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    Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins
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    5121 Engineering 5, Department of Bioengineering and Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States
    *E-mail: [email protected]. Fax: (+1) 310-794-5956.
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    Bioconjugate Chemistry

    Cite this: Bioconjugate Chem. 2017, 28, 3, 691–700
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    https://doi.org/10.1021/acs.bioconjchem.6b00696
    Published December 26, 2016
    Copyright © 2016 American Chemical Society
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    Recent developments in the modification of methionine and other thioether-containing residues in peptides, polypeptides, and proteins are reviewed. Properties and potential applications of the resulting functionalized products are also discussed. While much of this work is focused on natural Met residues, modifications at other side-chain residues have also emerged as new thioether-containing amino acids have been incorporated into peptidic materials. Functional modification of thioether-containing amino acids has many advantages and is a complementary methodology to the widely utilized methods for modification at cysteine residues.

    Copyright © 2016 American Chemical Society

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    Cite this: Bioconjugate Chem. 2017, 28, 3, 691–700
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    https://doi.org/10.1021/acs.bioconjchem.6b00696
    Published December 26, 2016
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