Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect
ACS Publications. Most Trusted. Most Cited. Most Read
Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2018, 90, 20, 11962-11971
    Article

    Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial
    Click to copy article linkArticle link copied!

    • Beatriz Jiménez
      Beatriz Jiménez
      MRC-NIHR National Phenome Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer  and  Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, QEQM Building, Saint Mary’s Hospital, London W2 1NY, United Kingdom
      More by Beatriz Jiménez
      Orcidhttp://orcid.org/0000-0003-4593-6075
    • Elaine Holmes
      Elaine Holmes
      Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      More by Elaine Holmes
      Orcidhttp://orcid.org/0000-0002-0556-8389
    • Clement Heude
      Clement Heude
      Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
      More by Clement Heude
    • Rose F. Tolson
      Rose F. Tolson
      MRC-NIHR National Phenome Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      More by Rose F. Tolson
    • Nikita Harvey
      Nikita Harvey
      MRC-NIHR National Phenome Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer  and  Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      More by Nikita Harvey
      Orcidhttp://orcid.org/0000-0002-2533-6980
    • Samantha L. Lodge
      Samantha L. Lodge
      The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, QEQM Building, Saint Mary’s Hospital, London W2 1NY, United Kingdom
      More by Samantha L. Lodge
    • Andrew J. Chetwynd
      Andrew J. Chetwynd
      Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
      More by Andrew J. Chetwynd
      Orcidhttp://orcid.org/0000-0001-6648-6881
    • Claire Cannet
      Claire Cannet
      Bruker Biospin GmbH, Silberstreifen, 76287 Rheinstetten, Germany
      More by Claire Cannet
    • Fang Fang
      Fang Fang
      Bruker Biospin GmbH, Silberstreifen, 76287 Rheinstetten, Germany
      More by Fang Fang
    • Jake T. M. Pearce
      Jake T. M. Pearce
      MRC-NIHR National Phenome Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer  and  Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, QEQM Building, Saint Mary’s Hospital, London W2 1NY, United Kingdom
      More by Jake T. M. Pearce
    • Matthew R. Lewis
      Matthew R. Lewis
      MRC-NIHR National Phenome Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer  and  Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, QEQM Building, Saint Mary’s Hospital, London W2 1NY, United Kingdom
      More by Matthew R. Lewis
    • Mark R. Viant
      Mark R. Viant
      Phenome Centre Birmingham, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
      More by Mark R. Viant
    • John C. Lindon
      John C. Lindon
      Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      More by John C. Lindon
    • Manfred Spraul
      Manfred Spraul
      Bruker Biospin GmbH, Silberstreifen, 76287 Rheinstetten, Germany
      More by Manfred Spraul
    • Hartmut Schäfer*
      Hartmut Schäfer
      Bruker Biospin GmbH, Silberstreifen, 76287 Rheinstetten, Germany
      *E-mail: [email protected]
      More by Hartmut Schäfer
    • Jeremy K. Nicholson*
      Jeremy K. Nicholson
      MRC-NIHR National Phenome Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer  and  Biomolecular Medicine, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, United Kingdom
      The Imperial Clinical Phenotyping Centre, Division of Integrative Systems Medicine and Digestive Disease, Department of Surgery and Cancer, QEQM Building, Saint Mary’s Hospital, London W2 1NY, United Kingdom
      *E-mail: [email protected]
      More by Jeremy K. Nicholson
    Other Access OptionsSupporting Information (1)

    Analytical Chemistry

    Cite this: Anal. Chem. 2018, 90, 20, 11962–11971
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.analchem.8b02412
    Published September 13, 2018
    Copyright © 2018 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    We report an extensive 600 MHz NMR trial of quantitative lipoprotein and small-molecule measurements in human blood serum and plasma. Five centers with eleven 600 MHz NMR spectrometers were used to analyze 98 samples including 20 quality controls (QCs), 37 commercially sourced, paired serum and plasma samples, and two National Institute of Science and Technology (NIST) reference material 1951c replicates. Samples were analyzed using rigorous protocols for sample preparation and experimental acquisition. A commercial lipoprotein subclass analysis was used to quantify 105 lipoprotein subclasses and 24 low molecular weight metabolites from the NMR spectra. For all spectrometers, the instrument specific variance in measuring internal QCs was lower than the percentage described by the National Cholesterol Education Program (NCEP) criteria for lipid testing [triglycerides <2.7%; cholesterol <2.8%; low-density lipoprotein (LDL) cholesterol <2.8%; high-density lipoprotein (HDL) cholesterol <2.3%], showing exceptional reproducibility for direct quantitation of lipoproteins in both matrixes. The average relative standard deviations (RSDs) for the 105 lipoprotein parameters in the 11 instruments were 4.6% and 3.9% for the two NIST samples, whereas they were 38% and 40% for the 37 commercially sourced plasmas and sera, respectively, showing negligible analytical compared to biological variation. The coefficient of variance (CV) obtained for the quantification of the small molecules across the 11 spectrometers was below 15% for 20 out of the 24 metabolites analyzed. This study provides further evidence of the suitability of NMR for high-throughput lipoprotein subcomponent analysis and small-molecule quantitation with the exceptional required reproducibility for clinical and other regulatory settings.

    Copyright © 2018 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.analchem.8b02412.

    • Collection protocol for human serum and plasma commercially sourced samples, trial structure and NMR measurements, statistical analysis, and additional figures and tables (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article is cited by 154 publications.

    1. Monique J. Ryan, Edward Raby, Luke Whiley, Reika Masuda, Samantha Lodge, Philipp Nitschke, Garth L. Maker, Julien Wist, Elaine Holmes, Fiona M. Wood, Jeremy K. Nicholson, Mark W. Fear, Nicola Gray. Nonsevere Burn Induces a Prolonged Systemic Metabolic Phenotype Indicative of a Persistent Inflammatory Response Postinjury. Journal of Proteome Research 2024, 23 (8) , 2893-2907. https://doi.org/10.1021/acs.jproteome.3c00516
    2. Samantha Lodge, Edward Litton, Nicola Gray, Monique Ryan, Oscar Millet, Mark Fear, Edward Raby, Andrew Currie, Fiona Wood, Elaine Holmes, Julien Wist, Jeremy K. Nicholson. Stratification of Sepsis Patients on Admission into the Intensive Care Unit According to Differential Plasma Metabolic Phenotypes. Journal of Proteome Research 2024, 23 (4) , 1328-1340. https://doi.org/10.1021/acs.jproteome.3c00803
    3. Jayden Lee Roberts, Luke Whiley, Nicola Gray, Melvin Gay, Philipp Nitschke, Reika Masuda, Elaine Holmes, Jeremy K. Nicholson, Julien Wist, Nathan G. Lawler. Rapid and Self-Administrable Capillary Blood Microsampling Demonstrates Statistical Equivalence with Standard Venous Collections in NMR-Based Lipoprotein Analysis. Analytical Chemistry 2024, 96 (11) , 4505-4513. https://doi.org/10.1021/acs.analchem.3c05152
    4. Muhammad Saeed Ahmad, Novia Minaee, Jose Ivan Serrano-Contreras, Manuja Kaluarachchi, Eric Yi-Liang Shen, Claire Boulange, Sultan Ahmad, Jutarop Phetcharaburanin, Elaine Holmes, Julien Wist, Ahmed Hakem Albaloshi, Tareef Alaama, Zoheir Abdullah Damanhouri, Samantha Lodge. Exploring the Interactions between Obesity and Diabetes: Implications for Understanding Metabolic Dysregulation in a Saudi Arabian Adult Population. Journal of Proteome Research 2024, 23 (2) , 809-821. https://doi.org/10.1021/acs.jproteome.3c00717
    5. Nikita Harvey, Panteleimon G Takis, John C Lindon, Jia V Li, Beatriz Jiménez. Optimization of Diffusion-Ordered NMR Spectroscopy Experiments for High-Throughput Automation in Human Metabolic Phenotyping. Analytical Chemistry 2023, 95 (6) , 3147-3152. https://doi.org/10.1021/acs.analchem.2c04066
    6. G. A. Nagana Gowda, Daniel Raftery. NMR Metabolomics Methods for Investigating Disease. Analytical Chemistry 2023, 95 (1) , 83-99. https://doi.org/10.1021/acs.analchem.2c04606
    7. Cristina Licari, Leonardo Tenori, Francesca Di Cesare, Claudio Luchinat, Betti Giusti, Ada Kura, Rosina De Cario, Domenico Inzitari, Benedetta Piccardi, Mascia Nesi, Cristina Sarti, Francesco Arba, Vanessa Palumbo, Patrizia Nencini, Rossella Marcucci, Anna Maria Gori, Elena Sticchi. Nuclear Magnetic Resonance-Based Metabolomics to Predict Early and Late Adverse Outcomes in Ischemic Stroke Treated with Intravenous Thrombolysis. Journal of Proteome Research 2023, 22 (1) , 16-25. https://doi.org/10.1021/acs.jproteome.2c00333
    8. Julia Debik, Sylvia Hetlelid Isaksen, Magnus Strømmen, Manfred Spraul, Hartmut Schäfer, Tone F. Bathen, Guro F. Giskeødegård. Effect of Delayed Centrifugation on the Levels of NMR-Measured Lipoproteins and Metabolites in Plasma and Serum Samples. Analytical Chemistry 2022, 94 (49) , 17003-17010. https://doi.org/10.1021/acs.analchem.2c02167
    9. Alessia Vignoli, Leonardo Tenori, Cristina Morsiani, Paola Turano, Miriam Capri, Claudio Luchinat. Serum or Plasma (and Which Plasma), That Is the Question. Journal of Proteome Research 2022, 21 (4) , 1061-1072. https://doi.org/10.1021/acs.jproteome.1c00935
    10. Reika Masuda, Samantha Lodge, Luke Whiley, Nicola Gray, Nathan Lawler, Philipp Nitschke, Sze-How Bong, Torben Kimhofer, Ruey Leng Loo, Berin Boughton, Annie X. Zeng, Drew Hall, Hartmut Schaefer, Manfred Spraul, Girish Dwivedi, Bu B. Yeap, Tammo Diercks, Ganeko Bernardo-Seisdedos, José M. Mato, John C. Lindon, Elaine Holmes, Oscar Millet, Julien Wist, Jeremy K. Nicholson. Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n-Dimensions (SHY-n): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection. Analytical Chemistry 2022, 94 (10) , 4426-4436. https://doi.org/10.1021/acs.analchem.1c05389
    11. Philipp Nitschke, Samantha Lodge, Torben Kimhofer, Reika Masuda, Sze-How Bong, Drew Hall, Hartmut Schäfer, Manfred Spraul, Nils Pompe, Tammo Diercks, Ganeko Bernardo-Seisdedos, José M. Mato, Oscar Millet, Daniella Susic, Amanda Henry, Emad M El-Omar, Elaine Holmes, John C. Lindon, Jeremy K. Nicholson, Julien Wist. J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum. Analytical Chemistry 2022, 94 (2) , 1333-1341. https://doi.org/10.1021/acs.analchem.1c04576
    12. Cristina Licari, Leonardo Tenori, Betti Giusti, Elena Sticchi, Ada Kura, Rosina De Cario, Domenico Inzitari, Benedetta Piccardi, Mascia Nesi, Cristina Sarti, Francesco Arba, Vanessa Palumbo, Patrizia Nencini, Rossella Marcucci, Anna Maria Gori, Claudio Luchinat, Edoardo Saccenti. Analysis of Metabolite and Lipid Association Networks Reveals Molecular Mechanisms Associated with 3-Month Mortality and Poor Functional Outcomes in Patients with Acute Ischemic Stroke after Thrombolytic Treatment with Recombinant Tissue Plasminogen Activator. Journal of Proteome Research 2021, 20 (10) , 4758-4770. https://doi.org/10.1021/acs.jproteome.1c00406
    13. Reika Masuda, Samantha Lodge, Philipp Nitschke, Manfred Spraul, Hartmut Schaefer, Sze-How Bong, Torben Kimhofer, Drew Hall, Ruey Leng Loo, Maider Bizkarguenaga, Chiara Bruzzone, Rubén Gil-Redondo, Nieves Embade, José M. Mato, Elaine Holmes, Julien Wist, Oscar Millet, Jeremy K. Nicholson. Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts. Journal of Proteome Research 2021, 20 (8) , 4139-4152. https://doi.org/10.1021/acs.jproteome.1c00458
    14. Elaine Holmes, Julien Wist, Reika Masuda, Samantha Lodge, Philipp Nitschke, Torben Kimhofer, Ruey Leng Loo, Sofina Begum, Berin Boughton, Rongchang Yang, Aude-Claire Morillon, Sung-Tong Chin, Drew Hall, Monique Ryan, Sze-How Bong, Melvin Gay, Dale W. Edgar, John C. Lindon, Toby Richards, Bu B. Yeap, Sven Pettersson, Manfred Spraul, Hartmut Schaefer, Nathan G. Lawler, Nicola Gray, Luke Whiley, Jeremy K. Nicholson. Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome. Journal of Proteome Research 2021, 20 (6) , 3315-3329. https://doi.org/10.1021/acs.jproteome.1c00224
    15. Guoxiang Xie, Lu Wang, Tianlu Chen, Kejun Zhou, Zechuan Zhang, Jiufeng Li, Beicheng Sun, Yike Guo, Xiaoning Wang, Yixing Wang, Hua Zhang, Ping Liu, Jeremy K. Nicholson, Weihong Ge, Wei Jia. A Metabolite Array Technology for Precision Medicine. Analytical Chemistry 2021, 93 (14) , 5709-5717. https://doi.org/10.1021/acs.analchem.0c04686
    16. Panteleimon G. Takis, Beatriz Jiménez, Nada M. S. Al-Saffar, Nikita Harvey, Elena Chekmeneva, Shivani Misra, Matthew R. Lewis. A Computationally Lightweight Algorithm for Deriving Reliable Metabolite Panel Measurements from 1D 1H NMR. Analytical Chemistry 2021, 93 (12) , 4995-5000. https://doi.org/10.1021/acs.analchem.1c00113
    17. Samantha Lodge, Philipp Nitschke, Torben Kimhofer, Julien Wist, Sze-How Bong, Ruey Leng Loo, Reika Masuda, Sofina Begum, Toby Richards, John C. Lindon, Wolfgang Bermel, Tony Reinsperger, Hartmut Schaefer, Manfred Spraul, Elaine Holmes, Jeremy K. Nicholson. Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection. Analytical Chemistry 2021, 93 (8) , 3976-3986. https://doi.org/10.1021/acs.analchem.0c04952
    18. G. A. Nagana Gowda, Natalie N. Hong, Daniel Raftery. Evaluation of Fumaric Acid and Maleic Acid as Internal Standards for NMR Analysis of Protein Precipitated Plasma, Serum, and Whole Blood. Analytical Chemistry 2021, 93 (6) , 3233-3240. https://doi.org/10.1021/acs.analchem.0c04766
    19. Samantha Lodge, Philipp Nitschke, Ruey Leng Loo, Torben Kimhofer, Sze-How Bong, Toby Richards, Sofina Begum, Manfred Spraul, Hartmut Schaefer, John C. Lindon, Elaine Holmes, Jeremy K. Nicholson. Low Volume in Vitro Diagnostic Proton NMR Spectroscopy of Human Blood Plasma for Lipoprotein and Metabolite Analysis: Application to SARS-CoV-2 Biomarkers. Journal of Proteome Research 2021, 20 (2) , 1415-1423. https://doi.org/10.1021/acs.jproteome.0c00815
    20. Samantha Lodge, Philipp Nitschke, Torben Kimhofer, Jerome D. Coudert, Sofina Begum, Sze-How Bong, Toby Richards, Dale Edgar, Edward Raby, Manfred Spraul, Hartmut Schaefer, John C. Lindon, Ruey Leng Loo, Elaine Holmes, Jeremy K. Nicholson. NMR Spectroscopic Windows on the Systemic Effects of SARS-CoV-2 Infection on Plasma Lipoproteins and Metabolites in Relation to Circulating Cytokines. Journal of Proteome Research 2021, 20 (2) , 1382-1396. https://doi.org/10.1021/acs.jproteome.0c00876
    21. Torben Kimhofer, Samantha Lodge, Luke Whiley, Nicola Gray, Ruey Leng Loo, Nathan G. Lawler, Philipp Nitschke, Sze-How Bong, David L. Morrison, Sofina Begum, Toby Richards, Bu B. Yeap, Chris Smith, Kenneth G. C. Smith, Elaine Holmes, Jeremy K. Nicholson. Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection. Journal of Proteome Research 2020, 19 (11) , 4442-4454. https://doi.org/10.1021/acs.jproteome.0c00519
    22. Ruey Leng Loo, Samantha Lodge, Torben Kimhofer, Sze-How Bong, Sofina Begum, Luke Whiley, Nicola Gray, John C. Lindon, Philipp Nitschke, Nathan G. Lawler, Hartmut Schäfer, Manfred Spraul, Toby Richards, Jeremy K. Nicholson, Elaine Holmes. Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples. Journal of Proteome Research 2020, 19 (11) , 4428-4441. https://doi.org/10.1021/acs.jproteome.0c00537
    23. Feng Wang, Julia Debik, Trygve Andreassen, Leslie R. Euceda, Tonje H. Haukaas, Claire Cannet, Hartmut Schäfer, Tone F. Bathen, Guro F. Giskeødegård. Effect of Repeated Freeze–Thaw Cycles on NMR-Measured Lipoproteins and Metabolites in Biofluids. Journal of Proteome Research 2019, 18 (10) , 3681-3688. https://doi.org/10.1021/acs.jproteome.9b00343
    24. Christoph Trautwein. Quantitative Blood Serum IVDr NMR Spectroscopy in Clinical Metabolomics of Cancer, Neurodegeneration, and Internal Medicine. 2025, 427-443. https://doi.org/10.1007/978-1-0716-4116-3_24
    25. Aswin Verhoeven. Lipoprotein (Sub)Fraction Analysis on the Bruker B.I. LISA Platform. 2025, 445-456. https://doi.org/10.1007/978-1-0716-4116-3_25
    26. R. Forlano, L. Martinez-Gili, P. Takis, J. Miguens-Blanco, T. Liu, E. Triantafyllou, C. Skinner, R Loomba, M. Thursz, J. R. Marchesi, B.H. Mullish, P. Manousou. Disruption of gut barrier integrity and host–microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus. Gut Microbes 2024, 16 (1) https://doi.org/10.1080/19490976.2024.2304157
    27. Xiongjie Xiao, Qianqian Wang, Xin Chai, Xu Zhang, Bin Jiang, Maili Liu. Using neural networks to obtain NMR spectra of both small and macromolecules from blood samples in a single experiment. Communications Chemistry 2024, 7 (1) https://doi.org/10.1038/s42004-024-01251-x
    28. Wen Peng, Lin Shi, Qingxia Huang, Tiemei Li, Wenxiu Jian, Lei Zhao, Ruijie Xu, Tianqi Liu, Bin Zhang, Haijing Wang, Li Tong, Huiru Tang, Youfa Wang. Metabolite profiles of distinct obesity phenotypes integrating impacts of altitude and their association with diet and metabolic disorders in Tibetans. Science of The Total Environment 2024, 949 , 174754. https://doi.org/10.1016/j.scitotenv.2024.174754
    29. Tingxi Tang, Zhenhua Zhou, Min Chen, Nan Li, Jianda Sun, Zekai Chen, Ting Xiao, Xiaoqing Wang, Longshan Zhang, Yingqiao Wang, Hanbin Zhang, Xiuting Zheng, Bei Chen, Feng Ye, Jian Guan. Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial. Clinical Cancer Research 2024, 30 (14) , 2925-2936. https://doi.org/10.1158/1078-0432.CCR-23-3608
    30. Nitish Kumar, Vikas Jaitak. Recent Advancement in NMR Based Plant Metabolomics: Techniques, Tools, and Analytical Approaches. Critical Reviews in Analytical Chemistry 2024, 1280 , 1-25. https://doi.org/10.1080/10408347.2024.2375314
    31. Andrés R. Martínez Bilesio, Francesc Puig-Castellví, Romà Tauler, Mariela Sciara, Fabián Fay, Rodolfo M. Rasia, Paula Burdisso, Alejandro G. García-Reiriz. Multivariate curve resolution-based data fusion approaches applied in 1H NMR metabolomic analysis of healthy cohorts. Analytica Chimica Acta 2024, 1309 , 342689. https://doi.org/10.1016/j.aca.2024.342689
    32. Jeanne Serrano, Lucy Martine, Yaël Grosjean, Niyazi Acar, Georges Alves, Elodie A.Y. Masson. The importance of choosing the appropriate cholesterol quantification method: enzymatic assay versus gas chromatography. Journal of Lipid Research 2024, 65 (6) , 100561. https://doi.org/10.1016/j.jlr.2024.100561
    33. Kui Deng, Xiong‐Fei Pan, Markus W. Voehler, Qiuyin Cai, Hui Cai, Xiao‐Ou Shu, Deepak K. Gupta, Loren Lipworth, Wei Zheng, Danxia Yu. Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations. Journal of the American Heart Association 2024, 13 (10) https://doi.org/10.1161/JAHA.124.034364
    34. Louis-Charles Desjardins, Francis Brière, André J Tremblay, Maryka Rancourt-Bouchard, Jean-Philippe Drouin-Chartier, Jacques Corbeil, Valéry Lemelin, Amélie Charest, Ernst J Schaefer, Benoît Lamarche, Patrick Couture. Substitution of dietary monounsaturated fatty acids from olive oil for saturated fatty acids from lard increases low-density lipoprotein apolipoprotein B-100 fractional catabolic rate in subjects with dyslipidemia associated with insulin resistance: a randomized controlled trial. The American Journal of Clinical Nutrition 2024, 119 (5) , 1270-1279. https://doi.org/10.1016/j.ajcnut.2024.03.015
    35. Changzhen Fu, Jianming Xu, Shao-Lang Chen, Chong-Bo Chen, Jia-Jian Liang, Zibo Liu, Chukai Huang, Zhenggen Wu, Tsz Kin Ng, Mingzhi Zhang, Qingping Liu. Profile of Lipoprotein Subclasses in Chinese Primary Open-Angle Glaucoma Patients. International Journal of Molecular Sciences 2024, 25 (8) , 4544. https://doi.org/10.3390/ijms25084544
    36. Laura Ansone, Vita Rovite, Monta Brīvība, Lauma Jagare, Līva Pelcmane, Daniella Borisova, Anne Thews, Roland Leiminger, Jānis Kloviņš. Longitudinal NMR-Based Metabolomics Study Reveals How Hospitalized COVID-19 Patients Recover: Evidence of Dyslipidemia and Energy Metabolism Dysregulation. International Journal of Molecular Sciences 2024, 25 (3) , 1523. https://doi.org/10.3390/ijms25031523
    37. Laila Aldars-García, Rubén Gil-Redondo, Nieves Embade, Sabino Riestra, Montserrat Rivero, Ana Gutiérrez, Iago Rodríguez-Lago, Luis Fernández-Salazar, Daniel Ceballos, José Manuel Benítez, Mariam Aguas, Iria Baston-Rey, Fernando Bermejo, María José Casanova, Rufo Lorente, Yolanda Ber, Daniel Ginard, María Esteve, Ruth de Francisco, María José García, Rubén Francés, Ainhoa Rodríguez Pescador, Benito Velayos, Elena Guerra del Río, Sandra Marín Pedrosa, Alejandro Minguez Sabater, Manuel Barreiro-de Acosta, Alicia Algaba, Cristina Verdejo Gil, Olga Rivas, Vanesa Royo, Montserrat Aceituno, Ana Garre, Montserrat Baldán-Martín, Cristina Ramírez, Ancor Sanz-García, Juan J Lozano, Julia Sidorova, Oscar Millet, David Bernardo, Javier P Gisbert, María Chaparro. Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients. Inflammatory Bowel Diseases 2024, 30 (2) , 167-182. https://doi.org/10.1093/ibd/izad154
    38. James L Alexander, Nicola J Wyatt, Stephane Camuzeaux, Elena Chekmeneva, Beatriz Jimenez, Caroline J Sands, Hannah Fuller, Panteleimon Takis, Tariq Ahmad, Jennifer A Doyle, Ailsa Hart, Peter M Irving, Nicholas A Kennedy, Charlie W Lees, James O Lindsay, Rebecca E McIntyre, Miles Parkes, Natalie J Prescott, Tim Raine, Jack Satsangi, Richard Alexander Speight, Luke Jostins-Dean, Nick Powell, Julian R Marchesi, Christopher J Stewart, Christopher A Lamb. Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research. Gut 2024, 73 (2) , 379.1-383. https://doi.org/10.1136/gutjnl-2022-329297
    39. Tai-Hua Chou, Chia-Hsuan Cheng, Chi-Jen Lo, Guang-Huar Young, Szu-Heng Liu, Robert Y-L Wang. New Advances in Rapid Pretreatment for Small Dense LDL Cholesterol Measurement Using Shear Horizontal Surface Acoustic Wave (SH-SAW) Technology. International Journal of Molecular Sciences 2024, 25 (2) , 1044. https://doi.org/10.3390/ijms25021044
    40. Yi Zheng, Ningxin Gao, Yucan Li, Min Fan, Weizhong Tian, Yanfeng Jiang, Yingzhe Wang, Mei Cui, Chen Suo, Tiejun Zhang, Li Jin, Kelin Xu, Xingdong Chen. Unraveling the role of serum metabolites in the relationship between plant-based diets and bone health in community-dwelling older adults. Current Research in Food Science 2024, 8 , 100687. https://doi.org/10.1016/j.crfs.2024.100687
    41. Yaopeng Qiu, Zhou Xu, Qingfeng Xie, Renyi Zhang, Luyao Wang, Liying Zhao, Hao Liu. Association of plasma lipid metabolism profiles with overall survival for patients with gastric cancer undergoing gastrectomy based on 1H-NMR spectroscopy. Nutrition & Metabolism 2023, 20 (1) https://doi.org/10.1186/s12986-023-00728-1
    42. Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojdaƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bologna, Marta Filidei, Enrico Ravera, Moreno Lelli, Fabio Moda, Marco Fragai, Lucilla Parnetti, Claudio Luchinat. Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays. Molecular Neurodegeneration 2023, 18 (1) https://doi.org/10.1186/s13024-023-00613-8
    43. Sofie Kaas Lanng, Mikkel Oxfeldt, Frank Ted Johansen, Jeyanthini Risikesan, Mette Hansen, Hanne Christine Bertram. Acute changes in the metabolome following resistance exercise combined with intake of different protein sources (cricket, pea, whey). Metabolomics 2023, 19 (12) https://doi.org/10.1007/s11306-023-02064-0
    44. Panteleimon G. Takis, Varvara A. Aggelidou, Caroline J. Sands, Alexandra Louka. Mapping of 1 H NMR chemical shifts relationship with chemical similarities for the acceleration of metabolic profiling: Application on blood products. Magnetic Resonance in Chemistry 2023, 61 (12) , 759-769. https://doi.org/10.1002/mrc.5392
    45. Veronica Ghini, Walter Vieri, Tommaso Celli, Valentina Pecchioli, Nunzia Boccia, Tania Alonso-Vásquez, Lorenzo Pelagatti, Marco Fondi, Claudio Luchinat, Laura Bertini, Vieri Vannucchi, Giancarlo Landini, Paola Turano, . COVID-19: A complex disease with a unique metabolic signature. PLOS Pathogens 2023, 19 (11) , e1011787. https://doi.org/10.1371/journal.ppat.1011787
    46. Veronica Ghini, Gaia Meoni, Alessia Vignoli, Francesca Di Cesare, Leonardo Tenori, Paola Turano, Claudio Luchinat. Fingerprinting and profiling in metabolomics of biosamples. Progress in Nuclear Magnetic Resonance Spectroscopy 2023, 138-139 , 105-135. https://doi.org/10.1016/j.pnmrs.2023.10.002
    47. Rui Li, Jun‐Xiang Chen, Qi Lu, Ting‐Ting Geng, Peng‐Fei Xia, Yi Wang, Liang‐Kai Chen, Zhi‐Lei Shan, An Pan, Gang Liu. Associations of lipoprotein subclasses with risk of all‐cause and cardiovascular disease mortality in individuals with type 2 diabetes: A prospective cohort study. Diabetes, Obesity and Metabolism 2023, 25 (11) , 3259-3267. https://doi.org/10.1111/dom.15224
    48. Heidi Sormunen-Harju, Emilia Huvinen, Polina V Girchenko, Eero Kajantie, Pia M Villa, Esa K Hämäläinen, Marius Lahti-Pulkkinen, Hannele Laivuori, Katri Räikkönen, Saila B Koivusalo. Metabolomic Profiles of Nonobese and Obese Women With Gestational Diabetes. The Journal of Clinical Endocrinology & Metabolism 2023, 108 (11) , 2862-2870. https://doi.org/10.1210/clinem/dgad288
    49. Zhenluan Tian, Qunxian Rao, Zhanghai He, Wei Zhao, Liangyu Chen, Jieqiong Liu, Ying Wang. Effect of 1 H‐NMR serum lipoproteins on immunotherapy response in advanced triple‐negative breast cancer patients. Cancer Science 2023, 114 (10) , 3924-3934. https://doi.org/10.1111/cas.15937
    50. Meghana D. Gadgil, David M. Herrington, Sukhmani K Singh, Namratha R. Kandula, Alka M. Kanaya. Association of lipoprotein subfractions with incidence of type 2 diabetes among five U.S. Race and Ethnic groups: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multi-Ethnic study of Atherosclerosis (MESA). Diabetes Research and Clinical Practice 2023, 204 , 110926. https://doi.org/10.1016/j.diabres.2023.110926
    51. Alessia Vignoli, Gianmaria Miolo, Leonardo Tenori, Angela Buonadonna, Davide Lombardi, Agostino Steffan, Simona Scalone, Claudio Luchinat, Giuseppe Corona. Novel metabolomics-biohumoral biomarkers model for predicting survival of metastatic soft-tissue sarcomas. iScience 2023, 26 (10) , 107678. https://doi.org/10.1016/j.isci.2023.107678
    52. Reika Masuda, Julien Wist, Samantha Lodge, Torben Kimhofer, Michael Hunter, Jennie Hui, John P. Beilby, John R. Burnett, Girish Dwivedi, Markus P. Schlaich, Sze-How Bong, Ruey Leng Loo, Elaine Holmes, Jeremy K. Nicholson, Bu B. Yeap. Plasma lipoprotein subclass variation in middle-aged and older adults: Sex-stratified distributions and associations with health status and cardiometabolic risk factors. Journal of Clinical Lipidology 2023, 17 (5) , 677-687. https://doi.org/10.1016/j.jacl.2023.06.004
    53. James Frampton, Jose Ivan Serrano‐Contreras, Isabel Garcia‐Perez, Georgia Franco‐Becker, Jack Penhaligan, Abbigail S. Y. Tan, Ana Claudia Cepas de Oliveira, Annabelle J. Milner, Kevin G. Murphy, Gary Frost, Edward S. Chambers. The metabolic interplay between dietary carbohydrate and exercise and its role in acute appetite regulation in males: a randomized controlled study. The Journal of Physiology 2023, 601 (16) , 3461-3480. https://doi.org/10.1113/JP284294
    54. Shona Pedersen, Morten Faarbæk Mikkelstrup, Søren Risom Kristensen, Najeha Rizwana Anwardeen, Mohamed A. Elrayess, Trygve Andreassen. Serum NMR-Based Metabolomics Profiling Identifies Lipoprotein Subfraction Variables and Amino Acid Reshuffling in Myeloma Development and Progression. International Journal of Molecular Sciences 2023, 24 (15) , 12275. https://doi.org/10.3390/ijms241512275
    55. Yukiko Okami, Queenie Chan, Katsuyuki Miura, Aya Kadota, Paul Elliott, Kamal Masaki, Akira Okayama, Nagako Okuda, Katsushi Yoshita, Naoko Miyagawa, Tomonori Okamura, Kiyomi Sakata, Shigeyuki Saitoh, Masaru Sakurai, Hideaki Nakagawa, Jeremiah Stamler (deceased), Hirotsugu Ueshima. Small High-Density Lipoprotein and Omega-3 Fatty Acid Intake Differentiates Japanese and Japanese-Americans: The INTERLIPID Study. Journal of Atherosclerosis and Thrombosis 2023, 30 (8) , 884-906. https://doi.org/10.5551/jat.63762
    56. Samantha Lodge, Nathan G. Lawler, Nicola Gray, Reika Masuda, Philipp Nitschke, Luke Whiley, Sze-How Bong, Bu B. Yeap, Girish Dwivedi, Manfred Spraul, Hartmut Schaefer, Rubén Gil-Redondo, Nieves Embade, Oscar Millet, Elaine Holmes, Julien Wist, Jeremy K. Nicholson. Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction. International Journal of Molecular Sciences 2023, 24 (14) , 11614. https://doi.org/10.3390/ijms241411614
    57. Alessia Trimigno, Bekzod Khakimov, Morten Arendt Rasmussen, Lars Ove Dragsted, Thomas Meinert Larsen, Arne Astrup, Søren Balling Engelsen. Human blood plasma biomarkers of diet and weight loss among centrally obese subjects in a New Nordic Diet intervention. Frontiers in Nutrition 2023, 10 https://doi.org/10.3389/fnut.2023.1198531
    58. Sofina Begum, Samantha Lodge, Drew Hall, Blair Z. Johnson, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Mark W. Fear, Elaine Holmes, Fiona M. Wood, Jeremy K. Nicholson. Cardiometabolic disease risk markers are increased following burn injury in children. Frontiers in Public Health 2023, 11 https://doi.org/10.3389/fpubh.2023.1105163
    59. Julie Caroline Sæther, Elisabeth Kleivhaug Vesterbekkmo, Bruna Gigante, Guro Fanneløb Giskeødegård, Tone Frost Bathen, Turid Follestad, Rune Wiseth, Erik Madssen, Anja Bye. The association between circulating lipoprotein subfractions and lipid content in coronary atheromatous plaques assessed by near-infrared spectroscopy. IJC Heart & Vasculature 2023, 46 , 101215. https://doi.org/10.1016/j.ijcha.2023.101215
    60. Yu Jin, Shuoqing Fan, Wenna Jiang, Jingya Zhang, Lexin Yang, Jiawei Xiao, Haohua An, Li Ren. Two effective models based on comprehensive lipidomics and metabolomics can distinguish BC versus HCs, and TNBC versus non‐TNBC. PROTEOMICS – Clinical Applications 2023, 17 (3) https://doi.org/10.1002/prca.202200042
    61. Claire Cannet, Georg Frauendienst‐Egger, Peter Freisinger, Hermann Götz, Madalina Götz, Nastassja Himmelreich, Vanessa Kock, Manfred Spraul, Christine Bus, Saskia Biskup, Friedrich Trefz. Ex vivo proton spectroscopy ( 1 H‐NMR) analysis of inborn errors of metabolism: Automatic and computer‐assisted analyses. NMR in Biomedicine 2023, 36 (4) https://doi.org/10.1002/nbm.4853
    62. Rasmus Bo Hasselbalch, Jonas Henrik Kristensen, Nina Strandkjær, Nicoline Jørgensen, Henning Bundgaard, Anders Malmendal, Kasper Karmark Iversen. Metabolomics of early myocardial ischemia. Metabolomics 2023, 19 (4) https://doi.org/10.1007/s11306-023-01999-8
    63. Xiaopeng Zhu, Qingxia Huang, Shuai Ma, Lingyan Chen, Qi Wu, Li Wu, Hui Ma, Xiaoming Li, Qian Li, Qiqige Aleteng, Yu Hu, Wanyuan He, Jian Gao, Huandong Lin, Huiru Tang, Xin Gao, Mingfeng Xia. Presence of sarcopenia identifies a special group of lean NAFLD in middle-aged and older people. Hepatology International 2023, 17 (2) , 313-325. https://doi.org/10.1007/s12072-022-10439-z
    64. Ram B. Khattri, Abhinandan Batra, Michael Matheny, Cora Hart, Spencer C. Henley‐Beasley, David Hammers, Huadong Zeng, Zoe White, Terence E. Ryan, Elisabeth Barton, Pascal Bernatchez, Glenn A. Walter. Magnetic resonance quantification of skeletal muscle lipid infiltration in a humanized mouse model of Duchenne muscular dystrophy. NMR in Biomedicine 2023, 36 (3) https://doi.org/10.1002/nbm.4869
    65. Cecilie Fredvik Torkildsen, Marie Austdal, Ann-Charlotte Iversen, Tone Frost Bathen, Guro Fanneløb Giskeødegård, Elisabeth Berge Nilsen, Grete Alræk Iversen, Ragnar Kvie Sande, Line Bjørge, Liv Cecilie Vestrheim Thomsen. Primary Treatment Effects for High-Grade Serous Ovarian Carcinoma Evaluated by Changes in Serum Metabolites and Lipoproteins. Metabolites 2023, 13 (3) , 417. https://doi.org/10.3390/metabo13030417
    66. Hélène Ruffieux, Aimee L. Hanson, Samantha Lodge, Nathan G. Lawler, Luke Whiley, Nicola Gray, Tui H. Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka de Sa, Victoria S. Pelly, , Prasanti Kotagiri, Nathalie Kingston, John R. Bradley, Elaine Holmes, Julien Wist, Jeremy K. Nicholson, Paul A. Lyons, Kenneth G. C. Smith, Sylvia Richardson, Glenn R. Bantug, Christoph Hess. A patient-centric modeling framework captures recovery from SARS-CoV-2 infection. Nature Immunology 2023, 24 (2) , 349-358. https://doi.org/10.1038/s41590-022-01380-2
    67. Kuo-Hsuan Chang, Mei-Ling Cheng, Chi-Jen Lo, Chun-Ming Fan, Yih-Ru Wu, Chiung-Mei Chen. Alternations of Lipoprotein Profiles in the Plasma as Biomarkers of Huntington’s Disease. Cells 2023, 12 (3) , 385. https://doi.org/10.3390/cells12030385
    68. Yongxin Ye, Jiahua Fan, Zhiteng Chen, Xiuwen Li, Maoxiong Wu, Wenhao Liu, Shiyi Zhou, Morten Arendt Rasmussen, Søren Balling Engelsen, Yangxin Chen, Bekzod Khakimov, Min Xia. Alterations of NMR-Based Lipoprotein Profile Distinguish Unstable Angina Patients with Different Severity of Coronary Lesions. Metabolites 2023, 13 (2) , 273. https://doi.org/10.3390/metabo13020273
    69. Qiumin Huang, Xiaofeng Zhou, Chuqi Zhang, Liyan Huang, Qi Wang, Qinsheng Chen, Huiru Tang, Jingchun Luo, Zhengyuan Wang, Changzheng Yuan, Yan Zheng. Relative Validity and Reproducibility of Dietary Measurements Assessed by a Semiquantitative Food Frequency Questionnaire among Chinese Healthy Adults. Nutrients 2023, 15 (3) , 545. https://doi.org/10.3390/nu15030545
    70. Banny Silva Barbosa Correia, Priscila Marques Firmiano Dalle Piagge, Luísa Souza Almeida, Gabriel Henrique Ribeiro, Cristina de Souza Peixoto, Luiz Alberto Colnago, Daniel Rodrigues Cardoso. The Use of NMR Based Metabolomics to Discriminate Patients with Viral Diseases. 2023, 129-174. https://doi.org/10.1007/978-3-031-15889-6_7
    71. Monica Emili Garcia‐Segura, Brenan R. Durainayagam, Sonia Liggi, Gonçalo Graça, Beatriz Jimenez, Abbas Dehghan, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Julian L. Griffin. Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers. Journal of Neurochemistry 2023, 164 (1) , 57-76. https://doi.org/10.1111/jnc.15719
    72. Julie Caroline Sæther, Marie Klevjer, Guro Fanneløb Giskeødegård, Tone Frost Bathen, Bruna Gigante, Sigrid Gjære, Marthe Myhra, Elisabeth Kleivhaug Vesterbekkmo, Rune Wiseth, Erik Madssen, Anja Bye. Small LDL subfractions are associated with coronary atherosclerosis despite no differences in conventional lipids. Physiological Genomics 2023, 55 (1) , 16-26. https://doi.org/10.1152/physiolgenomics.00098.2022
    73. Dalia Ahmed, Stefano Cacciatore, Luiz Fernando Zerbini. Metabolite Analyses Using Nuclear Magnetic Resonance (NMR) Spectroscopy in Plasma of Patients with Prostate Cancer. 2023, 195-204. https://doi.org/10.1007/978-1-0716-3247-5_15
    74. David Fernández-Ramos, Fernando Lopitz-Otsoa, Oscar Millet, Cristina Alonso, Shelly C. Lu, José M. Mato. One Carbon Metabolism and S-Adenosylmethionine in Non-Alcoholic Fatty Liver Disease Pathogenesis and Subtypes. Livers 2022, 2 (4) , 243-257. https://doi.org/10.3390/livers2040020
    75. Helena U. Zacharias, Christoph Kaleta, François Cossais, Eva Schaeffer, Henry Berndt, Lena Best, Thomas Dost, Svea Glüsing, Mathieu Groussin, Mathilde Poyet, Sebastian Heinzel, Corinna Bang, Leonard Siebert, Tobias Demetrowitsch, Frank Leypoldt, Rainer Adelung, Thorsten Bartsch, Anja Bosy-Westphal, Karin Schwarz, Daniela Berg. Microbiome and Metabolome Insights into the Role of the Gastrointestinal–Brain Axis in Parkinson’s and Alzheimer’s Disease: Unveiling Potential Therapeutic Targets. Metabolites 2022, 12 (12) , 1222. https://doi.org/10.3390/metabo12121222
    76. Titus Rössler, Georgy Berezhnoy, Yogesh Singh, Claire Cannet, Tony Reinsperger, Hartmut Schäfer, Manfred Spraul, Manfred Kneilling, Uta Merle, Christoph Trautwein. Quantitative Serum NMR Spectroscopy Stratifies COVID-19 Patients and Sheds Light on Interfaces of Host Metabolism and the Immune Response with Cytokines and Clinical Parameters. Metabolites 2022, 12 (12) , 1277. https://doi.org/10.3390/metabo12121277
    77. Julia Debik, Hartmut Schäfer, Trygve Andreassen, Feng Wang, Fang Fang, Claire Cannet, Manfred Spraul, Tone F. Bathen, Guro F. Giskeødegård. Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study. British Journal of Cancer 2022, 127 (8) , 1515-1524. https://doi.org/10.1038/s41416-022-01924-1
    78. Mohan Ghorasaini, Konstantina Ismini Tsezou, Aswin Verhoeven, Yassene Mohammed, Panayiotis Vlachoyiannopoulos, Emmanuel Mikros, Martin Giera. Congruence and Complementarity of Differential Mobility Spectrometry and NMR Spectroscopy for Plasma Lipidomics. Metabolites 2022, 12 (11) , 1030. https://doi.org/10.3390/metabo12111030
    79. Hsiang-Chun Lee, Alexander Akhmedov, Chu-Huang Chen. Spotlight on very-low-density lipoprotein as a driver of cardiometabolic disorders: Implications for disease progression and mechanistic insights. Frontiers in Cardiovascular Medicine 2022, 9 https://doi.org/10.3389/fcvm.2022.993633
    80. Eleni Papadopoulou, Alina Nicolescu, Line S. Haug, Trine Husøy, Calin Deleanu, Hubert Dirven, Birgitte Lindeman. Lipoprotein profiles associated with exposure to poly- and perfluoroalkyl substances (PFASs) in the EuroMix human biomonitoring study. Environmental Pollution 2022, 308 , 119664. https://doi.org/10.1016/j.envpol.2022.119664
    81. Jie Zeng, Jin Peng, Hua Jiang, Pengchi Deng, Kexun Li, Daolin Long, Kai Wang, . Establishment of an early diagnosis model of colon cancerous bowel obstruction based on 1H NMR. PLOS ONE 2022, 17 (8) , e0266730. https://doi.org/10.1371/journal.pone.0266730
    82. David S. Wishart, Leo L. Cheng, Valérie Copié, Arthur S. Edison, Hamid R. Eghbalnia, Jeffrey C. Hoch, Goncalo J. Gouveia, Wimal Pathmasiri, Robert Powers, Tracey B. Schock, Lloyd W. Sumner, Mario Uchimiya. NMR and Metabolomics—A Roadmap for the Future. Metabolites 2022, 12 (8) , 678. https://doi.org/10.3390/metabo12080678
    83. Lukas Streese, Hansjörg Habisch, Arne Deiseroth, Justin Carrard, Denis Infanger, Arno Schmidt-Trucksäss, Tobias Madl, Henner Hanssen. Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health. Molecules 2022, 27 (15) , 4760. https://doi.org/10.3390/molecules27154760
    84. Laura-Adina Stănciulescu, Alexandru Scafa, Cătălin Duduianu, Raluca Stan, Alina Nicolescu, Calin Deleanu, Maria Dorobanțu. Lipoprofiling Assessed by NMR Spectroscopy in Patients with Acute Coronary Syndromes: Is There a Need for Fasting Prior to Sampling?. Diagnostics 2022, 12 (7) , 1675. https://doi.org/10.3390/diagnostics12071675
    85. Guro F. Giskeødegård, Torfinn S. Madssen, Matteo Sangermani, Steinar Lundgren, Torgeir Wethal, Trygve Andreassen, Randi J. Reidunsdatter, Tone F. Bathen. Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment. Frontiers in Oncology 2022, 12 https://doi.org/10.3389/fonc.2022.919522
    86. Veronica Ghini, Gaia Meoni, Lorenzo Pelagatti, Tommaso Celli, Francesca Veneziani, Fabrizia Petrucci, Vieri Vannucchi, Laura Bertini, Claudio Luchinat, Giancarlo Landini, Paola Turano, . Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients. PLOS Pathogens 2022, 18 (4) , e1010443. https://doi.org/10.1371/journal.ppat.1010443
    87. Alessia Vignoli, Alessandra Fornaro, Leonardo Tenori, Gabriele Castelli, Elisabetta Cecconi, Iacopo Olivotto, Niccolò Marchionni, Brunetto Alterini, Claudio Luchinat. Metabolomics Fingerprint Predicts Risk of Death in Dilated Cardiomyopathy and Heart Failure. Frontiers in Cardiovascular Medicine 2022, 9 https://doi.org/10.3389/fcvm.2022.851905
    88. Veronica Ghini, Laura Maggi, Alessio Mazzoni, Michele Spinicci, Lorenzo Zammarchi, Alessandro Bartoloni, Francesco Annunziato, Paola Turano. Serum NMR Profiling Reveals Differential Alterations in the Lipoproteome Induced by Pfizer-BioNTech Vaccine in COVID-19 Recovered Subjects and Naïve Subjects. Frontiers in Molecular Biosciences 2022, 9 https://doi.org/10.3389/fmolb.2022.839809
    89. Eeva Sliz, Jean Shin, Shahzad Ahmad, Dylan M. Williams, Stefan Frenzel, Friederike Gauß, Sarah E. Harris, Ann-Kristin Henning, Maria Valdes Hernandez, Yi-Han Hu, Beatriz Jiménez, Muralidharan Sargurupremraj, Carole Sudre, Ruiqi Wang, Katharina Wittfeld, Qiong Yang, Joanna M. Wardlaw, Henry Völzke, Meike W. Vernooij, Jonathan M. Schott, Marcus Richards, Petroula Proitsi, Matthias Nauck, Matthew R. Lewis, Lenore Launer, Norbert Hosten, Hans J. Grabe, Mohsen Ghanbari, Ian J. Deary, Simon R. Cox, Nishi Chaturvedi, Josephine Barnes, Jerome I. Rotter, Stephanie Debette, M. Arfan Ikram, Myriam Fornage, Tomas Paus, Sudha Seshadri, Zdenka Pausova, . Circulating Metabolome and White Matter Hyperintensities in Women and Men. Circulation 2022, 145 (14) , 1040-1052. https://doi.org/10.1161/CIRCULATIONAHA.121.056892
    90. Francesca Di Cesare, Leonardo Tenori, Gaia Meoni, Anna Maria Gori, Rossella Marcucci, Betti Giusti, Raffaele Molino-Lova, Claudio Macchi, Silvia Pancani, Claudio Luchinat, Edoardo Saccenti. Lipid and metabolite correlation networks specific to clinical and biochemical covariate show differences associated with sexual dimorphism in a cohort of nonagenarians. GeroScience 2022, 44 (2) , 1109-1128. https://doi.org/10.1007/s11357-021-00404-3
    91. Mingfeng Xia, Shuai Ma, Qingxia Huang, Hailuan Zeng, Jieyu Ge, Wenjie Xu, Qi Wu, Li Wu, Xiaoming Li, Hui Ma, Lingyan Chen, Qian Li, Qiqige Aleteng, Yu Hu, Wanyuan He, Baishen Pan, Huandong Lin, Yan Zheng, Sijia Wang, Huiru Tang, Xin Gao. NAFLD‐related gene polymorphisms and all‐cause and cause‐specific mortality in an Asian population: the Shanghai Changfeng Study. Alimentary Pharmacology & Therapeutics 2022, 55 (6) , 705-721. https://doi.org/10.1111/apt.16772
    92. Cristina Stavarache, Alina Nicolescu, Cătălin Duduianu, Gabriela Liliana Ailiesei, Mihaela Balan-Porcăraşu, Mihaela Cristea, Ana-Maria Macsim, Oana Popa, Carmen Stavarache, Anca Hîrtopeanu, Lucica Barbeş, Raluca Stan, Horia Iovu, Calin Deleanu. A Real-Life Reproducibility Assessment for NMR Metabolomics. Diagnostics 2022, 12 (3) , 559. https://doi.org/10.3390/diagnostics12030559
    93. Maider Bizkarguenaga, Chiara Bruzzone, Rubén Gil‐Redondo, Itxaso SanJuan, Itziar Martin‐Ruiz, Diego Barriales, Ainhoa Palacios, Samuel T. Pasco, Beatriz González‐Valle, Ana Laín, Lara Herrera, Aida Azkarate, Miguel Angel Vesga, Cristina Eguizabal, Juan Anguita, Nieves Embade, José M. Mato, Oscar Millet. Uneven metabolic and lipidomic profiles in recovered COVID‐19 patients as investigated by plasma NMR metabolomics. NMR in Biomedicine 2022, 35 (2) https://doi.org/10.1002/nbm.4637
    94. Markus Nodeland, Marie Klevjer, Julie Sæther, Guro Giskeødegård, Tone Frost Bathen, Ulrik Wisløff, Anja Bye. Atherogenic lipidomics profile in healthy individuals with low cardiorespiratory fitness: The HUNT3 fitness study. Atherosclerosis 2022, 343 , 51-57. https://doi.org/10.1016/j.atherosclerosis.2022.01.001
    95. Yahui Lin, Qiong Yang, Zhaohui Liu, Baoman Su, Fen Xu, Yang Li, Jinsuo Kang, Zhou Zhou. Relationship between Apolipoprotein E Genotype and Lipoprotein Profile in Patients with Coronary Heart Disease. Molecules 2022, 27 (4) , 1377. https://doi.org/10.3390/molecules27041377
    96. Babak Tavana, Aicheng Chen. Determination of Drugs in Clinical Trials: Current Status and Outlook. Sensors 2022, 22 (4) , 1592. https://doi.org/10.3390/s22041592
    97. Maider Bizkarguenaga, Rubén Gil-Redondo, Chiara Bruzzone, Ganeko Bernardo-Seisdedos, Ana Laín, Beatriz González-Valle, Nieves Embade, José M. Mato, Oscar Millet. Prospective Metabolomic Studies in Precision Medicine: The AKRIBEA Project. 2022, 275-297. https://doi.org/10.1007/164_2022_610
    98. G. A. Nagana Gowda, Daniel Raftery. Quantitative NMR Methods in Metabolomics. 2022, 143-164. https://doi.org/10.1007/164_2022_612
    99. Raimund Pechlaner, Nele Friedrich, Anna Staudt, Nina Gande, Benoît Bernar, Katharina Stock, Sophia J. Kiechl, Christoph Hochmayr, Andrea Griesmacher, Astrid Petersmann, Kathrin Budde, Hermann Stuppner, Sonja Sturm, Marcus Dörr, Ulf Schminke, Claire Cannet, Fang Fang, Hartmut Schäfer, Manfred Spraul, Ralf Geiger, Manuel Mayr, Matthias Nauck, Stefan Kiechl, Ursula Kiechl-Kohlendorfer, Michael Knoflach, Anna Staudt, Benoît Bernar, Bernhard Winder, Carmen Reiter, Christina Burger, Christoph Hochmayr, Gregor Brössner, Hermann Stuppner, Julia Klingenschmid, Julia Marxer, Katharina Stock, Mandy Asare, Manuel Mayr, Manuela Bock-Bartl, Martina Kothmayer, Maximilian Bohl, Maximilian Pircher, Michael Knoflach, Nina Gande, Raimund Pechlaner, Ralf Geiger, Sonja Sturm, Sophia J. Kiechl, Stefan Kiechl, Tatjana Heisinger, Ursula Kiechl-Kohlendorfer. Association of adolescent lipoprotein subclass profile with carotid intima-media thickness and comparison to adults: Prospective population-based cohort studies. Atherosclerosis 2022, 341 , 34-42. https://doi.org/10.1016/j.atherosclerosis.2021.12.007
    100. Mika Jönsson, Emmanuel Bäckryd, Lena Jonasson, Björn Gerdle, Bijar Ghafouri. Differences in plasma lipoprotein profiles between patients with chronic peripheral neuropathic pain and healthy controls: an exploratory pilot study. PAIN Reports 2022, 7 (5) , e1036. https://doi.org/10.1097/PR9.0000000000001036
    Load all citations
    Download PDF
    Go to Analytical Chemistry
    Get e-Alerts
    Get e-Alerts

    Analytical Chemistry

    Cite this: Anal. Chem. 2018, 90, 20, 11962–11971
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.analchem.8b02412
    Published September 13, 2018
    Copyright © 2018 American Chemical Society
    Request reuse permissions

    Article Views

    3552

    Altmetric

    -

    Citations

    154
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.