Acute Exposure of Zebrafish (Danio rerio) to the Next-Generation Perfluoroalkyl Substance, Perfluoroethylcyclohexanesulfonate, Shows Similar Effects as Legacy Substances
- Hannah Mahoney*
- Jenna CantinJenna CantinToxicology Center, University of Saskatchewan, 44 Campus Dr, Saskatoon, Saskatchewan S7N 5B3, CanadaMore by Jenna Cantin
- Josephine RybchukJosephine RybchukToxicology Center, University of Saskatchewan, 44 Campus Dr, Saskatoon, Saskatchewan S7N 5B3, CanadaHealth Sciences, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, CanadaMore by Josephine Rybchuk
- Yuwei Xie
- John P. Giesy*John P. Giesy*John P. Giesy Email: [email protected]Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, CanadaDepartment of Integrative Biology and Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan48824, United StatesDepartment of Environmental Science, Baylor University, One Bear Place #97266, Waco, Texas 76798-7266, United StatesMore by John P. Giesy
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- Markus BrinkmannMarkus BrinkmannToxicology Center, University of Saskatchewan, 44 Campus Dr, Saskatoon, Saskatchewan S7N 5B3, CanadaSchool of Environment and Sustainability, University of Saskatchewan, 117 Science Pl, Saskatoon, Saskatchewan S7N 5C8, CanadaGlobal Institute for Water Security, University of Saskatchewan, 11 Innovation Blvd, Saskatoon, Saskatchewan S7N 3H5, CanadaCentre for Hydrology, University of Saskatchewan, 121 Research Dr, Saskatoon, Saskatchewan S7N 1K2, CanadaMore by Markus Brinkmann
Perfluoroethylcyclohexanesulfonate (PFECHS) is an emerging perfluoroalkyl substance (PFAS) that has been considered a potential replacement for perfluorooctanesulfonic acid (PFOS). However, there is little information characterizing the toxic potency of PFECHS to zebrafish embryos and its potential for effects in aquatic environments. This study assessed toxic potency of PFECHS in vivo during both acute (96-hour postfertilization) and chronic (21-day posthatch) exposures and tested concentrations of PFECHS from 500 ng/L to 2 mg/L. PFECHS was less likely to cause mortalities than PFOS for both the acute and chronic experiments based on previously published values for PFOS exposure, but exposure resulted in a similar incidence of deformities. Exposure to PFECHS also resulted in significantly increased abundance of transcripts of peroxisome proliferator activated receptor alpha (pparα), cytochrome p450 1a1 (cyp1a1), and apolipoprotein IV (apoaIV) at concentrations nearing those of environmental relevance. Overall, these results provide further insight into the safety of an emerging PFAS alternative in the aquatic environment and raise awareness that previously considered “safer” alternatives may show similar effects as legacy PFASs.
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