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Highly Selective Electrochemical Strategy for Monitoring of Cerebral Cu2+ Based on a Carbon Dot-TPEA Hybridized Surface

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    Highly Selective Electrochemical Strategy for Monitoring of Cerebral Cu2+ Based on a Carbon Dot-TPEA Hybridized Surface
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    † Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, People’s Republic of China, and
    ‡ Department of Chemistry, East China Normal University, Dongchuan Road 500, Shanghai 200241, People’s Republic of China
    *Phone: +86-21-65987075. Fax: +86-21-65981097. E-mail: [email protected]
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    Analytical Chemistry

    Cite this: Anal. Chem. 2013, 85, 1, 418–425
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    https://doi.org/10.1021/ac303113n
    Published December 10, 2012
    Copyright © 2012 American Chemical Society
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    Abstract

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    Direct determination of cerebral metal ions in small volume biological samples is still the bottleneck for evaluating the roles that metal ions play in the physiological and pathological processes. In this work, selected copper ion (Cu2+) as a model, a facile and direct electrochemical method for detection of Cu2+ has been developed on the basis of two new designed strategies: one is specific recognition molecule for Cu2+-AE-TPEA (N-(2-aminoethyl)-N,N′,N′-tris(pyridine-2-yl-methyl)ethane-1,2-diamine); another is carbon dots (C-Dots) with high electrocatalytic activity. Based on the high affinity between TPEA and Cu2+, the electrode assembled with C-Dot-TPEA hybridized nanocomposites shows high selectivity toward Cu2+ over other metal ions, amino acids, and biological coexisting species, such as uric acid (UA), ascorbic acid (AA), and so on, which makes it possible to be used for determination of Cu2+ in the complex brain system. By taking advantage of C-Dots, a dynamic linear range from 1 μM to 60 μM is first achieved with a detection limit of ∼100 nM in aCSF solution. In addition, the developed method with theoretical simplicity and less instrumental demands exhibits long-term stability and good reproducibility. As a result, the present strategy has been successfully applied in detection of cerebral Cu2+ in normal rat brain and that followed by global cerebral ischemia, combined with in vivo microdialysis. The determined concentrations of Cu2+ in the rat brain microdialysates by the present method are found to be identical to those obtained by the conventional ICP-AES method.

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    1H NMR, 13C NMR, ES-MS, HR-MS, IR characterization of AE-TPEA, FT-IR spectrum of C-Dots, and comparison of DPASV responses. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Analytical Chemistry

    Cite this: Anal. Chem. 2013, 85, 1, 418–425
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    https://doi.org/10.1021/ac303113n
    Published December 10, 2012
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