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Theragnostic pH-Sensitive Gold Nanoparticles for the Selective Surface Enhanced Raman Scattering and Photothermal Cancer Therapy

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2013, 85, 16, 7674-7681
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    Theragnostic pH-Sensitive Gold Nanoparticles for the Selective Surface Enhanced Raman Scattering and Photothermal Cancer Therapy
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    † ‡ †School of Interdisciplinary Bioscience and Bioengineering and ‡Department of Chemistry, Pohang University of Science & Technology (POSTECH), San 31, Hyojadong, Namgu, Pohang 790-784, Korea
    § Frontier Research Laboratory, Samsung Advanced Institute of Technology, Samsung Electronics, Yongin, Kyunggi-do 446-712, Korea
    *Phone: (+82) 054-279-2108. Fax: (+82) 054-279-1498. E-mail: [email protected]
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    Analytical Chemistry

    Cite this: Anal. Chem. 2013, 85, 16, 7674–7681
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    https://doi.org/10.1021/ac401390m
    Published July 24, 2013
    Copyright © 2013 American Chemical Society
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    Abstract

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    We report a nanoparticle-based probe that can be used for a “turn-on” theragnostic agent for simultaneous Raman imaging/diagnosis and photothermal therapy. The agent consists of a 10 nm spherical gold nanoparticle (NP) with pH-responsive ligands and Raman probes on the surface. They are engineered to exhibit the surface with both positive and negative charges upon mildly acidic conditions, which subsequently results in rapid aggregations of the gold NPs. This aggregation simultaneously provides hot spots for the SERS probe with the enhancement factor reaching 1.3 × 104 and shifts the absorption to far-red and near-infrared (which is optimal for deep tissue penetration) by the coupled plasmon resonances; this shift was successfully exploited for low-threshold photothermal therapy. The theragnostic gold NPs are cancer-specific because they aggregate rapidly and accumulate selectively in cancerous cells. As the result, both Raman imaging and photothermal efficacy were turned on under a cancerous local environment. In addition, the relatively small hydrodynamic size can have the potential for better access to targeted delivery in vivo and facilitated excretion after therapy.

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    Hydrodynamic sizes of gold NPs, surface ligand coverage calculation using UV–vis absorption spectroscopy, and hydrodynamic size time evolution of MBA/SMART-AuNPs dispersed in the cell medium. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Analytical Chemistry

    Cite this: Anal. Chem. 2013, 85, 16, 7674–7681
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    https://doi.org/10.1021/ac401390m
    Published July 24, 2013
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