Noncanonical Roles of Lipids in Different Cellular Fates
Abstract
Lipids are a diverse class of biomolecules. The biosynthesis and transport of these molecules are controlled by a considerable number of proteins, which facilitate spatiotemporal regulation of lipids during different fundamental cellular processes. Although lipids are traditionally considered as molecules for energy storage and as structural components of membranes, they are being increasingly recognized for their signaling roles. There is a growing appreciation of lipids’ chemical diversity, which approaches that of proteins. In this Perspective, we discuss recent studies that suggest novel functions for distinct lipid species during different cellular processes. In particular, we discuss findings from our laboratory that illuminate the involvement of ceramides, polyunsaturated triacylglycerols, and very long chain fatty acids in different cellular fates. We also highlight recent innovative methods that have enabled the recognition of previously unknown lipid classes and/or roles of these molecules in different biological processes. We envision that advances in lipid identification, visualization, and perturbation will pave the way for broader investigations into this fascinating and influential class of biomolecules.
Cited By
This article is cited by 14 publications.
- Ying Xu, Xiaoli Hou, Qiaoqiao Zhu, Shijie Mao, Jie Ren, Jidong Lin, Ning Xu. Phenotype Identification of HeLa Cells Knockout CDK6 Gene Based on Label-Free Raman Imaging. Analytical Chemistry 2022, 94 (25) , 8890-8898. https://doi.org/10.1021/acs.analchem.2c00188
- Mason L. Valentine, Maya K. Waterland, Arman Fathizadeh, Ron Elber, Carlos R. Baiz. Interfacial Dynamics in Lipid Membranes: The Effects of Headgroup Structures. The Journal of Physical Chemistry B 2021, 125 (5) , 1343-1350. https://doi.org/10.1021/acs.jpcb.0c08755
- Laura R. Parisi, Lauren M. Morrow, Michelle B. Visser, G. Ekin Atilla-Gokcumen. Turning the Spotlight on Lipids in Non-Apoptotic Cell Death. ACS Chemical Biology 2018, 13 (3) , 506-515. https://doi.org/10.1021/acschembio.7b01082
- Bahar Faramarzi, Martina Moggio, Nadia Diano, Marianna Portaccio, Maria Lepore. A Brief Review of FT-IR Spectroscopy Studies of Sphingolipids in Human Cells. Biophysica 2023, 3 (1) , 158-180. https://doi.org/10.3390/biophysica3010011
- Cátia Vilas-Boas, Logan Running, Daniela Pereira, Honorina Cidade, Marta Correia-da-Silva, Gunes Ekin Atilla-Gokcumen, Diana S. Aga. Impact of Tralopyril and Triazolyl Glycosylated Chalcone in Human Retinal Cells’ Lipidome. Molecules 2022, 27 (16) , 5247. https://doi.org/10.3390/molecules27165247
- Prema K. Agarwala, Ritu Aneja, Shobhna Kapoor. Lipidomic landscape in cancer: Actionable insights for membrane‐based therapy and diagnoses. Medicinal Research Reviews 2022, 42 (2) , 983-1018. https://doi.org/10.1002/med.21868
- Mason L. Valentine, Alfredo E. Cardenas, Ron Elber, Carlos R. Baiz. Calcium-Lipid Interactions Observed with Isotope-Edited Infrared Spectroscopy. Biophysical Journal 2020, 118 (11) , 2694-2702. https://doi.org/10.1016/j.bpj.2020.04.013
- Yixiao Wang, Guangshu Wang, Ru’nan Jing, Ting Hu, Sergei Likhodii, Guang Sun, Edward Randell, Guihua Jia, Tianmiao Yu, Weidong Zhang. Metabolomics analysis of human plasma metabolites reveals the age- and sex-specific associations. Journal of Liquid Chromatography & Related Technologies 2020, 43 (5-6) , 185-194. https://doi.org/10.1080/10826076.2019.1701016
- Hector Flores-Romero, Uris Ros, Ana J. García-Sáez. A lipid perspective on regulated cell death. 2020, 197-236. https://doi.org/10.1016/bs.ircmb.2019.11.004
- Xiujuan Cui, Xiaoyan Yu, Guang Sun, Ting Hu, Sergei Likhodii, Jingmin Zhang, Edward Randell, Xiang Gao, Zhaozhi Fan, Weidong Zhang, . Differential metabolomics networks analysis of menopausal status. PLOS ONE 2019, 14 (9) , e0222353. https://doi.org/10.1371/journal.pone.0222353
- N. G. Chavez Soria, D. S. Aga, G. E. Atilla-Gokcumen. Lipidomics reveals insights on the biological effects of copper oxide nanoparticles in a human colon carcinoma cell line. Molecular Omics 2019, 15 (1) , 30-38. https://doi.org/10.1039/C8MO00162F
- Timothy W. Bumpus, Jeremy M. Baskin. Greasing the Wheels of Lipid Biology with Chemical Tools. Trends in Biochemical Sciences 2018, 43 (12) , 970-983. https://doi.org/10.1016/j.tibs.2018.09.011
- Svitlana Levchenko, Junle Qu. Biomolecular Component Analysis of Phospholipids Composition in Live HeLa Cells. Biosensors 2018, 8 (4) , 123. https://doi.org/10.3390/bios8040123
- Mason L. Valentine, Alfredo E. Cardenas, Ron Elber, Carlos R. Baiz. Physiological Calcium Concentrations Slow Dynamics at the Lipid-Water Interface. Biophysical Journal 2018, 115 (8) , 1541-1551. https://doi.org/10.1016/j.bpj.2018.08.044