Top-Down Proteomics: Ready for Prime Time?
- Bifan ChenBifan ChenDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United StatesMore by Bifan Chen,
- Kyle A. BrownKyle A. BrownDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United StatesMore by Kyle A. Brown,
- Ziqing LinZiqing LinDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United StatesHuman Proteomics Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United StatesMore by Ziqing Lin, and
- Ying Ge*Ying Ge*E-mail: [email protected]Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United StatesDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, Wisconsin 53705, United StatesHuman Proteomics Program, University of Wisconsin-Madison, Madison, Wisconsin 53705, United StatesMore by Ying Ge
Cited By
This article is cited by 64 publications.
- Zhe Wang, Dahang Yu, Kellye A. Cupp-Sutton, Xiaowen Liu, Kenneth Smith, Si Wu. Development of an Online 2D Ultrahigh-Pressure Nano-LC System for High-pH and Low-pH Reversed Phase Separation in Top-Down Proteomics. Analytical Chemistry 2020, 92 (19) , 12774-12777. https://doi.org/10.1021/acs.analchem.0c03395
- Victor Yin, Derek Holzscherer, Lars Konermann. Delineating Heme-Mediated versus Direct Protein Oxidation in Peroxidase-Activated Cytochrome c by Top-Down Mass Spectrometry. Biochemistry 2020, Article ASAP.
- Mathieu Dupré, Magalie Duchateau, Christian Malosse, Diogo Borges-Lima, Valeria Calvaresi, Isabelle Podglajen, Dominique Clermont, Martial Rey, Julia Chamot-Rooke. Optimization of a Top-Down Proteomics Platform for Closely Related Pathogenic Bacterial Discrimination. Journal of Proteome Research 2020, Article ASAP.
- John F. Kellie, John C. Tran, Wenying Jian, Barry Jones, John T. Mehl, Ying Ge, Jack Henion, Kevin P. Bateman. Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective. Journal of the American Society for Mass Spectrometry 2020, Article ASAP.
- Ayako Takemori, David S. Butcher, Victoria M. Harman, Philip Brownridge, Keisuke Shima, Daisuke Higo, Jun Ishizaki, Hitoshi Hasegawa, Junpei Suzuki, Masakatsu Yamashita, Joseph A. Loo, Rachel R. Ogorzalek Loo, Robert J. Beynon, Lissa C. Anderson, Nobuaki Takemori. PEPPI-MS: Polyacrylamide-Gel-Based Prefractionation for Analysis of Intact Proteoforms and Protein Complexes by Mass Spectrometry. Journal of Proteome Research 2020, 19 (9) , 3779-3791. https://doi.org/10.1021/acs.jproteome.0c00303
- Zhijie Wu, David S. Roberts, Jake A. Melby, Kent Wenger, Molly Wetzel, Yiwen Gu, Sudharshanan Govindaraj Ramanathan, Elizabeth F. Bayne, Xiaowen Liu, Ruixiang Sun, Irene M. Ong, Sean J. McIlwain, Ying Ge. MASH Explorer: A Universal Software Environment for Top-Down Proteomics. Journal of Proteome Research 2020, 19 (9) , 3867-3876. https://doi.org/10.1021/acs.jproteome.0c00469
- Leah V. Schaffer, Robert J. Millikin, Michael R. Shortreed, Mark Scalf, Lloyd M. Smith. Improving Proteoform Identifications in Complex Systems Through Integration of Bottom-Up and Top-Down Data. Journal of Proteome Research 2020, 19 (8) , 3510-3517. https://doi.org/10.1021/acs.jproteome.0c00332
- Mowei Zhou, Naomi Uwugiaren, Sarah M. Williams, Ronald J. Moore, Rui Zhao, David Goodlett, Irena Dapic, Ljiljana Paša-Tolić, Ying Zhu. Sensitive Top-Down Proteomics Analysis of a Low Number of Mammalian Cells Using a Nanodroplet Sample Processing Platform. Analytical Chemistry 2020, 92 (10) , 7087-7095. https://doi.org/10.1021/acs.analchem.0c00467
- Sean J. McIlwain, Zhijie Wu, Molly Wetzel, Daniel Belongia, Yutong Jin, Kent Wenger, Irene M. Ong, Ying Ge. Enhancing Top-Down Proteomics Data Analysis by Combining Deconvolution Results through a Machine Learning Strategy. Journal of the American Society for Mass Spectrometry 2020, 31 (5) , 1104-1113. https://doi.org/10.1021/jasms.0c00035
- Jennifer S. Brodbelt, Lindsay J. Morrison, Inês Santos. Ultraviolet Photodissociation Mass Spectrometry for Analysis of Biological Molecules. Chemical Reviews 2020, 120 (7) , 3328-3380. https://doi.org/10.1021/acs.chemrev.9b00440
- Daoyang Chen, Rachele A. Lubeckyj, Zhichang Yang, Elijah N. McCool, Xiaojing Shen, Qianjie Wang, Tian Xu, Liangliang Sun. Predicting Electrophoretic Mobility of Proteoforms for Large-Scale Top-Down Proteomics. Analytical Chemistry 2020, 92 (5) , 3503-3507. https://doi.org/10.1021/acs.analchem.9b05578
- Donald F. Smith, Greg T. Blakney, Steven C. Beu, Lissa C. Anderson, Chad R. Weisbrod, Christopher L. Hendrickson. Ultrahigh Resolution Ion Isolation by Stored Waveform Inverse Fourier Transform 21 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Analytical Chemistry 2020, 92 (4) , 3213-3219. https://doi.org/10.1021/acs.analchem.9b04954
- Rian L. Griffiths, James W. Hughes, Susan E. Abbatiello, Michael W. Belford, Iain B. Styles, Helen J. Cooper. Comprehensive LESA Mass Spectrometry Imaging of Intact Proteins by Integration of Cylindrical FAIMS. Analytical Chemistry 2020, 92 (4) , 2885-2890. https://doi.org/10.1021/acs.analchem.9b05124
- Luis A. Macias, Inês C. Santos, Jennifer S. Brodbelt. Ion Activation Methods for Peptides and Proteins. Analytical Chemistry 2020, 92 (1) , 227-251. https://doi.org/10.1021/acs.analchem.9b04859
- Jake A. Melby, Yutong Jin, Ziqing Lin, Trisha Tucholski, Zhijie Wu, Zachery R. Gregorich, Gary M. Diffee, Ying Ge. Top-Down Proteomics Reveals Myofilament Proteoform Heterogeneity among Various Rat Skeletal Muscle Tissues. Journal of Proteome Research 2020, 19 (1) , 446-454. https://doi.org/10.1021/acs.jproteome.9b00623
- Romain Huguet, Christopher Mullen, Kristina Srzentić, Joseph B. Greer, Ryan T. Fellers, Vlad Zabrouskov, John E. P. Syka, Neil L. Kelleher, Luca Fornelli. Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms. Analytical Chemistry 2019, 91 (24) , 15732-15739. https://doi.org/10.1021/acs.analchem.9b03925
- Yutong Jin, Gary M. Diffee, Ricki J. Colman, Rozalyn M. Anderson, Ying Ge. Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle. Journal of the American Society for Mass Spectrometry 2019, 30 (12) , 2460-2469. https://doi.org/10.1021/jasms.8b06267
- Zhijie Wu, Yutong Jin, Bifan Chen, Morgan K. Gugger, Chance L. Wilkinson-Johnson, Timothy N. Tiambeng, Song Jin, Ying Ge. Comprehensive Characterization of the Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2019, 30 (12) , 2561-2570. https://doi.org/10.1021/jasms.8b06294
- Yunxiang Dai, Katherine E. Buxton, Leah V. Schaffer, Rachel M. Miller, Robert J. Millikin, Mark Scalf, Brian L. Frey, Michael R. Shortreed, Lloyd M. Smith. Constructing Human Proteoform Families Using Intact-Mass and Top-Down Proteomics with a Multi-Protease Global Post-Translational Modification Discovery Database. Journal of Proteome Research 2019, 18 (10) , 3671-3680. https://doi.org/10.1021/acs.jproteome.9b00339
- Scott A. Ugrin, A. Michelle English, John E. P. Syka, Dina L. Bai, Lissa C. Anderson, Jeffrey Shabanowitz, Donald F. Hunt. Ion-Ion Proton Transfer and Parallel Ion Parking for the Analysis of Mixtures of Intact Proteins on a Modified Orbitrap Mass Analyzer. Journal of the American Society for Mass Spectrometry 2019, 30 (10) , 2163-2173. https://doi.org/10.1021/jasms.8b06235
- Bifan Chen, Ziqing Lin, Yanlong Zhu, Yutong Jin, Eli Larson, Qingge Xu, Cexiong Fu, Zhaorui Zhang, Qunying Zhang, Wayne A. Pritts, Ying Ge. Middle-Down Multi-Attribute Analysis of Antibody-Drug Conjugates with Electron Transfer Dissociation. Analytical Chemistry 2019, 91 (18) , 11661-11669. https://doi.org/10.1021/acs.analchem.9b02194
- Leah V. Schaffer, Trisha Tucholski, Michael R. Shortreed, Ying Ge, Lloyd M. Smith. Intact-Mass Analysis Facilitating the Identification of Large Human Heart Proteoforms. Analytical Chemistry 2019, 91 (17) , 10937-10942. https://doi.org/10.1021/acs.analchem.9b02343
- Laura F. Dagley, Giuseppe Infusini, Rune H. Larsen, Jarrod J. Sandow, Andrew I. Webb. Universal Solid-Phase Protein Preparation (USP3) for Bottom-up and Top-down Proteomics. Journal of Proteome Research 2019, 18 (7) , 2915-2924. https://doi.org/10.1021/acs.jproteome.9b00217
- Trisha Tucholski, Samantha J. Knott, Bifan Chen, Paige Pistono, Ziqing Lin, Ying Ge. A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Analytical Chemistry 2019, 91 (6) , 3835-3844. https://doi.org/10.1021/acs.analchem.8b04082
- Yu Liang, Yutong Jin, Zhijie Wu, Trisha Tucholski, Kyle A. Brown, Lihua Zhang, Yukui Zhang, Ying Ge. Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-Down Proteomics. Analytical Chemistry 2019, 91 (3) , 1743-1747. https://doi.org/10.1021/acs.analchem.8b05817
- Upneet Kaur, Danté T. Johnson, Emily E. Chea, Daniel J. Deredge, Jessica A. Espino, Lisa M. Jones. Evolution of Structural Biology through the Lens of Mass Spectrometry. Analytical Chemistry 2019, 91 (1) , 142-155. https://doi.org/10.1021/acs.analchem.8b05014
- Kristina Srzentić, Konstantin O. Nagornov, Luca Fornelli, Anna A. Lobas, Daniel Ayoub, Anton N. Kozhinov, Natalia Gasilova, Laure Menin, Alain Beck, Mikhail V. Gorshkov, Konstantin Aizikov, Yury O. Tsybin. Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody. Analytical Chemistry 2018, 90 (21) , 12527-12535. https://doi.org/10.1021/acs.analchem.8b02398
- Leah V. Schaffer, Jarred W. Rensvold, Michael R. Shortreed, Anthony J. Cesnik, Adam Jochem, Mark Scalf, Brian L. Frey, David J. Pagliarini, Lloyd M. Smith. Identification and Quantification of Murine Mitochondrial Proteoforms Using an Integrated Top-Down and Intact-Mass Strategy. Journal of Proteome Research 2018, 17 (10) , 3526-3536. https://doi.org/10.1021/acs.jproteome.8b00469
- Lingpeng Zhan, Yu Liu, Xiaobo Xie, Caiqiao Xiong, Zongxiu Nie. Heat-Induced Rearrangement of the Disulfide Bond of Lactoglobulin Characterized by Multiply Charged MALDI-TOF/TOF Mass Spectrometry. Analytical Chemistry 2018, 90 (18) , 10670-10675. https://doi.org/10.1021/acs.analchem.8b02563
- Yuchao Chen, Pan Mao, Daojing Wang. Quantitation of Intact Proteins in Human Plasma Using Top-Down Parallel Reaction Monitoring-MS. Analytical Chemistry 2018, 90 (18) , 10650-10653. https://doi.org/10.1021/acs.analchem.8b02699
- Matthew J. P. Rush, Nicholas M. Riley, Michael S. Westphall, Joshua J. Coon. Top-Down Characterization of Proteins with Intact Disulfide Bonds Using Activated-Ion Electron Transfer Dissociation. Analytical Chemistry 2018, 90 (15) , 8946-8953. https://doi.org/10.1021/acs.analchem.8b01113
- Nicholas M. Riley, Jacek W. Sikora, Henrique S. Seckler, Joseph B. Greer, Ryan T. Fellers, Richard D. LeDuc, Michael S. Westphall, Paul M. Thomas, Neil L. Kelleher, Joshua J. Coon. The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins. Analytical Chemistry 2018, 90 (14) , 8553-8560. https://doi.org/10.1021/acs.analchem.8b01638
- Bifan Chen, Ziqing Lin, Andrew J. Alpert, Cexiong Fu, Qunying Zhang, Wayne A. Pritts, Ying Ge. Online Hydrophobic Interaction Chromatography–Mass Spectrometry for the Analysis of Intact Monoclonal Antibodies. Analytical Chemistry 2018, 90 (12) , 7135-7138. https://doi.org/10.1021/acs.analchem.8b01865
- Timothy N. Tiambeng, David S. Roberts, Kyle A. Brown, Yanlong Zhu, Bifan Chen, Zhijie Wu, Stanford D. Mitchell, Tania M. Guardado-Alvarez, Song Jin, Ying Ge. Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum. Nature Communications 2020, 11 (1) https://doi.org/10.1038/s41467-020-17643-1
- Trisha Tucholski, Wenxuan Cai, Zachery R. Gregorich, Elizabeth F. Bayne, Stanford D. Mitchell, Sean J. McIlwain, Willem J. de Lange, Max Wrobbel, Hannah Karp, Zachary Hite, Petr G. Vikhorev, Steven B. Marston, Sean Lal, Amy Li, Cristobal dos Remedios, Takushi Kohmoto, Joshua Hermsen, J. Carter Ralphe, Timothy J. Kamp, Richard L. Moss, Ying Ge. Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics. Proceedings of the National Academy of Sciences 2020, 117 (40) , 24691-24700. https://doi.org/10.1073/pnas.2006764117
- Shixiang Liu, Zhihua Li, Bing Yu, Song Wang, Youqing Shen, Hailin Cong. Recent advances on protein separation and purification methods. Advances in Colloid and Interface Science 2020, 284 , 102254. https://doi.org/10.1016/j.cis.2020.102254
- Barbara Steigenberger, Henk W. P. van den Toorn, Emiel Bijl, Jean-François Greisch, Oliver Räther, Markus Lubeck, Roland J. Pieters, Albert J. R. Heck, Richard A. Scheltema. Benefits of Collisional Cross Section Assisted Precursor Selection (caps-PASEF) for Cross-linking Mass Spectrometry. Molecular & Cellular Proteomics 2020, 19 (10) , 1677-1687. https://doi.org/10.1074/mcp.RA120.002094
- Trisha Tucholski, Ying Ge. Fourier-transform ion cyclotron resonance mass spectrometry for characterizing proteoforms. Mass Spectrometry Reviews 2020, 14 https://doi.org/10.1002/mas.21653
- Jucélia da Silva Araújo, Olga Lima Tavares Machado. Proteoforms: General Concepts and Methodological Process for Identification. 2020,,https://doi.org/10.5772/intechopen.89914
- Ray Bacala, Bin Xiao Fu, Hélène Perreault, Dave W. Hatcher. Quantitative LC-MS proteoform profiling of intact wheat glutenin subunits. Journal of Cereal Science 2020, 94 , 102963. https://doi.org/10.1016/j.jcs.2020.102963
- Yujia Ying, Huilin Li. Recent progress in the analysis of protein deamidation using mass spectrometry. Methods 2020, https://doi.org/10.1016/j.ymeth.2020.06.009
- Kyle A. Brown, Trisha Tucholski, Christian Eken, Samantha Knott, Yanlong Zhu, Song Jin, Ying Ge. High‐Throughput Proteomics Enabled by a Photocleavable Surfactant. Angewandte Chemie 2020, 132 (22) , 8484-8488. https://doi.org/10.1002/ange.201915374
- Kyle A. Brown, Trisha Tucholski, Christian Eken, Samantha Knott, Yanlong Zhu, Song Jin, Ying Ge. High‐Throughput Proteomics Enabled by a Photocleavable Surfactant. Angewandte Chemie International Edition 2020, 59 (22) , 8406-8410. https://doi.org/10.1002/anie.201915374
- Raegyn B. Taylor, Bridgett N. Hill, Jonathan M. Bobbitt, Amanda S. Hering, Bryan W. Brooks, C. Kevin Chambliss. Suspect and non-target screening of acutely toxic Prymnesium parvum. Science of The Total Environment 2020, 715 , 136835. https://doi.org/10.1016/j.scitotenv.2020.136835
- Kyowon Jeong, Jihyung Kim, Manasi Gaikwad, Siti Nurul Hidayah, Laura Heikaus, Hartmut Schlüter, Oliver Kohlbacher. FLASHDeconv: Ultrafast, High-Quality Feature Deconvolution for Top-Down Proteomics. Cell Systems 2020, 10 (2) , 213-218.e6. https://doi.org/10.1016/j.cels.2020.01.003
- Valeriu Bortnov, Marco Tonelli, Woonghee Lee, Ziqing Lin, Douglas S. Annis, Omar N. Demerdash, Alex Bateman, Julie C. Mitchell, Ying Ge, John L. Markley, Deane F. Mosher. Solution structure of human myeloid-derived growth factor suggests a conserved function in the endoplasmic reticulum. Nature Communications 2019, 10 (1) https://doi.org/10.1038/s41467-019-13577-5
- Fabio P. Gomes, John R. Yates. Recent trends of capillary electrophoresis‐mass spectrometry in proteomics research. Mass Spectrometry Reviews 2019, 38 (6) , 445-460. https://doi.org/10.1002/mas.21599
- Danté T. Johnson, Luciano H. Di Stefano, Lisa M. Jones. Fast photochemical oxidation of proteins (FPOP): A powerful mass spectrometry–based structural proteomics tool. Journal of Biological Chemistry 2019, 294 (32) , 11969-11979. https://doi.org/10.1074/jbc.REV119.006218
- David S. Roberts, Bifan Chen, Timothy N. Tiambeng, Zhijie Wu, Ying Ge, Song Jin. Reproducible large-scale synthesis of surface silanized nanoparticles as an enabling nanoproteomics platform: Enrichment of the human heart phosphoproteome. Nano Research 2019, 12 (6) , 1473-1481. https://doi.org/10.1007/s12274-019-2418-4
- Paul Dowling, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck. Characterization of Contractile Proteins from Skeletal Muscle Using Gel-Based Top-Down Proteomics. Proteomes 2019, 7 (2) , 25. https://doi.org/10.3390/proteomes7020025
- Leah V. Schaffer, Robert J. Millikin, Rachel M. Miller, Lissa C. Anderson, Ryan T. Fellers, Ying Ge, Neil L. Kelleher, Richard D. LeDuc, Xiaowen Liu, Samuel H. Payne, Liangliang Sun, Paul M. Thomas, Trisha Tucholski, Zhe Wang, Si Wu, Zhijie Wu, Dahang Yu, Michael R. Shortreed, Lloyd M. Smith. Identification and Quantification of Proteoforms by Mass Spectrometry. PROTEOMICS 2019, 19 (10) , 1800361. https://doi.org/10.1002/pmic.201800361
- Parviz Ghezellou, Vannuruswamy Garikapati, Seyed Mahdi Kazemi, Kerstin Strupat, Alireza Ghassempour, Bernhard Spengler. A perspective view of top‐down proteomics in snake venom research. Rapid Communications in Mass Spectrometry 2019, 33 (S1) , 20-27. https://doi.org/10.1002/rcm.8255
- Kyle A. Brown, Bifan Chen, Tania M. Guardado-Alvarez, Ziqing Lin, Leekyoung Hwang, Serife Ayaz-Guner, Song Jin, Ying Ge. A photocleavable surfactant for top-down proteomics. Nature Methods 2019, 16 (5) , 417-420. https://doi.org/10.1038/s41592-019-0391-1
- Marie Locard-Paulet, Julien Parra, Renaud Albigot, Emmanuelle Mouton-Barbosa, Laurent Bardi, Odile Burlet-Schiltz, Julien Marcoux, . VisioProt-MS: interactive 2D maps from intact protein mass spectrometry. Bioinformatics 2019, 35 (4) , 679-681. https://doi.org/10.1093/bioinformatics/bty680
- Sille Štěpánová, Václav Kašička. Recent developments and applications of capillary and microchip electrophoresis in proteomics and peptidomics (2015-mid 2018). Journal of Separation Science 2019, 42 (1) , 398-414. https://doi.org/10.1002/jssc.201801090
- Michelle R. Robinson, Ronald A. Miller, Daniel S. Spellman. Mass Spectrometry-Based Biomarkers in Drug Development. 2019,,, 435-449. https://doi.org/10.1007/978-3-030-15950-4_25
- Timothy N. Tiambeng, Trisha Tucholski, Zhijie Wu, Yanlong Zhu, Stanford D. Mitchell, David S. Roberts, Yutong Jin, Ying Ge. Analysis of cardiac troponin proteoforms by top-down mass spectrometry. 2019,,, 347-374. https://doi.org/10.1016/bs.mie.2019.07.029
- Stanislav Naryzhny. Inventory of proteoforms as a current challenge of proteomics: Some technical aspects. Journal of Proteomics 2019, 191 , 22-28. https://doi.org/10.1016/j.jprot.2018.05.008
- Jean Lesne, Marie-Pierre Bousquet, Julien Marcoux, Marie Locard-Paulet. Top-Down and Intact Protein Mass Spectrometry Data Visualization for Proteoform Analysis Using VisioProt-MS. Bioinformatics and Biology Insights 2019, 13 , 117793221986822. https://doi.org/10.1177/1177932219868223
- Erin R. Bonner, Miriam Bornhorst, Roger J. Packer, Javad Nazarian. Liquid biopsy for pediatric central nervous system tumors. npj Precision Oncology 2018, 2 (1) https://doi.org/10.1038/s41698-018-0072-z
- Yuri E.M. van der Burgt, Christa M. Cobbaert. Proteoform Analysis to Fulfill Unmet Clinical Needs and Reach Global Standardization of Protein Measurands in Clinical Chemistry Proteomics. Clinics in Laboratory Medicine 2018, 38 (3) , 487-497. https://doi.org/10.1016/j.cll.2018.05.001
- Juan J. Calvete. Snake venomics – from low-resolution toxin-pattern recognition to toxin-resolved venom proteomes with absolute quantification. Expert Review of Proteomics 2018, 15 (7) , 555-568. https://doi.org/10.1080/14789450.2018.1500904
- Liyun Zhang, Lisa A Vasicek, SuChun Hsieh, Shuli Zhang, Kevin P Bateman, Jack Henion. Top-down LC–MS quantitation of intact denatured and native monoclonal antibodies in biological samples. Bioanalysis 2018, 10 (13) , 1039-1054. https://doi.org/10.4155/bio-2017-0282
- Ruedi Aebersold, Jeffrey N Agar, I Jonathan Amster, Mark S Baker, Carolyn R Bertozzi, Emily S Boja, Catherine E Costello, Benjamin F Cravatt, Catherine Fenselau, Benjamin A Garcia, Ying Ge, Jeremy Gunawardena, Ronald C Hendrickson, Paul J Hergenrother, Christian G Huber, Alexander R Ivanov, Ole N Jensen, Michael C Jewett, Neil L Kelleher, Laura L Kiessling, Nevan J Krogan, Martin R Larsen, Joseph A Loo, Rachel R Ogorzalek Loo, Emma Lundberg, Michael J MacCoss, Parag Mallick, Vamsi K Mootha, Milan Mrksich, Tom W Muir, Steven M Patrie, James J Pesavento, Sharon J Pitteri, Henry Rodriguez, Alan Saghatelian, Wendy Sandoval, Hartmut Schlüter, Salvatore Sechi, Sarah A Slavoff, Lloyd M Smith, Michael P Snyder, Paul M Thomas, Mathias Uhlén, Jennifer E Van Eyk, Marc Vidal, David R Walt, Forest M White, Evan R Williams, Therese Wohlschlager, Vicki H Wysocki, Nathan A Yates, Nicolas L Young, Bing Zhang. How many human proteoforms are there?. Nature Chemical Biology 2018, 14 (3) , 206-214. https://doi.org/10.1038/nchembio.2576




