ACS Publications. Most Trusted. Most Cited. Most Read
Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Environ. Sci. Technol. 2016, 50, 7, 4054-4060
    Article

    Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver
    Click to copy article linkArticle link copied!

    View Author Information
    † State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China
    ‡ Jiangsu Key Lab Environmental Change & Ecological Construct, School of Geography Science, Nanjing Normal University, Nanjing, Jiangsu 210023, China
    *Phone: +86 25 89680160; e-mail: [email protected] (Yan Zhang).
    *E-mail: [email protected] (Hongqiang Ren).
    Other Access OptionsSupporting Information (1)

    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2016, 50, 7, 4054–4060
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.est.6b00183
    Published March 7, 2016
    Copyright © 2016 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated in fish gills, liver, and gut, while 20 μm diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.

    Copyright © 2016 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.est.6b00183.

    • Figures S1–S4 and Table S1 (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!
    Citation Statements
    Explore this article's citation statements on scite.ai
    powered by  Scite

    This article is cited by 1645 publications.

    1. Guanhao Li, Jinyu Rong, Xueran Xu, Eunbi Kwak, Shunhao Wang, Guangbo Qu, Sijie Lin, Guotao Peng. Distinct Effects between Polystyrene Micro- and Nanoplastics: Exacerbation of Adverse Outcomes in Inflammatory Bowel Disease-like Zebrafish and Mice. ACS Nano 2025, Article ASAP.
    2. Tianyi Zhang, Sheng Yang, Yiling Ge, Lihong Yin, Yuepu Pu, Zhongze Gu, Zaozao Chen, Geyu Liang. Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip. ACS Nano 2024, 18 (45) , 31569-31585. https://doi.org/10.1021/acsnano.4c13262
    3. Lanpeng Yang, Lin Yuan, Wen-Xiong Wang. Visible Combined Near-Infrared in Situ Imaging Revealed Dynamic Effects of Microplastic Fibers and Beads in Zebrafish. Environmental Science & Technology 2024, 58 (37) , 16269-16281. https://doi.org/10.1021/acs.est.4c04578
    4. Jiaqi Sun, Miaomiao Teng, Wentao Zhu, Xiaoli Zhao, Lihui Zhao, Yunxia Li, Zixuan Zhang, Yunjie Liu, Sheng Bi, Fengchang Wu. MicroRNA and Gut Microbiota Alter Intergenerational Effects of Paternal Exposure to Polyethylene Nanoplastics. ACS Nano 2024, 18 (27) , 18085-18100. https://doi.org/10.1021/acsnano.4c06298
    5. Fangtian Liu, Yang Wu, Min Long, Yifan Ma, Min Zheng, Shiyi Cao, Shixiong Chen, Yumin Du, Chaoji Chen, Hongbing Deng. Activating Adsorption Sites of Waste Crayfish Shells via Chemical Decalcification for Efficient Capturing of Nanoplastics. ACS Nano 2024, 18 (24) , 15779-15789. https://doi.org/10.1021/acsnano.4c02511
    6. Xiaoqian Cao, Wenjie Xie, Meilan Feng, Juntao Chen, Jiannan Zhang, Juanjuan Luo, Yajun Wang. Nanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (Danio rerio). ACS Omega 2024, 9 (14) , 16508-16518. https://doi.org/10.1021/acsomega.4c00231
    7. Michael Taylor Bryant, Xingmao Ma. Machine Learning Prediction of Adsorption Behavior of Xenobiotics on Microplastics under Different Environmental Conditions. ACS ES&T Water 2024, 4 (3) , 991-999. https://doi.org/10.1021/acsestwater.3c00151
    8. Jiazhen Wang, Wenhui Qiu, Haodong Cheng, Tao Chen, Yuanyuan Tang, Jason T. Magnuson, Xiangrong Xu, Elvis Genbo Xu, Chunmiao Zheng. Caught in Fish Gut: Uptake and Inflammatory Effects of Nanoplastics through Different Routes in the Aquatic Environment. ACS ES&T Water 2024, 4 (1) , 91-102. https://doi.org/10.1021/acsestwater.3c00392
    9. Cuizhu Ma, Qiqing Chen, Zhuo Gao, Yan Yang, Jinping Cheng, Huahong Shi. Diel Pattern of Microplastic Residues in Zebrafish. Environmental Science & Technology 2023, 57 (44) , 16779-16787. https://doi.org/10.1021/acs.est.3c04018
    10. Suphatra Hiranphinyophat, Tomoki Hiraoka, Mako Kobayashi, Sho Fujii, Akio Kishida, Tadao Tanabe, Tsuyoshi Kimura, Masaya Yamamoto. Fabrication of Polypropylene Nanoplastics Via Thermal Oxidation Reaction for Human Cells Responsiveness Studies. Langmuir 2023, 39 (44) , 15563-15571. https://doi.org/10.1021/acs.langmuir.3c01858
    11. Yue Li, Le Tao, Qiong Wang, Fengbang Wang, Gang Li, Maoyong Song. Potential Health Impact of Microplastics: A Review of Environmental Distribution, Human Exposure, and Toxic Effects. Environment & Health 2023, 1 (4) , 249-257. https://doi.org/10.1021/envhealth.3c00052
    12. Lanpeng Yang, Ben Zhong Tang, Wen-Xiong Wang. Near-Infrared-II In Vivo Visualization and Quantitative Tracking of Micro/Nanoplastics in Fish. ACS Nano 2023, 17 (19) , 19410-19420. https://doi.org/10.1021/acsnano.3c07571
    13. Weiyu Wang, Xuan Mao, Rui Zhang, Xiao-Xia Zhou, Yujiao Liu, Hongyu Zhou, Jianbo Jia, Bing Yan. Nanoplastic Exposure at Environmental Concentrations Disrupts Hepatic Lipid Metabolism through Oxidative Stress Induction and Endoplasmic Reticulum Homeostasis Perturbation. Environmental Science & Technology 2023, 57 (38) , 14127-14137. https://doi.org/10.1021/acs.est.3c02769
    14. Juan Li, Xin Mao, Ronglian Xing, Zhenhua Wang, Qinghui Sun, Huihui Liu, Yongning Wu, Yanshen Li. Microplastics Pollution and Their Potential Impact in Marine Systems: A Case Study in Shandong Peninsula, China. ACS ES&T Water 2023, 3 (8) , 2373-2383. https://doi.org/10.1021/acsestwater.3c00087
    15. Wenchao Li, Hongjian Zhou, Xinyuan Zhang, Zeyang Li, Zidan Zou, Yue Shen, Guozhong Wang. Oxidation-Resistant Silicon Nanosystem for Intelligent Controlled Ferrous Foliar Delivery to Crops. ACS Nano 2023, 17 (15) , 15199-15215. https://doi.org/10.1021/acsnano.3c05120
    16. Vincent Tournier, Sophie Duquesne, Frédérique Guillamot, Henri Cramail, Daniel Taton, Alain Marty, Isabelle André. Enzymes’ Power for Plastics Degradation. Chemical Reviews 2023, 123 (9) , 5612-5701. https://doi.org/10.1021/acs.chemrev.2c00644
    17. Chao Wang, Xinyue Gu, Ruochen Dong, Zeyou Chen, Xin Jin, Juan Gao, Yong Sik Ok, Cheng Gu. Natural Solar Irradiation Produces Fluorescent and Biodegradable Nanoplastics. Environmental Science & Technology 2023, 57 (16) , 6626-6635. https://doi.org/10.1021/acs.est.2c07537
    18. Mohammad Wazne, Florian Mermillod-Blondin, Manon Vallier, Frédéric Hervant, Adeline Dumet, Holly A. Nel, Anna Kukkola, Stefan Krause, Laurent Simon. Microplastics in Freshwater Sediments Impact the Role of a Main Bioturbator in Ecosystem Functioning. Environmental Science & Technology 2023, 57 (8) , 3042-3052. https://doi.org/10.1021/acs.est.2c05662
    19. Tianwei Hao, Yan Gao, Ze-Chen Li, Xiao-Xia Zhou, Bing Yan. Size-Dependent Uptake and Depuration of Nanoplastics in Tilapia (Oreochromis niloticus) and Distinct Intestinal Impacts. Environmental Science & Technology 2023, 57 (7) , 2804-2812. https://doi.org/10.1021/acs.est.2c08059
    20. Xiaomei Liu, Yu Li, Jingchun Tang, Dan Wang, Saisai Guo, Qinglong Liu, John P. Giesy. Nano- and Microplastics Aided by Extracellular Polymeric Substances Facilitate the Conjugative Transfer of Antibiotic Resistance Genes in Bacteria. ACS ES&T Water 2022, 2 (12) , 2528-2537. https://doi.org/10.1021/acsestwater.2c00330
    21. Yongfeng Deng, Hexia Chen, Yichao Huang, Yan Zhang, Hongqiang Ren, Mingliang Fang, Qing Wang, Wen Chen, Robert C. Hale, Tamara S. Galloway, Da Chen. Long-Term Exposure to Environmentally Relevant Doses of Large Polystyrene Microplastics Disturbs Lipid Homeostasis via Bowel Function Interference. Environmental Science & Technology 2022, 56 (22) , 15805-15817. https://doi.org/10.1021/acs.est.1c07933
    22. Laura Monclús, Eliana McCann Smith, Tomasz Maciej Ciesielski, Martin Wagner, Veerle L.B. Jaspers. Microplastic Ingestion Induces Size-Specific Effects in Japanese Quail. Environmental Science & Technology 2022, 56 (22) , 15902-15911. https://doi.org/10.1021/acs.est.2c03878
    23. Shepherd Yuen Chan, Max Wang-Tang Wong, Bonnie Tsz Ching Kwan, James Kar-Hei Fang, Song Lin Chua. Microbial–Enzymatic Combinatorial Approach to Capture and Release Microplastics. Environmental Science & Technology Letters 2022, 9 (11) , 975-982. https://doi.org/10.1021/acs.estlett.2c00558
    24. Jing Wen, Hang Sun, Zixuan Liu, Xiangyu Zhu, Zongming Qin, Erqun Song, Yang Song. Aging Processes Dramatically Alter the Protein Corona Constitution, Cellular Internalization, and Cytotoxicity of Polystyrene Nanoplastics. Environmental Science & Technology Letters 2022, 9 (11) , 962-968. https://doi.org/10.1021/acs.estlett.2c00650
    25. Claire Fuschi, Haihui Pu, Margaret MacDonell, Kurt Picel, Maria Negri, Junhong Chen. Microplastics in the Great Lakes: Environmental, Health, and Socioeconomic Implications and Future Directions. ACS Sustainable Chemistry & Engineering 2022, 10 (43) , 14074-14091. https://doi.org/10.1021/acssuschemeng.2c02896
    26. Meilan Feng, Juanjuan Luo, Yiping Wan, Jiannan Zhang, Chunjiao Lu, Maya Wang, Lu Dai, Xiaoqian Cao, Xiaojun Yang, Yajun Wang. Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio). ACS Omega 2022, 7 (36) , 32153-32163. https://doi.org/10.1021/acsomega.2c03378
    27. Miaomiao Teng, Xiaoli Zhao, Chengju Wang, Chen Wang, Jason C. White, Wentian Zhao, Lingfeng Zhou, Manman Duan, Fengchang Wu. Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis. ACS Nano 2022, 16 (5) , 8190-8204. https://doi.org/10.1021/acsnano.2c01872
    28. Siyi Zhang, Zhenzhen He, Chenyuan Wu, Zihe Wang, Yingwen Mai, Ruiwen Hu, Xiaojie Zhang, Wei Huang, Yuehui Tian, Dehua Xia, Cheng Wang, Qingyun Yan, Zhili He, Longfei Shu. Complex Bilateral Interactions Determine the Fate of Polystyrene Micro- and Nanoplastics and Soil Protists: Implications from a Soil Amoeba. Environmental Science & Technology 2022, 56 (8) , 4936-4949. https://doi.org/10.1021/acs.est.1c06178
    29. Dae Sik Choi, Sohee Lim, Jin-Sung Park, Chang-Ho Kim, Hanju Rhee, Minhaeng Cho. Label-Free Live-Cell Imaging of Internalized Microplastics and Cytoplasmic Organelles with Multicolor CARS Microscopy. Environmental Science & Technology 2022, 56 (5) , 3045-3055. https://doi.org/10.1021/acs.est.1c06255
    30. Yong Jie Yip, Gayathiri D/O Sivananthan, Serina Siew Chen Lee, Mei Lin Neo, Serena Lay-Ming Teo, Suresh Valiyaveettil. Transfer of Poly(methyl methacrylate) Nanoparticles from Parents to Offspring and the Protection Mechanism in Two Marine Invertebrates. ACS Sustainable Chemistry & Engineering 2022, 10 (1) , 37-49. https://doi.org/10.1021/acssuschemeng.1c01818
    31. Zehua Yan, Yafei Liu, Ting Zhang, Faming Zhang, Hongqiang Ren, Yan Zhang. Analysis of Microplastics in Human Feces Reveals a Correlation between Fecal Microplastics and Inflammatory Bowel Disease Status. Environmental Science & Technology 2022, 56 (1) , 414-421. https://doi.org/10.1021/acs.est.1c03924
    32. Xiaowei Wu, Peng Liu, Zhimin Gong, Hanyu Wang, Hexinyue Huang, Yanqi Shi, Xiaoli Zhao, Shixiang Gao. Humic Acid and Fulvic Acid Hinder Long-Term Weathering of Microplastics in Lake Water. Environmental Science & Technology 2021, 55 (23) , 15810-15820. https://doi.org/10.1021/acs.est.1c04501
    33. Hayley K. McIlwraith, Joel Kim, Paul Helm, Satyendra P. Bhavsar, Jeremy S. Metzger, Chelsea M. Rochman. Evidence of Microplastic Translocation in Wild-Caught Fish and Implications for Microplastic Accumulation Dynamics in Food Webs. Environmental Science & Technology 2021, 55 (18) , 12372-12382. https://doi.org/10.1021/acs.est.1c02922
    34. Carola Murano, Vincenzo Donnarumma, Ilaria Corsi, Raffaella Casotti, Anna Palumbo. Impact of Microbial Colonization of Polystyrene Microbeads on the Toxicological Responses in the Sea Urchin Paracentrotus lividus. Environmental Science & Technology 2021, 55 (12) , 7990-8000. https://doi.org/10.1021/acs.est.1c00618
    35. Carolin L. Schultz, Sylvain Bart, Elma Lahive, David J. Spurgeon. What Is on the Outside Matters—Surface Charge and Dissolve Organic Matter Association Affect the Toxicity and Physiological Mode of Action of Polystyrene Nanoplastics to C. elegans. Environmental Science & Technology 2021, 55 (9) , 6065-6075. https://doi.org/10.1021/acs.est.0c07121
    36. Jiaxin Feng, Hansen Zhao, Xiaoyun Gong, Meng-Chan Xia, Lesi Cai, Huan Yao, Xu Zhao, Zihe Yan, Zhanping Li, Honggang Nie, Xiaoxiao Ma, Sichun Zhang. In Situ Identification and Spatial Mapping of Microplastic Standards in Paramecia by Secondary-Ion Mass Spectrometry Imaging. Analytical Chemistry 2021, 93 (13) , 5521-5528. https://doi.org/10.1021/acs.analchem.0c05383
    37. Yuxuan Liu, Yonghua Wang, Xin Ling, Zhenhua Yan, Donghai Wu, Jianchao Liu, Guanghua Lu. Effects of Nanoplastics and Butyl Methoxydibenzoylmethane on Early Zebrafish Embryos Identified by Single-Cell RNA Sequencing. Environmental Science & Technology 2021, 55 (3) , 1885-1896. https://doi.org/10.1021/acs.est.0c06479
    38. Nan Hai, Xue Liu, Yaqi Li, Fanyu Kong, Yizhi Zhang, Song Fang. Effects of Microplastics on the Adsorption and Bioavailability of Three Strobilurin Fungicides. ACS Omega 2020, 5 (47) , 30679-30686. https://doi.org/10.1021/acsomega.0c04787
    39. Seora Han, Junah Bang, Daheui Choi, Jangsun Hwang, Taeho Kim, Yoogyeong Oh, Youngdeok Hwang, Jonghoon Choi, Jinkee Hong. Surface Pattern Analysis of Microplastics and Their Impact on Human-Derived Cells. ACS Applied Polymer Materials 2020, 2 (11) , 4541-4550. https://doi.org/10.1021/acsapm.0c00645
    40. Xiao Wang, Hao Zheng, Jian Zhao, Xianxiang Luo, Zhenyu Wang, Baoshan Xing. Photodegradation Elevated the Toxicity of Polystyrene Microplastics to Grouper (Epinephelus moara) through Disrupting Hepatic Lipid Homeostasis. Environmental Science & Technology 2020, 54 (10) , 6202-6212. https://doi.org/10.1021/acs.est.9b07016
    41. Hugo Jacob, Marc Besson, Peter W. Swarzenski, David Lecchini, Marc Metian. Effects of Virgin Micro- and Nanoplastics on Fish: Trends, Meta-Analysis, and Perspectives. Environmental Science & Technology 2020, 54 (8) , 4733-4745. https://doi.org/10.1021/acs.est.9b05995
    42. Qun Zhang, Elvis Genbo Xu, Jiana Li, Qiqing Chen, Liping Ma, Eddy Y. Zeng, Huahong Shi. A Review of Microplastics in Table Salt, Drinking Water, and Air: Direct Human Exposure. Environmental Science & Technology 2020, 54 (7) , 3740-3751. https://doi.org/10.1021/acs.est.9b04535
    43. Li Yang, Ying-li Yu, Li-yuan Cheng, Pan-yang Zhang, Yue Zhang, Kun Zhou. The Accumulation of Psoralen Contributes to Its Hepatotoxicity Revealed by Pharmacokinetic and Toxicokinetic Study after Repeated Administration. ACS Omega 2020, 5 (13) , 7307-7315. https://doi.org/10.1021/acsomega.9b04153
    44. Marie-Theres Mueller, Hendrik Fueser, Lam Ngoc Trac, Philipp Mayer, Walter Traunspurger, Sebastian Höss. Surface-Related Toxicity of Polystyrene Beads to Nematodes and the Role of Food Availability. Environmental Science & Technology 2020, 54 (3) , 1790-1798. https://doi.org/10.1021/acs.est.9b06583
    45. Lei Mai, Shan-Ni You, Hui He, Lian-Jun Bao, Liang-Ying Liu, Eddy Y. Zeng. Riverine Microplastic Pollution in the Pearl River Delta, China: Are Modeled Estimates Accurate?. Environmental Science & Technology 2019, 53 (20) , 11810-11817. https://doi.org/10.1021/acs.est.9b04838
    46. Ting Luo, Caiyun Wang, Zihong Pan, Cuiyuan Jin, Zhengwei Fu, Yuanxiang Jin. Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring. Environmental Science & Technology 2019, 53 (18) , 10978-10992. https://doi.org/10.1021/acs.est.9b03191
    47. Christoph D. Rummel, Beate I. Escher, Oskar Sandblom, Merle M. Plassmann, Hans Peter H. Arp, Matthew MacLeod, Annika Jahnke. Effects of Leachates from UV-Weathered Microplastic in Cell-Based Bioassays. Environmental Science & Technology 2019, 53 (15) , 9214-9223. https://doi.org/10.1021/acs.est.9b02400
    48. Jinfeng Ding, Fenghua Jiang, Jingxi Li, Zongxing Wang, Chengjun Sun, Zhangyi Wang, Liang Fu, Neal Xiangyu Ding, Changfei He. Microplastics in the Coral Reef Systems from Xisha Islands of South China Sea. Environmental Science & Technology 2019, 53 (14) , 8036-8046. https://doi.org/10.1021/acs.est.9b01452
    49. Kecheng Zhu, Hanzhong Jia, Song Zhao, Tianjiao Xia, Xuetao Guo, Tiecheng Wang, Lingyan Zhu. Formation of Environmentally Persistent Free Radicals on Microplastics under Light Irradiation. Environmental Science & Technology 2019, 53 (14) , 8177-8186. https://doi.org/10.1021/acs.est.9b01474
    50. Roman Lehner, Christoph Weder, Alke Petri-Fink, Barbara Rothen-Rutishauser. Emergence of Nanoplastic in the Environment and Possible Impact on Human Health. Environmental Science & Technology 2019, 53 (4) , 1748-1765. https://doi.org/10.1021/acs.est.8b05512
    51. Giedrė Ašmonaitė, Henrik Sundh, Noomi Asker, Bethanie Carney Almroth. Rainbow Trout Maintain Intestinal Transport and Barrier Functions Following Exposure to Polystyrene Microplastics. Environmental Science & Technology 2018, 52 (24) , 14392-14401. https://doi.org/10.1021/acs.est.8b04848
    52. Giedrė Ašmonaitė, Karin Larsson, Ingrid Undeland, Joachim Sturve, Bethanie Carney Almroth. Size Matters: Ingestion of Relatively Large Microplastics Contaminated with Environmental Pollutants Posed Little Risk for Fish Health and Fillet Quality. Environmental Science & Technology 2018, 52 (24) , 14381-14391. https://doi.org/10.1021/acs.est.8b04849
    53. Chang-Bum Jeong, Hye-Min Kang, Young Hwan Lee, Min-Sub Kim, Jin-Sol Lee, Jung Soo Seo, Minghua Wang, Jae-Seong Lee. Nanoplastic Ingestion Enhances Toxicity of Persistent Organic Pollutants (POPs) in the Monogonont Rotifer Brachionus koreanus via Multixenobiotic Resistance (MXR) Disruption. Environmental Science & Technology 2018, 52 (19) , 11411-11418. https://doi.org/10.1021/acs.est.8b03211
    54. Rachel R. Hurley, Jamie C. Woodward, and James J. Rothwell . Ingestion of Microplastics by Freshwater Tubifex Worms. Environmental Science & Technology 2017, 51 (21) , 12844-12851. https://doi.org/10.1021/acs.est.7b03567
    55. Mark E. Hodson, Calum A. Duffus-Hodson, Andy Clark, Miranda T. Prendergast-Miller, and Karen L. Thorpe . Plastic Bag Derived-Microplastics as a Vector for Metal Exposure in Terrestrial Invertebrates. Environmental Science & Technology 2017, 51 (8) , 4714-4721. https://doi.org/10.1021/acs.est.7b00635
    56. Lisa Baumann, Heike Schmidt-Posthaus, Helmut Segner, and Jeffrey C. Wolf . Comment on “Uptake and Accumulation of Polystyrene Microplastics in zebrafish (Danio rerio) and Toxic Effects in Liver”. Environmental Science & Technology 2016, 50 (22) , 12521-12522. https://doi.org/10.1021/acs.est.6b04193
    57. Yifeng Lu, Yan Zhang, Yongfeng Deng, Wei Jiang, Yanping Zhao, Jinju Geng, Lili Ding, and Hongqiang Ren . Response to Comment on “Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver”. Environmental Science & Technology 2016, 50 (22) , 12523-12524. https://doi.org/10.1021/acs.est.6b04379
    58. Austin K. Baldwin, Steven R. Corsi, and Sherri A. Mason . Plastic Debris in 29 Great Lakes Tributaries: Relations to Watershed Attributes and Hydrology. Environmental Science & Technology 2016, 50 (19) , 10377-10385. https://doi.org/10.1021/acs.est.6b02917
    59. Eram Rashid, Syed Makhdoom Hussain, Shafaqat Ali, Dariusz Kucharczyk, Joanna Nowosad, Khalid A. Al-Ghanim, Nadia Nazish. An assessment of physiological and health responses in Catla catla fingerlings after polystyrene microplastic exposure. Scientific Reports 2025, 15 (1) https://doi.org/10.1038/s41598-025-85291-w
    60. Weerachon Sawangproh, Paiphan Paejaroen. Thailand's animals in peril: a systematic review of microplastic contamination and its ecological consequences. Environmental Sciences Europe 2025, 37 (1) https://doi.org/10.1186/s12302-024-01043-z
    61. Xiangying Deng, Yajun Gui, Lin Zhao. The micro(nano)plastics perspective: exploring cancer development and therapy. Molecular Cancer 2025, 24 (1) https://doi.org/10.1186/s12943-025-02230-z
    62. Mengqi Jia, Runjuan Yang, Cui Ma, Chao Gu, Dongying Wu, Xucong Huang, Lili Jing, Guorong Fan. Assessment of the hepatoprotective effects of Bicyclol's forced degradation products using a zebrafish model. Journal of Pharmaceutical and Biomedical Analysis 2025, 262 , 116871. https://doi.org/10.1016/j.jpba.2025.116871
    63. Yi Guo, Mei Li, Xiaoyu Liu, Huiling Duo, Boya Huang, Hengtai Lu, Xiangyu Zhang, Xuzhe Li, Ye Zhao, Kaoqi Lian, Tengfei Liu, Yun Shi, Yuan Gao, Li Meng, Di Zhao, Li Song, Rui Jiang, Haishui Shi. Perinatal exposure to polystyrene nanoplastics alters socioemotional behaviors via the microbiota–gut–brain axis in adult offspring mice. Brain, Behavior, and Immunity 2025, 128 , 121-133. https://doi.org/10.1016/j.bbi.2025.04.002
    64. Qingwen Li, Xuan Niu, Yuli Cai, Lili Li, Zhongyuan Xia. Exposure to submicroplastics promotes the progression of nonalcoholic fatty liver disease in ApoE-deficient mice. Toxicology 2025, 515 , 154137. https://doi.org/10.1016/j.tox.2025.154137
    65. Ji Liu, Yanru Chen, Baiqin Sun, Dongxue Xu, Jinye Wang, Zhenlong Sun, Peng Liu, Futao Jing, Yize Song, Bin Xia. Toxicological effects of micro/nanoplastics and benzo[a]pyrene on cellular and molecular responses of Apostichopus japonicus (Selenka, 1867) during intestinal regeneration. Journal of Hazardous Materials 2025, 491 , 138003. https://doi.org/10.1016/j.jhazmat.2025.138003
    66. Yiting Wu, Fangxing Yang. Co-exposure to microplastics enhances the allergenic potentials of house dust mite allergen Der p 1. Environmental Research 2025, 277 , 121613. https://doi.org/10.1016/j.envres.2025.121613
    67. Dawu Lin, Xiangyu Chen, Xiaojun Lin, Chaonan Zhang, Taojie Liang, Li Zheng, Yanbin Xu, Lu Huang, Qingxia Qiao, Kairong Xiong. New insight into intestinal toxicity accelerated by aged microplastics with triclosan: Inflammation regulation by gut microbiota-bile acid axis. Journal of Hazardous Materials 2025, 492 , 138308. https://doi.org/10.1016/j.jhazmat.2025.138308
    68. Abhishek Mandal, Arpan Sarkar, Sangeetha Thykandi, Soumadip Guchhait, Gopala Krishna Darbha. Engineered MnO2-Multiwalled carbon Nanotube nanoheterostructures for efficient removal of nanoplastics and plastic-derived contaminant Bisphenol S from contaminated water. Environmental Nanotechnology, Monitoring & Management 2025, 23 , 101038. https://doi.org/10.1016/j.enmm.2024.101038
    69. Runlan Yang, Xu Han, Yutao Wang, Yanxin Liu, Qingqing Sun, Haijie Su, Shuchan Peng, Peili Lu, Daijun Zhang, Shangbo Zhou. The Three Gorges Dam alters the spatial distribution and flux of microplastics in the Yangtze River. Environmental Research 2025, 275 , 121440. https://doi.org/10.1016/j.envres.2025.121440
    70. Živilė Jurgelėnė, Augustas Morkvėnas, Reda Dzingelevičienė, Nerijus Dzingelevičius, Kęstutis Baranauskis, Danguolė Montvydienė, Tomasz Kowalkowski, Saulius Raugelė, Boguslaw Buszewski, Vitalijus Karabanovas. Effects of co-treatment with nano/microplastics and hydroxychloroquine on early development stages of Salmo trutta. Marine Environmental Research 2025, 208 , 107096. https://doi.org/10.1016/j.marenvres.2025.107096
    71. Md. Emran Ahammed Emon, Subrata Sarker, Md. Nazmul Hasan Niloy, Md. Monjurul Hasan, Md. Mehedi Hasan Pramanik, Gawsia Wahidunnessa Chowdhury. Abundance of Microplastics and Heavy Metals in the Riverine Shad (Tenualosa ilisha) from the Northern Bay of Bengal. Water, Air, & Soil Pollution 2025, 236 (6) https://doi.org/10.1007/s11270-025-07926-y
    72. Saurabh Shukla, Sakshum Khanna, Kushagra Khanna. Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications. Toxicology Reports 2025, 14 , 101844. https://doi.org/10.1016/j.toxrep.2024.101844
    73. Tapas Ghosh. Microplastics bioaccumulation in fish: Its potential toxic effects on hematology, immune response, neurotoxicity, oxidative stress, growth, and reproductive dysfunction. Toxicology Reports 2025, 14 , 101854. https://doi.org/10.1016/j.toxrep.2024.101854
    74. Yanwen Ma, Yingying Ye, Jiji Li, Xinjie Liang, Jing Li. Buoyant polyethylene rope fragments might be vehicles of migration for larval mussels (Mytilus coruscus). Journal of Hazardous Materials 2025, 489 , 137641. https://doi.org/10.1016/j.jhazmat.2025.137641
    75. Camila Gomes de Oliveira, Túlio Pacheco Boaventura, Fabio Aremil Costa dos Santos, André de Sena Souza, Sidney dos Santos Silva, Camila Silva Brey Gil, Ronald Kennedy Luz, Rodrigo Lambert Oréfice. Effects of polypropylene microparticles ingestion on the growth and physiology of Piaractus brachypomus, and its accumulation and tissue damage. Aquatic Toxicology 2025, 283 , 107338. https://doi.org/10.1016/j.aquatox.2025.107338
    76. Yu Liu, Yujun Ning, Yi Jiang, Yiquan Ou, Xiaobing Chen, Chiting Zhong, Ru Wang, Zhibo Zhang, Kongfan Wang, Dingxin Long, Weichao Zhao. Effects of combined exposure to polyethylene and oxidized polycyclic aromatic hydrocarbons on growth, development, and neurobehavior in Zebrafish. Aquatic Toxicology 2025, 283 , 107361. https://doi.org/10.1016/j.aquatox.2025.107361
    77. Cristiana Roberta Multisanti, Serafina Ferrara, Giuseppe Piccione, Caterina Faggio. Plastics and their derivatives are impacting animal ecophysiology: A review. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2025, 291 , 110149. https://doi.org/10.1016/j.cbpc.2025.110149
    78. Hongping Liao, Dandan Gao, Chunmiao Kong, Ye Li, Min Zeng, Guanglong Chen, Jun Wang. Effects of acute and chronic exposure and elimination of nanoplastics and F-53B on inflammatory response and lipid metabolism in GIFT tilapia (Oreochromis niloticus). Aquaculture 2025, 602 , 742330. https://doi.org/10.1016/j.aquaculture.2025.742330
    79. Liqun Chen, Bin Han, Shushuai Yang, Liqiong Guo, Lei Zhao, Ping Liu, Xiaoming Hong, Yan Zhao, Yahang Peng, Shiyong Qi, Lidan Hu, Yue Chen. Toxicological effects and mechanisms of renal injury induced by inhalation exposure to airborne nanoplastics. Journal of Hazardous Materials 2025, 488 , 137393. https://doi.org/10.1016/j.jhazmat.2025.137393
    80. Yejin Kim, Hyerin Lee, Yun Hak Kim, Chang-Kyu Oh. Polyethylene microplastics perforate the chorion defense, triggering developmental cardiotoxicity at zebrafish. Aquatic Toxicology 2025, 282 , 107331. https://doi.org/10.1016/j.aquatox.2025.107331
    81. Veeramuthu Ashokkumar, V.P. Chandramughi, Kaustubha Mohanty, Sathyanarayana N. Gummadi. Microplastic pollution: Critical analysis of global hotspots and their impact on health and ecosystems. Journal of Environmental Management 2025, 381 , 124995. https://doi.org/10.1016/j.jenvman.2025.124995
    82. Marlene Pinheiro, Clara Lopes, Nélson Alves, Eunice Almeida, Hugo Morais, Marta Ribeiro, Susana Barros, Joana Raimundo, Miguel Caetano, Teresa Neuparth, Miguel M. Santos. Microplastics in the deep: Suspended particles affect the model species Mytilus galloprovincialis under hyperbaric conditions. Environmental Pollution 2025, 373 , 126195. https://doi.org/10.1016/j.envpol.2025.126195
    83. Minji Kim, Sang Don Kim. Neurobehavioral and neurochemical effects of nano-sized polypropylene accumulation in zebrafish (Danio rerio). Science of The Total Environment 2025, 977 , 179404. https://doi.org/10.1016/j.scitotenv.2025.179404
    84. Thi Be Ta Truong, Do Tuong Ha, Hien Duy Tong, Thuat T. Trinh. ReaxFF molecular dynamics studies on the impact of reaction conditions in polystyrene conversion through hydrothermal gasification. Chemical Engineering Journal Advances 2025, 22 , 100716. https://doi.org/10.1016/j.ceja.2025.100716
    85. Abbas Shahsavani, Hasan Pasalari, Majid Kermani, Mahbubeh Tangestani, Fatemeh Ahmadi. Health outcomes attributed to inhalation of microplastic released from mask during COVID-19 pandemic: A systematic review. Journal of Hazardous Materials Advances 2025, 18 , 100696. https://doi.org/10.1016/j.hazadv.2025.100696
    86. Chuanning Peng, Jie Tang, Xuan Yu, Xuerui Zhou, Mingji Wang, Yingyue Zhang, Hu Zhou, Siqi Huang, Qi Wen, Siqi Chen, Wenliang Xiang, Qing Zhang, Ting Cai. Biodegradation of various phthalic acid esters at high concentrations by Gordonia alkanivorans GH-1 and its degradation mechanism. Environmental Technology & Innovation 2025, 38 , 104066. https://doi.org/10.1016/j.eti.2025.104066
    87. Hao Wu, Tong Xu, Naixi Yang, Shiwen Xu. Polystyrene-microplastics and Emamectin Benzoate co-exposure induced lipid remodeling by suppressing PPARα signals to drive ACSL4-dependent ferroptosis and carp splenic injury. Pesticide Biochemistry and Physiology 2025, 210 , 106396. https://doi.org/10.1016/j.pestbp.2025.106396
    88. Sanket Dey Chowdhury, Sudeep Kumar Mishra, Puspendu Bhunia, Rao Y. Surampalli, Tian C. Zhang. Human Exposures to Microplastics. 2025, 347-381. https://doi.org/10.1002/9781394251100.ch13
    89. Akash Tripathi, Makarand M. Ghangrekar, Rao Y. Surampalli. Characterizing Microplastics in the Context of Risk Assessment. 2025, 135-152. https://doi.org/10.1002/9781394251100.ch6
    90. Kaitlyn E. Woodworth, Zachary S.C.S. Froom, Natasha D. Osborne, Christian N. Rempe, Brenden Wheeler, Kyle Medd, Neal I. Callaghan, Huikang Qian, Abhinav P. Acharya, Carlie Charron, Locke Davenport Huyer. Development of Itaconate Polymers Microparticles for Intracellular Regulation of Pro‐Inflammatory Macrophage Activation. Advanced Healthcare Materials 2025, 11 https://doi.org/10.1002/adhm.202405257
    91. Arti Hansda, Soubhagya Keshari Chand, Bhubaneswar Pradhan, Sasmita Chand, Anoop Kumar Shukla, Prangya Ranjan Rout. Toxicological Impacts and Microbial-Mediated Degradation Processes of Microplastics. Journal of Hazardous, Toxic, and Radioactive Waste 2025, 29 (2) https://doi.org/10.1061/JHTRBP.HZENG-1400
    92. Ming-Yih Leu, Sun-Hon Lin, Te-Yu Chen, Fung-Chi Ko, Shao-Hung Peng. Microplastic contamination in the gastrointestinal tracts of larval fish assemblages from coastal waters in southwestern Taiwan. Regional Studies in Marine Science 2025, 83 , 104076. https://doi.org/10.1016/j.rsma.2025.104076
    93. Tiantian Wang, Miquel Perelló Amorós, Gemma Lopez Llao, Cinta Porte. Distinctive lipidomic responses induced by polystyrene micro- and nano-plastics in zebrafish liver cells. Aquatic Toxicology 2025, 281 , 107291. https://doi.org/10.1016/j.aquatox.2025.107291
    94. Yanming Sui, Yingying Zhang, Shihao Chen, Yangyang Shi, Jiaxin Zou, Mohsen Mohamed, Kunyun Qin, Yebing Yu, Zhiquan Liu, Liang Zheng, Linlan Lv. Microplastic Ingestion by Fish with Different Feeding Habits from Different Habitats in a Typical Semi-Enclosed Haizhou Bay. Journal of Ocean University of China 2025, 24 (2) , 343-354. https://doi.org/10.1007/s11802-025-5791-5
    95. Khouloud Sebteoui, Zoltán Csabai, Jelena Stanković, Viktor Baranov, Boris Jovanović, Djuradj Milošević. Downsizing plastics, upsizing impact: How microplastic particle size affects Chironomus riparius bioturbation activity. Environmental Research 2025, 270 , 121055. https://doi.org/10.1016/j.envres.2025.121055
    96. Barbara Mognetti, Claudio Cecone, Katia Fancello, Astrid Saraceni, Erika Cottone, Patrizia Bovolin. Interaction of Polystyrene Nanoplastics with Biomolecules and Environmental Pollutants: Effects on Human Hepatocytes. International Journal of Molecular Sciences 2025, 26 (7) , 2899. https://doi.org/10.3390/ijms26072899
    97. Yanqing Wu, Ziying Zhu, Riying Zhong, Xilin Fang, Xiaocui Wang, Yuanyin Huang, Han Gong, Muting Yan. Microplastics Enhance the Toxic Effects of Tetracycline on the Early Development of Zebrafish in a Dose-Dependent Manner. Fishes 2025, 10 (4) , 150. https://doi.org/10.3390/fishes10040150
    98. Hojun Lee, Junho Park, Taeyeon Hong, Gwonhwa Song. Impact and mechanisms of microplastics and nanoplastics on the reproductive system. Molecular & Cellular Toxicology 2025, 21 (2) , 339-350. https://doi.org/10.1007/s13273-024-00498-8
    99. Junting Wang, Caiwei Zhang, Yiou Wang. Current Advances in the Photoconversion of Plastics: the Catalysts and Reaction Pathways. ChemSusChem 2025, 18 (7) https://doi.org/10.1002/cssc.202401700
    100. Jiaxin Dong, Rui Su, Xiaokang Wu, Deming Dong, Yining Wang, Chenni Huang, Tao Qiu, Yu Gu, Xiuyi Hua, Dapeng Liang. Probing PFOA-induced Metabolic Disorders in Tilapia Through Fish Skin Mucus. Chemical Research in Chinese Universities 2025, 41 (2) , 358-366. https://doi.org/10.1007/s40242-025-5008-x
    Load more citations
    Download PDF
    Go to Environmental Science & Technology
    Get e-Alerts
    Get e-Alerts

    Environmental Science & Technology

    Cite this: Environ. Sci. Technol. 2016, 50, 7, 4054–4060
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.est.6b00183
    Published March 7, 2016
    Copyright © 2016 American Chemical Society
    Request reuse permissions

    Article Views

    27k

    Altmetric

    -

    Citations

    1645
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.