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Vinyl Ether Maleic Acid Polymers: Tunable Polymers for Self-Assembled Lipid Nanodiscs and Environments for Membrane Proteins

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Biomacromolecules 2024, XXXX, XXX, XXX-XXX
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    Vinyl Ether Maleic Acid Polymers: Tunable Polymers for Self-Assembled Lipid Nanodiscs and Environments for Membrane Proteins
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    • Muhammad Zeeshan Shah
      Muhammad Zeeshan Shah
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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      Orcidhttps://orcid.org/0000-0003-0249-3892
    • Nancy C. Rotich
      Nancy C. Rotich
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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    • Evelyn A. Okorafor
      Evelyn A. Okorafor
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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      Zachery Oestreicher
      Center for Advanced Microscopy and Imaging, Miami University, Oxford, Ohio 45056, United States
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    • Gabrielle Demidovich
      Gabrielle Demidovich
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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    • Jeremy Eapen
      Jeremy Eapen
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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    • Quinton Henoch
      Quinton Henoch
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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    • Julia Kilbey
      Julia Kilbey
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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    • Godfred Prempeh
      Godfred Prempeh
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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    • Alison Bates
      Alison Bates
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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      Orcidhttps://orcid.org/0009-0005-7313-0345
    • Richard C. Page
      Richard C. Page
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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      Orcidhttps://orcid.org/0000-0002-3006-3171
    • Gary A. Lorigan
      Gary A. Lorigan
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
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      Orcidhttps://orcid.org/0000-0002-2395-3459
    • Dominik Konkolewicz*
      Dominik Konkolewicz
      Department of Chemistry and Biochemistry, Miami University, 651 E High St, Oxford, Ohio 45056, United States
      *Email: [email protected]
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      Orcidhttps://orcid.org/0000-0002-3828-5481
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    Biomacromolecules

    Cite this: Biomacromolecules 2024, XXXX, XXX, XXX-XXX
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    https://doi.org/10.1021/acs.biomac.4c00772
    Published September 16, 2024
    © 2024 American Chemical Society
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    Abstract

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    Native lipid bilayer mimetics, including those that use amphiphilic polymers, are important for the effective study of membrane-bound peptides and proteins. Copolymers of vinyl ether monomers and maleic anhydride were developed with controlled molecular weights and hydrophobicity through reversible addition–fragmentation chain-transfer polymerization. After polymerization, the maleic anhydride units can be hydrolyzed, giving dicarboxylates. The vinyl ether and maleic anhydride copolymerized in a close to alternating manner, giving essentially alternating hydrophilic maleic acid units and hydrophobic vinyl ether units along the backbone after hydrolysis. The vinyl ether monomers and maleic acid polymers self-assembled with lipids, giving vinyl ether maleic acid lipid particles (VEMALPs) with tunable sizes controlled by either the vinyl ether hydrophobicity or the polymer molecular weight. These VEMALPs were able to support membrane-bound proteins and peptides, creating a new class of lipid bilayer mimetics.

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    • Experimental details and instrumentation details, supplemental kinetics, supplemental molecular weight distribution of polymers, infrared spectral polymers before and after hydrolysis, supplemental TEM micrographs of VEMA lipid nanodiscs, UV–vis spectra of VEMA with and without the end group removed, DLS data for the GP28 peptide and KCNE1 protein in POPC:POPG = 3:1 lipids both with vesicles and VEMALPs, and NMR spectra of synthesized VEMA copolymers (PDF)

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    Biomacromolecules

    Cite this: Biomacromolecules 2024, XXXX, XXX, XXX-XXX
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.biomac.4c00772
    Published September 16, 2024
    © 2024 American Chemical Society
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