Bringing life to center stage (HTML) by Randall C. Willis PDF version (196 KB) Efforts to expand on various forms of live-cell and whole-body imaging are coming from many directions. Engineers are designing microscopes and cameras to handle an array of sample types and sizes, while chemists and biologists are developing more versatile fluorescent and luminescent probes. Ultimately, their success hinges on providing useful information in the context of life. Pushing the frontiers of diagnosis (HTML) by Randall C. Willis PDF version (96 KB) Molecular analyses are improving medical odds as clinicians join with scientists and engineers to develop tests to speed up diagnosis and improve prognosis. Among the approaches being explored in the growing clinical diagnostics area are microscopy, GC, MS-MS, reverse-transcriptase PCR, and the identification of serum and gene expression biomarkers. Download the "New Frontiers of Diagnosis" poster (200 KB PDF) Targeting the transcriptome (HTML) by Jeffrey Augen PDF version (228 KB) A genome-centric view of molecular biology is slowly being replaced by a broader systems view. An important aspect of this will be a comprehensive understanding of the transcriptome, or transcriptional state of all genes involved in a metabolic profile. And researchers are using new methods, including microarrays, SAGE, and MPSS, to scan a broad range of cellular messages.

On the Calendar
Microplates and MS (64 KB PDF)
Find out what’s new in microplates and mass spectrometry.

Product Info Now (HTML)

Diseases and Disorders
Body dysmorphic disorder (60 KB PDF)
by Felicia M. Willis

Content in Context
What lies beneath (28 KB PDF)
by Ann M. Thayer

New and Noteworthy (232 KB PDF)
Stem cells have a heart • SARS in the sights • Microfluidics: Cheaper and easier • FDA: More with less? • Lilly joins Sirna in RNAi • Nonprofit drug development • Quantum dot toxicity? • Nanofiber brain probes

Focus on Business

	Marketplace, deals, and people (56 KB PDF)
	Industry earnings on an uptick (52 KB PDF) by Ann M. Thayer Leading pharma and biotech firms grew in 2003.
	Antibiotic: Is it or isn’t it? (56 KB PDF) by David Filmore The answer could mean a lot for some companies’ profits.

People and Perspectives
The discovery doldrums (64 KB PDF)
by Randall C. Willis
NCEs are coming slowly; JÙrgen Drews explains why.

The Time Line
Memories of Mannheim (80 KB PDF)
by Richard A. Pizzi
Roche took the lead role in diagnostics by absorbing an historic innovator.

Sites and Software
Gene expression learned (76 KB PDF)
by David Filmore
ñSupervisedî statistical techniques are gaining popularity for microarray analysis.

The Tool Box
Benchtop cell-health monitoring (76 KB PDF)
by Lawrence Lem and Keith Olson
A baseline for cell-based screening assays

Rules and Regulators
HIPAA and human tissues (108 KB PDF)
by Alan L. Jakimo and Karen Owen Dunlop
A framework for applying the new privacy regulations in drug R&D

Clinical Trials Track
Enlisting apoptosis (68 KB PDF)
by Mark S. Lesney
Histone deacetylase inhibitors that trigger cell death are the subjects of several cancer clinical trials.

For Your Health
Strand by strand (72 KB PDF)
by Julie L. McDowell
Hair loss afflicts millions of men and women.

Ready to Read (76 KB PDF)

	Protecting America's Health Reviewed by Randall C. Willis [Buy from Amazon.com]
	Introduction to Macromolecular Crystallography Reviewed by Timothy C. Umland [Buy from Amazon.com]

Affymetrix
3380 Central Exwy.
Santa Clara, CA 95051
888-362-2447, 408-731-5441
www.affymetrix.com

Agilent Technologies
395 Page Mill Rd.
Palo Alto, CA 94303
800-227-9770, 302-633-8901
www.agilent.com/chem

Albemarle Corporation
866-361-9993
www.albemarle.com

Alfa Aesar
26 Parkridge Rd.
Ward Hill, MA 01835
978-521-6300, 978-521-6350
www.alfa.com

Applied Biosystems
850 Lincoln Centre Drive
Foster City, CA 94404
650-638-5800, 650-638-5884
www.appliedbiosystems.com

Biacore, Inc.
200 Centennial Ave.
Suite 100
Piscataway, NJ 08854
800-242-2599, 732-885-5669
www.biacore.com

Bio-Rad Laboratories
1000 Alfred Nobel Dr.
Hercules, CA 94547
800-424-6723
www.biorad.com

Brinkmann Instruments
One Cantiague Rd.
Westbury, NY 11590
800-645-3050, 516-334-7506
www.brinkmann.com

Bruker Biospin Corp.
15 Fortune Dr.
Manning Park
Billerica, MA 01821
978-667-9580, 978-667-0985
www.bruker-biospin.com

Cellomics
100 Technology Dr.
Pittsburgh, PA 15219
412-770-2200, 412-770-2201
www.cellomics.com

CEM Corporation
3100 Smith Farm Rd.
Matthews, NC 28106
800-726-3331, 704-821-8710
www.cemsynthesis.com

Ciphergen Biosystems, Inc.
6611 Dumbarton Circle
Fremont, CA 94555
888-864-3770, 510-505-2101
www.ciphergen.com

Dionex
1228 Titan Way
Sunnyvale, CA 94088-3603
408-737-0700, 408-730-9403
www.dionex.com

Eppendorf AG
Barkhausenweg 1 22331
Hamburg, Germany
+49-40-53-8010, +49-40-53-801-556
www.eppendorf.com

Gateway Chemical Technology
11810 Borman Dr.
Saint Louis, MO 63146
314-220-2691, 314-991-2834
www.gatewaychemical.com

Gene Express, Inc.
975 Research Dr.
Toledo, OH 43614
419-380-9930, 800-820-8343
www.geneexpressinc.com

Gene Logic
708 Quince Orchard Rd.
Gaithersburg, MD 20878
301-987-1700, 301-987-1701
www.genelogic.com/toxscreen

IBC Life Sciences
One Research Dr.
Ste. 400A
Westborough, MA 01581
508-616-5550, 508-616-5522
www.lifesciencesinfo.com

J-Kem Scientific
6970 Olive Blvd.
St. Louis, MO 63130
800-827-4849, 314-863-6070
www.jkem.com

MWG Biotech AG
Anzinger Strasse 7a
D-85560
Ebersberg bei Munchen
Germany
08092-8289-0, 08092-21084
www.the-mwg.com

NoAb Biodiscoveries, Inc.
2820 Argentia Rd.
Unit 8
Mississauga, Ontario
Canada L5N-8G4
866-729-6622
www.noabbiodiscoveries.com

Pall Life Sciences
600 South Wagner Road
Ann Arbor, MI 48103
800-521-1520, 734-913-6114
www.pall.com

Pierce Biotechnology
P.O. Box 117
Rockford, IL. 61105
800-874-3723, 800-842-5007
www.piercenet.com

Preanalytix
1 Becton Drive
Franklin Lakes, NJ 07417
201-847-5343, 201-847-4851
www.preanalytix.com

Thermo Electron Corp.
81 Wyman St.
Waltham, MA 02054
781-622-1000, 781-622-1207
www.thermo.com

Treff AG
Taastrasse 16 CH-9113
Degersheim Switzerland
+41 (0) 713725555, +41 (0) 713725646
www.treff-ag.ch

Waters Corporation
34 Maple Street
Milford, Massachusetts 01757
800-252-4752, 508-872-1990
www.waters.com