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Residue-Specific Peptide Modification: A Chemist’s Guide

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Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
Cite this: Biochemistry 2017, 56, 30, 3863–3873
Publication Date (Web):June 27, 2017
https://doi.org/10.1021/acs.biochem.7b00536
Copyright © 2017 American Chemical Society

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    Abstract

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    Advances in bioconjugation and native protein modification are appearing at a blistering pace, making it increasingly time consuming for practitioners to identify the best chemical method for modifying a specific amino acid residue in a complex setting. The purpose of this perspective is to provide an informative, graphically rich manual highlighting significant advances in the field over the past decade. This guide will help triage candidate methods for peptide alteration and will serve as a starting point for those seeking to solve long-standing challenges.

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    • Delineation of Amino Acid Side-Chain Modification Report Card assessments, including references (PDF)

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