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Enhancing Separation and Constriction of Ion Mobility Distributions in Drift Tubes at Atmospheric Pressure Using Varying Fields

  • Xi Chen
    Xi Chen
    Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States
    Purdue University, West Lafayette, Indiana 47907, United States
    More by Xi Chen
  • Mohsen Latif
    Mohsen Latif
    Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States
    More by Mohsen Latif
  • Viraj D. Gandhi
    Viraj D. Gandhi
    Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States
    Purdue University, West Lafayette, Indiana 47907, United States
  • Xuemeng Chen
    Xuemeng Chen
    Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States
    Institute of Physics, University of Tartu, W. Ostwaldi 1, EE-50411 Tartu, Estonia
    More by Xuemeng Chen
  • Leyan Hua
    Leyan Hua
    Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States
    More by Leyan Hua
  • Nobuhiko Fukushima
    Nobuhiko Fukushima
    Kanomax Japan, Inc., Shimizu, Suita-shi, Osaka 565-0805, Japan
  • , and 
  • Carlos Larriba-Andaluz*
    Carlos Larriba-Andaluz
    Department of Mechanical Engineering, Indiana University-Purdue University Indianapolis (IUPUI), 723 West Michigan Street, Indianapolis, Indiana 46202, United States
    *E-mail: [email protected]
Cite this: Anal. Chem. 2022, 94, 14, 5690–5698
Publication Date (Web):March 31, 2022
https://doi.org/10.1021/acs.analchem.2c00467
Copyright © 2022 American Chemical Society

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    Abstract

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    A linearly decreasing electric field has been previously proven to be effective for diffusional correction of ions in a varying field drift tube (VFDT) system, leading to higher resolving powers compared to a conventional drift tube due to its capacity to narrow distributions midflight. However, the theoretical predictions in resolving power of the VFDT were much higher than what was observed experimentally. The reason behind this discrepancy has been identified as the difference between the theoretically calculated resolving power (spatial) and the experimental one (time). To match the high spatial resolving power experimentally, a secondary high voltage pulse (HVP) at a properly adjusted time is used to provide the ions with enough momentum to increase their drift velocity and hence their time-resolving power. A series of systematic numerical simulations and experimental tests have been designed to corroborate our theoretical findings. The HVP-VFDT atmospheric pressure portable system improves the resolving power from the maximum expected of 60–80 for a regular drift tube to 250 in just 21 cm in length and 7kV, an unprecedent accomplishment.

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.analchem.2c00467.

    • Theoretical proof of the solution to the Nernst–Planck equation for the ion swarm inside a varying field drift tube and the calculation of the resolving power (PDF)

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    Cited By

    This article is cited by 1 publications.

    1. David L. Williamson, Gabe Nagy. Evaluating the Utility of Temporal Compression in High-Resolution Traveling Wave-Based Cyclic Ion Mobility Separations. ACS Measurement Science Au 2022, 2 (4) , 361-369. https://doi.org/10.1021/acsmeasuresciau.2c00016

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