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Versatile Capillary Column Temperature Control Using a Thermoelectric Array Based Platform

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† Irish Separation Science Cluster (ISSC), National Centre for Sensor Research, Dublin, City University, Glasnevin, Dublin 9, Ireland
‡ Irish Separation Science Cluster (ISSC), Faculty of Engineering & Computing, Dublin City University, Glasnevin, Dublin 9, Ireland
§ Australian Centre for Research on Separation Science (ACROSS), University of Tasmania, Hobart, Australia
∥ School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland
*E-mail: [email protected]
Cite this: Anal. Chem. 2011, 83, 11, 4307–4313
Publication Date (Web):April 30, 2011
https://doi.org/10.1021/ac2004955
Copyright © 2011 American Chemical Society
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    Abstract

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    A new direct contact platform for capillary column precise temperature control based upon the use of individually controlled sequentially aligned Peltier thermoelectric units is presented. The platform provides rapid temperature control for capillary and microbore liquid chromatography columns and allows simultaneous temporal and spatial temperature programming. The operating temperature range of the platform was between 15 and 200 °C for each of 10 aligned Peltier units, with a ramp rate of approximately 400 °C/min. The system was evaluated for a number of nonstandard capillary based applications, such as the direct application of temperature gradients with both linear and nonlinear profiles, including both static column temperature gradients and temporal temperature gradients, and the formation of in-capillary monolithic stationary phases with gradient polymerization through precise temperature control.

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