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Family of Bioactive Heparin-Coated Iron Oxide Nanoparticles with Positive Contrast in Magnetic Resonance Imaging for Specific Biomedical Applications

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    Family of Bioactive Heparin-Coated Iron Oxide Nanoparticles with Positive Contrast in Magnetic Resonance Imaging for Specific Biomedical Applications
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    † UMR CNRS 7266 LIENSs, Approches Moléculaires Environnement-Santé environnement (AMES), University of La Rochelle, La Rochelle, France
    ‡ Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain
    § UMR CNRS 7356 LaSIE, University of La Rochelle, La Rochelle, France
    *E-mail: [email protected]. Phone: +33 (0)5-464-582-77.
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    Biomacromolecules

    Cite this: Biomacromolecules 2017, 18, 10, 3156–3167
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    https://doi.org/10.1021/acs.biomac.7b00797
    Published August 29, 2017
    Copyright © 2017 American Chemical Society
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    Abstract

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    Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) are well-known for their anticoagulant properties. There is also currently a growing interest in using LMWH in targeted cancer therapy. In particular, several types inhibit heparanase, a key enzyme overexpressed in the tumor microenvironment that promotes angiogenesis progression and metastasis spreading. Here, we propose iron oxide nanoparticles (HEP-IONP) coated with different heparins of distinct anticoagulant/anti-heparanase activity ratios and suitable for positive contrast in magnetic resonance imaging. As a proof of concept, magnetic resonance angiography (MRA) was conducted in mice up to 3 h after intravenous administration. This new IONP-based positive contrast appropriate for clinic together with the long vascular circulating times can enable innovative theranostic applications if combined with the various bioactivities of the heparins. Indeed, we showed, using advanced in vitro tests, how HEP-IONP anticoagulant or anti-heparanase activities were maintained depending on the heparin species used for the coating. Overall, the study allowed presenting an IONP coated with a commercial LMWH (Lovenox) suggested as a theranostic translational probe for MRA diagnostic and treatment of thrombosis, and an antitumor IONP coated with a specific depolymerized heparin to be used in targeted therapy and diagnostic modalities.

    Copyright © 2017 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.biomac.7b00797.

    • TEM-HADDF of HEP-IONP (Figure S1), iron oxide core size distributions of HEP-IONP (Figure S2), analysis of selected area diffraction (SAED) patterns of HEP-IONP (Figure S3), calculation of heparin content on IONP (Figure S4), viability of HEK 293 cells after 24 and 48 h incubation with HEP-IONP and free heparins (Figure S5), and coagulometric measurements of HEP-IONP compared to their corresponding free heparins (Figure S6) (PDF)

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    Biomacromolecules

    Cite this: Biomacromolecules 2017, 18, 10, 3156–3167
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.biomac.7b00797
    Published August 29, 2017
    Copyright © 2017 American Chemical Society
    Request reuse permissions

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