Isolation, Identification, and Anti-Inflammatory Activity of Polysaccharides of Typha angustifoliaClick to copy article linkArticle link copied!
- Huan WeiHuan WeiJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Huan Wei
- Yuqi ShiYuqi ShiCollege of Plant Protection, Nanjing Agricultural University, Nanjing 210095, ChinaMore by Yuqi Shi
- Zhixiang YuanZhixiang YuanCollege of Plant Protection, Nanjing Agricultural University, Nanjing 210095, ChinaMore by Zhixiang Yuan
- Zhinan HuangZhinan HuangJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Zhinan Huang
- Fuhong CaiFuhong CaiJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Fuhong Cai
- Jingfeng ZhuJingfeng ZhuJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Jingfeng Zhu
- Wanwan ZhangWanwan ZhangJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Wanwan Zhang
- Jia LiJia LiJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Jia Li
- Qingping XiongQingping XiongJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Qingping Xiong
- Yunpeng WangYunpeng WangJiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Yunpeng Wang
- Xiaoli Wang*Xiaoli Wang*Tel.: +86-517-83559216. Fax: +86-517-83559216. E-mail: [email protected]Jiangsu Provincial Key Construction Laboratory of Probiotics Preparation, College of Life Science and Food Engineering, Huaiyin Institute of Technology, Huai’an 223003, ChinaMore by Xiaoli Wang
Abstract
The present study aimed to purify, structurally characterize, and evaluate the anti-inflammatory activity of the polysaccharide extracted from Typha angustifolia. Two purified polysaccharides (PTA-1 and PTA-2) were obtained via DEAE-52 cellulose chromatography. Their structural characterizations and antioxidant activity were in vitro analyzed. To evaluate the anti-inflammatory activity of PTA-2, the levels of inflammatory cytokines, intracellular ROS production, and the inhibitory effects of the transcriptional activation of the nuclear factor kappa B (NF-κB) signaling pathway were determined. PTA-1 comprises glucose (100%) with α-(1 → 3) glycosidic bonds, and PTA-2 comprises glucose (66.7%) and rhamnose (33.3%) formed by β-(1 → 3) glycosidic bonds. PTA-1 and PTA-2 showed strong antioxidant activity in vitro. Moreover, PTA-2 intervention (50, 100, and 200 μg/mL) suppressed the production of inflammatory cytokines, the activation of NF-κB signaling, and reactive oxygen species production significantly. The results identified PTA-2 as a natural product that could be applied in anti-inflammatory drugs.
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