered Masked Enediyne Using an Automated Synthesizer

Synthesis of the NK1 Receptor Antagonist GW597599. Part 3: Development of a Scalable Route to a Key Chirally Pure Arylpiperazine Urea, A Happy End

A Practical Solid Form Screen Approach To Identify a Pharmaceutical Glutaric Acid Cocrystal for Development

Turning DSC Charts of Polymorphs into Phase Diagrams: A Tutorial Paper

A Practical Approach for Using Solubility to Design Cooling Crystallisations

Removal of Heavy Metals from Organic Reaction Mixtures: Preparation and Application of Functionalized Resins

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About the Journal

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Reports on practical chemistry for more easily reproducible results, particularly on large scale (kg). Reporting work in the broad field of process chemistry encompassing aspects of organic chemistry, catalysis, analytical chemistry, and chemical engineering.

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Just Accepted manuscripts are peer-reviewed and accepted for publication. They are posted online prior to technical editing, formatting for publication and author proofing.

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Articles ASAP (As Soon As Publishable)

ASAP articles are edited and published online ahead of print.

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Flow Processing of Microwave-Assisted (Heterogeneous) Organic Reactions

Mark H. C. L. Dressen, Bastiaan H. P. van de Kruijs, Jan Meuldijk, Jef A. J. M. Vekemans and Lumbertus A. Hulshof

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 9, 2010 (Article)

DOI: 10.1021/op900257f

Abstract | Supporting Info

Nonchromatographic Isolation of 2-Alkyl-2H-1,2,3-Triazoles in the Synthesis of NK3 Receptor Antagonists

Huan Wang and Hao Yin

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 4, 2010 (Technical Note)

DOI: 10.1021/op900320j

A Synthesis of 3,5-Disubstituted Phenols

James P. Davidson, Keshab Sarma, Dan Fishlock, Michael H. Welch, Sunil Sukhtankar, Gary M. Lee, Michael Martin and Gary F. Cooper

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 4, 2010 (Technical Note)

DOI: 10.1021/op900322u

ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing

Catherine F. Carter, Heiko Lange, Steven V. Ley, Ian R. Baxendale, Brian Wittkamp, Jon G. Goode and Nigel L. Gaunt

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 1, 2010 (Article)

DOI: 10.1021/op900305v

Scaleable Preparation of Functionalized Organometallics via Directed Ortho Metalation Using Mg- and Zn-Amide Bases

Stefan H. Wunderlich, Christoph J. Rohbogner, Andreas Unsinn and Paul Knochel

Org. Process Res. Dev., Articles ASAP (As Soon As Publishable)

Publication Date (Web): February 1, 2010 (Article)

DOI: 10.1021/op9002888

Abstract | Supporting Info

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Current Issue

The latest published issue of Organic Process Research & Development.

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Polymorphism - Still Unpredictable?

Trevor Laird

Org. Process Res. Dev., 2010, 14 (1), p 1

Publication Date (Web): January 15, 2010 (Editorial)

DOI: 10.1021/op9003345

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Some Items of Interest to Process R&D Chemists and Engineers

Mark McLaughlin, Matthew Pfeiffer, Ulf Tilstam, Andrei A. Zlota, Trevor Laird

Org. Process Res. Dev., 2010, 14 (1), pp 2–7

Publication Date (Web): December 28, 2009 (Highlights from the Literature)

DOI: 10.1021/op900331x

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A Review of U.S. Patents in the Field of Organic Process Development Published During August and September 2009

Keith Turner

Org. Process Res. Dev., 2010, 14 (1), pp 8–18

Publication Date (Web): December 22, 2009 (Highlights From Patents)

DOI: 10.1021/op900318s

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Green Chemistry Articles of Interest to the Pharmaceutical Industry

Ian Andrews, Jian Cui, Jimmy DaSilva, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy White, Fuyao Zhang

Org. Process Res. Dev., 2010, 14 (1), pp 19–29

Publication Date (Web): December 11, 2009 (Green Chemistry Highlights)

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Practical Aspects of Carbon−Carbon Cross-Coupling Reactions Using Heteroarenes

Vincent F. Slagt, Andr

H. M. de Vries, Johannes G. de Vries and Richard M. Kellogg

Org. Process Res. Dev., 2010, 14 (1), pp 30–47

Publication Date (Web): December 3, 2009 (Review)

DOI: 10.1021/op900221v

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Most Read Articles

Most Read articles are updated on a monthly basis and available as 1 month and 12 month lists. Below is a Top 5 excerpt from the 1 month list.

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Some Items of Interest to Process R&D Chemists and Engineers

Mark McLaughlin, Matthew Pfeiffer, Ulf Tilstam, Andrei A. Zlota, Trevor Laird

Org. Process Res. Dev., 2010, 14 (1), pp 2–7

Publication Date (Web): December 28, 2009 (Highlights from the Literature)

DOI: 10.1021/op900331x

Sponsored Access

Sponsored Access

Polymorphism - Still Unpredictable?

Trevor Laird

Org. Process Res. Dev., 2010, 14 (1), p 1

Publication Date (Web): January 15, 2010 (Editorial)

DOI: 10.1021/op9003345

Sponsored Access

Sponsored Access

Green Chemistry Articles of Interest to the Pharmaceutical Industry

Ian Andrews, Jian Cui, Jimmy DaSilva, Leo Dudin, Peter Dunn, John Hayler, Bill Hinkley, David Hughes, Bernard Kaptein, Kurt Lorenz, Suju Mathew, Thomas Rammeloo, Lijun Wang, Andrew Wells, Timothy White, Fuyao Zhang

Org. Process Res. Dev., 2010, 14 (1), pp 19–29

Publication Date (Web): December 11, 2009 (Green Chemistry Highlights)

Sponsored Access

Sponsored Access

Practical Aspects of Carbon−Carbon Cross-Coupling Reactions Using Heteroarenes

Vincent F. Slagt, Andr

H. M. de Vries, Johannes G. de Vries and Richard M. Kellogg

Org. Process Res. Dev., 2010, 14 (1), pp 30–47

Publication Date (Web): December 3, 2009 (Review)

DOI: 10.1021/op900221v

Sponsored Access

Sponsored Access

A Review of U.S. Patents in the Field of Organic Process Development Published During August and September 2009

Keith Turner

Org. Process Res. Dev., 2010, 14 (1), pp 8–18

Publication Date (Web): December 22, 2009 (Highlights From Patents)

DOI: 10.1021/op900318s

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Most Cited Articles

Most Cited articles are updated on a monthly basis and available as Last 3 Years and All Time lists. Citation data is made available by participants in CrossRef's Cited-by Linking service. Below is an excerpt from the Last 3 Years list (published across all volumes). For a more comprehensive list of citations, users are encouraged to perform a search in SciFinder.

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Dealing with the Impact of Ritonavir Polymorphs on the Late Stages of Bulk Drug Process Development

Sanjay R. Chemburkar, John Bauer, Kris Deming, Harry Spiwek, Ketan Patel, John Morris, Rodger Henry, Stephen Spanton, Walter Dziki, William Porter, John Quick, Phil Bauer, John Donaubauer, B. A. Narayanan, Mauro Soldani, Dave Riley, and Kathyrn McFarland

Org. Process Res. Dev., 2000, 4 (5), pp 413–417

Publication Date (Web): June 21, 2000 (Article)

DOI: 10.1021/op000023y

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A Scalable Synthesis of Meso-Substituted Dipyrromethanes

Joydev K. Laha, Savithri Dhanalekshmi, Masahiko Taniguchi, Arounaguiry Ambroise, and Jonathan S. Lindsey

Org. Process Res. Dev., 2003, 7 (6), pp 799–812

Publication Date (Web): September 09, 2003 (Article)

DOI: 10.1021/op034083q

Abstract | Supporting Info

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Penicillin Acylase in the Industrial Production of β-Lactam Antibiotics

Alle Bruggink, Eric C. Roos, and Erik de Vroom

Org. Process Res. Dev., 1998, 2 (2), pp 128–133

Publication Date (Web): February 28, 1998 (Review)

DOI: 10.1021/op9700643

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Concepts of Nature in Organic Synthesis: Cascade Catalysis and Multistep Conversions in Concert

Alle Bruggink, Rob Schoevaart, and Tom Kieboom

Org. Process Res. Dev., 2003, 7 (5), pp 622–640

Publication Date (Web): August 16, 2003 (Review)

DOI: 10.1021/op0340311

Abstract | Supporting Info

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Seeding the Desired Polymorph: Background, Possibilities, Limitations, and Case Studies

Wolfgang Beckmann

Org. Process Res. Dev., 2000, 4 (5), pp 372–383

Publication Date (Web): August 26, 2000 (Review)

DOI: 10.1021/op0000778

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Now you can enjoy FREE Web access to the "Editorials" and "Highlights from the Literature" appearing in OPR&D.

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Since 2000, selected issues of OPR&D have been supplemented with Special Feature sections focused on particular topics of interest.

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OPR&D total citations increased to 2,062 in 2008

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