Label-Free SERS Analysis of Urine Using a 3D-Stacked AgNW-Glass Fiber Filter Sensor for the Diagnosis of Pancreatic Cancer and Prostate CancerClick to copy article linkArticle link copied!
- Jung Bin PhyoJung Bin PhyoDepartment of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaSmart Healthcare Research Institute, Samsung Medical Center, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaMore by Jung Bin Phyo
- Ayoung WooAyoung WooDepartment of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaMore by Ayoung Woo
- Ho Jae YuHo Jae YuDepartment of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaMore by Ho Jae Yu
- Kyongmook LimKyongmook LimSmart Healthcare Research Institute, Samsung Medical Center, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaMore by Kyongmook Lim
- Baek Hwan ChoBaek Hwan ChoDepartment of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaSmart Healthcare Research Institute, Samsung Medical Center, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaMore by Baek Hwan Cho
- Ho Sang Jung*Ho Sang Jung*Email: [email protected]. Phone: +82 55 280 3633.Department of Nano-Bio Convergence, Korea Institute of Materials Science (KIMS), Changwon, Gyeongnam 51508, Republic of KoreaMore by Ho Sang Jung
- Min-Young Lee*Min-Young Lee*Email: [email protected]. Phone: +82 2 6007 5416.Department of Medical Device Management and Research, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaSmart Healthcare Research Institute, Samsung Medical Center, 81, Irwon-ro, Gangnam-gu, Seoul 06351, Republic of KoreaMore by Min-Young Lee
Abstract

Metabolomics shows tremendous potential for the early diagnosis and screening of cancer. For clinical application as an effective diagnostic tool, however, improved analytical methods for complex biological fluids are required. Here, we developed a reliable rapid urine analysis system based on surface-enhanced Raman spectroscopy (SERS) using 3D-stacked silver nanowires (AgNWs) on a glass fiber filter (GFF) sensor and applied it to the diagnosis of pancreatic cancer and prostate cancer. Urine samples were pretreated with centrifugation to remove large debris and with calcium ion addition to improve the binding of metabolites to AgNWs. The label-free urine-SERS detection using the AgNW-GFF SERS sensor showed different spectral patterns and distinguishable specific peaks in three groups: normal control (n = 30), pancreatic cancer (n = 22), and prostate cancer (n = 22). Multivariate analyses of SERS spectra using unsupervised principal component analysis and supervised orthogonal partial least-squares discriminant analysis showed excellent discrimination between the pancreatic cancer group and the prostate cancer group as well as between the normal control group and the combined cancer groups. The results demonstrate the great potential of the urine-SERS analysis system using the AgNW-GFF SERS sensor for the noninvasive diagnosis and screening of cancers.
Cited By
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by ACS Publications if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
This article is cited by 70 publications.
- Zhaoxian Chen, Yao Liu, Wenrou Yu, Shihong Liu, Yingzhou Huang. Machine Learning-Driven Wearable Sweat Sensors with AgNW/MXene for Non-Invasive SERS-Based Cardiovascular Disease Detection. ACS Applied Nano Materials 2025, Article ASAP.
- Dechan Lu, Zufang Huang, Jingbo Chen, Yudong Lu. pH-Adjusted Liquid SERS Approach: Toward a Reliable Plasma-Based Early Stage Lung Cancer Detection. Analytical Chemistry 2025, 97
(1)
, 508-515. https://doi.org/10.1021/acs.analchem.4c04671
- Thu Thuy Bui, Doanh Cong Sai, An Bang Ngac, Tien Duc Pham, Bach Pham, Hoeil Chung, Tung Duy Vu. Highly Durable and Reusable 3D Copper Foam-Based SERS Substrate with CuO-Ag Nanorods for Ultrasensitive Measurements of Rhodamine-6G and Human Urine. ACS Applied Nano Materials 2025, 8
(1)
, 844-853. https://doi.org/10.1021/acsanm.4c06298
- Zhaoxian Chen, Kejin Chen, Wenrou Yu, Xiang Wang, Xi He, Qiang Zhang, Chunling Ge, Haiyang Shi, Yingzhou Huang. SERS-AI Based Detection and Bioanalysis of Malodorous Components in Kitchen Waste. Analytical Chemistry 2024, 96
(49)
, 19615-19622. https://doi.org/10.1021/acs.analchem.4c04699
- Yuqing Gu, Jiayi Wang, Zhewen Luo, Xingyi Luo, Linley Li Lin, Shuang Ni, Cong Wang, Haoran Chen, Zehou Su, Yao Lu, Li-Yong Gan, Zhou Chen, Jian Ye. Multiwavelength Surface-Enhanced Raman Scattering Fingerprints of Human Urine for Cancer Diagnosis. ACS Sensors 2024, 9
(11)
, 5999-6010. https://doi.org/10.1021/acssensors.4c01873
- Qi Liu, Wenrou Yu, Anping Liu, Zhaoxian Chen, Xuliang Xia, Yingzhou Huang, Haiyang Shi. AI Algorithm-Assisted SERS Detection of Levothyroxine Sodium in Urine by an Optoplasmonic Film. The Journal of Physical Chemistry C 2024, 128
(43)
, 18376-18383. https://doi.org/10.1021/acs.jpcc.4c05034
- Sila Jin, Igor K. Lednev, Young Mee Jung. Recent Trends in Surface-Enhanced Raman Spectroscopy-Based Biosensors: Label-Free Early Disease Diagnosis. The Journal of Physical Chemistry C 2024, 128
(22)
, 8861-8873. https://doi.org/10.1021/acs.jpcc.4c02011
- Marios Constantinou, Katerina Hadjigeorgiou, Sara Abalde-Cela, Chrysafis Andreou. Label-Free Sensing with Metal Nanostructure-Based Surface-Enhanced Raman Spectroscopy for Cancer Diagnosis. ACS Applied Nano Materials 2022, 5
(9)
, 12276-12299. https://doi.org/10.1021/acsanm.2c02392
- Zhengxia Yang, Hai-Sheng Su, En-Ming You, Siying Liu, Zihang Li, Yun Zhang. High Uniformity and Enhancement Au@AgNS 3D Substrates for the Diagnosis of Breast Cancer. ACS Omega 2022, 7
(17)
, 15223-15230. https://doi.org/10.1021/acsomega.2c01453
- Javier Plou, Pablo S. Valera, Isabel García, Carlos D. L. de Albuquerque, Arkaitz Carracedo, Luis M. Liz-Marzán. Prospects of Surface-Enhanced Raman Spectroscopy for Biomarker Monitoring toward Precision Medicine. ACS Photonics 2022, 9
(2)
, 333-350. https://doi.org/10.1021/acsphotonics.1c01934
- Siying Liu, Hai-Sheng Su, Zhengxia Yang, Yun Zhang. Ag Nanorods for Label-Free Surface-Enhanced Raman Scattering Analysis of Cancer Cells from Cell Lysates. ACS Applied Nano Materials 2022, 5
(1)
, 269-276. https://doi.org/10.1021/acsanm.1c02790
- Yingqiu Gu, Di Xu, Kun Zou, Tingrong Zhou, Gen Zhu, Guohai Yang, Lu-Lu Qu. Combined Paper Centrifugal Chromatographic Separation and SERS Detection for Multicomponent Substances. Analytical Chemistry 2021, 93
(25)
, 8693-8697. https://doi.org/10.1021/acs.analchem.1c01625
- Zhejun Yang, Ren Zhang, Chenlei Cai, Hua Zhang, Hui Chen, Jilie Kong. Improved ensemble learning enhanced serum fingerprinting spectroscopy for lung cancer diagnosis. Sensors and Actuators B: Chemical 2025, 430 , 137353. https://doi.org/10.1016/j.snb.2025.137353
- Jiaqi Wang, Fanxiang Meng, Zhiyong Ma, Mo Chen, Weigang Wang, Shuping Xu. Surface-enhanced Raman spectroscopy (SERS)-based urine biopsy for kidney transplant patients. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025, 332 , 125822. https://doi.org/10.1016/j.saa.2025.125822
- Ailiyaer Ainiwaer, ShuWen Sun, Ayinuer Bohetiyaer, Yuchao Liu, Yufeng Jiang, Wentao Zhang, JingCheng Zhang, Tianyuan Xu, Hanyang Chen, Xudong Yao, Chengyou Jia, Yang Yan. Application of raman spectroscopy in the non-invasive diagnosis of urological diseases via urine. Photodiagnosis and Photodynamic Therapy 2025, 52 , 104477. https://doi.org/10.1016/j.pdpdt.2025.104477
- Liping Chen, Xuanjiang Zeng, Rui Tan, Ting Li, Ruxi Lin, Chuanfeng Wang, Yahui Zhang, Xiaojun Luo. Raman spectroscopic fingerprinting for the identification and quantitative analysis of sports doping β − agonists based on gold nanopolyhedra. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025, 330 , 125698. https://doi.org/10.1016/j.saa.2025.125698
- Haonan Wang, Peipei Xu, Jiaru Wei, Liting Qiu, Jing Zou, ChengLu Lin, Ruiyun You, Yuhua Hu, Li Zhang, Yudong Lu. Urine collection by sodium alginate/CMC composite self-calibrating aerogel SERS platform for accurate screening and staging of chronic kidney disease. International Journal of Biological Macromolecules 2025, 302 , 140520. https://doi.org/10.1016/j.ijbiomac.2025.140520
- Zhewen Luo, Haoran Chen, Xinyuan Bi, Jian Ye. Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy. Advanced Drug Delivery Reviews 2025, 217 , 115483. https://doi.org/10.1016/j.addr.2024.115483
- Xianli Tian, Peng Wang, Guoqiang Fang, Xiang Lin, Jing Gao. Simultaneous quantitative analysis of multiple metabolites using label-free surface-enhanced Raman spectroscopy and explainable deep learning. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2025, 327 , 125386. https://doi.org/10.1016/j.saa.2024.125386
- Jingjing Wu, Baohong Zhang, Lei Xu, Yanyu Zhao, Tao Chen, Jie Lin, Anran Li. Surface-enhanced Raman scattering on nanomaterials for cancer and pathogens diagnosis. Nano Research 2025, 18
(2)
, 94907096. https://doi.org/10.26599/NR.2025.94907096
- David Andras, Ramona G. Cozan, Delia E. Muresan, Vlad Moisoiu, George Crisan, Vasile Bintintan, George C. Dindelegan, Nicolae Leopold, Stefania D. Iancu. Advancing Breast Cancer Diagnosis: Optimization of Raman Spectroscopy for Urine-Based Early Detection. Biomedicines 2025, 13
(2)
, 505. https://doi.org/10.3390/biomedicines13020505
- Shivani Devi, Ashik Babu Parambath, Kavita Arora. Challenges, significance, and prospects of nanomaterials based next generation biosensors. 2025, 337-423. https://doi.org/10.1016/B978-0-443-19146-6.00001-0
- Xinyuan Bi, Bin Ma, Wei Liu, Wei-Qiang Gao, Jian Ye, Hanyu Rao. Transcriptome-aligned metabolic profiling by SERSome reflects biological changes following mesenchymal stem cells expansion. Stem Cell Research & Therapy 2024, 15
(1)
https://doi.org/10.1186/s13287-024-04109-0
- Kangseok Jo, Vo Thi Nhat Linh, Jun-Yeong Yang, Boyou Heo, Jun Young Kim, Na Eun Mun, Jin Hee Im, Ki Su Kim, Sung-Gyu Park, Min-Young Lee, Su Woong Yoo, Ho Sang Jung. Machine learning-assisted label-free colorectal cancer diagnosis using plasmonic needle-endoscopy system. Biosensors and Bioelectronics 2024, 264 , 116633. https://doi.org/10.1016/j.bios.2024.116633
- Indrajit Mondal, Elias Mansour, Youbin Zheng, Ritu Gupta, Hossam Haick. Self‐Sustaining Triboelectric Nanosensors for Real‐Time Urine Analysis in Smart Toilets. Small 2024, 20
(42)
https://doi.org/10.1002/smll.202403385
- Kun Xu, Junjie Ren, Xiangcheng Shan, Min Zhang, Chuanyong Jing. Detecting antimony(III) on-site using novel gel-based techniques: Colorimetric diffusive equilibrium in thin films for two-dimensional imaging and surface-enhanced Raman scattering for sensitive quantification. Talanta 2024, 278 , 126502. https://doi.org/10.1016/j.talanta.2024.126502
- Daniel Rivera, Tirone Young, Akhil Rao, Jack Y. Zhang, Cole Brown, Lily Huo, Tyree Williams, Benjamin Rodriguez, Alexander J. Schupper. Current Applications of Raman Spectroscopy in Intraoperative Neurosurgery. Biomedicines 2024, 12
(10)
, 2363. https://doi.org/10.3390/biomedicines12102363
- Uğur Köroğlu, Necdet Saglam, Uğur Tamer, Ramazan Akçan. Altın Nano Çubuklar ve Gümüş Nano Parçacıklar Kullanılarak Yüzeyde Zenginleştirilmiş Raman Spektroskopisi Yoluyla Saf ve Karışık İdrar Lekelerinin Tanımlanması. Politeknik Dergisi 2024, 27
(4)
, 1335-1343. https://doi.org/10.2339/politeknik.1216163
- Muhammad Shalahuddin Al Ja’farawy, Vo Thi Nhat Linh, Jun-Yeong Yang, Chaewon Mun, Seunghun Lee, Sung-Gyu Park, In Woong Han, Samjin Choi, Min-Young Lee, Dong-Ho Kim, Ho Sang Jung. Whole urine-based multiple cancer diagnosis and metabolite profiling using 3D evolutionary gold nanoarchitecture combined with machine learning-assisted SERS. Sensors and Actuators B: Chemical 2024, 412 , 135828. https://doi.org/10.1016/j.snb.2024.135828
- Yijiao Qu, Ming Chen, Yiran Wang, Liangliang Qu, Ruiyue Wang, Huihui Liu, Liping Wang, Zongxiu Nie. Rapid screening of infertility-associated gynecological conditions via ambient glow discharge mass spectrometry utilizing urine metabolic fingerprints. Talanta 2024, 274 , 125969. https://doi.org/10.1016/j.talanta.2024.125969
- Sungwoon Lee, Hajun Dang, Joung-Il Moon, Kihyun Kim, Younju Joung, Sohyun Park, Qian Yu, Jiadong Chen, Mengdan Lu, Lingxin Chen, Sang-Woo Joo, Jaebum Choo. SERS-based microdevices for use as
in vitro
diagnostic biosensors. Chemical Society Reviews 2024, 53
(11)
, 5394-5427. https://doi.org/10.1039/D3CS01055D
- Wenwen Li, Changrui Yang, Hulin Zhao, Mengtao Sun, Zhouzhou Bao. Surface enhanced Raman spectroscopy on diagnosis of malignant tumors. Applied Spectroscopy Reviews 2024, 59
(5)
, 678-709. https://doi.org/10.1080/05704928.2023.2250875
- Lin Chen, Bin Chen, Takuya Matsuo, Fumihiro Sassa, Kenshi Hayashi. Recognition of Mixture Vapors Using SERS Gas Sensor Fabricated by the Sputtering Method. IEEE Sensors Journal 2024, 24
(10)
, 15773-15783. https://doi.org/10.1109/JSEN.2024.3383053
- Min Fan, Youliang Weng, Yi Liu, Yudong Lu, Luyun Xu, Jianqing Ye, Duo Lin, Sufang Qiu, Shangyuan Feng. Surface‐Enhanced Raman Spectroscopy‐Based Optical Biosensor for Liquid Biopsy: Toward Precision Medicine. Laser & Photonics Reviews 2024, 18
(5)
https://doi.org/10.1002/lpor.202301072
- Bogdan Adrian Buhas, Valentin Toma, Jean-Baptiste Beauval, Iulia Andras, Răzvan Couți, Lucia Ana-Maria Muntean, Radu-Tudor Coman, Teodor Andrei Maghiar, Rareș-Ionuț Știufiuc, Constantin Mihai Lucaciu, Nicolae Crisan. Label-Free SERS of Urine Components: A Powerful Tool for Discriminating Renal Cell Carcinoma through Multivariate Analysis and Machine Learning Techniques. International Journal of Molecular Sciences 2024, 25
(7)
, 3891. https://doi.org/10.3390/ijms25073891
- Jianli Sun, Wangqi Mao, Chuansheng Xia, Weian Wang, Qiannan Cui, Zengliang Shi, Gangyi Zhu, Mingliang Wang, Chunxiang Xu. Plasmon‐Coupled GaN Microcavity for WGM Lasing and Label‐Free SERS Sensing of Biofluids. Advanced Optical Materials 2024, 12
(7)
https://doi.org/10.1002/adom.202301989
- Ho-Jae Yu, Eunji Jang, Ayoung Woo, In Woong Han, Hwang Gyun Jeon, Vo Thi Nhat Linh, Sung-Gyu Park, Ho Sang Jung, Min-Young Lee. Cancer screening through surface-enhanced Raman spectroscopy fingerprinting analysis of urinary metabolites using surface-carbonized silver nanowires on a filter membrane. Analytica Chimica Acta 2024, 1292 , 342233. https://doi.org/10.1016/j.aca.2024.342233
- Min Fan, Kaiming Peng, Youliang Weng, Yuanmei Chen, Qiyi Zhang, Minqi Lin, Duo Lin, Yudong Lu, Shangyuan Feng. LC-MS/MS-assisted label-free SERS blood analysis by self-position plasmonic platform for tumor screening. Chemical Engineering Journal 2024, 483 , 149348. https://doi.org/10.1016/j.cej.2024.149348
- Lei Xu, Yujiao Xie, Jie Lin, Aiguo Wu, Tianan Jiang. Advancements in SERS‐based biological detection and its application and perspectives in pancreatic cancer. VIEW 2024, 5
(1)
https://doi.org/10.1002/VIW.20230070
- Vo Thi Nhat Linh, Muhammad Shalahuddin Al Ja’farawy, Eun Hye Koh, Min-Young Lee, Sung-Gyu Park, Dong-Ho Kim, Ho Sang Jung. Flexible surface-enhanced Raman scattering substrates toward sampling approaches for on-site sensing and diagnosis applications. Applied Spectroscopy Reviews 2024, 59
(1)
, 90-123. https://doi.org/10.1080/05704928.2023.2181818
- Vo Thi Nhat Linh, Hongyoon Kim, Min-Young Lee, Jungho Mun, Yeseul Kim, Byeong-Ho Jeong, Sung-Gyu Park, Dong-Ho Kim, Junsuk Rho, Ho Sang Jung. 3D plasmonic hexaplex paper sensor for label-free human saliva sensing and machine learning-assisted early-stage lung cancer screening. Biosensors and Bioelectronics 2024, 244 , 115779. https://doi.org/10.1016/j.bios.2023.115779
- Guoqun Li, Xingce Fan, Xiao Tang, Xing Zhao, Qi Hao, Jiaqi Li, Teng Qiu. Challenges and Prospects of Personalized Healthcare Based on Surface-Enhanced Raman Spectroscopy. Research 2024, 7 https://doi.org/10.34133/research.0572
- Ho Sang Jung, Muhammad Shalahuddin Al Ja’farawy, Vo Thi Nhat Linh, Jun-Yeong Yang, Chaewon Mun, Seunghun Lee, Sung-Gyu Park, In Woong Han, Samjin Choi, Min-Young Lee, Dong-Ho Kim. 3D Plasmonic Multilayered Gold Nanoarchitecture for Multiple Cancer Diagnosis Using SERS and Machine Learning-Assisted Liquid-Phase Human Urine Sensing. 2023https://doi.org/10.21203/rs.3.rs-3612675/v1
- Edoardo Farnesi, Silvia Rinaldi, Chen Liu, Jonas Ballmaier, Orlando Guntinas-Lichius, Michael Schmitt, Dana Cialla-May, Juergen Popp. Label-Free SERS and MD Analysis of Biomarkers for Rapid Point-of-Care Sensors Detecting Head and Neck Cancer and Infections. Sensors 2023, 23
(21)
, 8915. https://doi.org/10.3390/s23218915
- Keyu Yi, Zilin Fan, Qimeng Ran, Kun Jia, Xiaobo Liu, Lei Wang. Scalable fabrication of silver covered polyurethane nanofibers as flexible SERS nanosensors for aflatoxin detection. Talanta 2023, 263 , 124636. https://doi.org/10.1016/j.talanta.2023.124636
- Ciyong Gu, Delong Meng, Xiaolei Yu, Lin Li, Zhimin Zhao. Highly Sensitive and Flexible GFF/Au/AgNPs SERS Substrate and Its Application for Rapid Hazardous Residues Detection on Food. Plasmonics 2023, 18
(4)
, 1541-1552. https://doi.org/10.1007/s11468-023-01864-3
- Rareș-Mario Borșa, Valentin Toma, Anca Onaciu, Cristian-Silviu Moldovan, Radu Mărginean, Diana Cenariu, Gabriela-Fabiola Știufiuc, Cristian-Mihail Dinu, Simion Bran, Horia-Octavian Opriș, Sergiu Văcăraș, Florin Onișor-Gligor, Dorin Sentea, Mihaela-Felicia Băciuț, Cristina-Adela Iuga, Rareș-Ionuț Știufiuc. Developing New Diagnostic Tools Based on SERS Analysis of Filtered Salivary Samples for Oral Cancer Detection. International Journal of Molecular Sciences 2023, 24
(15)
, 12125. https://doi.org/10.3390/ijms241512125
- Xue Deng, Song Wang, Wei Zhou, Minghao Xu, Bo Chen, Wenqiang Zhang. Wrinkle-bioinspired silver nanowire surface enhanced Raman scattering sensors for pesticide molecule detection. Analytical and Bioanalytical Chemistry 2023, 415
(16)
, 3255-3264. https://doi.org/10.1007/s00216-023-04702-x
- Huan Zhang, HuaKun Wan, XiuYuan Hu, QingHua Zhao, JianGuo Lu, Dong Wang, ZhenTan Lu. Antimicrobial-free knitted fabric as wound dressing and the mechanism of promoting infected wound healing. Science China Technological Sciences 2023, 66
(7)
, 2147-2154. https://doi.org/10.1007/s11431-022-2260-x
- Yixin Chen, Shujun Zheng, Xiaoya Tang, Fei Wang, Linjie Wang, Caolong Li. Recent Research Progress of Surface‐Enhanced Raman Scattering Dominated Analysis Strategies in Early Diagnosis of Diseases. Chemistry – An Asian Journal 2023, 18
(12)
https://doi.org/10.1002/asia.202300264
- Sabareeswaran Krishnan, Shruthi Kanthaje, Devasya Rekha Punchappady, M. Mujeeburahiman, Chandrahas Koumar Ratnacaram. Circulating metabolite biomarkers: a game changer in the human prostate cancer diagnosis. Journal of Cancer Research and Clinical Oncology 2023, 149
(3)
, 951-967. https://doi.org/10.1007/s00432-022-04113-y
- Vo Thi Nhat Linh, Min-Young Lee, Jungho Mun, Yeseul Kim, Hongyoon Kim, In Woong Han, Sung-Gyu Park, Samjin Choi, Dong-Ho Kim, Junsuk Rho, Ho Sang Jung. 3D plasmonic coral nanoarchitecture paper for label-free human urine sensing and deep learning-assisted cancer screening. Biosensors and Bioelectronics 2023, 224 , 115076. https://doi.org/10.1016/j.bios.2023.115076
- Jae Hyun Kim, Yong Jin An, Tae Min Kim, Jeong Eun Kim, Sunghyouk Park, Seung Hong Choi. Ex vivo
NMR
metabolomics approach using cerebrospinal fluid for the diagnosis of primary
CNS
lymphoma: Correlation with
MR
imaging characteristics. Cancer Medicine 2023, 12
(4)
, 4679-4689. https://doi.org/10.1002/cam4.5083
- Jinyong Lin, Shangyuan Feng, Xianzeng Zhang. Combining urine surface-enhanced Raman spectroscopy with PCA-SVM algorithm for improving the identification of colorectal cancer at different stages. Optoelectronics Letters 2023, 19
(2)
, 101-104. https://doi.org/10.1007/s11801-023-2157-3
- María del Carmen Díaz-Liñán, Rafael Lucena, Soledad Cárdenas, Ángela I. López-Lorente. Surface-enhanced Raman spectroscopy (SERS) Sensors for Clinical Analysis. 2023, 693-708. https://doi.org/10.1016/B978-0-12-822548-6.00111-4
- Xiaotian Huang, Bin Li, Tianlu Mo, Qing Liu, Ying Yu, Yafang Wu, Yinglin Wang, Jiaye Jiang. Advances in tumor marker detection using surface-enhanced Raman spectroscopy. Chinese Science Bulletin 2023, 391 https://doi.org/10.1360/TB-2022-1063
- Samir Kumar, Shashank K. Gahlaut, J.P. Singh. Sculptured thin films: Overcoming the limitations of surface-enhanced Raman scattering substrates. Applied Surface Science Advances 2022, 12 , 100322. https://doi.org/10.1016/j.apsadv.2022.100322
- Tudor Moisoiu, Mihnea P. Dragomir, Stefania D. Iancu, Simon Schallenberg, Giovanni Birolo, Giulio Ferrero, Dan Burghelea, Andrei Stefancu, Ramona G. Cozan, Emilia Licarete, Alessandra Allione, Giuseppe Matullo, Gheorghita Iacob, Zoltán Bálint, Radu I. Badea, Alessio Naccarati, David Horst, Barbara Pardini, Nicolae Leopold, Florin Elec. Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer. Molecular Medicine 2022, 28
(1)
https://doi.org/10.1186/s10020-022-00462-z
- Xin Zhao, Qingjiang Xu, Yamin Lin, Weiwei Du, Xin Bai, Jiamin Gao, Tao Li, Yimei Huang, Yun Yu, Xiang Wu, Juqiang Lin. Label‐free surface‐enhanced Raman spectroscopy detection of prostate cancer combined with multivariate statistical algorithm. Journal of Raman Spectroscopy 2022, 53
(11)
, 1861-1870. https://doi.org/10.1002/jrs.6428
- Heebo Ha, Chiara Amicucci, Paolo Matteini, Byungil Hwang. Mini review of synthesis strategies of silver nanowires and their applications. Colloid and Interface Science Communications 2022, 50 , 100663. https://doi.org/10.1016/j.colcom.2022.100663
- Tao Xie, Pan Li, Meihong Ge, Siyu Chen, Guangyao Huang, Junxiang Li, Meiting Gong, Shirui Weng, Liangbao Yang. Construction of Ag nanowire@Au nanoparticle nano nests with densely stacked small gaps for actively trapping molecules to realize diversity SERS detection. The Analyst 2022, 147
(11)
, 2541-2548. https://doi.org/10.1039/D2AN00527A
- Stefania D. Iancu, Ramona G. Cozan, Andrei Stefancu, Maria David, Tudor Moisoiu, Cristiana Moroz-Dubenco, Adel Bajcsi, Camelia Chira, Anca Andreica, Loredana F. Leopold, Daniela Eniu, Adelina Staicu, Iulian Goidescu, Carmen Socaciu, Dan T. Eniu, Laura Diosan, Nicolae Leopold. SERS liquid biopsy in breast cancer. What can we learn from SERS on serum and urine?. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2022, 273 , 120992. https://doi.org/10.1016/j.saa.2022.120992
- Kit Man Chan, Jonathan M. Gleadle, Michael O’Callaghan, Krasimir Vasilev, Melanie MacGregor. Prostate cancer detection: a systematic review of urinary biosensors. Prostate Cancer and Prostatic Diseases 2022, 25
(1)
, 39-46. https://doi.org/10.1038/s41391-021-00480-8
- Fortis Gaba, William J. Tipping, Mark Salji, Karen Faulds, Duncan Graham, Hing Y. Leung. Raman Spectroscopy in Prostate Cancer: Techniques, Applications and Advancements. Cancers 2022, 14
(6)
, 1535. https://doi.org/10.3390/cancers14061535
- Tudor Moisoiu, Stefania D. Iancu, Dan Burghelea, Mihnea P. Dragomir, Gheorghita Iacob, Andrei Stefancu, Ramona G. Cozan, Oana Antal, Zoltán Bálint, Valentin Muntean, Radu I. Badea, Emilia Licarete, Nicolae Leopold, Florin I. Elec. SERS Liquid Biopsy Profiling of Serum for the Diagnosis of Kidney Cancer. Biomedicines 2022, 10
(2)
, 233. https://doi.org/10.3390/biomedicines10020233
- Yao Lu, Li Lin, Jian Ye. Human metabolite detection by surface-enhanced Raman spectroscopy. Materials Today Bio 2022, 13 , 100205. https://doi.org/10.1016/j.mtbio.2022.100205
- Junyu Chen, Yuze Li, Yuming Jiang, Liucheng Mao, Mi Lai, Lixia Jiang, Huihui Liu, Zongxiu Nie. TiO
2
/MXene‐Assisted LDI‐MS for Urine Metabolic Profiling in Urinary Disease. Advanced Functional Materials 2021, 31
(52)
https://doi.org/10.1002/adfm.202106743
- Iris Baffour Ansah, Sunho Kim, Jun‐Yeong Yang, ChaeWon Mun, Ho Sang Jung, Seunghun Lee, Dong‐Ho Kim, Shin‐Hyun Kim, Sung‐Gyu Park. In Situ Electrodeposition of Gold Nanostructures in 3D Ultra‐Thin Hydrogel Skins for Direct Molecular Detection in Complex Mixtures with High Sensitivity. Laser & Photonics Reviews 2021, 15
(12)
https://doi.org/10.1002/lpor.202100316
- Xiao Xia Han, Rebeca S. Rodriguez, Christy L. Haynes, Yukihiro Ozaki, Bing Zhao. Surface-enhanced Raman spectroscopy. Nature Reviews Methods Primers 2021, 1
(1)
https://doi.org/10.1038/s43586-021-00083-6
- Xiaoyuan Geng, Chen Wu, Siying Liu, Yu Han, Liang Song, Yun Zhang. Fabrication optimization and application of 3D hybrid SERS substrates. RSC Advances 2021, 11
(50)
, 31400-31407. https://doi.org/10.1039/D1RA04473G
- Tao Li, Zhinan Yu, Zhengkun Wang, Yong Zhu, Jie Zhang. Optimized Tapered Fiber Decorated by Ag Nanoparticles for Raman Measurement with High Sensitivity. Sensors 2021, 21
(7)
, 2300. https://doi.org/10.3390/s21072300
Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.
The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.