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June 4, 2008

The twin toxics: nanotubes and asbestos

A new study shows that carbon nanotubes that look like asbestos can cause similar health effects.

Corrections were made to this story on June 9, 2008 regarding observed health impacts of nanotubes.

Sales of carbon nanotubes could reach $2 billion annually within the next 4 years, according to forecasting firms, but a new study suggests caution and more research on human exposure and health impacts.
PROJECT ON EMERGING NANOTECHNOLOGIES
Sales of carbon nanotubes could reach $2 billion annually within the next 4 years, according to forecasting firms, but a new study suggests caution and more research on human exposure and health impacts.

Like other nanomaterials, tiny but strong-as-steel carbon nanotubes are touted as this century's wonder materials. Researchers and manufacturers expect these nanomaterials to usher in a new era of drugs, high-efficiency batteries, and exciting electronics. But scientists fear that some nanotubes' striking resemblance to asbestos also implies a likelihood of asbestos-like impacts on humans. A new study published in Nature Nanotechnology on May 20 indicates that these fears may be well founded. It shows that the materials can induce precancerous growths in mice.

In the study, Ken Donaldson of the University of Edinburgh (U.K.) and his colleagues exposed the mice to 50 micrograms of multiwalled carbon nanotubes by injecting the nanotubes into the mice's abdominal cavities. The effects—inflamed mesothelium (a membrane that lines many organs, including lungs), development of lesions, and precancerous masses called granulomas—were similar to those that precede mesothelioma, a known health hazard caused by inhaling asbestos over an extended period of time.

The study "really confirms that the fiber hypothesis applies to carbon nanotubes," says coauthor Andrew Maynard of the Woodrow Wilson International Center for Scholars Project on Emerging Nanotechology. According to this hypothesis, fibers that are long, thin, straight, and durable have similar effects on the body, regardless of whether they are made of asbestos or carbon atoms, Maynard adds.

The results provide evidence of potential harm if people are exposed to carbon nanotubes in sufficient quantities. But the study cannot say whether people will be exposed and, if so, under what conditions. "That's one of the big unknowns here that's really got to be addressed as fast as possible," says Maynard. Still, the results show the need for more research on exposure scenarios, the health effects of nanomaterials, and guidelines from industries and regulators for "working as safely as possible with these materials," he adds. RHITU CHATTERJEE

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