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Endothelial Cell Migration on Poly(ε-caprolactone) Nanofibers Coated with a Nanohybrid Shish-Kebab Structure Mimicking Collagen Fibrils

  • Xin Guo
    Xin Guo
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    More by Xin Guo
  • Xiaofeng Wang*
    Xiaofeng Wang
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    *E-mail: [email protected] (X.W.).
  • Xuyan Li
    Xuyan Li
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    More by Xuyan Li
  • Yong-Chao Jiang
    Yong-Chao Jiang
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 45001, China
  • Shanshan Han
    Shanshan Han
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    More by Shanshan Han
  • Lei Ma
    Lei Ma
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 45001, China
    More by Lei Ma
  • Haiyang Guo
    Haiyang Guo
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    More by Haiyang Guo
  • Zhenxing Wang
    Zhenxing Wang
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
  • , and 
  • Qian Li*
    Qian Li
    School of Mechanics Science and Security Engineering, Zhengzhou University, Zhengzhou 45001, China
    National Center for International Research of Micro-Nano Molding Technology, Zhengzhou University, Zhengzhou 45001, China
    School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 45001, China
    *E-mail: [email protected] (Q.L.).
    More by Qian Li
Cite this: Biomacromolecules 2020, 21, 3, 1202–1213
Publication Date (Web):January 2, 2020
https://doi.org/10.1021/acs.biomac.9b01638
Copyright © 2020 American Chemical Society

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    Abstract

    Abstract Image

    Regulating cell migration dynamics is of significance in tissue engineering and regenerative medicine. A 3D scaffold was created to provide various topographies based on a poly(ε-caprolactone) (PCL) self-induced nanohybrid shish-kebab structure, which consisted of aligned PCL nanofibers and spaced PCL crystal lamellae grown on the fibers. Electrospinning was applied followed by self-induced crystallization. The results resembled natural collagen fibrils in an extracellular matrix. This variable microstructure enabled control of cell adhesion and migration. The kebab size was controlled by initial PCL concentrations. The geometry of cells seeded on the fibers was less elongated, but the adhesion was more polarized with a higher nuclear shape index and faster migration speed. These results could aid in rapid endothelialization in tissue engineering.

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