ASMS Technical Progam
Sunday, June 1, to Thursday, June 5, 2008
Denver, Colorado
ORAL SESSIONS ARE LISTED BELOW.
Sunday evening
Tutorial: Interactions of Ions with Surfaces
Tutorial: Metastable Ions
Awards: Presentations of the Thermo Scientific Research Award, the Waters Corp. Research Award, and the ASMS Research Award
Plenary: Improbable Research, Spectrometric and Otherwise
Monday morning
Label-Free Quantitation of Proteins
Workflow checkpoints in label-free quantitative proteomics: an applied biomarker investigation for renal cell carcinoma from tissue interstitial fluid
Differential analysis and annotation of the CHO cytosolic proteome using a label-free LC/MS strategy
Absolute quantification based on ion accounting: technical considerations and biological implications
Refined label-free method for quantitative proteomic genetic linkage analysis
Proteome-wide accurate label-free quantitation of cell lines and tissues
Absolute and relative quantitation of proteins in mouse and rat brains
Fundamentals of Ion/Ion Reactions
Gas-phase bio-ion/ion reactions: hows and whys of reagent selection
Theoretical study of ETD/ECD mechanisms
Charge-state dependence of proton transfer versus electron transfer in a gas-phase ion/ion ETD process on tryptic peptides
Crown ether alkane-1,n-diammonium complexes: electron capture, femtosecond electron transfer, and theory
Ion/ion reactions between chelators and nucleic acid substrates induce gas-phase transfer of metal ions
How to maximize the ETD MS/MS duty cycle for shotgun proteomics
Developments in Ion Mobility: Instrumentation, Theory, and Applications
Ion mobility MS applications and instrumentation
New structural measurement strategies using ion mobility MS
Cryogenic ion mobility MS: theory and applications
Fundamentals of collisional heating and dipole alignment of macromolecular ions in FAIMS and implications for differential mobility analyses
Design and operation of a new high-resolution ion mobility mass spectrometer
S/N gains in digitally multiplexed atmospheric-pressure drift tube ion mobility spectrometry
Challenges in Elemental Analysis Using MS
Elemental analysis of laboratory and ambient organic aerosols using electron ionization MS
Off-line coupling of CE to laser ablation ICPMS for elemental speciation
Xenon as a universal ICPMS collision cell gas via sulfur optimization with application to bottled-water contaminants
Collision/reaction cell ICPMS with shielded-torch and high-resolution ICPMS for the determination of selenium isotope ratios in different matrices
Characterization of an ICP/ESI dual-source TOF mass spectrometer for metallomic and speciation analysis
Imaging MS by LA-ICPMS in life sciences
Discovering Peptide Biomarkers
Class II MHC restricted phosphopeptides as cancer immunotherapeutics or diagnostics
Novel MS immunoassay for the structural characterization of C-peptide within healthy and diabetes mellitus type 2 populations
Neuropeptidomic approaches for specific and sensitive identification of endogenous peptides
Development of independent urinary biomarker panels for differential diagnosis and evaluation of ANCA-associated vasculitis disease activity
Designed by MS: structural reporter peptides for the early diagnosis of invasive aspergillosis
Isoform distribution and reduced levels of apolipoprotein C1 in persons with a T45S polymorphism determined by MALDI TOF profiles
Endogenous Metabolite Profiling
LC/MS approach for comprehensive metabolomics analysis
Absolute quantitation of intracellular metabolites in E. coli
Effects of drought and heat stress combination on Arabidopsis plants: metabolomics analysis
Biochemical mapping of metabolic alterations in lungs of rat embryos
Using metabolomics of animal models to understand complex human biochemistry and disease
Metabolite profiles for phenotyping: lipidomics of twins
MS Characterization of Carbohydrates
Quantitation of glycans for disease marker discovery in breast cancer
Targeted glycomics from high-energy CID MALDI MS/MS to nanospray-based total ion mapping and MSn analysis
Ion mobility separation coupled with negative-ion fragmentation of N-linked carbohydrates
Glycomics approach for characterization of bacterial lipopolysaccharides
Tandem MS analysis of glycosaminoglycan oligosaccharides using EID, EDD, and IRMPD
MS of glycosaminoglycan domain structure
Monday afternoon
Advances in Top-Down Proteomics
What can top-down proteomics do for you?
Optimization of intact protein funnel–skimmer dissociation for FTICR MS
Isotopic resolution MS and MS/MS of intact human serum albumin
Top-down disease proteomics: deciphering protein modifications for understanding and diagnosis of human diseases
Top-down protein characterization: comparison of MALDI TOFMS versus ESI FTMS
Top-down proteomics: the teenage years
Spectroscopy of Gaseous Ions
IR spectroscopy of deprotonated amino acid and peptide anions
Structure of ECD fragments from charge-tagged peptides probed by tunable IRMPD
Implementation of a continuous-wave optical parametric oscillator laser to obtain IR spectra of gaseous ions
Vibrational and electronic spectroscopy of intermediates of methane-to-methanol conversion by transition metal oxide cations
IR and UV spectroscopy of gas-phase helical peptides
IR action spectroscopy of hydrated multiply charged ions in the gas phase
Developments in Ion-Trapping Instrumentation
Optimized image current detection geometry for FTICR MS
Dual reaction cell, ETD-enabled Orbitrap mass spectrometer for top-down proteomics
How far can ion trap miniaturization go?
New mass-independent inlet for introducing massive ions into mass spectrometers without expansion-induced kinetic energy
FTICR MS instrumentation design and development: reduction of ion cloud de-phasing and TOF discrimination
Novel, high-sensitivity cryogenic FTICR MS
Emerging MS Techniques in Environmental Analysis
Real-time detection and identification of aqueous chlorine transformation products using Q-TOFMS
Advances in the identification of environmental degradates using hybrid-FTMS combined with UPLC, IRMPD, and chip-based nanospray
Measurement of methyl-polycyclic aromatic hydrocarbon metabolites in human urine by GC/high-resolution MS
Response of green algae (Chlamydomonas reinhardtii) to environmental stressors, evaluated by high-throughput proteomics
MS of ambient nanoparticles
Chemical ionization MS for measuring gas-phase ammonia
Paradigm Shift in Clinical Diagnostics Using MS
Impact of tandem MS in clinical diagnostics
Neonatal diagnosis of metachromatic leukodystrophy in dried blood spots by tandem MS
Label-free detection of enzyme activities with self-assembled monolayer desorption/ionization TOFMS
High-throughput MRM quantitative targeted proteomics platform for influenza viral particles
Top-down lipidomics screens for assessing metabolic risk in obesity-related disorders
Simultaneous high-throughput detection and characterization of broad groups of respiratory viruses by PCR coupled with high-throughput MS
Quantitation of Drug Metabolites
Metabolite quantification: why and how
Does microdosing produce a metabolic profile indicative of a normal dose in rats?
Rapid approach to quantitative in vivo metabolite profiling without the need for authentic standards or labeled compounds
Quantification of metabolites using chemiluminescent nitrogen detection and MS/MS
Quantitative imaging of cocaine and its metabolites in postmortem brain tissue by intermediate pressure MALDI/linear ion trap tandem MS
Incurred samples investigation: sudden and unusual disappearance of metabolite and its stable-labeled internal standard response during LC/MS/MS GLP bioanalysis
Characterizing Protein–Ligand Interactions with MS
Hydrogen/deuterium exchange characterization of transmembrane signaling proteins
Hyphenation of surface plasmon resonance imaging to MS by on-chip MALDI MS analysis
Functional consequences of conformational changes in the ClpP N-terminus and ligand-driven ClpA hexamer formation: structural MS of a molecular machine
Ion mobility MS reveals subtle stability differences in multiprotein complex ligand assemblies
Protein–ligand binding assay with proteomic potential
Temperature-dependent cooperativity in donor–acceptor substrate binding to the human blood group glycosyltransferases
Award: Recipient of the Award for a Distinguished Contribution in MS
Tuesday morning
Protein Quantitation Using Labeling
Protein quantitation and quantitative proteomics
How reproducible is iTRAQ? Triplicate LC/MS/MS analysis of normal colon tissue tryptic peptides labeled with iTRAQ; 4-plex reagents
Rapid 18O labeling for quantitative proteomics by microwave-assisted enzymatic proteolysis
ANIBAL, stable-isotope-based quantitative proteomics by aniline and benzoic acid labeling of amino and carboxylic groups
Development of defined SILAC media conditions to prevent arginine to proline conversion
High-throughput multiplexed absolute protein quantification
Structure and Energetics of Metal Ions Reacting with Biomolecules
Versatility of MS applied to metal–biomolecule interactions
Structure of metal–biomolecule complexes probed by ion mobility methods
IRMPD spectroscopy of doubly charged metal ion/tryptophan complexes
Structures of hydrated metallated DNA bases by IRMPD spectroscopy
IRMPD spectroscopy of cationized serine and threonine: effects of alkali-metal cation size on gas-phase conformation
Interaction of lead(II) ions with 5′-mononucleotides: tandem MS and IRMPD spectroscopy
Novel Developments in MS Instrumentation
Application of superconducting detectors to ionization cross-section measurements of doubly charged monoisotopic diatomic molecules
Current-controlled nanospray for the analysis of less-than-ideal samples
Low-temperature plasma probe for ambient desorption ionization
Reverse-Taylor-cone ESI for transient imaging in solution
Novel MALDI ion trap MS for large biomolecule detection
Nanostructure-initiator MS for metabolomics and enzyme activity profiling
Role of MS in the Petroleum Field
Petroleomics: chemistry from the underworld
Moving toward accurate molecular compositions of petroleum products using ion mobility MS
Analysis of asphaltenes by laser-induced acoustic desorption/FTICR MS
Atmospheric-pressure laser-ionization FTICR MS: new approach to analyze nonvolatile components from complex crude-oil mixtures
Combining chip-ESI with APLI as a multimode source for the analysis of complex mixtures with ultrahigh-resolution MS
Elemental MS (ICPMS) detection and µHPLC for speciation analysis of metals in petroleum
Disease Protein Biomarker Discovery by MS
Progress toward a biomarker discovery-to-development pipeline in clinical proteomics
Proteomic analysis of lung tumor tissue interstitial fluid for biomarker discovery
Using proteomic tools to identify markers of fatty liver disease
Processing of urinary proteins as biomarkers for diabetic complications
Combining MALDI FTMS, comparative glycoproteomics, and bioinformatics for the discovery of biomarkers in prion disease
Absolute protein quantitation for biomarker studies in cancer cell lines: discovery, verification, and database compilation
Identification of Reactive Metabolites in Drug Discovery: Significance of MS toward Detection
High-throughput screening and characterization of reactive metabolites using polarity switching of hybrid triple-quadrupole linear ion trap MS
UHPLC/MS/MS with on-line fraction collection in glass-coated plates: advantages for reactive metabolite profiling in the drug development process
Generation and identification of reactive metabolites and protein adducts by electrochemistry coupled on-line to LC/MS
Detection and identification of depurinating DNA adducts by electrophilic metabolites of p-cresol and its related 4-alkylphenols from Prempro
Ultrasensitive glutathione conjugate screening in biological samples using accurate mass measurement
Novel methodology for screening reactive metabolites using isotope pattern filtering of high-resolution MS data
Biological Applications of Chemical Cross-Linking
Ionic cross-linking reagents and multistage tandem MS for mapping protein–protein interactions
Novel collision-induced dissociative chemical cross-linking reagents and methodology to characterize protein–protein interactions using tandem MS
Novel subunit-specific protein footprinting method reveals HIV integrase contacts with viral DNA
Profiling protein–protein interactions in vivo by cross-linking and MS
Identification of cross-linked peptides in proteomic-scale experiments
Identification of cross-linked peptides by an open-modification search tool
Tuesday afternoon
Role of MS in Understanding Cellular Pathways
Charting cellular pathways and networks using MS
Proteomic insights into autophagosomal composition
Protein profiling of specific synapses in specific cell types in the mammalian brain
Integrated mouse genetic–proteomic approach to uncover and characterize novel protein complexes and their involved cellular pathways in living animals
Protein and phosphorylation expression at the synapse
Signaling pathways driving the differentiation of neural stem cells
Fundamentals of Ion–Surface Interactions
Deciphering protein–protein assemblies: just hitting the surface
Immobilization of α-helical peptides on self-assembled monolayer surfaces using soft landing and reactive landing of mass-selected ions
Reactive and soft landing of horseradish peroxidase cations on in situ plasma-treated dry metal surfaces
Control of chemical bond scission by site-specific core excitation of ester-terminated self-assembled monolayer
Directed energy deposition in laser desorption/ionization from laser-induced silicon microcolumn arrays
SIMS on nano-objects: evidence of sample-size-dependent secondary ion response
Developments in TOF
New MALDI TOFMS with very high resolving power and mass accuracy
Automated de novo sequencing of complex peptide mixtures by LC/MALDI photodissociation TOF-TOFMS
Accessing collision energies of up to 500 V per charge on a Qq-TOF instrument: structure characterization of fullerenes and large peptides
New API-Qq-TOF mass spectrometer with ultrahigh mass resolution and mass accuracy at high scan speed
Effects of background gas type and pressure on the fragmentation of laser-generated ions in an elevated-pressure MALDI ion source
Nanosecond time-resolved ion imaging system
Pharmaceutical Drugs as Environmental Pollutants
Pharmaceuticals as environmental pollutants: analysis
Direct, trace-level, environmental drug residues analysis by Orbitrap MS
Identification of new biodegradation products of atenolol and glibenclamide in sewage sludge by UPLC/Qq-TOF and HPLC/Qq-LIT
Illicit drugs from wastewaters to tap water? A UPLC/MS/MS study
Determination of steroid hormones in environmental samples by GC/MS/MS with isotope dilution
Analysis of emerging contaminants in drinking water by on-line SPE/LC/MS/MS
H/D Exchange and Protein Folding
Resolving protein-folding mechanisms with MS
Probing the conformation and dynamics of a monoclonal antibody by H/D exchange MS
Conformational dynamics of Hsp90 chaperones measured by amide hydrogen exchange MS
Conformational consequences of covalent modification of protein pharmaceuticals under stresslike conditions: ESI MS study of interferon β
Structural mechanism of HK97 capsid expansion monitored by X-ray crystallography and H/D exchange coupled with MS
Are the conformational dynamics of enzymes enhanced during catalytic turnover? H/D exchange ESI MS study
Biomarker Applications in the Clinical Setting
Prognostic significance of head-and-neck cancer biomarkers previously discovered and identified using iTRAQ labeling and multidimensional LC/tandem MS
Concurrent proteomic profiling of human tissues and peripheral blood specimens for cancer biomarker discovery
Evaluation of performance characteristics of peptide immunoaffinity enrichment for protein quantitation using a panel of candidate cancer biomarkers
Lectin glycoarray platform for biomarker discovery in colon cancer
Breath analysis as a method for breast cancer detection
Identification and validation of a Tamoxifen-therapy-response protein profile in breast cancer by nanoLC/FTICR MS
Advances in the Characterization of Glycoproteins
IDAWG: in vivo isotopic labeling of glycans for comparative glycomics/glycoproteomics
Tags with a unique isotopic signature for glycoprotein identification and quantitation by MS
Integrated methodology for proteomics analysis of glycoproteins
Dynamic analysis of protein N-glycosylations in complex samples using LC/tandem MS
Differential analysis of influenza hemagglutinin glycosylation by LC/MS/MS
Mining the plasma glycoproteome for epithelial ovarian cancer biomarker discovery
Award: Recipient of the Biemann Medal
Wednesday morning
New Approaches to Metabolomics
Structural annotation of small molecules by MS libraries, substructure information, and accurate mass GC/MS data
Spatially resolved and integrated transcriptomics, proteomics, and metabolomics of Medicago border cells
mzROCK: automating analysis of targeted metabolomics data
Neurometabolomics, a cell at a time
High-throughput and exhaustive analysis of diverse lipids by using SFC/MS for metabolomics
Novel global, nontargeted metabolomics platform utilizing UPLC and MS/MS spectral library matching for rapid compound identification
Fundamentals and Applications of Ion Activation: Alternatives to CID
Intercluster chemistry of cationic betaine clusters upon CID and electron-induced dissociation
Peptide fragmentation induced by low-temperature plasma-activated surface
[60]Fullerene complexes and fullerene reversible hydrogenation studies in the gas phase
Kinetics of surface-induced dissociation of N(CH3)4+, N(CD3)4+, and substituted benzyl-pyridinium ions using silicon nanoparticle assisted laser desorption/ionization
Characterization of ECD of multiply charged proteolytic peptides from Lys N, Lys C, and Glu-C digestion
Enhancement of photodissociation in a quadrupole ion trap by selective derivatization strategies
New Developments in Hybrid MS/MS Instruments
Parts-per-billion mass accuracy for proteomic studies: toward zero mass error with broadband FTICR MS analysis
ECD in an rf ion trap versus FTICR MS
MALDI-produced ions inspected with a linear ion trap–Orbitrap mass analyzer
Decision-tree-driven tandem MS for shotgun proteomics
Using dynamic ejection of high-abundance ions to enhance the dynamic range of LTQ-FT proteomics measurements
Alignment and combination of LC/MS and LC/MS/MS data sets in bottom-up proteomics
Imaging of Polymers/Materials and Surfaces
Imaging samples via molecular printing
Bringing imaging MS from biology to synthetics
PDMS transfer in microcontact printing as a contrast agent for TOF SIMS imaging
Construction of complex 2D and 3D molecular devices: combined TOF SIMS and electron microscopy studies
Human fingerprint imaging by direct laser desorption MS
Functional nanomaterial arrays for imaging LDIMS of biomolecules and pharmaceuticals
LC/MS Techniques for Discovering Biomarkers of Toxicity and Efficacy
Discovery and translation of biomarkers for early clinical development studies
Proteomics: from basic research to the clinic
Protein damage by reactive electrophiles and its consequences
Targeted and robust analysis of the plasma metabolome using automated sample preparation and fast FIA/MS
UPLC/MS for the investigation of galactosamine-mediated liver damage through specific serum bile acid changes
Monitoring changes in drug-to-antibody ratio distributions of antibody drug conjugates in vivo by affinity MS
Protein Gas-Phase Structure
From solution to gas phase: how protein structure evolves after desolvation
Gas-phase protein structure: biological significance and comparison with X-ray and NMR measurements
Structural and functional analysis of viral protein complexes by native MS
Fluorescence quenching mechanism of dye-derivatized peptides: experiment and simulation
Amino acid nature role in electron capture/transfer dissociation of peptides: primary versus secondary structure effects
Gas-phase small-angle X-ray scattering from trapped ions
Applications of Ion Mobility Spectrometry
Overtone mobility spectrometry
Profiling histone modifications in response to HDAC inhibitors using FAIMS on an Orbitrap mass spectrometer
Aggregation in amyloid systems: amylin peptide in diabetes type 2 using IMS/MS methods
High-throughput proteomics platform based on ion mobility TOFMS
Coulombic denaturing of gas-phase proteins electrosprayed from neutral aqueous solutions studied by IMS (DMA) MS
Role of charge state on protein conformation and protein complexes probed by IMS and MS
Wednesday afternoon
Characterization of Membrane Proteins
Posttranslational modifications in transmembrane domains of integral membrane proteins resolved by top-down FTMS
Identification of posttranslationally modified membrane proteins in HEK293 cells
Proteomic pipeline for the topology of integral membrane proteins: leucine and dopamine transporters
Global topology analysis of pancreatic zymogen granule membrane proteins
Automated analysis of complex protein mixtures using on-line digestion prior to µLC/MS/MS
Maximizing protein identification efficiency in 2D-LC/ESI-Q-TOFMS/MS for large-scale membrane proteomics
Understanding Peptide Fragmentation: Theory and Experiment
Peptide ion fragmentation mechanisms: an overview
Surface-induced dissociation of peptide radical anions
Probing H atom transfer and fragmentation of a model peptide using tandem MS and density functional theory
Peptide fragmentation modeling from low-energy CID data through the use of an iterative database search
Effect of phosphorylation on the electron capture dissociation of peptide ions
To B or not to B: unique fragmentation chemistry of β-alanine and its peptides
Developments and Application of APPI
APPI for LC/MS: state of the art and future prospects
Unique high-sensitivity approach to quantitatively resolving steroids in plasma
Photoionization at atmospheric pressure: interaction between UV radiation with a spray of biomolecules
Trace-level analysis of nitroaromatics and nitroamines by LC/negative-ion APPI MS
Single-drop laser ionization combined with ultrahigh-resolution MS
CE/MS through APPI: achieving mixed-mode ionization on a single-mode source
MS in Biodefense
Detection, differentiation, quantification, and subtyping of botulinum neurotoxins with MS
Intact protein LC/MS for bacteria strain differentiation and bacterial toxin detection
Top-down analysis of biological threat agents using DESI and ETD MS
Atmospheric-pressure MALDI MS/MS-based high-throughput automated multiplexed assay system for rapid detection and identification of bioagents
Metaproteomic approach for phylogenetic classification of bacterial mixtures using LC/MS/MS analysis of tryptic peptides and SEQUEST outputs
Simultaneous detection and characterization of multiple bacterial and viral bioweapons agents in a multiplexed PCR assay with high-throughput ESI MS
Lipid Analysis by MS
Systems biology approach for molecular characterization of the S. cerevisiae lipidome
Lipidome profiling with IMS/MS
Modulation of glycolipidomics of NS11 glioblastoma stem cells after induced differentiation
Novel and flexible LC/MS/MS-based enzymatic assay to analyze activity and substrate preference of lysophospholipid acyltransferases
Formation of oxidized bioactive lipids during carcinogen activation by human lung cells
Imaging MS of electrophoretically separated membrane-bound species
Metabolites and Degradation Products of Environmental Contaminants
Environmental contaminants that degrade in the environment: do they really disappear?
Investigations of the metabolism of fluorinated alkylsulfonates utilizing different LC/MS/MS methods
Analysis of pesticides and their metabolites in environmental samples by LC coupled to TOFMS
Accurate mass databases for comprehensive screening of pesticide residues in food by LC/TOFMS
Analysis of polar organic compounds in surface waters collected near lead–zinc mine and milling operations by ESI MS
Identification of PBDE 47, 99, and 153 metabolites from human liver microsomes by GC/MS
Imaging MS for Small-Molecule Applications
Imaging MS for the investigation of individual small-molecule tissue distributions
Strategies for small-molecule imaging by MALDI MSI
Imaging drugs and metabolites in tissue using FTMS
Imaging MS of mouse lung following ozone exposure
2D and 3D molecular imaging of live tissues by IR laser ablation ESI MS
UV-LDI-o-TOFMS imaging of hydrocarbons from single, intact fruit flies
Thursday morning
Novel Applications of Bioinformatics
Validation and expansion of the Arabidopsis gene annotation
Comparative proteogenomics: combining MS and comparative genomics to analyze multiple genomes
Identification of dominant signaling pathways from independent proteomics expression data sets
Unique ion signature MS: a deterministic method for peptide identification and its implications
Measuring run-to-run and lab-to-lab variability in shotgun proteomics experiments
Dimensionality reduction and visualization in principal component analysis as applied to an LC/MS metabolomics study
Metal-Ion-Activated Dissociation
Key issues in metal-ion-activated dissociation
ECD and CID of metal/peptide complexes
Gas-phase activation study of the coordination of lead dications with amino acids
Dissociation studies of alkali metal cation complexes of aspartic acid, glutamic acid, asparagine, and glutamine
Sodium induces unimolecular decay pathways in the metastable decay of protonated oligonucleotides in the gas phase
Mg(I) reagent anion, [MgCl2]·–, forms coordinated ketyl radical anions which fragment via radical-driven pathways
Ion Trap Applications
Data-independent outperforms data-dependent gas-phase fractionation-based shotgun proteomics
Dinosaur sequences and their evolutionary tale
Multistage-fragmentation analysis for phosphopeptide identification on an ion trap mass spectrometer
New approach to IR multiphoton photodissociation for controlled dissociation in a quadrupole ion trap mass spectrometer
Investigation of gas-phase reactions of charged aromatic s,s-biradicals with dipeptides in a FTICR mass spectrometer
Slow energy transfer: fluorescence and spectrometry study of rhodamine 575 cations confined to a Paul trap
Structural Biology and Biophysics of Nucleic Acids
Approaches, applications, and future directions in the structural biology and biophysics of nucleic acids as studied by MS
DNA-mediated ref1 conformational changes: possible mechanism for protein recruitment in base excision repair pathway
Modeling stable conformers of the 5′ noncoding region of HIV-1 genome using sparse constraints provided by MS-based strategies
Top-down analysis reveals a complete subunit interaction map for the 13-subunit eIF3 complex and its interaction with RNA
Influence of zwitterions on salt bridge stabilization on single- and double-stranded DNA/peptide complexes
IR and UV spectroscopic signatures of DNA higher-order structures in the gas phase
Characterizing PTMs
Mapping protein PTMs with MS
Phosphoproteome analysis of the tumor suppressor SYK induction in breast cancer cells by a novel soluble nanopolymer-based phosphopeptide enrichment method
Efficient identification of phosphorylation by MS phosphopeptide fingerprinting
PTMap—software for identifying full-spectrum PTMs with high accuracy and low false positives
Unbiased and comprehensive mapping of chromatin PTMs and simultaneous determination of in vivo methylation kinetics
Analysis of ADP-ribosylated peptides using electron capture dissociation high-resolution MS and ion mobility analysis
Increasing Throughput for Pharmacokinetic Assays through MS
Strategies for increasing throughput when using LC/MS/MS for PK assays: short overview
Improving the reproducibility and practicability of DART for the direct quantification of drugs in biological fluids
Full-scan data acquisition for rapid quantitative and qualitative analysis using a benchtop nonhybrid ESI-Orbitrap mass spectrometer
Opportunities in the evolution of multiplexed LC/MS/MS assay methodology for increased PK/PD productivity
Using MALDI triple-quadrupole MS for the high-throughput quantitative analysis of antidepressants in plasma
SPE-enhanced desorption ESI
Analyte Fingerprinting with No Sample Prep
Extractive ESI MS in metabolomics and medical diagnostics
Identifying materials, formulations, and other complex substances by direct analysis and exact mass measurements
Endogenous metabolites excreted through the skin analyzed by geometry-independent desorption ESI
Real-time MS monitoring of a continuous-flow microreactor for organic synthesis optimization
Development of a new ionization source: liquid MALD ESI and investigation of the mechanism
Fingerprinting quality control of media for in vitro bovine embryo production using direct-infusion automated chip-based nano-electrospray MS
Thursday afternoon
New Developments in Bioinformatics
RAId_DbS: peptide identification with knowledge integration using database searches with realistic statistics
Peptide fragment mass information required to identify peptides and their PTMs
Combining peptide identification results
Statistical approach to quantifying uncertainties in the AMT tag pipeline
Quantification of correlations within and between imaging MS data sets
Knowledge Exchange KnowEX: sharing resources for data-intensive collaborative MS projects in the Amsterdam Virtual Laboratory
Polymer/Material Ionization and Structural Elucidation
Reactive MALDI MS of polyolefins
Surface-mediated laser desorption/ionization TOFMS of low-molecular-weight polymers
ESI MS studies of exchange mechanisms in zeolite precursors: isomorphous substitution of silicon against germanium or gallium
Polymers, polymer additives, and petroleum by the ASAP method on Synapt and Orbitrap mass spectrometers
Characterization of in-chain functionalized copolymers by tandem MS
Utilizing ion mobility and tandem MS for the characterization of polyethers
Developments in Imaging Instrumentation and Methodology
Ion mobility imaging MS: new tool for in situ identification
Laser desorption and VUV postionization imaging TOFMS
Toward nanoscale chemical imaging: investigation of tip-enhanced, near-field optical methods for desorption/ionization MS at atmospheric pressure
MS imaging of MRI contrast agents in histopathological sections
Development of fundamental technology for phosphoimaging MS
Specific MALDI imaging: missing link that brings MALDI imaging to biomolecules validation
Characterizing DNA, RNA, and Adducts
MS for DNA and RNA adduct analysis: overview
Noncovalent adducts of small-molecule ligands affect the stability of conformer-specific interactions in HIV-1 5′-UTR
Developing approaches for quantitative LC/MS/MS of nucleic acids
Adenosine methylations of ribosomal RNA characterized by ion trap nanoLC/MS3
Stable-isotope-labeling HPLC/ESI-MS/MS approach to investigate DNA sequence preferences for the formation of oxidative DNA lesions
Analysis of the formation and mutagenesis of N2-(1-carboxyethyl)-2′-deoxyguanosine in vivo by LC/MS/MS
Ionization and Characterization of Macromolecules and Complexes
Modularity of the human signalosome complex revealed by MS
Influence of small-charge carrier field emission on the charge states of proteins in ESI
Characterization of 800 kDa macromolecular complexes from HeLa cells: effects of collision activation and solvent disruption using ion mobility MS
Identification of proteins essential for human telomerase function using affinity purification and MS
Combined covalent labeling methods for studying β2m oligomer assembly by MS
Structure analysis of acrylic copolymers by LC/MSn
Matrix Effects: LC/MS Challenges and Solutions
Matrix effects in LC/MS/MS analyses of biological samples
Study of the matrix enhancement of streptomycin?s electrospray LC/MS response in honey extracts
Reduction of ion suppression and interference using turbulent-flow chromatography and FAIMS for drug discovery bioanalysis
Ion suppression due to the locking solution used in the cannulation of rodents
Sample matrix effects in quantitative small-molecule MALDI MS
High-throughput LC/IMS/MS platform for sensitive and quantitative proteomics analysis
Application of ETD/ECD
New trends in ECD/ETD applications
LC/tandem MS using ion-trap-based ECD
ETD has a sweet tooth: MS method for characterizing O-GlcNAc sites on a chromatographic timescale
ECD beyond proteomics: application to phosphate-containing metabolites via metal adduction
Toward full proteomics coverage of RNA polymerase II and III using a combination of multiple proteases and multiple MS/MS techniques
On-line LC ECD for phosphoproteomics
Plenary: Beauty of Beer: Sublime Science Meets Art and Humanity
ASMS Poster Sessions
Monday, June 2, to Thursday, June 5, 2008
Monday
Instrumentation: new concepts I
Direct ionization I
Instrumentation: ion sources, ESI-related
APPI
Ion structures/energetics I
Environmental analysis
Atmospheric/aerosol chemistry
Imaging MS for small molecules and lipids
Computer applications: general
Homeland security
Small-molecule analysis: pharmaceuticals
Quantitation of small molecules: pharmaceutical focus
Toxicology
Drug metabolism: high throughput
Drug metabolism: xenobiotic metabolite profiling
Metabolomics I
Peptides: quantitation
Peptides: fragmentation
LC/MS sample prep: protein analysis
Phosphoproteins: characterizations
PTMs: histones
Proteins: cross-linking
Proteins: membranes
Protein conformation
Protein quantitation I
Protein sequencing
Proteomics: plasma
Proteomics: new approaches for sample preparation
Proteomics: biomarker discovery I
Proteomics: clinical applications
Bioinformatics I
Systems biology: quantitative
Tuesday
Instrumentation: FTMS
Direct ionization II
MALDI: sample prep
MALDI/tandem MS
ECD/ETD/EDD
Emerging contaminants I
Imaging MS instrumentation and sample prep
High-throughput analysis/robotics
Carbohydrates/oligosaccharides: general
Lipids: biochemistry and steroids I
Lipid structural analysis
Noncovalent interactions I
Microbial analysis
Small-molecule analysis: biologically relevant compounds
Quantitation of small molecules/plasma matrix
Drug metabolism: pharmacokinetics
Drug metabolism: quantitation I
Drug metabolism: accelerating metabolite identification
Metabolomics II
Neuropeptides
Peptides: general
Peptides: sequencing
LC/MS sample prep: phospholipid removal
Phosphoproteins: methods
PTMs: methylation, acetylation, glycosylation, ubiquitination
Proteins: general I
Protein conformation: oxidative and covalent labeling
Protein quantitation II
Proteins: modified, methodology and in vitro modifications
Proteomics: new approaches to data analysis
Proteomics: biomarker discovery II
Bioinformatics II
Systems biology: discovery
Wednesday
Instrumentation: TOF
Instrumentation: quadrupoles and traps I
Ion mobility
Elemental analysis and speciation
Agriculture
Ion activation
Ion molecule reactions I
Emerging contaminants II
Hydrocarbon and petrochemical
Imaging MS proteins and peptides
Computer applications: proteomics
Materials and polymers
Carbohydrates/oligosaccharides: structural characterization
Noncovalent interactions II
Nucleic acids
LC/MS I
Clinical chemistry: small molecule
Small-molecule analysis: data processing/instrumentation
Quantitation of small molecules
Immunology
Drug metabolism: quantitation II
Drug metabolism: reactive metabolites
PTMs: sulfation, nitration, and strategies
Phosphoproteomics
Proteins: glycoproteins
Protein conformation H/D exchange I
Protein quantitation III
Proteins: modified, biological applications
Proteomics: biomarker assays I
Proteomics: new approaches to instrumentation
Proteomics: biomarker discovery III
Bioinformatics III
Systems biology: interactions
Thursday
Instrumentation: new concepts II
Instrumentation: quadrupoles and traps II
Ion mobility applications
Instrumentation: ion sources general
Ionization mechanisms
Ion structures/energetics II
Ion molecule reactions II
Analysis of pesticides and herbicides
Natural products
GC/MS
Forensics
Microscale separation MS
Carbohydrates/oligosaccharides: biomarker discovery
Lipids: biochemistry and steroids II
LC/MS II
Clinical chemistry: large molecules
Small-molecule analysis: food-related and other
Quantitation of small molecules/bioanalysis
Metabolomics III: methods
Peptides: glycopeptides
LC/MS sample preparation
Phosphopeptide enrichment
PTMs: deamindation, disulfides
Proteins: general II
Proteins: recombinant
Protein conformation H/D exchange II
Proteins: general, methods
Proteomics: biomarker assays II
Proteomics: applications
Proteomics: biomarker discovery IV
Proteomics: tissue
Bioinformatics IV
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