Animal models of disease by Chaoyong Ma PDF version (192 KB PDF) In vivo assays are not usually performed until or after lead optimization is complete. This is partly due to the low speed and high cost of conventional animal models (typically rodents) and the relatively high number of preliminary hits from HTS. With alternative small-animal models emerging, however, it is now possible to perform in vivo testing earlier in the process. Thus, researchers have developed model systems using both invertebrates (the fruit fly and the nematode) and vertebrates (zebrafish) for drug screening. The small size, high fecundity, and experimental tractability of these animals enable cost-effective and rapid screening of numerous compounds. Automating R&D by Kimberly S. Cleaves PDF version (152 KB PDF) Drug discovery is now predicated on automated instrumentation, experimentation, and analysis. For example, the race to map the human genome helped drive the need for robotic and automated methods in gene sequencing and data handling. R&D in pharmaceuticals, genomics, proteomics, and molecular diagnostics relies on automated technologies. America’s biotech heartland by Randall C. Willis PDF version (108 KB PDF) Milwaukee and Madison are just two of the centers of scientific excellence in Wisconsin, which is rapidly expanding its role in America’s biotech industry.

The Tool Box
Lipomic profiling, profiled (72 KB PDF)
by Amy Adams and Jan Kingsbury
In functional genomics, toxicology, and drug discovery, knowing the full breadth of lipid metabolism can help.

Ready to Read (64 KB PDF)
Mavericks, Miracles, and Medicine
Reviewed by Randall C. Willis
[Buy from Amazon.com]

Product Info Now (html)

On the Calendar
DDT 2004 (56 KB PDF)
A Boston perennial for drug scientists

Content in Context
Watercooler talk (32 KB PDF)
by Ann M. Thayer

New and Noteworthy (88 KB PDF)
IBM activities • Inhibiting autoimmunity • On the critical path • FDA: Increasing interaction, selectively • Meeting for minds • Profiling Parkinson’s • SPEEDy siRNA • Delivering a nuclear payload

Focus on Business

	Marketplace, deals, and people (56 KB PDF)
	Looking for value (56 KB PDF) by Randall C. Willis In developing next-generation technology platforms, many biotech companies have forgotten to generate equity.
	Blockbuster model breaking down (60 KB PDF) by Ann M. Thayer Pharma industry reaches new sales peak, despite rising costs and bigger challenges for drug R&D.

People and Perspectives
Moving from drugs to medicine (48 KB PDF)
by Randall C. Willis
By following a systems approach, researchers and clinicians move toward predicting and preventing disease.

Diseases and Disorders
Cystic fibrosis: Pipeline of promise (68 KB PDF)
by Linda Richards
After more than a decade of work, drugs help, but a real cure is still a decade away

Rules and Regulators
Arrays and the FDA (76 KB PDF)
by David Filmore
A new product from Roche Diagnostics is testing the regulatory waters for diagnostic microarrays.

Clinical Trials Track
Assessing antisense (60 KB PDF)
by David Filmore
An NDA withdrawal signals another setback, but hope remains for next-generation drugs.

Applications Notebook
Mass identification (156 KB PDF)
Dale H. Patterson and Matthew Willetts
Advancing protein and biomarker discovery with MALDI-TOF/TOF MS technology

Sites and Software
The PDA: Making headway into a new frontier (72 KB PDF)
by Kimberly S. Cleaves
Life sciences in the palm of your hand

Agilent Technologies
395 Page Mill Rd.
Palo Alto, CA 94303
800-227-9770, 302-633-8901
www.agilent.com/chem

Aldrich Chemical
Box 355
Milwaukee, WI 53201
800-558-9160, 414-273-4979
www.sigma-aldrich.com

Applied Biosystems
850 Lincoln Centre Drive
Foster City, CA 94404
650-638-5800, 650-638-5884
www.appliedbiosystems.com

BASi
2701 Kent Ave.
West Lafayette, IN 47906
800-845-4246, 765-497-1102
www.bioanalytical.com

Beckman Coulter
4300 Harbor Blvd
Fullerton, CA 92834
800-742-2345
www.beckmancoulter.com

Biotage
2020 Avon Ct.
Charlottesville, VA 22902
800-446-4752, 434-979-4743
www.biotage.com

Brinkmann Instruments
One Cantiague Rd.
Westbury, NY 11590
800-645-3050, 516-334-7506
www.brinkmann.com

CEM Corporation
3100 Smith Farm Rd.
Matthews, NC 28106
800-726-3331, 704-821-8710
www.cemsynthesis.com

Dionex
1228 Titan Way
Sunnyvale, CA 94088-3603
408-737-0700, 408-730-9403
www.dionex.com

EMD Biosciences - Novagen
441 Charmany Dr.
Madison, WI 53719
800-526-7319, 608-238-1388
www.novagen.com

Epicentre
726 Post Rd.
Madison, WI 53713
608-258-3080
www.epicentre.com

Expresson Biosystems, LTD.
Logan Building
Roslin BioCentre
Roslin Midlothian EH25 9TT
+44-0-131-527-4607, +44-0-131-527-4521
www.expresson.co.uk

Gateway Chemical Technology
11810 Borman Dr.
Saint Louis, MO 63146
314-220-2691, 314-991-2834
www.gatewaychemical.com

Gene Express, Inc.
975 Research Dr.
Toledo, OH 43614
419-380-9930, 800-820-8343
www.geneexpressinc.com

Gilson, Inc.
3000 W. Beltline Hwy.
Middleton, WI 53562-0027
800-445-7661, 608-831-4451
www.gilson.com

Hamilton Company
4970 Energy Way
Reno, NV 89502
800-648-5950, 775-856-7259
www.hamiltoncompany.com

IBC Life Sciences
One Research Dr.
Ste. 400A
Westborough, MA 01581
508-616-5550, 508-616-5522
www.lifesciencesinfo.com

Michigan Economic Development Corp.
300 N. Washington Square
Lansing, MI 48913
800-946-6829
www.michigan.org

MWG Biotech AG
Anzinger Strasse 7a
D-85560
Ebersberg bei Munchen
Germany
08092-8289-0, 08092-21084
www.the-mwg.com

Pall Life Sciences
600 South Wagner Road
Ann Arbor, MI 48103
800-521-1520, 734-913-6114
www.pall.com

Pierce Biotechnology
P.O. Box 117
Rockford, IL. 61105
800-874-3723, 800-842-5007
www.piercenet.com

Society for Biomolecular Screening
36 Tamarack Ave., #348
Danbury, CT 06811
203-743-1336, 203-748-7557
www.sbsonline.org

Takara Mirus Bio
505 South Rosa Rd., Ste. 104
Madison, WI 53719
888-251-6618, 608-441-2845
www.takaramirusbio.com

Thermo Electron Corp.
81 Wyman St.
Waltham, MA 02054
781-622-1000, 781-622-1207
www.thermo.com

Thermo Electron Corp. (Sample Prep Group)
450 Fortune Dr.
Milford, MA 01757
508-482-7000
www.thermo.com