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In Vivo Determination of the Molecular Composition of Artery Wall by Intravascular Raman Spectroscopy

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2000, 72, 16, 3771-3775
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    In Vivo Determination of the Molecular Composition of Artery Wall by Intravascular Raman Spectroscopy
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    Leiden University Medical Center, Leiden, The Netherlands, Erasmus University Rotterdam, Rotterdam, The Netherlands, Visionex Inc., Atlanta, Georgia 30318, and Spectroscopy Division, Renishaw plc, Wotton-under-Edge, U.K.
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    Analytical Chemistry

    Cite this: Anal. Chem. 2000, 72, 16, 3771–3775
    Click to copy citationCitation copied!
    https://doi.org/10.1021/ac000298b
    Published July 14, 2000
    Copyright © 2000 American Chemical Society
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    Abstract

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    Atherosclerotic plaque vulnerability is suggested to be determined by its chemical composition. However, at present there are no in vivo techniques available that can adequately type atherosclerotic plaques in terms of chemical composition. Previous in vitro experiments have shown that Raman spectroscopy can provide such information in great detail. Here we present the results of in vitro and in vivo intravascular Raman spectroscopic experiments, in which dedicated, miniaturized fiber-optic probes were used to illuminate the blood vessel wall and to collect Raman scattered light. The results make clear that an important hurdle to clinical application of Raman spectroscopy in atherosclerosis has been overcome, namely, the ability to obtain in vivo intravascular Raman spectra of high quality. Of equal importance is the finding that the in vivo intravascular Raman signal obtained from a blood vessel is a simple summation of signal contributions of the blood vessel wall and of blood. It means that detailed information about the chemical composition of a blood vessel wall can be obtained by adapting a multiple least-squares fitting method, which was developed previously for the analysis of in vitro spectra, to account for signal contributions of blood.

    Copyright © 2000 American Chemical Society

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    †

     Leiden University Medical Center.

    ‡

     Present address:  Twente Institute for Neuromodulation (TWIN), Medisch Spectrum Twente, P.O. Box 50000, 7500 KA Enschede, The Netherlands.

    §

     Erasmus University Rotterdam.

    ‖

     Visionex Inc..

    ⊥

     Renishaw plc.

    *

     Corresponding author:  (mail) Department of Cardiology, C5-P, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands; (tel) (31)-71 526 2020; (fax) (31)-71 526 6809; (e-mail) [email protected].

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    This article is cited by 143 publications.

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    Analytical Chemistry

    Cite this: Anal. Chem. 2000, 72, 16, 3771–3775
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    https://doi.org/10.1021/ac000298b
    Published July 14, 2000
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