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Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges
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    Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges
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    • Matteo Panza
      Matteo Panza
      Department of Chemistry and Biochemistry, University of Missouri−St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States
      More by Matteo Panza
    • Salvatore G. Pistorio
      Salvatore G. Pistorio
      Department of Chemistry and Biochemistry, University of Missouri−St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States
    • Keith J. Stine
      Keith J. Stine
      Department of Chemistry and Biochemistry, University of Missouri−St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States
    • Alexei V. Demchenko*
      Alexei V. Demchenko
      Department of Chemistry and Biochemistry, University of Missouri−St. Louis, One University Boulevard, St. Louis, Missouri 63121, United States
      *E-mail: [email protected]
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    Cite this: Chem. Rev. 2018, 118, 17, 8105–8150
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    https://doi.org/10.1021/acs.chemrev.8b00051
    Published June 28, 2018
    Copyright © 2018 American Chemical Society

    Abstract

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    Advances in carbohydrate chemistry have certainly made common oligosaccharides much more accessible. However, many current methods still rely heavily upon specialized knowledge of carbohydrate chemistry. The application of automated technologies to chemical and life science applications such as genomics and proteomics represents a vibrant field. These automated technologies also present opportunities for their application to organic synthesis, including that of the synthesis of oligosaccharides. However, application of automated methods to the synthesis of carbohydrates is an underdeveloped area as compared to other classes of biomolecules. The overarching goal of this review article is to present the advances that have been made at the interface of carbohydrate chemistry and automated technology.

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    Cite this: Chem. Rev. 2018, 118, 17, 8105–8150
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    Published June 28, 2018
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