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Toxicities of Legacy and Current-Use PFAS in an Anuran: Do Larval Exposures Influence Responses to a Terrestrial Pathogen Challenge?

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Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2023, 57, 48, 19180-19189
    Ecotoxicology and Public Health

    Toxicities of Legacy and Current-Use PFAS in an Anuran: Do Larval Exposures Influence Responses to a Terrestrial Pathogen Challenge?
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    • Evelyn M. Barragan
      Evelyn M. Barragan
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
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    • Tyler D. Hoskins*
      Tyler D. Hoskins
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
      *Email: [email protected]. Phone: +1(765.496.3428).
      More by Tyler D. Hoskins
      Orcidhttps://orcid.org/0000-0002-0173-4511
    • Elizabeth B. Allmon
      Elizabeth B. Allmon
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
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    • Jessica L. McQuigg
      Jessica L. McQuigg
      Department of Biology, Drew University, Madison, New Jersey 07940, United States
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    • Matthew T. Hamilton
      Matthew T. Hamilton
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
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    • Erin N. Christian
      Erin N. Christian
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
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    • Grace S. M. Coogan
      Grace S. M. Coogan
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
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    • Catherine L. Searle
      Catherine L. Searle
      Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, United States
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    • Youn Jeong Choi
      Youn Jeong Choi
      Agronomy, Purdue University, West Lafayette, Indiana 47907, United States
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    • Linda S. Lee
      Linda S. Lee
      Agronomy, Purdue University, West Lafayette, Indiana 47907, United States
      More by Linda S. Lee
      Orcidhttps://orcid.org/0000-0003-4471-7284
    • Jason T. Hoverman
      Jason T. Hoverman
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
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    • Maria S. Sepúlveda
      Maria S. Sepúlveda
      Department of Forestry and Natural Resources, Purdue University, West Lafayette, Indiana 47907, United States
      Sustainability Research Center and PhD in Conservation Medicine, Life Sciences Faculty, Universidad Andres Bello, Santiago 7550196, Chile
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      Orcidhttps://orcid.org/0000-0003-0473-5760
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    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2023, 57, 48, 19180–19189
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    https://doi.org/10.1021/acs.est.3c03191
    Published November 14, 2023
    Copyright © 2023 American Chemical Society
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    Abstract

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    Legacy polyfluoroalkyl substances (PFAS) [perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA)] are being replaced by various other fluorinated compounds, such as hexafluoropropylene oxide dimer acid (GenX). These alternatives are thought to be less bioaccumulative and, therefore, less toxic than legacy PFAS. Contaminant exposures occur concurrently with exposure to natural stressors, including the fungal pathogen Batrachocytrium dendrobatidis (Bd). Despite evidence that other pollutants can increase the adverse effects of Bd on anurans, no studies have examined the interactive effects of Bd and PFAS. This study tested the growth and developmental effects of PFOS, PFOA, and GenX on gray treefrog (Hyla versicolor) tadpoles, followed by a Bd challenge after metamorphosis. Despite PFAS exposure only occurring during the larval stage, carry-over effects on growth were observed post metamorphosis. Further, PFAS interacted with Bd exposure to influence growth; Bd-exposed animals had significantly shorter SVL [snout–vent length (mm)] with significantly increased body condition, among other time-dependent effects. Our data suggest that larval exposure to PFAS can continue to impact growth in the juvenile stage after exposure has ended. Contrary to predictions, GenX affected terrestrial performance more consistently than its legacy congener, PFOA. Given the role of Bd in amphibian declines, further investigation of interactions of PFAS with Bd and other environmentally relevant pathogens is warranted.

    Copyright © 2023 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.est.3c03191.

    • Water temperatures from the larval phase in outdoor mesocosms and ambient air temperatures of terraria; means of body mass, SVL, and SMI by PFAS treatment for metamorphs; means of body mass, SVL, and SMI by Bd treatment for metamorphs; PFAS LODs and LOQs; means ± SEM, minimum, and maximum values for all end points measured across the larval stage; statistical results for larvae; and statistical results for metamorphs (PDF)

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    This article is cited by 3 publications.

    1. Xiaoqing Li, Zulin Hua, Jianyun Zhang, Junliang Jin, Dawei Wang. Concentration-dependent cellular responses of coontail (Ceratophyllum demersum) during the substitutions to perfluorooctanoic acid by its two alternatives. Journal of Hazardous Materials 2024, 480 , 135837. https://doi.org/10.1016/j.jhazmat.2024.135837
    2. Alexandra T. Lion, Sophie M. Bodine, Kelley R. McCutcheon, Mayank Ghogale, Santhan Chandragiri, Deema Abayawardena, Bikram D. Shrestha, Abigail Descoteaux, Kathryn Alvarez, J’nesse A. Balkman, Breelyn Cocke, Athula H. Wikramanayake, Jennifer Schlezinger, Joyce Y. Wong, Vivek N. Prakash, Cynthia A. Bradham. PFAS Compounds PFOA and Gen X are Teratogenic to Sea Urchin Embryos. 2024https://doi.org/10.1101/2024.11.21.624751
    3. Wenshan Shi, Zengli Zhang, Mei Li, Huiyu Dong, Jiafu Li. Reproductive toxicity of PFOA, PFOS and their substitutes: A review based on epidemiological and toxicological evidence. Environmental Research 2024, 250 , 118485. https://doi.org/10.1016/j.envres.2024.118485
    4. Charles P. Humphrey, Guy Iverson, Eli Hvastkovs, Sushama Pradhan. Occurrence and concentrations of traditional and emerging contaminants in onsite wastewater systems and water supply wells in eastern North Carolina, USA. Journal of Water and Health 2024, 22 (3) , 550-564. https://doi.org/10.2166/wh.2024.299
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    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2023, 57, 48, 19180–19189
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.est.3c03191
    Published November 14, 2023
    Copyright © 2023 American Chemical Society
    Request reuse permissions

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