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Lab on Paper: Iodometric Titration on a Printed Card

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Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States
University of Toledo, Toledo, Ohio 43606, United States
*Phone: (574) 631-4665. E-mail: [email protected]
Cite this: Anal. Chem. 2015, 87, 7, 3764–3770
Publication Date (Web):February 25, 2015
https://doi.org/10.1021/ac504269q
Copyright © 2015 American Chemical Society
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Abstract

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A paper test card has been engineered to perform an iodometric titration, an application that requires storage and mixing on demand of several mutually incompatible reagents. The titration is activated when a user applies a test solution to the test card: the dried reagents are reconstituted and combined through a surface-tension-enabled mixing (STEM) mechanism. The device quantifies 0.8–15 ppm of iodine atoms from iodate in aqueous solutions. This is useful, for example, to quantify iodine levels in fortified salt. A blinded internal laboratory validation established the accuracy as 1.4 ppm I and the precision as 0.9 ppm I when the test card was read by newly trained users. Using computer software to process images, the accuracy and precision both improved to 0.9 ppm I. The paper card can also detect substandard β lactam antibiotics using an iodometric back-titration. When used to quantify amoxicillin, good distinction is achieved between solutions that differ by 0.15 mg/mL over a working range of 0–0.9 mg/mL. The test card was designed to meet the World Health Organization ASSURED criteria for use in low resource settings, where laboratory-based analytical procedures are often not available.

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Fabrication details, full set of standard images for known iodine concentrations, additional analysis of data from expert readers and computer image analysis, calibration for amoxicillin analysis, Adobe Illustrator print files, and Powerpoint presentation used for training card readers. This material is available free of charge via the Internet at http://pubs.acs.org.

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