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Graphene Enhanced Electron Transfer at Aptamer Modified Electrode and Its Application in Biosensing

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State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China
*Tel.: +86 431 85262101. Fax: +86 431 85689711. E-mail: [email protected]
Cite this: Anal. Chem. 2012, 84, 17, 7301–7307
Publication Date (Web):July 26, 2012
https://doi.org/10.1021/ac300521d
Copyright © 2012 American Chemical Society
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    Abstract

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    Graphene (GN), a two-dimensional and one-atom thick carbon sheet, is showing exciting applications because of its unique morphology and properties. In this work, a new electrochemical biosensing platform by taking advantage of the ultrahigh electron transfer ability of GN and its unique GN/ssDNA interaction was reported. Adenosine triphosphate binding aptamer (ABA) immobilized on Au electrode could strongly adsorb GN due to the strong π–π interaction and resulted in a large decrease of the charge transfer resistance (Rct) of the electrode. However, the binding reaction between ABA and its target adenosine triphosphate (ATP) inhibited the adsorption of GN, and Rct could not be decreased. On the basis of this, we developed a new GN-based biosensing platform for the detection of small molecule ATP. The experimental results confirmed that the electrochemical aptasensor we developed possessed a good sensitivity and high selectivity for ATP. The detection range for ATP was from 15 × 10–9 to 4 × 10–3 M. The method here was label-free and sensitive and did not require sophisticated fabrication. Furthermore, we can generalize this strategy to detect Hg2+ using a thymine (T)-rich, mercury-specific oligonucleotide. Therefore, we expected that this method may offer a promising approach for designing high-performance electrochemical aptasensors for the sensitive and selective detection of a spectrum of targets.

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    2. Alejandra Tello, Roberto Cao, María José Marchant, and Humberto Gomez . Conformational Changes of Enzymes and Aptamers Immobilized on Electrodes. Bioconjugate Chemistry 2016, 27 (11) , 2581-2591. https://doi.org/10.1021/acs.bioconjchem.6b00553
    3. Rahul Kalel, Aruna K. Mora, Rajib Ghosh, Dilip D. Dhavale, Dipak K. Palit, and Sukhendu Nath . Interaction of a Julolidine-Based Neutral Ultrafast Molecular Rotor with Natural DNA: Spectroscopic and Molecular Docking Studies. The Journal of Physical Chemistry B 2016, 120 (37) , 9843-9853. https://doi.org/10.1021/acs.jpcb.6b04811
    4. Liang Yuan, Xian Wang, Yimin Fang, Chenbin Liu, Dan Jiang, Xiang Wo, Wei Wang, and Hong-Yuan Chen . Digitizing Gold Nanoparticle-Based Colorimetric Assay by Imaging and Counting Single Nanoparticles. Analytical Chemistry 2016, 88 (4) , 2321-2326. https://doi.org/10.1021/acs.analchem.5b04244
    5. Wang Ren, Ying Zhang, Hong Guo Chen, Zhong Feng Gao, Nian Bing Li, and Hong Qun Luo . Ultrasensitive Label-Free Resonance Rayleigh Scattering Aptasensor for Hg2+ Using Hg2+-Triggered Exonuclease III-Assisted Target Recycling and Growth of G-Wires for Signal Amplification. Analytical Chemistry 2016, 88 (2) , 1385-1390. https://doi.org/10.1021/acs.analchem.5b03972
    6. Yueting Liu, Jianping Lei, Yin Huang, and Huangxian Ju . “Off-On” Electrochemiluminescence System for Sensitive Detection of ATP via Target-Induced Structure Switching. Analytical Chemistry 2014, 86 (17) , 8735-8741. https://doi.org/10.1021/ac501913c
    7. Fuan Wang, Chun-Hua Lu, and Itamar Willner . From Cascaded Catalytic Nucleic Acids to Enzyme–DNA Nanostructures: Controlling Reactivity, Sensing, Logic Operations, and Assembly of Complex Structures. Chemical Reviews 2014, 114 (5) , 2881-2941. https://doi.org/10.1021/cr400354z
    8. Yu Xiang and Yi Lu . DNA as Sensors and Imaging Agents for Metal Ions. Inorganic Chemistry 2014, 53 (4) , 1925-1942. https://doi.org/10.1021/ic4019103
    9. Liang Wu, Xiaohua Zhang, Wei Liu, Erhu Xiong, and Jinhua Chen . Sensitive Electrochemical Aptasensor by Coupling “Signal-on’’ and “Signal-off’’ Strategies. Analytical Chemistry 2013, 85 (17) , 8397-8402. https://doi.org/10.1021/ac401810t
    10. Lei Ge, Panpan Wang, Shenguang Ge, Nianqiang Li, Jinghua Yu, Mei Yan, and Jiadong Huang . Photoelectrochemical Lab-on-Paper Device Based on an Integrated Paper Supercapacitor and Internal Light Source. Analytical Chemistry 2013, 85 (8) , 3961-3970. https://doi.org/10.1021/ac4001496
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    12. Camilla Zanoni, Stefano Spina, Lisa Rita Magnaghi, Marta Guembe-Garcia, Raffaela Biesuz, Giancarla Alberti. Potentiometric MIP-Modified Screen-Printed Cell for Phenoxy Herbicides Detection. International Journal of Environmental Research and Public Health 2022, 19 (24) , 16488. https://doi.org/10.3390/ijerph192416488
    13. Shupan Ge, Xiaohua Ma. Electrochemical aptamer-based sensors for the detection of heavy metals. International Journal of Electrochemical Science 2022, 17 (9) , 220926. https://doi.org/10.20964/2022.09.06
    14. Tianwei Tang, Yinghuan Liu, Ying Jiang. Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors. Chemical Research in Chinese Universities 2022, 38 (4) , 866-878. https://doi.org/10.1007/s40242-022-2084-z
    15. Kaiyan Fan, Junlun Zhu, Xiaowei Wu, Xiuhua Zhang, Shengfu Wang, Wei Wen. A flexible label-free electrochemical aptasensor based on target-induced conjunction of two split aptamers and enzyme amplification. Sensors and Actuators B: Chemical 2022, 363 , 131766. https://doi.org/10.1016/j.snb.2022.131766
    16. Shashanka Rajendrachari, Dileep Ramakrishna. Functionalized nanomaterial-based electrochemical sensors: A sensitive sensor platform. 2022, 3-25. https://doi.org/10.1016/B978-0-12-823788-5.00010-7
    17. Zhi-Hong Xu, Zi-Yuan Zhao, Hui Wang, Shu-Min Wang, Hong-Yuan Chen, Jing-Juan Xu. CRISPR-Cas12a-based efficient electrochemiluminescence biosensor for ATP detection. Analytica Chimica Acta 2021, 1188 , 339180. https://doi.org/10.1016/j.aca.2021.339180
    18. Eva Alvarez de Eulate, Alexandru Gheorghiu, Cherine Amoura, Amelia Whiteley, Craig Priest, Melanie N. MacGregor. Plasma Deposited Polyoxazoline Thin Films for the Biofunctionalization of Electrochemical Sensors. Advanced Materials Technologies 2021, 6 (8) https://doi.org/10.1002/admt.202001292
    19. Abu Hashem, M.A. Motalib Hossain, Ab Rahman Marlinda, Mohammad Al Mamun, Khanom Simarani, Mohd Rafie Johan. Nanomaterials based electrochemical nucleic acid biosensors for environmental monitoring: A review. Applied Surface Science Advances 2021, 4 , 100064. https://doi.org/10.1016/j.apsadv.2021.100064
    20. Aneesh Koyappayil, Min-Ho Lee. Ultrasensitive Materials for Electrochemical Biosensor Labels. Sensors 2021, 21 (1) , 89. https://doi.org/10.3390/s21010089
    21. Alessandra Bonanni. Advances on the Use of Graphene as a Label for Electrochemical Biosensors. ChemElectroChem 2020, 7 (20) , 4177-4185. https://doi.org/10.1002/celc.202000521
    22. Qiwen Wang, Haipei Si, Lihui Zhang, Ling Li, Xiaohong Wang, Shengtian Wang. A fast and facile electrochemical method for the simultaneous detection of epinephrine, uric acid and folic acid based on ZrO2/ZnO nanocomposites as sensing material. Analytica Chimica Acta 2020, 1104 , 69-77. https://doi.org/10.1016/j.aca.2020.01.012
    23. Lili Wei, Hui Cheng, Yong Chen, Juan Liu, Shaohui Jia, Wei Sun. Sensitive Electrochemical Determination of Adenosine-5’- triphosphate with 1-Butyl-2,3-dimethylimidazolium Hexafluorophosphate Based Carbon Paste Electrode. International Journal of Electrochemical Science 2019, 14 (11) , 10070-10078. https://doi.org/10.20964/2019.11.21
    24. Meng Zhang, Jia Chen, Xiaomei Pi, Chunyan Deng, Juan Xiang. Construction and Electrochemical Property Studies of DNA Duplexes Tethered to Gold Electrode via Au−C Bond. Electroanalysis 2019, 31 (3) , 477-484. https://doi.org/10.1002/elan.201800673
    25. Jyoti Yadav, Ankush, Khushboo, Mony Thakur, Karuna Yadav, Manisha Sharma, Kashyap Kumar Dubey. Aptasensor-Possible Design and Strategy for Aptamer Based Sensor. 2019, 133-154. https://doi.org/10.1007/978-981-13-8836-1_9
    26. Richa Sharma, K.S.M.S. Raghavarao. Nanoparticle-Based Aptasensors for Food Contaminant Detection. 2019, 123-145. https://doi.org/10.1016/B978-0-12-814130-4.00006-3
    27. Bo Peng, Siyuan Fang, Lin Tang, Xilian Ouyang, Guangming Zeng. Nanohybrid Materials Based Biosensors for Heavy Metal Detection. 2019, 233-264. https://doi.org/10.1016/B978-0-12-814154-0.00008-6
    28. Vangelis George Kanellis. Sensitivity limits of biosensors used for the detection of metals in drinking water. Biophysical Reviews 2018, 10 (5) , 1415-1426. https://doi.org/10.1007/s12551-018-0457-9
    29. Leila Farzin, Mojtaba Shamsipur, Leila Samandari, Shahab Sheibani. Advances in the design of nanomaterial-based electrochemical affinity and enzymatic biosensors for metabolic biomarkers: A review. Microchimica Acta 2018, 185 (5) https://doi.org/10.1007/s00604-018-2820-8
    30. Guixiang Wang, Xiaoli Su, Qingjun Xu, Guiyun Xu, Jiehua Lin, Xiliang Luo. Antifouling aptasensor for the detection of adenosine triphosphate in biological media based on mixed self-assembled aptamer and zwitterionic peptide. Biosensors and Bioelectronics 2018, 101 , 129-134. https://doi.org/10.1016/j.bios.2017.10.024
    31. Alina Vasilescu, Akhtar Hayat, Szilveszter Gáspár, Jean-Louis Marty. Advantages of Carbon Nanomaterials in Electrochemical Aptasensors for Food Analysis. Electroanalysis 2018, 30 (1) , 2-19. https://doi.org/10.1002/elan.201700578
    32. Shirinaz I. Khan, Kiran Kumar Tadi, Rakesh R. Chillawar, Ramani V. Motghare. Interfacing Electrochemically Reduced Graphene Oxide with Poly(erichrome black T) for Simultaneous Determination of Epinephrine, Uric Acid and Folic Acid. Journal of The Electrochemical Society 2018, 165 (16) , B804-B813. https://doi.org/10.1149/2.0121816jes
    33. Amir M. Ashrafi, Zuzana Koudelkova, Eliska Sedlackova, Lukas Richtera, Vojtech Adam. Review—Electrochemical Sensors and Biosensors for Determination of Mercury Ions. Journal of The Electrochemical Society 2018, 165 (16) , B824-B834. https://doi.org/10.1149/2.0381816jes
    34. Shalini Muniandy, Ignatius Julian Dinshaw, Swe Jyan Teh, Chin Wei Lai, Fatimah Ibrahim, Kwai Lin Thong, Bey Fen Leo. Graphene-based label-free electrochemical aptasensor for rapid and sensitive detection of foodborne pathogen. Analytical and Bioanalytical Chemistry 2017, 409 (29) , 6893-6905. https://doi.org/10.1007/s00216-017-0654-6
    35. Sabine Szunerits, Qian Wang, Alina Vasilescu, Musen Li, Rabah Boukherroub. Graphene/gold Nanoparticles for Electrochemical Sensing. 2017, 139-172. https://doi.org/10.1002/9781119243915.ch6
    36. Mohammad Hossein Mashhadizadeh, Niloofar Naseri, Masoud A. Mehrgardi. A simple non-enzymatic strategy for adenosine triphosphate electrochemical aptasensor using silver nanoparticle-decorated graphene oxide. Journal of the Iranian Chemical Society 2017, 14 (9) , 2007-2016. https://doi.org/10.1007/s13738-017-1138-5
    37. Joao Henrique Lopes, Francois-Xavier Colson, Jake E. Barralet, Geraldine Merle. Electrically wired enzyme/TiO2 composite for glucose detection. Materials Science and Engineering: C 2017, 76 , 991-996. https://doi.org/10.1016/j.msec.2017.03.113
    38. Jiu-Jun Yang, Jun-Tao Cao, Hui Wang, Yan-Ming Liu, Shu-Wei Ren. Ferrocene-graphene sheets for high-efficiency quenching of electrochemiluminescence from Au nanoparticles functionalized cadmium sulfide flower-like three dimensional assemblies and sensitive detection of prostate specific antigen. Talanta 2017, 167 , 325-332. https://doi.org/10.1016/j.talanta.2017.01.077
    39. Bin He, Ya-Li Mao, Ya Zhang, Wei Yin, Chang-Jun Hou, Dan-Qun Huo, Huan-Bao Fa. A Porphyrin Molecularly Imprinted Biomimetic Electrochemical Sensor Based on Gold Nanoparticles and Carboxyl Graphene Composite for the Highly Efficient Detection of Methyl Parathion. Nano 2017, 12 (04) , 1750046. https://doi.org/10.1142/S1793292017500461
    40. Aixue Li, Jian Zhang, Jichuan Qiu, Zhenhuan Zhao, Cheng Wang, Chunjiang Zhao, Hong Liu. A novel aptameric biosensor based on the self-assembled DNA–WS2 nanosheet architecture. Talanta 2017, 163 , 78-84. https://doi.org/10.1016/j.talanta.2016.10.088
    41. Mojtaba Shamsipur, Leila Farzin, Mahmoud Amouzadeh Tabrizi, Maryam Shanehsaz. CdTe amplification nanoplatforms capped with thioglycolic acid for electrochemical aptasensing of ultra-traces of ATP. Materials Science and Engineering: C 2016, 69 , 1354-1360. https://doi.org/10.1016/j.msec.2016.08.038
    42. Asif Ali Tahir, Habib Ullah, Pitchaimuthu Sudhagar, Mohd Asri Mat Teridi, Anitha Devadoss, Senthilarasu Sundaram. The Application of Graphene and Its Derivatives to Energy Conversion, Storage, and Environmental and Biosensing Devices. The Chemical Record 2016, 16 (3) , 1591-1634. https://doi.org/10.1002/tcr.201500279
    43. Ailiang Chen, Mengmeng Yan, Shuming Yang. Split aptamers and their applications in sandwich aptasensors. TrAC Trends in Analytical Chemistry 2016, 80 , 581-593. https://doi.org/10.1016/j.trac.2016.04.006
    44. Junjun Wu, Lu Wang, Qinqin Wang, Lina Zou, Baoxian Ye. The novel voltammetric method for determination of hesperetin based on a sensitive electrochemical sensor. Talanta 2016, 150 , 61-70. https://doi.org/10.1016/j.talanta.2015.12.026
    45. Chunhua Ma, Chunshui Lin, Yiru Wang, Xi Chen. DNA-based ATP sensing. TrAC Trends in Analytical Chemistry 2016, 77 , 226-241. https://doi.org/10.1016/j.trac.2016.01.013
    46. Xiaofang Jia, Shaojun Dong, Erkang Wang. Engineering the bioelectrochemical interface using functional nanomaterials and microchip technique toward sensitive and portable electrochemical biosensors. Biosensors and Bioelectronics 2016, 76 , 80-90. https://doi.org/10.1016/j.bios.2015.05.037
    47. Qing Guan, Wei Xiong, Lan Zhou, Shantang Liu. Facile Synthesis of Nitrogen‐Doped Porous Carbon‐Gold Hybrid Nanocomposite for Mercury(II) Ion Electrochemical Determination. Electroanalysis 2016, 28 (1) , 133-139. https://doi.org/10.1002/elan.201500481
    48. Xueru Zhang, Yong Zhang, Maria C. DeRosa. Progress in graphene-based optical and electrochemical aptasensors. 2016, 393-431. https://doi.org/10.1016/B978-0-323-42861-3.00013-3
    49. Junjun Wu, Lu Wang, Zhengkun Xie, Lina Zou, Baoxian Ye. Electrochemical behavior of isofraxidin at an electrodeposition reduced graphene oxide electrode and its analytical application. Analytical Methods 2016, 8 (7) , 1473-1482. https://doi.org/10.1039/C5AY02760H
    50. Wei Zhang, Shuyun Zhu, Rafael Luque, Shuang Han, Lianzhe Hu, Guobao Xu. Recent development of carbon electrode materials and their bioanalytical and environmental applications. Chemical Society Reviews 2016, 45 (3) , 715-752. https://doi.org/10.1039/C5CS00297D
    51. Mohammad Hossein Mashhadizadeh, Niloofar Naseri, Masoud A. Mehrgardi. A digoxin electrochemical aptasensor using Ag nanoparticle decorated graphene oxide. Analytical Methods 2016, 8 (39) , 7247-7253. https://doi.org/10.1039/C6AY02474B
    52. Yongxiang Wang, Lihui Zhou, Sen Wang, Jinxia Li, Jing Tang, Shaolei Wang, Ying Wang. Sensitive and selective detection of Hg 2+ based on an electrochemical platform of PDDA functionalized rGO and glutaraldehyde cross-linked chitosan composite film. RSC Advances 2016, 6 (74) , 69815-69821. https://doi.org/10.1039/C6RA10075A
    53. Richa Sharma, K.V. Ragavan, M.S. Thakur, K.S.M.S. Raghavarao. Recent advances in nanoparticle based aptasensors for food contaminants. Biosensors and Bioelectronics 2015, 74 , 612-627. https://doi.org/10.1016/j.bios.2015.07.017
    54. Liang Wu, Yue Yao, Zhenzhen Li, Xiaohua Zhang, Jinhua Chen. A new amplified impedimetric aptasensor based on the electron transfer ability of Au nanoparticles and their affinity with aptamer. Journal of Electroanalytical Chemistry 2015, 757 , 243-249. https://doi.org/10.1016/j.jelechem.2015.09.042
    55. Lin Cui, Jie Wu, Miaoqi Li, Huangxian Ju. Highly sensitive electrochemical detection of mercury (II) via single ion-induced three-way junction of DNA. Electrochemistry Communications 2015, 59 , 77-80. https://doi.org/10.1016/j.elecom.2015.07.012
    56. Adeline Huiling Loo, Alessandra Bonanni, Martin Pumera. Mycotoxin Aptasensing Amplification by using Inherently Electroactive Graphene‐Oxide Nanoplatelet Labels. ChemElectroChem 2015, 2 (5) , 743-747. https://doi.org/10.1002/celc.201402403
    57. Shao Su, Jie Chao, Dun Pan, Lianhui Wang, Chunhai Fan. Electrochemical Sensors Using Two-Dimensional Layered Nanomaterials. Electroanalysis 2015, 27 (5) , 1062-1072. https://doi.org/10.1002/elan.201400655
    58. Lingyan Feng, Arumugam Sivanesan, Zhaozi Lyu, Andreas Offenhäusser, Dirk Mayer. Electrochemical current rectification–a novel signal amplification strategy for highly sensitive and selective aptamer-based biosensor. Biosensors and Bioelectronics 2015, 66 , 62-68. https://doi.org/10.1016/j.bios.2014.10.057
    59. Jiyang Liu, Tianshu Wang, Jin Wang, Erkang Wang. Mussel-inspired biopolymer modified 3D graphene foam for enzyme immobilization and high performance biosensor. Electrochimica Acta 2015, 161 , 17-22. https://doi.org/10.1016/j.electacta.2015.02.034
    60. Keyu Hou, Lei Huang, Yongbo Qi, Caixia Huang, Haibo Pan, Min Du. A bisphenol A sensor based on novel self-assembly of zinc phthalocyanine tetrasulfonic acid-functionalized graphene nanocomposites. Materials Science and Engineering: C 2015, 49 , 640-647. https://doi.org/10.1016/j.msec.2015.01.064
    61. Jiyang Liu, Jiao Wang, Tianshu Wang, Dan Li, Fengna Xi, Jin Wang, Erkang Wang. Three-dimensional electrochemical immunosensor for sensitive detection of carcinoembryonic antigen based on monolithic and macroporous graphene foam. Biosensors and Bioelectronics 2015, 65 , 281-286. https://doi.org/10.1016/j.bios.2014.10.016
    62. Bangrong Zhuo, Yuqin Li, Xiang Huang, Yuejuan Lin, Yaowen Chen, Wenhua Gao. An electrochemiluminescence aptasensing platform based on ferrocene-graphene nanosheets for simple and rapid detection of thrombin. Sensors and Actuators B: Chemical 2015, 208 , 518-524. https://doi.org/10.1016/j.snb.2014.11.064
    63. Liang Wu, Erhu Xiong, Yue Yao, Xia Zhang, Xiaohua Zhang, Jinhua Chen. A new electrochemical aptasensor based on electrocatalytic property of graphene toward ascorbic acid oxidation. Talanta 2015, 134 , 699-704. https://doi.org/10.1016/j.talanta.2014.12.011
    64. Jianfeng Ping, Yubin Zhou, Yuanyuan Wu, Vladislav Papper, Souhir Boujday, Robert S. Marks, Terry W.J. Steele. Recent advances in aptasensors based on graphene and graphene-like nanomaterials. Biosensors and Bioelectronics 2015, 64 , 373-385. https://doi.org/10.1016/j.bios.2014.08.090
    65. Yuwei Hu, Fenghua Li, Dongxue Han, Li Niu. Graphene for Detection of Adenosine Triphosphate, Nicotinamide Adenine Dinucleotide, Other Molecules, Gas, and Ions. 2015, 81-102. https://doi.org/10.1007/978-3-662-45695-8_5
    66. Lin Cui, Jie Wu, Huangxian Ju. Electrochemical sensing of heavy metal ions with inorganic, organic and bio-materials. Biosensors and Bioelectronics 2015, 63 , 276-286. https://doi.org/10.1016/j.bios.2014.07.052
    67. Xinhao Shi, Wei Gu, Cuiling Zhang, Longyun Zhao, Weidong Peng, Yuezhong Xian. A label-free colorimetric sensor for Pb 2+ detection based on the acceleration of gold leaching by graphene oxide. Dalton Transactions 2015, 44 (10) , 4623-4629. https://doi.org/10.1039/C4DT03883E
    68. Shenguang Ge, Feifei Lan, Feng Yu, Jinghua Yu. Applications of graphene and related nanomaterials in analytical chemistry. New Journal of Chemistry 2015, 39 (4) , 2380-2395. https://doi.org/10.1039/C4NJ01783H
    69. Zhen Zhao, Hongda Chen, Lina Ma, Dianjun Liu, Zhenxin Wang. A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine–graphene nanocomposites. The Analyst 2015, 140 (16) , 5570-5577. https://doi.org/10.1039/C5AN00704F
    70. Xiang Huang, Yuqin Li, Xiaoshan Zhang, Xin Zhang, Yaowen Chen, Wenhua Gao. An efficient signal-on aptamer-based biosensor for adenosine triphosphate detection using graphene oxide both as an electrochemical and electrochemiluminescence signal indicator. The Analyst 2015, 140 (17) , 6015-6024. https://doi.org/10.1039/C5AN00769K
    71. Rui Wang, Kangbing Wu, Can Wu. Highly sensitive electrochemical detection of bisphenol A based on the cooperative enhancement effect of the graphene–Ni(OH) 2 hybrid and hexadecyltrimethylammonium bromide. Analytical Methods 2015, 7 (21) , 9261-9267. https://doi.org/10.1039/C5AY02301G
    72. Zhanming Li, Yue Yu, Zhiliang Li, Tao Wu, Jinjin Yin. The art of signal transforming: electrodes and their smart applications in electrochemical sensing. Analytical Methods 2015, 7 (23) , 9732-9743. https://doi.org/10.1039/C5AY02373D
    73. Jiawan Zhou, Xiaohua Zhang, Erhu Xiong, Peng Yu, Jinhua Chen. A label-free electrochemical strategy for highly sensitive methyltransferase activity assays. Chemical Communications 2015, 51 (24) , 5081-5084. https://doi.org/10.1039/C5CC00658A
    74. Aiqun Wu, Qingxiang Wang, Qionghua Zhu, Jiancong Ni, Feng Gao. A facile and highly sensitive impedimetric DNA biosensor with ultralow background response based on in situ reduced graphene oxide. RSC Advances 2015, 5 (110) , 90983-90990. https://doi.org/10.1039/C5RA16233E
    75. Kostiantyn Turcheniuk, Rabah Boukherroub, Sabine Szunerits. Gold–graphene nanocomposites for sensing and biomedical applications. Journal of Materials Chemistry B 2015, 3 (21) , 4301-4324. https://doi.org/10.1039/C5TB00511F
    76. Lingyan Feng, Zhijun Zhang, Jinsong Ren, Xiaogang Qu. Functionalized graphene as sensitive electrochemical label in target-dependent linkage of split aptasensor for dual detection. Biosensors and Bioelectronics 2014, 62 , 52-58. https://doi.org/10.1016/j.bios.2014.06.008
    77. Lei Shi, Zhenyu Chu, Yu Liu, Wanqin Jin, Nanping Xu. In Situ Fabrication of Three-Dimensional Graphene Films on Gold Substrates with Controllable Pore Structures for High-Performance Electrochemical Sensing. Advanced Functional Materials 2014, 24 (44) , 7032-7041. https://doi.org/10.1002/adfm.201402095
    78. Xiaojun Chen, Lingna Ge, Buhua Guo, Ming Yan, Ning Hao, Lin Xu. Homogeneously ultrasensitive electrochemical detection of adenosine triphosphate based on multiple signal amplification strategy. Biosensors and Bioelectronics 2014, 58 , 48-56. https://doi.org/10.1016/j.bios.2014.02.043
    79. Weibing Qiang, Haiping Liu, Wei Li, Xiang Chen, Danke Xu. Label-free detection of adenosine based on fluorescence resonance energy transfer between fluorescent silica nanoparticles and unmodified gold nanoparticles. Analytica Chimica Acta 2014, 828 , 92-98. https://doi.org/10.1016/j.aca.2014.04.043
    80. Weiwei Yue, Shouzhen Jiang, Shicai Xu, Chengjie Bai. Fabrication of integrated field-effect transistors and detecting system based on CVD grown graphene. Sensors and Actuators B: Chemical 2014, 195 , 467-472. https://doi.org/10.1016/j.snb.2014.01.071
    81. Ioannis V. Pavlidis, Michaela Patila, Angeliki C. Polydera, Dimitrios Gournis, Haralampos Stamatis. Immobilization of Enzymes and other Biomolecules on Graphene. 2014, 139-172. https://doi.org/10.1002/9783527672790.ch5
    82. Liang Wu, Erhu Xiong, Xia Zhang, Xiaohua Zhang, Jinhua Chen. Nanomaterials as signal amplification elements in DNA-based electrochemical sensing. Nano Today 2014, 9 (2) , 197-211. https://doi.org/10.1016/j.nantod.2014.04.002
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    84. Pengbo Wan, Shengyan Yin, Lili Liu, Yuangang Li, Yuanjun Liu, Xiaotian Wang, Wanru Leow, Bing Ma, Xiaodong Chen. Graphene Carrier for Magneto-Controllable Bioelectrocatalysis. Small 2014, 10 (4) , 647-652. https://doi.org/10.1002/smll.201302014
    85. Wei Wen, Ting Bao, Jing Yang, Ming-Zhen Zhang, Wei Chen, Hua-Yu Xiong, Xiu-Hua Zhang, Yuan-Di Zhao, Sheng-Fu Wang. A novel amperometric adenosine triphosphate biosensor by immobilizing graphene/dual-labeled aptamers complex onto poly(o-phenylenediamine) modified electrode. Sensors and Actuators B: Chemical 2014, 191 , 695-702. https://doi.org/10.1016/j.snb.2013.10.061
    86. Chengzhou Zhu, Shaojun Dong. Energetic Graphene‐Based Electrochemical Analytical Devices in Nucleic Acid, Protein and Cancer Diagnostics and Detection. Electroanalysis 2014, 26 (1) , 14-29. https://doi.org/10.1002/elan.201300056
    87. Yunfeng Bai, Feng Feng, Lu zhao, Zezhong Chen, Haiyan Wang, Yali Duan. A label-free fluorescent sensor for Hg 2+ based on target-induced structure-switching of G-quadruplex. Anal. Methods 2014, 6 (3) , 662-665. https://doi.org/10.1039/C3AY42023J
    88. Seyyed Mehdi Khoshfetrat, Masoud A. Mehrgardi. Dual amplification of single nucleotide polymorphism detection using graphene oxide and nanoporous gold electrode platform. The Analyst 2014, 139 (20) , 5192-5199. https://doi.org/10.1039/C4AN01171F
    89. Bangrong Zhuo, Yuqin Li, An Zhang, Fushen Lu, Yaowen Chen, Wenhua Gao. An electrochemiluminescence biosensor for sensitive and selective detection of Hg 2+ based on π–π interaction between nucleotides and ferrocene–graphene nanosheets. J. Mater. Chem. B 2014, 2 (21) , 3263-3270. https://doi.org/10.1039/C4TB00115J
    90. Suli Liu, Jinxing Zhang, Wenwen Tu, Jianchun Bao, Zhihui Dai. Using ruthenium polypyridyl functionalized ZnO mesocrystals and gold nanoparticle dotted graphene composite for biological recognition and electrochemiluminescence biosensing. Nanoscale 2014, 6 (4) , 2419. https://doi.org/10.1039/c3nr05944h
    91. Xiaoli Zhu, Huihui Zhang, Chang Feng, Zonghuang Ye, Genxi Li. A dual-colorimetric signal strategy for DNA detection based on graphene and DNAzyme. RSC Advances 2013, 4 (5) , 2421-2426. https://doi.org/10.1039/C3RA44033H
    92. Weiwei Yue, Shouzhen Jiang, Shicai Xu, Fazhong Huang, Chengjie Bai. Fabrication of capacitive type biosensor based on CVD grown graphene. 2013, 711-714. https://doi.org/10.1109/MEC.2013.6885154
    93. Hai-Bo Wang, Li-Juan Ou, Ke-Jing Huang, Xin-Ge Wen, Ling-Ling Wang, Yan-Ming Liu. A sensitive biosensing strategy for DNA detection based on graphene oxide and T7 exonuclease assisted target recycling amplification. Canadian Journal of Chemistry 2013, 91 (12) , 1266-1271. https://doi.org/10.1139/cjc-2013-0285
    94. Genping Yan, Yonghong Wang, Xiaoxiao He, Kemin Wang, Jinquan Liu, Yudan Du. A highly sensitive label-free electrochemical aptasensor for interferon-gamma detection based on graphene controlled assembly and nuclease cleavage-assisted target recycling amplification. Biosensors and Bioelectronics 2013, 44 , 57-63. https://doi.org/10.1016/j.bios.2013.01.010
    95. F. Valentini, M. Carbone, G. Palleschi. Graphene oxide nanoribbons (GNO), reduced graphene nanoribbons (GNR), and multi-layers of oxidized graphene functionalized with ionic liquids (GO–IL) for assembly of miniaturized electrochemical devices. Analytical and Bioanalytical Chemistry 2013, 405 (11) , 3449-3474. https://doi.org/10.1007/s00216-012-6615-1
    96. Koichi Abe, Wataru Yoshida, Kazunori Ikebukuro. Electrochemical Biosensors Using Aptamers for Theranostics. 2013, 183-202. https://doi.org/10.1007/10_2013_226
    97. Jing Rong Chen, Xiao Xia Jiao, Hong Qun Luo, Nian Bing Li. Probe-label-free electrochemical aptasensor based on methylene blue-anchored graphene oxide amplification. J. Mater. Chem. B 2013, 1 (6) , 861-864. https://doi.org/10.1039/C2TB00267A
    98. Adeline Huiling Loo, Alessandra Bonanni, Martin Pumera. Thrombin aptasensing with inherently electroactive graphene oxide nanoplatelets as labels. Nanoscale 2013, 5 (11) , 4758. https://doi.org/10.1039/c3nr00511a
    99. Adeline Huiling Loo, Alessandra Bonanni, Martin Pumera. Inherently electroactive graphene oxide nanoplatelets as labels for specific protein-target recognition. Nanoscale 2013, 5 (17) , 7844. https://doi.org/10.1039/c3nr02101g
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