logo

OR SEARCH CITATIONS

My Activity
Publications
CONTENT TYPES

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Bioconjugate Chem. 2016, 27, 4, 1153-1164
RETURN TO ISSUEPREVArticleNEXT

Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice

View Author Information
† Centro de Ciências e Tecnologias Nucleares, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
‡ Centro de Química-Física Molecular, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
§ Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal
∥Departments of Radiology, ⊥MU-iCATS, #BioEngineering, and ∇International Center for Nano/Micro Systems and Nanotechnology, University of Missouri, Columbia, Missouri 65211, United States
*(M.P.C.C.) E-mail: [email protected]
*(A.P.) E-mail: [email protected]
*(R.K.) Department of Radiology, One Hospital Dr., Columbia, MO 65211, USA. E-mail: [email protected]
Cite this: Bioconjugate Chem. 2016, 27, 4, 1153–1164
Publication Date (Web):March 22, 2016
https://doi.org/10.1021/acs.bioconjchem.6b00102
Copyright © 2016 American Chemical Society
RIGHTS & PERMISSIONS
Article Views
936
Altmetric
-
Citations
12
LEARN ABOUT THESE METRICS

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.

Read OnlinePDF (3 MB)
Supporting Info (1)»
SUBJECTS:

Abstract

Abstract Image

To get a better insight on the transport mechanism of peptide-conjugated nanoparticles to tumors, we performed in vivo biological studies of bombesin (BBN) peptide functionalized gold nanoparticles (AuNPs) in human prostate tumor bearing mice. Initially, we sought to compare AuNPs with thiol derivatives of acyclic and macrocyclic chelators of DTPA and DOTA types. The DTPA derivatives were unable to provide a stable coordination of 67Ga, and therefore, the functionalization with the BBN analogues was pursued for the DOTA-containing AuNPs. The DOTA-coated AuNPs were functionalized with BBN[7–14] using a unidentate cysteine group or a bidentate thioctic group to attach the peptide. AuNPs functionalized with thioctic-BBN displayed the highest in vitro cellular internalization (≈ 25%, 15 min) in gastrin releasing peptide (GRP) receptor expressing cancer cells. However, these results fail to translate to in vivo tumor uptake. Biodistribution studies following intravenous (IV) and intraperitoneal (IP) administration of nanoconjugates in tumor bearing mice indicated that the presence of BBN influences to some degree the biological profile of the nanoconstructs. For IV administration, the receptor-mediated pathway appears to be outweighed by the EPR effect. By contrast, in IP administration, it is reasoned that the GRPr-mediated mechanism plays a role in pancreas uptake.

Supporting Information

ARTICLE SECTIONS
Jump To

The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.bioconjchem.6b00102.

  • Experimental procedures (PDF)

Terms & Conditions

Electronic Supporting Information files are available without a subscription to ACS Web Editions. The American Chemical Society holds a copyright ownership interest in any copyrightable Supporting Information. Files available from the ACS website may be downloaded for personal use only. Users are not otherwise permitted to reproduce, republish, redistribute, or sell any Supporting Information from the ACS website, either in whole or in part, in either machine-readable form or any other form without permission from the American Chemical Society. For permission to reproduce, republish and redistribute this material, requesters must process their own requests via the RightsLink permission system. Information about how to use the RightsLink permission system can be found at http://pubs.acs.org/page/copyright/permissions.html.

Cited By

This article is cited by 12 publications.

  1. Francisco Silva, António Paulo, Agnès Pallier, Sandra Même, Éva Tóth, Lurdes Gano, Fernanda Marques, Carlos F.G.C. Geraldes, M. Margarida C.A. Castro, Ana M. Cardoso, Amália S. Jurado, Pilar López-Larrubia, Sara Lacerda, Maria Paula Cabral Campello. Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics. Materials 2020, 13 (3) , 513. https://doi.org/10.3390/ma13030513
  2. Lurdes Gano, Teresa Pinheiro, António P. Matos, Francisco Tortosa, Tiago F. Jorge, Maria S. Gonçalves, Marta Martins, Tânia S. Morais, Andreia Valente, Ana I. Tomaz, Maria H. Garcia, Fernanda Marques. Antitumour and Toxicity Evaluation of a Ru(II)-Cyclopentadienyl Complex in a Prostate Cancer Model by Imaging Tools. Anti-Cancer Agents in Medicinal Chemistry 2019, 19 (10) , 1262-1275. https://doi.org/10.2174/1871520619666190318152726
  3. Maria Cristina Oliveira, João D.G. Correia. Biomedical applications of radioiodinated peptides. European Journal of Medicinal Chemistry 2019, 179 , 56-77. https://doi.org/10.1016/j.ejmech.2019.06.014
  4. Deep Pooja, Anusha Gunukula, Nitin Gupta, David J. Adams, Hitesh Kulhari. Bombesin receptors as potential targets for anticancer drug delivery and imaging. The International Journal of Biochemistry & Cell Biology 2019, 114 , 105567. https://doi.org/10.1016/j.biocel.2019.105567
  5. Jingwen Peng, Xiaoqiu Liang. Progress in research on gold nanoparticles in cancer management. Medicine 2019, 98 (18) , e15311. https://doi.org/10.1097/MD.0000000000015311
  6. Ayuob Aghanejad, Yadollah Omidi. Radiolabeled Theranostics. 2019,,, 535-547. https://doi.org/10.1016/B978-0-12-814134-2.00025-5
  7. Myriam Laprise-Pelletier, Teresa Simão, Marc-André Fortin. Gold Nanoparticles in Radiotherapy and Recent Progress in Nanobrachytherapy. Advanced Healthcare Materials 2018, 7 (16) , 1701460. https://doi.org/10.1002/adhm.201701460
  8. Tsai-Jung Wu, Hsiao-Yu Chiu, John Yu, Mafalda P. Cautela, Bruno Sarmento, José das Neves, Carme Catala, Nicolas Pazos-Perez, Luca Guerrini, Ramon A. Alvarez-Puebla, Sanja Vranješ-Đurić, Nenad L. Ignjatović. Nanotechnologies for early diagnosis, in situ disease monitoring, and prevention. 2018,,, 1-92. https://doi.org/10.1016/B978-0-323-48063-5.00001-0
  9. Richard Bayford, Tom Rademacher, Ivan Roitt, Scarlet Xiaoyan Wang. Emerging applications of nanotechnology for diagnosis and therapy of disease: a review. Physiological Measurement 2017, 38 (8) , R183-R203. https://doi.org/10.1088/1361-6579/aa7182
  10. Jingyi Zong, Steven L. Cobb, Neil R. Cameron. Peptide-functionalized gold nanoparticles: versatile biomaterials for diagnostic and therapeutic applications. Biomaterials Science 2017, 5 (5) , 872-886. https://doi.org/10.1039/C7BM00006E
  11. Francisco Silva, Lurdes Gano, Maria Paula Cabral Campello, Rosa Marques, Isabel Prudêncio, Ajit Zambre, Anandhi Upendran, António Paulo, Raghuraman Kannan. In vitro/in vivo “peeling” of multilayered aminocarboxylate gold nanoparticles evidenced by a kinetically stable 99m Tc-label. Dalton Transactions 2017, 46 (42) , 14572-14583. https://doi.org/10.1039/C7DT00864C
  12. Sedigheh Khamehchian, Maryam Nikkhah, Rasool Madani, Saman Hosseinkhani. Enhanced and selective permeability of gold nanoparticles functionalized with cell penetrating peptide derived from maurocalcine animal toxin. Journal of Biomedical Materials Research Part A 2016, 104 (11) , 2693-2700. https://doi.org/10.1002/jbm.a.35806

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

Pair your accounts.

Export articles to Mendeley

Get article recommendations from ACS based on references in your Mendeley library.

You’ve supercharged your research process with ACS and Mendeley!

STEP 1:
Click to create an ACS ID

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

OOPS

You have to login with your ACS ID befor you can login with your Mendeley account.

MENDELEY PAIRING EXPIRED
Your Mendeley pairing has expired. Please reconnect

This website uses cookies to improve your user experience. By continuing to use the site, you are accepting our use of cookies. Read the ACS privacy policy.

CONTINUE