Controlling the Hydration Structure with a Small Amount of Fluorine To Produce Blood Compatible Fluorinated Poly(2-methoxyethyl acrylate)Click to copy article linkArticle link copied!
- Ryohei KoguchiRyohei KoguchiSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Build. CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanAGC Incorporation New Product R&D Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Ryohei Koguchi
- Katja JankovaKatja JankovaSoft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Build. CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanDepartment of Energy Conversion and Storage, Technical University of Denmark, Elektrovej, Build. 375, 2800 Kongens Lyngby, DenmarkMore by Katja Jankova
- Noriko TanabeNoriko TanabeAGC Incorporation Innovative Technology Research Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Noriko Tanabe
- Yosuke AminoYosuke AminoAGC Incorporation Innovative Technology Research Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Yosuke Amino
- Yuki HayasakaYuki HayasakaAGC Incorporation Innovative Technology Research Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Yuki Hayasaka
- Daisuke KobayashiDaisuke KobayashiAGC Incorporation Innovative Technology Research Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Daisuke Kobayashi
- Tatsuya MiyajimaTatsuya MiyajimaAGC Incorporation Innovative Technology Research Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Tatsuya Miyajima
- Kyoko YamamotoKyoko YamamotoAGC Incorporation New Product R&D Center, 1150 Hazawa-cho, Kanagawa-ku, Yokohama, Kanagawa 221-8755, JapanMore by Kyoko Yamamoto
- Masaru Tanaka*Masaru Tanaka*E-mail: [email protected]Soft Materials Chemistry, Institute for Materials Chemistry and Engineering, Kyushu University, Build. CE41, 744 Motooka, Nishi-ku, Fukuoka 819-0395, JapanMore by Masaru Tanaka
Abstract
Poly(2-methoxyethyl acrylate) (PMEA) shows excellent blood compatibility because of the existence of intermediate water. Various modifications of PMEA by changing its main or side chain’s chemical structure allowed tuning of the water content and the blood compatibility of numerous novel polymers. Here, we exploit a possibility of manipulating the surface hydration structure of PMEA by incorporation of small amounts of hydrophobic fluorine groups in MEA polymers using atom-transfer radical polymerization and the (macro) initiator concept. Two kinds of fluorinated MEA polymers with similar molecular weights and the same 5.5 mol % of fluorine content were synthesized using the bromoester of 2,2,3,3,4,4,5,5,6,6,7,7,8,8-pentadecafluoro-1-octanol (F15) and poly(2,2,2-trifluoroethyl methacrylate) (PTFEMA) as (macro) initiators, appearing liquid and solid at room temperature, respectively. The fibrinogen adsorption of the two varieties of fluorinated MEA polymers was different, which could not be explained only by the bulk hydration structure. Both polymers show a nanostructured morphology in the hydrated state with different sizes of the features. The measured elastic modulus of the domains appearing in atomic force microscopy and the intermediate water content shed light on the distinct mechanism of blood compatibility. Contact angle measurements reveal the surface hydration dynamics—while in the hydrated state, F15-b-PMEA reorients easily to the surface exposing its PMEA part to the water, the small solid PTFEMA block with high glass-transition temperature suppresses the movement of PTFEMA-b-PMEA and its reconstruction on the surface. These findings illustrate that in order to make a better blood compatible polymer, the chains containing sufficient intermediate water need to be mobile and efficiently oriented to the water surface.
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