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Absolute Quantification of Uric Acid in Human Urine Using Surface Enhanced Raman Scattering with the Standard Addition Method

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School of Chemistry, Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom
St George’s, University of London and St George’s University Hospitals NHS Foundation Trust Clinical Sciences Research Centre, London, SW17 0RE, United Kingdom
§ Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, United Kingdom
Cite this: Anal. Chem. 2017, 89, 4, 2472–2477
Publication Date (Web):January 19, 2017
Copyright © 2017 American Chemical Society

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    High levels of uric acid in urine and serum can be indicative of hypertension and the pregnancy related condition, preeclampsia. We have developed a simple, cost-effective, portable surface enhanced Raman scattering (SERS) approach for the routine analysis of uric acid at clinically relevant levels in urine patient samples. This approach, combined with the standard addition method (SAM), allows for the absolute quantification of uric acid directly in a complex matrix such as that from human urine. Results are highly comparable and in very good agreement with HPLC results, with an average <9% difference in predictions between the two analytical approaches across all samples analyzed, with SERS demonstrating a 60-fold reduction in acquisition time compared with HPLC. For the first time, clinical prepreeclampsia patient samples have been used for quantitative uric acid detection using a simple, rapid colloidal SERS approach without the need for complex data analysis.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.analchem.6b04588.

    • Full experimental details of all supplementary methods, including: reagents and materials, methods, instrumentation, and data processing; pictorial representation of the overall process described in this paper (Figure S1); optimization of the developed SERS process (Figure S2); pH profiling of uric acid to check for ionization and the effect this has on SERS (Figure S3); an annotated mean average Raman spectra of uric acid (Figure S4); UV absorbance of five different hydroxylamine-reduced silver colloids showing excellent reproducibility of synthesis (Figure S5); a comparison of the SERS method developed with HPLC from the same patient sample (Figure S6) (PDF)

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