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Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2008, 80, 12, 4761-4766
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    Nanoparticle-Assisted Laser Desorption/Ionization Based Mass Imaging with Cellular Resolution
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    Molecular Gerontology Group, Mitsubishi Kagaku Institute of Life Sciences (MITILS), Machida, Tokyo 194-8511, Japan, Department of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Kanagawa 226-8501, Japan, Department of Physics, Graduate School of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan, Okazaki Institute for Integrative Bioscience, National Institute of Natural Sciences, Okazaki, Aichi 444-8787, Japan, and Molecular Imaging Advanced Research Center, Department of Molecular Anatomy, Hamamatsu Medical School, 1-20-1 Handayama, Hamamatsu, Shizuoka, Japan
    * Corresponding author. E-mail: [email protected]. Phone and Fax: +81-053-435-2292 .
    †Mitsubishi Kagaku Institute of Life Sciences (MITILS).
    ‡Tokyo Institute of Technology.
    §Yokohama National University.
    ∥Okazaki Institute for Integrative Bioscience.
    ⊥Hamamatsu Medical School.
    #Present address: TOSEI Electrobeam Co. Ltd., 651-6 Takane, Mizuho-machi, Nishitama-gun, Tokyo 190-1203.
    ▽Present address: Department of Physics, Graduate School of Science, Osaka University, 1-1 Machikaneyama-chou, Toyonaka City, Osaka 560-0043, Japan.
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    Analytical Chemistry

    Cite this: Anal. Chem. 2008, 80, 12, 4761–4766
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    https://doi.org/10.1021/ac800081z
    Published May 14, 2008
    Copyright © 2008 American Chemical Society
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    Abstract

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    Today, two-dimensional mass spectrometry analysis of biological tissues by means of a technique called mass imaging, mass spectrometry imaging (MSI), or imaging mass spectrometry (IMS) has found application in investigating the distribution of molecules—MSI with matrix-assisted laser desorption/ionization (MALDI) and secondary ion MS (SIMS). However, the size of the matrix crystal and the migration of analytes can decrease the spatial resolution in MALDI, and SIMS can only ionize compounds with relatively low molecular weights. To overcome these problems, we developed a nanoparticle-assisted laser desorption/ionization (nano-PALDI)-based MSI. We used nano-PALDI MSI to visualize lipids and peptides at a resolution of 15 µm in mammalian tissues.

    Copyright © 2008 American Chemical Society

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    Further characterization of fNPs, nano-PALDI MS, and small-molecule MSI analysis. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Analytical Chemistry

    Cite this: Anal. Chem. 2008, 80, 12, 4761–4766
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    https://doi.org/10.1021/ac800081z
    Published May 14, 2008
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