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“Click” Modification of Silica Surfaces and Glass Microfluidic Channels

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Department of Mechanical Science and Engineering and Department of Chemistry, University of Illinois at UrbanaChampaign, Urbana, Illinois 61801
Cite this: Anal. Chem. 2007, 79, 4, 1661–1667
Publication Date (Web):December 22, 2006
Copyright © 2007 American Chemical Society

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    This paper demonstrates a chemical surface modification method for covalent attachment of various polymers by using silane-based “click” chemistry on silica surfaces and within glass microchannels suitable for CE systems. Modified surfaces are characterized by contact angle measurements, X-ray photoelectron spectroscopy, and Fourier transform infrared-attenuated total reflection spectroscopy. Electroosmotic flow (EOF) measurements in modified and unmodified channels are provided. Spectroscopic and transport data show that various polymers can be covalently attached to glass surfaces with a measurable change in EOF.

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     Department of Mechanical Science and Engineering.

     Department of Chemistry.


     To whom correspondence should be addressed. E-mail:  [email protected]; [email protected].

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