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Novel Ru(bpy)2(cpaphen)2+/TPrA/TiO2 Ternary ECL System: An Efficient Platform for the Detection of Glutathione with Mn2+ as Substitute Target

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    Novel Ru(bpy)2(cpaphen)2+/TPrA/TiO2 Ternary ECL System: An Efficient Platform for the Detection of Glutathione with Mn2+ as Substitute Target
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    • Rui Zhang
      Rui Zhang
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by Rui Zhang
    • Xia Zhong
      Xia Zhong
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by Xia Zhong
    • An-Yi Chen
      An-Yi Chen
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by An-Yi Chen
    • Jia-Li Liu
      Jia-Li Liu
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by Jia-Li Liu
    • Sheng-Kai Li
      Sheng-Kai Li
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by Sheng-Kai Li
    • Ya-Qin Chai
      Ya-Qin Chai
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by Ya-Qin Chai
      Orcidhttp://orcid.org/0000-0003-4392-9592
    • Ying Zhuo*
      Ying Zhuo
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      *Tel.: +86 23 68253172. Fax: +86 23 68253172. E-mail: [email protected] (Y.Z.).
      More by Ying Zhuo
      Orcidhttp://orcid.org/0000-0002-4491-1186
    • Ruo Yuan
      Ruo Yuan
      Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
      More by Ruo Yuan
      Orcidhttp://orcid.org/0000-0003-3664-6236
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    Analytical Chemistry

    Cite this: Anal. Chem. 2019, 91, 5, 3681–3686
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    https://doi.org/10.1021/acs.analchem.8b05795
    Published January 30, 2019
    Copyright © 2019 American Chemical Society
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    Abstract

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    A sensitive electrochemiluminescence (ECL) biosensor was developed for glutathione (GSH) detection based on a novel Ru(bpy)2(cpaphen)2+/TPrA/TiO2 ternary ECL system with Mn2+ as substitute target for signal amplification. Specifically, the TiO2 nanoneedles (TiO2 NNs) were used as the coreaction accelerator for the first time to promote the oxidation process of coreactant tripropylamine (TPrA) in the anode and significantly increase the ECL signal of Ru(bpy)2(cpaphen)2+ for an amplified initial signal. Meanwhile, a novel target conversion strategy for GSH was developed by reducing MnO2 nanosheets to Mn2+ as a substitute target, which played the role of a coenzyme factor for cleaving DNA double strands intercalated with Ru(bpy)2(cpaphen)2+ to markedly weaken initial signal. As a result, the novel “on–off” biosensor achieved a sensitive detection of GSH range from 5 μM to 215 μM with a detection limit of 0.33 μM. Importantly, the proposed strategy enriched the application of Ru complex and TPrA ECL system in bioanalytical applications, and provided a new signal amplification strategy for bioactive small molecules.

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.analchem.8b05795.

    • Reagents and samples, instrumentation, preparation of Pt NPs, preparation of MnO2 nanosheets, procedures of GSH detection, selection of the scan rate, optimal conditions for the ECL biosensor, CV characterization of the biosensor and comparison of different methods for GSH detection (DOC)

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    Cite this: Anal. Chem. 2019, 91, 5, 3681–3686
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    https://doi.org/10.1021/acs.analchem.8b05795
    Published January 30, 2019
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