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Flexible Software Platform for Fast-Scan Cyclic Voltammetry Data Acquisition and Analysis

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† Department of Chemistry and Neuroscience Center University of North Carolina at Chapel Hill Chapel Hill, NC 27599-3290
‡ Department of Chemistry, Roanoke College, Salem, VA 24153
*E-mail: [email protected]. Fax: (919) 962-2388. Tel.: (919) 962-1472.
Cite this: Anal. Chem. 2013, 85, 21, 10344–10353
Publication Date (Web):October 1, 2013
https://doi.org/10.1021/ac402263x
Copyright © 2013 American Chemical Society
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    Abstract

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    Over the last several decades, fast-scan cyclic voltammetry (FSCV) has proved to be a valuable analytical tool for the real-time measurement of neurotransmitter dynamics in vitro and in vivo. Indeed, FSCV has found application in a wide variety of disciplines including electrochemistry, neurobiology, and behavioral psychology. The maturation of FSCV as an in vivo technique led users to pose increasingly complex questions that require a more sophisticated experimental design. To accommodate recent and future advances in FSCV application, our lab has developed High Definition Cyclic Voltammetry (HDCV). HDCV is an electrochemical software suite that includes data acquisition and analysis programs. The data collection program delivers greater experimental flexibility and better user feedback through live displays. It supports experiments involving multiple electrodes with customized waveforms. It is compatible with transistor–transistor logic-based systems that are used for monitoring animal behavior, and it enables simultaneous recording of electrochemical and electrophysiological data. HDCV analysis streamlines data processing with superior filtering options, seamlessly manages behavioral events, and integrates chemometric processing. Furthermore, analysis is capable of handling single files collected over extended periods of time, allowing the user to consider biological events on both subsecond and multiminute time scales. Here we describe and demonstrate the utility of HDCV for in vivo experiments.

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