Articles ASAP (As Soon As Publishable)

ASAP articles are edited and published online ahead of print.

ACS AuthorChoice indicates the article is freely available through sponsorship by the author or related funding agency. More about this program.
For Selected Content:

November 20, 2009

Synthesis, Affinity Profile and Functional Activity of Potent Chiral Muscarinic Antagonists with a Pyrrolidinylfuran Structure

Publication Date (Web): November 20, 2009 (Article)
DOI: 10.1021/jm901048j

Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ Agonists

Publication Date (Web): November 20, 2009 (Article)
DOI: 10.1021/jm9007399

November 19, 2009

9-Arylpurines as a Novel Class of Enterovirus Inhibitors

Publication Date (Web): November 19, 2009 (Article)
DOI: 10.1021/jm901240p

X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Publication Date (Web): November 19, 2009 (Article)
DOI: 10.1021/jm9012196

Perspectives of P-Glycoprotein Modulating Agents in Oncology and Neurodegenerative Diseases: Pharmaceutical, Biological, and Diagnostic Potentials

Publication Date (Web): November 19, 2009 (Perspective)
DOI: 10.1021/jm900743c

The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)

Publication Date (Web): November 19, 2009 (Article)
DOI: 10.1021/jm901473s

November 18, 2009

Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity

Publication Date (Web): November 18, 2009 (Article)
DOI: 10.1021/jm901214q

Chloro-Substituted 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-Dioxides as ATP-Sensitive Potassium Channel Activators: Impact of the Position of the Chlorine Atom on the Aromatic Ring on Activity and Tissue Selectivity

Publication Date (Web): November 18, 2009 (Article)
DOI: 10.1021/jm9010093

Janus Kinase 2 Inhibitors. Synthesis and Characterization of a Novel Polycyclic Azaindole

Publication Date (Web): November 18, 2009 (Letter)
DOI: 10.1021/jm901383u

November 17, 2009

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

Publication Date (Web): November 17, 2009 (Letter)
DOI: 10.1021/jm9015334

Novel Organic Proteasome Inhibitors Identified by Virtual and in Vitro Screening

Publication Date (Web): November 17, 2009 (Brief Article)
DOI: 10.1021/jm9011092

November 16, 2009

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

Publication Date (Web): November 16, 2009 (Article)
DOI: 10.1021/jm901059x
ACS AuthorChoice

Morpholine Derivatives Greatly Enhance the Selectivity of Mammalian Target of Rapamycin (mTOR) Inhibitors

Publication Date (Web): November 16, 2009 (Letter)
DOI: 10.1021/jm901415x

November 13, 2009

DNA Loop Sequence as the Determinant for Chiral Supramolecular Compound G-Quadruplex Selectivity

Publication Date (Web): November 13, 2009 (Article)
DOI: 10.1021/jm9014795

Deciphering the Mechanism of Carbonic Anhydrase Inhibition with Coumarins and Thiocoumarins

Publication Date (Web): November 13, 2009 (Article)
DOI: 10.1021/jm901287j

Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes

Publication Date (Web): November 13, 2009 (Article)
DOI: 10.1021/jm900872z

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential Residues

Publication Date (Web): November 13, 2009 (Article)
DOI: 10.1021/jm9010466

November 12, 2009

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

Publication Date (Web): November 12, 2009 (Letter)

Enhancement of the Antimalarial Activity of Ciprofloxacin Using a Double Prodrug/Bioorganometallic Approach

Publication Date (Web): November 12, 2009 (Letter)

Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease

Publication Date (Web): November 12, 2009 (Article)
DOI: 10.1021/jm901070c

Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone

Publication Date (Web): November 12, 2009 (Brief Article)
DOI: 10.1021/jm901209q

Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatB

Publication Date (Web): November 12, 2009 (Article)

November 11, 2009

Corrections to Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells

Publication Date (Web): November 11, 2009 (Addition/Correction)
DOI: 10.1021/jm901634z

Discovery of (Z)-5-(4-Methoxybenzylidene)thiazolidine-2,4-dione, a Readily Available and Orally Active Glitazone for the Treatment of Concanavalin A-Induced Acute Liver Injury of BALB/c Mice

Publication Date (Web): November 11, 2009 (Article)
DOI: 10.1021/jm901183d

4-Oxo-β-lactams (Azetidine-2,4-diones) Are Potent and Selective Inhibitors of Human Leukocyte Elastase

Publication Date (Web): November 11, 2009 (Article)
DOI: 10.1021/jm901082k

November 10, 2009

Human P2Y14 Receptor Agonists: Truncation of the Hexose Moiety of Uridine-5′-Diphosphoglucose and Its Replacement with Alkyl and Aryl Groups

Publication Date (Web): November 10, 2009 (Article)
DOI: 10.1021/jm901432g

Corrections to Design, Synthesis, and Biological Evaluation of 6α- and 6β-N-Heterocyclic Substituted Naltrexamine Derivatives as μ Opioid Receptor Selective Antagonists

Publication Date (Web): November 10, 2009 (Addition/Correction)
DOI: 10.1021/jm9016224

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

Publication Date (Web): November 10, 2009 (Letter)
DOI: 10.1021/jm901434t

November 9, 2009

Phosphinic Tripeptides as Dual Angiotensin-Converting Enzyme C-Domain and Endothelin-Converting Enzyme-1 Inhibitors

Publication Date (Web): November 9, 2009 (Article)
DOI: 10.1021/jm9010803

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Publication Date (Web): November 9, 2009 (Article)
DOI: 10.1021/jm900861d

November 6, 2009

The Discodermolide Hairpin Structure Flows from Conformationally Stable Modular Motifs

Publication Date (Web): November 6, 2009 (Article)
DOI: 10.1021/jm9015284

In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats

Publication Date (Web): November 6, 2009 (Article)
DOI: 10.1021/jm901023f

Fluorinated Rhodacyanine (SJL-01) Possessing High Efficacy for Visceral Leishmaniasis (VL)

Publication Date (Web): November 6, 2009 (Article)
DOI: 10.1021/jm9013086

Design, Synthesis, and Characterization of Peptide-Based Rab Geranylgeranyl Transferase Inhibitors

Publication Date (Web): November 6, 2009 (Article)
DOI: 10.1021/jm901117d

N-Sulfonylanthranilic Acid Derivatives as Allosteric Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase

Publication Date (Web): November 6, 2009 (Letter)
DOI: 10.1021/jm901044z

Discovery of 4-Morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as Highly Potent and Selective ATP-Competitive Inhibitors of the Mammalian Target of Rapamycin (mTOR): Optimization of the 6-Aryl Substituent

Publication Date (Web): November 6, 2009 (Article)
DOI: 10.1021/jm9013828

Design, Synthesis, and Biological Evaluations of 2,5-Diaryl-2,3-dihydro-1,3,4-oxadiazoline Analogs of Combretastatin-A4

Publication Date (Web): November 6, 2009 (Article)
DOI: 10.1021/jm901268n

November 5, 2009

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

Publication Date (Web): November 5, 2009 (Letter)
DOI: 10.1021/jm901543m

1,2,4-Triazolyl Azabicyclo[3.1.0]hexanes: A New Series of Potent and Selective Dopamine D3 Receptor Antagonists

Publication Date (Web): November 5, 2009 (Article)
DOI: 10.1021/jm901319p

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Publication Date (Web): November 5, 2009 (Article)

Poly-N-methylated Amyloid β-Peptide (Aβ) C-Terminal Fragments Reduce Aβ Toxicity in Vitro and in Drosophila melanogaster

Publication Date (Web): November 5, 2009 (Article)
DOI: 10.1021/jm901092h

Drug Effects Viewed from a Signal Transduction Network Perspective

Publication Date (Web): November 5, 2009 (Article)
DOI: 10.1021/jm901001p

October 29, 2009

Structure−Activity Relationships of Polymyxin Antibiotics

Publication Date (Web): October 29, 2009 (Perspective)
DOI: 10.1021/jm900999h

October 27, 2009

Selectively Nonselective Kinase Inhibition: Striking the Right Balance

Publication Date (Web): October 27, 2009 (Perspective)
DOI: 10.1021/jm901132v

Highlights in the Discovery of Antiviral Drugs: A Personal Retrospective

Publication Date (Web): October 27, 2009 (Perspective)
DOI: 10.1021/jm900932g

October 21, 2009

18F Stilbenes and Styrylpyridines for PET Imaging of Aβ Plaques in Alzheimer’s Disease: A Miniperspective

Publication Date (Web): October 21, 2009 (Perspective)
DOI: 10.1021/jm901039z

October 20, 2009

Design, Synthesis, and Structure−Activity Relationship of Indole-3-glyoxylamide Libraries Possessing Highly Potent Activity in a Cell Line Model of Prion Disease

Publication Date (Web): October 20, 2009 (Article)

Exploring the Importance of Piperazine N-Atoms for σ2 Receptor Affinity and Activity in a Series of Analogs of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28)

Publication Date (Web): October 20, 2009 (Article)
DOI: 10.1021/jm9007505

October 19, 2009

Synthesis and Biological Evaluation of 2-Alkynyl-N6-methyl-5′-N-methylcarboxamidoadenosine Derivatives as Potent and Highly Selective Agonists for the Human Adenosine A3 Receptor

Publication Date (Web): October 19, 2009 (Brief Article)
DOI: 10.1021/jm900754g

October 15, 2009

Three-Dimensional Pharmacophore Methods in Drug Discovery

Publication Date (Web): October 15, 2009 (Perspective)
DOI: 10.1021/jm900817u

October 8, 2009

Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks

Publication Date (Web): October 8, 2009 (Brief Article)
DOI: 10.1021/jm901123n

October 5, 2009

Scope and Difficulty in Generating Theoretical Insights Regarding Ligand Recognition and Activation of the β2 Adrenergic Receptor

Publication Date (Web): October 5, 2009 (Perspective)
DOI: 10.1021/jm900419a

October 2, 2009

Imidazoquines as Antimalarial and Antipneumocystis Agents

Publication Date (Web): October 2, 2009 (Article)
DOI: 10.1021/jm900738c

September 30, 2009

Amide Linkage Isomerism As an Activity Switch for Organometallic Osmium and Ruthenium Anticancer Complexes

Publication Date (Web): September 30, 2009 (Article)
DOI: 10.1021/jm900731j

September 29, 2009

Pentapeptides Displaying μ Opioid Receptor Agonist and δ Opioid Receptor Partial Agonist/Antagonist Properties

Publication Date (Web): September 29, 2009 (Article)
DOI: 10.1021/jm9007483

Further Studies on Arylpiperazinyl Alkyl Pyridazinones: Discovery of an Exceptionally Potent, Orally Active, Antinociceptive Agent in Thermally Induced Pain

Publication Date (Web): September 29, 2009 (Article)
DOI: 10.1021/jm900458r

September 28, 2009

Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?

Publication Date (Web): September 28, 2009 (Perspective)
DOI: 10.1021/jm900492g

September 24, 2009

Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development

Publication Date (Web): September 24, 2009 (Letter)
DOI: 10.1021/jm900786r

September 23, 2009

Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections

Publication Date (Web): September 23, 2009 (Article)
DOI: 10.1021/jm900729s

September 22, 2009

Synthesis of New Alkylaminooxysterols with Potent Cell Differentiating Activities: Identification of Leads for the Treatment of Cancer and Neurodegenerative Diseases

Publication Date (Web): September 22, 2009 (Article)
DOI: 10.1021/jm901063e

September 21, 2009

Inhibitors of Human Immunodeficiency Virus Type 1 (HIV-1) Attachment. 5. An Evolution from Indole to Azaindoles Leading to the Discovery of 1-(4-Benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a Drug Candidate That Demonstrates Antiviral Activity in HIV-1-Infected Subjects

Publication Date (Web): September 21, 2009 (Article)
DOI: 10.1021/jm900843g

September 16, 2009

Design, Synthesis, and Biological Evaluation of Substituted Naphthalene Imides and Diimides as Anticancer Agent

Publication Date (Web): September 16, 2009 (Brief Article)
DOI: 10.1021/jm901131m

Mechanistic Insight into the Inhibition of Matrix Metalloproteinases by Platinum Substrates

Publication Date (Web): September 16, 2009 (Article)
DOI: 10.1021/jm900845t

Heat Shock Protein 90: Inhibitors in Clinical Trials

Publication Date (Web): September 16, 2009 (Perspective)
DOI: 10.1021/jm9004708

Identification of N-(5-tert-Butyl-isoxazol-3-yl)-N′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Publication Date (Web): September 16, 2009 (Article)
DOI: 10.1021/jm9007533

September 11, 2009

Design, Synthesis, and Structure−Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl)furans as HIV-1 Entry Inhibitors

Publication Date (Web): September 11, 2009 (Article)
DOI: 10.1021/jm900450n

Design, Synthesis, Protein−Ligand X-ray Structure, and Biological Evaluation of a Series of Novel Macrocyclic Human Immunodeficiency Virus-1 Protease Inhibitors to Combat Drug Resistance

Publication Date (Web): September 11, 2009 (Article)
DOI: 10.1021/jm900695w

September 10, 2009

Foreword: American Chemical Society Division of Medicinal Chemistry. Celebrating 100 Years of Excellence

Publication Date (Web): September 10, 2009 (Perspective)
DOI: 10.1021/jm901089d

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a New Scaffold To Obtain Potent and Selective Human A3 Adenosine Receptor Antagonists: New Insights into the Receptor−Antagonist Recognition

Publication Date (Web): September 10, 2009 (Article)
DOI: 10.1021/jm900718w

September 9, 2009

The Medicinal Chemistry of Dengue Fever

Publication Date (Web): September 9, 2009 (Perspective)
DOI: 10.1021/jm900652e

September 8, 2009

Rapid Generation of a High Quality Lead for Transforming Growth Factor-β (TGF-β) Type I Receptor (ALK5)

Publication Date (Web): September 8, 2009 (Brief Article)
DOI: 10.1021/jm900807w

September 4, 2009

Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits

Publication Date (Web): September 4, 2009 (Article)
DOI: 10.1021/jm900683d

September 1, 2009

A Strategy to Minimize Reactive Metabolite Formation: Discovery of (S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a Potent, Orally Bioavailable Corticotropin-Releasing Factor-1 Receptor Antagonist

Publication Date (Web): September 1, 2009 (Article)
DOI: 10.1021/jm900716v

September 3, 2009

(3R,5S,7as)-(3,5-Bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol, a Novel Neuroprotective Agent

Publication Date (Web): September 3, 2009 (Article)
DOI: 10.1021/jm900254k

August 25, 2009

Synthesis and Characterization of Environment-Sensitive Fluorescent Ligands for Human 5-HT1A Receptors with 1-Arylpiperazine Structure

Publication Date (Web): August 25, 2009 (Brief Article)
DOI: 10.1021/jm900706d

Discovery of Potent and Selective Histone Deacetylase Inhibitors via Focused Combinatorial Libraries of Cyclic α3β-Tetrapeptides

Publication Date (Web): August 25, 2009 (Article)
DOI: 10.1021/jm900850t

August 26, 2009

August 24, 2009

Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity

Publication Date (Web): August 24, 2009 (Article)
DOI: 10.1021/jm900752a

August 19, 2009

Pyrrolidine Analogues of Lobelane: Relationship of Affinity for the Dihydrotetrabenazine Binding Site with Function of the Vesicular Monoamine Transporter 2 (VMAT2)

Publication Date (Web): August 19, 2009 (Brief Article)
DOI: 10.1021/jm900770h

August 12, 2009

Design, Synthesis, and Examination of Neuron Protective Properties of Alkenylated and Amidated Dehydro-Silybin Derivatives

Publication Date (Web): August 12, 2009 (Article)
DOI: 10.1021/jm900735p

August 10, 2009

Vascular Disrupting Activity of Tubulin-Binding 1,5-Diaryl-1H-imidazoles

Publication Date (Web): August 10, 2009 (Brief Article)
DOI: 10.1021/jm900968s

August 5, 2009

Discovery of Trp-His and His-Arg Analogues as New Structural Classes of Short Antimicrobial Peptides

Publication Date (Web): August 5, 2009 (Article)
DOI: 10.1021/jm900622d

August 3, 2009

Synthesis of New Linear Guanidines and Macrocyclic Amidinourea Derivatives Endowed with High Antifungal Activity against Candida spp. and Aspergillus spp.

Publication Date (Web): August 3, 2009 (Letter)
DOI: 10.1021/jm900760k

July 31, 2009

Synthesis and Biological Evaluation of C-5 Methyl Substituted 4-Arylthio and 4-Aryloxy-3-Iodopyridin-2(1H)-one Type Anti-HIV Agents

Publication Date (Web): July 31, 2009 (Article)
DOI: 10.1021/jm900802y

July 30, 2009

Crystallographic Snapshots of Nonaged and Aged Conjugates of Soman with Acetylcholinesterase, and of a Ternary Complex of the Aged Conjugate with Pralidoxime

Publication Date (Web): July 30, 2009 (Article)
DOI: 10.1021/jm900433t

July 27, 2009

Preclinical Efficacy of a Carboxylesterase 2-Activated Prodrug of Doxazolidine

Publication Date (Web): July 27, 2009 (Article)
DOI: 10.1021/jm900694z

Univalent and Bivalent Ligands of Butorphan: Characteristics of the Linking Chain Determine the Affinity and Potency of Such Opioid Ligands

Publication Date (Web): July 27, 2009 (Article)
DOI: 10.1021/jm900379p

July 24, 2009

Probes for Narcotic Receptor Mediated Phenomena. 39. Enantiomeric N-Substituted Benzofuro[2,3-c]pyridin-6-ols: Synthesis and Topological Relationship to Oxide-Bridged Phenylmorphans

Publication Date (Web): July 24, 2009 (Article)
DOI: 10.1021/jm9004225

July 21, 2009

Discovery of Dermorphin-Based Affinity Labels with Subnanomolar Affinity for Mu Opioid Receptors

Publication Date (Web): July 21, 2009 (Letter)
DOI: 10.1021/jm9007592

July 17, 2009

Increasing Selectivity of CC Chemokine Receptor 8 Antagonists by Engineering Nondesolvation Related Interactions with the Intended and Off-Target Binding Sites

Publication Date (Web): July 17, 2009 (Article)
DOI: 10.1021/jm900713y

Small-Sized Human Immunodeficiency Virus Type-1 Protease Inhibitors Containing Allophenylnorstatine to Explore the S2′ Pocket

Publication Date (Web): July 17, 2009 (Article)
DOI: 10.1021/jm9005115

July 14, 2009

New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies

Publication Date (Web): July 14, 2009 (Article)
DOI: 10.1021/jm900016t

July 16, 2009

Neglected Tropical Diseases: Multi-Target-Directed Ligands in the Search for Novel Lead Candidates against Trypanosoma and Leishmania

Publication Date (Web): July 16, 2009 (Perspective)
DOI: 10.1021/jm9004835

July 8, 2009

Malaria-Infected Mice Live until at Least Day 30 after a New Monomeric Trioxane Combined with Mefloquine Are Administered Together in a Single Low Oral Dose

Publication Date (Web): July 8, 2009 (Article)
DOI: 10.1021/jm9005934

July 10, 2009

3,4-Diaryl-isoxazoles and -imidazoles as Potent Dual Inhibitors of p38α Mitogen Activated Protein Kinase and Casein Kinase 1δ

Publication Date (Web): July 10, 2009 (Article)
DOI: 10.1021/jm9005127

July 7, 2009

Synthesis and in Vitro Evaluation of N-Substituted Maleimide Derivatives as Selective Monoglyceride Lipase Inhibitors

Publication Date (Web): July 7, 2009 (Article)
DOI: 10.1021/jm900461w

July 6, 2009

Nucleoside-5′-monophosphates as Prodrugs of Adenosine A2A Receptor Agonists Activated by ecto-5′-Nucleotidase†

Contribution to celebrate the 100th anniversary of the Division of Medicinal Chemistry of the American Chemical Society.

Publication Date (Web): July 6, 2009 (Article)
DOI: 10.1021/jm900538v

July 2, 2009

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture

Publication Date (Web): July 2, 2009 (Article)
DOI: 10.1021/jm900256f

June 18, 2009

Discovery of the First Series of Small Molecule H5N1 Entry Inhibitors

Publication Date (Web): June 18, 2009 (Letter)
DOI: 10.1021/jm900275m

June 9, 2009

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

Publication Date (Web): June 9, 2009 (Letter)
DOI: 10.1021/jm900518f

June 15, 2009

Betulinic Acid Derivatives as Human Immunodeficiency Virus Type 2 (HIV-2) Inhibitors

Publication Date (Web): June 15, 2009 (Brief Article)
DOI: 10.1021/jm9004253

June 8, 2009

Functionalized Congeners of A3 Adenosine Receptor-Selective Nucleosides Containing a Bicyclo[3.1.0]hexane Ring System

Publication Date (Web): June 8, 2009 (Article)
DOI: 10.1021/jm900426g

April 23, 2009

Novel, Broad-Spectrum Anticonvulsants Containing a Sulfamide Group: Advancement of N-((Benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into Human Clinical Studies

Publication Date (Web): April 23, 2009 (Article)
DOI: 10.1021/jm801432r

April 14, 2009

Identification and Structure−Activity Relationships of Chromene-Derived Selective Estrogen Receptor Modulators for Treatment of Postmenopausal Symptoms

Publication Date (Web): April 14, 2009 (Article)
DOI: 10.1021/jm900146e

October 23, 2009

Identification of Lead Compounds As Antagonists of Protein Bcl-xL with a Diversity-Oriented Multidisciplinary Approach

Publication Date (Web): October 23, 2009 (Article)
DOI: 10.1021/jm9010687

October 30, 2009

Carborane Derivatives Loaded into Liposomes as Efficient Delivery Systems for Boron Neutron Capture Therapy

Publication Date (Web): October 30, 2009 (Article)
DOI: 10.1021/jm900763b
For Selected Content:
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