Connecting the Oxidative Potential of Secondary Organic Aerosols with Reactive Oxygen Species in Exposed Lung CellsClick to copy article linkArticle link copied!
- Pratiti Home ChowdhuryPratiti Home ChowdhuryDepartment of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, IsraelMore by Pratiti Home Chowdhury
- Quanfu HeQuanfu HeDepartment of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, IsraelMore by Quanfu He
- Raanan CarmieliRaanan CarmieliDepartment of Chemical Support Services, Weizmann Institute of Science, Rehovot 76100, IsraelMore by Raanan Carmieli
- Chunlin LiChunlin LiDepartment of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, IsraelMore by Chunlin Li
- Yinon RudichYinon RudichDepartment of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, IsraelMore by Yinon Rudich
- Michal Pardo*Michal Pardo*E-mail: [email protected] (M.P.).Department of Earth and Planetary Sciences, Weizmann Institute of Science, Rehovot 76100, IsraelMore by Michal Pardo
Abstract

It has been hypothesized that the cytotoxicity of secondary organic aerosols (SOA) is mediated through the formation of reactive oxygen species (ROS) in the exposed cells. Here, lung epithelial cells (A549) residing at the air–liquid interface were exposed to proxies of anthropogenic and biogenic SOA that were photochemically aged under varying nitrogen oxide (NOx) concentrations in an oxidation flow reactor. The total organic peroxides and ROS radical content in the SOA were quantified by the iodometric spectrophotometric method and by continuous-wave electron paramagnetic resonance. The effect of the exposure was evaluated by measuring cell viability and cellular ROS production following the exposure. The results demonstrate that SOA that aged in the absence of NOx contained more ROS than fresh SOA and were more toxic toward the cells, while varying NOx conditions had no significant influence on levels of the ROS content in fresh SOA and their toxicity. Analysis of ROS in the exposed cells using flow cytometry showed a similar trend with the total ROS content in the SOA. This study provides a first and direct observation of such association.
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(19)
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(15)
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(4)
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(11)
, 1814-1825. https://doi.org/10.1021/acs.chemrestox.3c00278
- Fobang Liu, Taekyu Joo, Jenna C. Ditto, Maria G. Saavedra, Masayuki Takeuchi, Alexandra J. Boris, Yuhan Yang, Rodney J. Weber, Ann M. Dillner, Drew R. Gentner, Nga L. Ng. Oxidized and Unsaturated: Key Organic Aerosol Traits Associated with Cellular Reactive Oxygen Species Production in the Southeastern United States. Environmental Science & Technology 2023, 57
(38)
, 14150-14161. https://doi.org/10.1021/acs.est.3c03641
- Haley E. Plaas, Jin Yan, Cade Christensen, Seyong Chang, Cintia Cortez, Spencer Fern, Leah Nelson, Alexandrea Sabo, N. Cazimir Armstrong, Barbara J. Turpin, Yue Zhang, Hans W. Paerl, Jason D. Surratt. Secondary Organic Aerosol Formation from Cyanobacterial-Derived Volatile Organic Compounds. ACS Earth and Space Chemistry 2023, 7
(9)
, 1798-1813. https://doi.org/10.1021/acsearthspacechem.3c00177
- LiuFobangAssociate Professor, Department of Environmental Science & Engineeringfobang.
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(4)
, 1635-1679. https://doi.org/10.1021/acs.chemrev.2c00430
- Fobang Liu, Tianchang Xu, Nga Lee Ng, Hang Lu. Linking Cell Health and Reactive Oxygen Species from Secondary Organic Aerosols Exposure. Environmental Science & Technology 2023, 57
(2)
, 1039-1048. https://doi.org/10.1021/acs.est.2c05171
- Kasey C. Edwards, Alexandra L. Klodt, Tommaso Galeazzo, Meredith Schervish, Jinlai Wei, Ting Fang, Neil M. Donahue, Bernard Aumont, Sergey A. Nizkorodov, Manabu Shiraiwa. Effects of Nitrogen Oxides on the Production of Reactive Oxygen Species and Environmentally Persistent Free Radicals from α-Pinene and Naphthalene Secondary Organic Aerosols. The Journal of Physical Chemistry A 2022, 126
(40)
, 7361-7372. https://doi.org/10.1021/acs.jpca.2c05532
- Ziying Lei, Yuzhi Chen, Yue Zhang, Madeline E. Cooke, Isabel R. Ledsky, N. Cazimir Armstrong, Nicole E. Olson, Zhenfa Zhang, Avram Gold, Jason D. Surratt, Andrew P. Ault. Initial pH Governs Secondary Organic Aerosol Phase State and Morphology after Uptake of Isoprene Epoxydiols (IEPOX). Environmental Science & Technology 2022, 56
(15)
, 10596-10607. https://doi.org/10.1021/acs.est.2c01579
- Tanguy Déméautis, Marie Delles, Sophie Tomaz, Guillaume Monneret, Olivier Glehen, Gilles Devouassoux, Christian George, Abderrazzak Bentaher. Pathogenic Mechanisms of Secondary Organic Aerosols. Chemical Research in Toxicology 2022, 35
(7)
, 1146-1161. https://doi.org/10.1021/acs.chemrestox.1c00353
- Ruolan Hu, Shuxiao Wang, Haotian Zheng, Bin Zhao, Chengrui Liang, Xing Chang, Yueqi Jiang, Rujing Yin, Jingkun Jiang, Jiming Hao. Variations and Sources of Organic Aerosol in Winter Beijing under Markedly Reduced Anthropogenic Activities During COVID-2019. Environmental Science & Technology 2022, 56
(11)
, 6956-6967. https://doi.org/10.1021/acs.est.1c05125
- Eliane El Hayek, Sebastian Medina, Jimin Guo, Achraf Noureddine, Katherine E. Zychowski, Russell Hunter, Carmen A. Velasco, Marco Wiesse, Angelea Maestas-Olguin, C. Jeffrey Brinker, Adrian Brearley, Michael Spilde, Tamara Howard, Fredine T. Lauer, Guy Herbert, Abdul Mehdi Ali, Scott Burchiel, Matthew J. Campen, José M. Cerrato. Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity. Environmental Science & Technology 2021, 55
(14)
, 9949-9957. https://doi.org/10.1021/acs.est.1c01205
- Enrico Tapavicza, Guido Falk von Rudorff, David O. De Haan, Mario Contin, Christian George, Matthieu Riva, O. Anatole von Lilienfeld. Elucidating an Atmospheric Brown Carbon Species—Toward Supplanting Chemical Intuition with Exhaustive Enumeration and Machine Learning. Environmental Science & Technology 2021, 55
(12)
, 8447-8457. https://doi.org/10.1021/acs.est.1c00885
- Shunyao Wang, Manpreet Takhar, Yue Zhao, Loay Nasser Salim Al Rashdi, Arthur W. H. Chan. Dynamic Oxidative Potential of Organic Aerosol from Heated Cooking Oil. ACS Earth and Space Chemistry 2021, 5
(5)
, 1150-1162. https://doi.org/10.1021/acsearthspacechem.1c00038
- Faria Khan, Karina Kwapiszewska, Yue Zhang, Yuzhi Chen, Andrew T. Lambe, Agata Kołodziejczyk, Nasir Jalal, Krzysztof Rudzinski, Alicia Martínez-Romero, Rebecca C. Fry, Jason D. Surratt, Rafal Szmigielski. Toxicological Responses of α-Pinene-Derived Secondary Organic Aerosol and Its Molecular Tracers in Human Lung Cell Lines. Chemical Research in Toxicology 2021, 34
(3)
, 817-832. https://doi.org/10.1021/acs.chemrestox.0c00409
- Christopher P. Rüger, Johann Le Maître, Eleanor Riches, Martin Palmer, Jürgen Orasche, Olli Sippula, Jorma Jokiniemi, Carlos Afonso, Pierre Giusti, Ralf Zimmermann. Cyclic Ion Mobility Spectrometry Coupled to High-Resolution Time-of-Flight Mass Spectrometry Equipped with Atmospheric Solid Analysis Probe for the Molecular Characterization of Combustion Particulate Matter. Journal of the American Society for Mass Spectrometry 2021, 32
(1)
, 206-217. https://doi.org/10.1021/jasms.0c00274
- Jinlai Wei, Ting Fang, Cynthia Wong, Pascale S. J. Lakey, Sergey A. Nizkorodov, Manabu Shiraiwa. Superoxide Formation from Aqueous Reactions of Biogenic Secondary Organic Aerosols. Environmental Science & Technology 2021, 55
(1)
, 260-270. https://doi.org/10.1021/acs.est.0c07789
- Fobang Liu, Josh Whitley, Nga Lee Ng, Hang Lu. Time-Resolved Single-Cell Assay for Measuring Intracellular Reactive Oxygen Species upon Exposure to Ambient Particulate Matter. Environmental Science & Technology 2020, 54
(20)
, 13121-13130. https://doi.org/10.1021/acs.est.0c02889
- Michal Pardo, Xinghua Qiu, Ralf Zimmermann, Yinon Rudich. Particulate Matter Toxicity Is Nrf2 and Mitochondria Dependent: The Roles of Metals and Polycyclic Aromatic Hydrocarbons. Chemical Research in Toxicology 2020, 33
(5)
, 1110-1120. https://doi.org/10.1021/acs.chemrestox.0c00007
- Fobang Liu, Maria G. Saavedra, Julie A. Champion, Kathy K. Griendling, Nga L. Ng. Prominent Contribution of Hydrogen Peroxide to Intracellular Reactive Oxygen Species Generated upon Exposure to Naphthalene Secondary Organic Aerosols. Environmental Science & Technology Letters 2020, 7
(3)
, 171-177. https://doi.org/10.1021/acs.estlett.9b00773
- Chunlin Li, Dongmei Cai, Michal Pardo, Hongwei Pang, Zheng Fang, Jianmin Chen, Ke Hao, Yinon Rudich. Redox potential and cytotoxicity of N-heterocyclic aromatic SOA from indole oxidation in the atmosphere. Atmospheric Environment 2025, 344 , 121049. https://doi.org/10.1016/j.atmosenv.2025.121049
- Kaihui Xia, Meng Qin, Mingming Han, Xianming Zhang, Xiaoguo Wu, Mingyuan Liu, Shang Liu, Xinkai Wang, Wei Liu, Zhouqing Xie, Renmin Yuan, Qifan Liu. Elucidating the size distribution of p‑Phenylenediamine-Derived quinones in atmospheric particles. Environment International 2025, 21 , 109329. https://doi.org/10.1016/j.envint.2025.109329
- Juying Lin, Wei Sun, Shuyi Peng, Yaohao Hu, Guohua Zhang, Wei Song, Bin Jiang, Yuhong Liao, Chenglei Pei, Jinpu Zhang, Jianwei Dai, Xinming Wang, Ping’an Peng, Xinhui Bi. Molecular characteristics of organic matters in PM2.5 associated with upregulation of respiratory virus infection in vitro. Journal of Hazardous Materials 2025, 482 , 136583. https://doi.org/10.1016/j.jhazmat.2024.136583
- Shanshan Yu, Long Jia, Yongfu Xu, Yuepeng Pan. Molecular interaction between ammonium sulfate and secondary organic aerosol from styrene. Science of The Total Environment 2024, 954 , 176414. https://doi.org/10.1016/j.scitotenv.2024.176414
- Sudheer Salana, Vishal Verma. Review of
in vitro
studies evaluating respiratory toxicity of aerosols: impact of cell types, chemical composition, and atmospheric processing. Environmental Science: Processes & Impacts 2024, 26
(11)
, 1922-1954. https://doi.org/10.1039/D4EM00475B
- Hendryk Czech, Pasi Yli-Pirilä, Petri Tiitta, Mika Ihalainen, Anni Hartikainen, Eric Schneider, Patrick Martens, Andreas Paul, Thorsten Hohaus, Christopher P. Rüger, Jorma Jokiniemi, Ralf Zimmermann, Olli Sippula. The effect of aging conditions at equal OH exposure in an oxidation flow reactor on the composition of toluene-derived secondary organic aerosols. Environmental Science: Atmospheres 2024, 4
(7)
, 718-731. https://doi.org/10.1039/D4EA00027G
- Zhansheng Yan, Pengxiang Ge, Zhenyu Lu, Xiaoming Liu, Maoyu Cao, Wankang Chen, Mindong Chen. The Cytotoxic Effects of Fine Particulate Matter (PM2.5) from Different Sources at the Air–Liquid Interface Exposure on A549 Cells. Toxics 2024, 12
(1)
, 21. https://doi.org/10.3390/toxics12010021
- Wei Yuan, Ru-Jin Huang, Chao Luo, Lu Yang, Wenjuan Cao, Jie Guo, Huinan Yang. Measurement report: Oxidation potential of water-soluble aerosol components in the south and north of Beijing. Atmospheric Chemistry and Physics 2024, 24
(23)
, 13219-13230. https://doi.org/10.5194/acp-24-13219-2024
- Chunlin Li, Diego Calderon-Arrieta, Michal Pardo, Dongmei Cai, Alexander Laskin, Jianmin Chen, Yinon Rudich. Atmospheric aging modifies the redox potential and toxicity of humic-like substances (HULIS) from biomass burning. Environmental Science: Atmospheres 2023, 3
(12)
, 1791-1804. https://doi.org/10.1039/D3EA00104K
- Marten in 't Veld, Peeyush Khare, Yufang Hao, Cristina Reche, Noemi Pérez, Andres Alastuey, Jesús Yus-Díez, Nicolas Marchand, Andre S.H. Prevot, Xavier Querol, Kaspar R. Daellenbach. Characterizing the sources of ambient PM10 organic aerosol in urban and rural Catalonia, Spain. Science of The Total Environment 2023, 902 , 166440. https://doi.org/10.1016/j.scitotenv.2023.166440
- Ruoyuan Lei, Ziqian Wei, Meijuan Chen, Haifeng Meng, Yun Wu, Xinlei Ge. Aging Effects on the Toxicity Alteration of Different Types of Organic Aerosols: A Review. Current Pollution Reports 2023, 9
(3)
, 590-601. https://doi.org/10.1007/s40726-023-00272-9
- Huanhuan Wang, Mingqiang Huang, Hao Chen, Xiaobin Shan, Zhenya Wang, Fuyi Liu, Liusi Sheng. Experimental and theoretical study on the photoionization of styrene. Journal of Mass Spectrometry 2023, 58
(8)
https://doi.org/10.1002/jms.4967
- Wang Xiang, Weigang Wang, Libo Du, Bin Zhao, Xingyang Liu, Xiaojie Zhang, Li Yao, Maofa Ge. Toxicological Effects of Secondary Air Pollutants. Chemical Research in Chinese Universities 2023, 39
(3)
, 326-341. https://doi.org/10.1007/s40242-023-3050-0
- Ju-Rui Yang, Ai Liu, Bo Long. An unexpected feasible route for the formation of organosulfates by the gas phase reaction of sulfuric acid with acetaldehyde catalyzed by dimethylamine in the atmosphere. Environmental Science: Atmospheres 2023, 3
(4)
, 672-682. https://doi.org/10.1039/D2EA00159D
- Ming‐Qiang Huang, Huan‐Huan Wang, Xiao‐Bin Shan, Liu‐Si Sheng, Chang‐Jin Hu, Xue‐Jun Gu, Wei‐Jun Zhang. Experimental study on synchrotron radiation photoionization of secondary organic aerosol derived from styrene ozonolysis. Journal of the Chinese Chemical Society 2023, 70
(4)
, 938-948. https://doi.org/10.1002/jccs.202200557
- Ting Fang, Brian C. H. Hwang, Sukriti Kapur, Katherine S. Hopstock, Jinlai Wei, Vy Nguyen, Sergey A. Nizkorodov, Manabu Shiraiwa. Wildfire particulate matter as a source of environmentally persistent free radicals and reactive oxygen species. Environmental Science: Atmospheres 2023, 3
(3)
, 581-594. https://doi.org/10.1039/D2EA00170E
- Linchen He, Junfeng (Jim) Zhang. Particulate matter (PM) oxidative potential: Measurement methods and links to PM physicochemical characteristics and health effects. Critical Reviews in Environmental Science and Technology 2023, 53
(2)
, 177-197. https://doi.org/10.1080/10643389.2022.2050148
- A. Pozzer, S. C. Anenberg, S. Dey, A. Haines, J. Lelieveld, S. Chowdhury. Mortality Attributable to Ambient Air Pollution: A Review of Global Estimates. GeoHealth 2023, 7
(1)
https://doi.org/10.1029/2022GH000711
- Marten in 't Veld, Peeyush Khare, Yufang Hao, Cristina Reche, Noemi Pérez, Andrés Alastuey, Jesús Yus-Díez, Nicolas Marchand, Andre S.H. Prevot, Xavier Querol, Kaspar R. Daellenbach. Characterizing the Sources of Ambient PM10 Organic Aerosol in Urban and Rural Catalonia, Spain. SSRN Electronic Journal 2023, 41 https://doi.org/10.2139/ssrn.4463228
- Alessandro Bigi, Giorgio Veratti, Elisabeth Andrews, Martine Collaud Coen, Lorenzo Guerrieri, Vera Bernardoni, Dario Massabò, Luca Ferrero, Sergio Teggi, Grazia Ghermandi. Aerosol absorption using in situ filter-based photometers and ground-based sun photometry in the Po Valley urban atmosphere. Atmospheric Chemistry and Physics 2023, 23
(23)
, 14841-14869. https://doi.org/10.5194/acp-23-14841-2023
- Marten in 't Veld, M. Pandolfi, F. Amato, N. Pérez, C. Reche, P. Dominutti, J. Jaffrezo, A. Alastuey, X. Querol, G. Uzu. Discovering oxidative potential (OP) drivers of atmospheric PM10, PM2.5, and PM1 simultaneously in North-Eastern Spain. Science of The Total Environment 2023, 857 , 159386. https://doi.org/10.1016/j.scitotenv.2022.159386
- Chunlin Li, Maria V. Misovich, Michal Pardo, Zheng Fang, Alexander Laskin, Jianmin Chen, Yinon Rudich. Secondary organic aerosol formation from atmospheric reactions of anisole and associated health effects. Chemosphere 2022, 308 , 136421. https://doi.org/10.1016/j.chemosphere.2022.136421
- Kamaljeet Kaur, Raziye Mohammadpour, Hamidreza Ghandehari, Christopher A. Reilly, Robert Paine, Kerry E. Kelly. Effect of combustion particle morphology on biological responses in a Co-culture of human lung and macrophage cells. Atmospheric Environment 2022, 284 , 119194. https://doi.org/10.1016/j.atmosenv.2022.119194
- Maria Chiara Pietrogrande, Dimitri Bacco, Giorgia Demaria, Mara Russo, Fabiana Scotto, Arianna Trentini. Polycyclic aromatic hydrocarbons and their oxygenated derivatives in urban aerosol: levels, chemical profiles, and contribution to PM2.5 oxidative potential. Environmental Science and Pollution Research 2022, 29
(36)
, 54391-54406. https://doi.org/10.1007/s11356-021-16858-z
- Chunlin Li, Zheng Fang, Hendryk Czech, Eric Schneider, Christopher P. Rüger, Michal Pardo, Ralf Zimmermann, Jianmin Chen, Alexandre Laskin, Yinon Rudich. pH modifies the oxidative potential and peroxide content of biomass burning HULIS under dark aging. Science of The Total Environment 2022, 834 , 155365. https://doi.org/10.1016/j.scitotenv.2022.155365
- Michal Pardo, Svenja Offer, Elena Hartner, Sebastiano Di Bucchianico, Christoph Bisig, Stefanie Bauer, Jana Pantzke, Elias J. Zimmermann, Xin Cao, Stephanie Binder, Evelyn Kuhn, Anja Huber, Seongho Jeong, Uwe Käfer, Eric Schneider, Arunas Mesceriakovas, Jan Bendl, Ramona Brejcha, Angela Buchholz, Daniela Gat, Thorsten Hohaus, Narges Rastak, Erwin Karg, Gert Jakobi, Markus Kalberer, Tamara Kanashova, Yue Hu, Christoph Ogris, Annalisa Marsico, Fabian Theis, Tali Shalit, Thomas Gröger, Christopher P. Rüger, Sebastian Oeder, Jürgen Orasche, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Thomas Adam, Olli Sippula, Martin Sklorz, Jürgen Schnelle-Kreis, Hendryk Czech, Astrid Kiendler-Scharr, Ralf Zimmermann, Yinon Rudich. Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells. Environment International 2022, 166 , 107366. https://doi.org/10.1016/j.envint.2022.107366
- Qing Yu, Jing Chen, Weihua Qin, Mushtaq Ahmad, Yuepeng Zhang, Yuewei Sun, Ke Xin, Jing Ai. Oxidative potential associated with water-soluble components of PM2.5 in Beijing: The important role of anthropogenic organic aerosols. Journal of Hazardous Materials 2022, 433 , 128839. https://doi.org/10.1016/j.jhazmat.2022.128839
- Vincent Laiman, Ta-Chih Hsiao, Yu-Hui Wang, Li-Hao Young, How-Ran Chao, Tang-Huang Lin, Didik Setyo Heriyanto, Hsiao-Chi Chuang. Contributions of acidic ions in secondary aerosol to PM2.5 bioreactivity in an urban area. Atmospheric Environment 2022, 275 , 119001. https://doi.org/10.1016/j.atmosenv.2022.119001
- Svenja Offer, Elena Hartner, Sebastiano Di Bucchianico, Christoph Bisig, Stefanie Bauer, Jana Pantzke, Elias J. Zimmermann, Xin Cao, Stefanie Binder, Evelyn Kuhn, Anja Huber, Seongho Jeong, Uwe Käfer, Patrick Martens, Arunas Mesceriakovas, Jan Bendl, Ramona Brejcha, Angela Buchholz, Daniella Gat, Thorsten Hohaus, Narges Rastak, Gert Jakobi, Markus Kalberer, Tamara Kanashova, Yue Hu, Christoph Ogris, Annalisa Marsico, Fabian Theis, Michal Pardo, Thomas Gröger, Sebastian Oeder, Jürgen Orasche, Andreas Paul, Till Ziehm, Zhi-Hui Zhang, Thomas Adam, Olli Sippula, Martin Sklorz, Jürgen Schnelle-Kreis, Hendryk Czech, Astrid Kiendler-Scharr, Yinon Rudich, Ralf Zimmermann. Effect of Atmospheric Aging on Soot Particle Toxicity in Lung Cell Models at the Air–Liquid Interface: Differential Toxicological Impacts of Biogenic and Anthropogenic Secondary Organic Aerosols (SOAs). Environmental Health Perspectives 2022, 130
(2)
https://doi.org/10.1289/EHP9413
- Chunlin Li, Yinon Rudich, Zheng Fang, Hendryk Czech, Eric Schneider, Christopher Rüger, Michal Pardo, Ralf Zimmermann, Jianmin Chen, Alexandre Laskin. Ph Modifies the Oxidative Potential and Peroxide Content of Biomass Burning Hulis Under Dark Aging. SSRN Electronic Journal 2022, 21 https://doi.org/10.2139/ssrn.4045471
- Marten in 't Veld, Marco Pandolfi, Fulvio Amato, Noemi Pérez, Cristina Reche, Gaelle Uzu, Pamela Dominutti, Jean-Luc Jaffrezo, Andrés Alastuey, Xavier Querol. Discovering Oxidative Potential (Op) Drivers of Atmospheric Pm10, Pm2.5, and Pm1 Simultaneously in North-Eastern Spain. SSRN Electronic Journal 2022, 21 https://doi.org/10.2139/ssrn.4188616
- Zhi-Hui Zhang, Elena Hartner, Battist Utinger, Benjamin Gfeller, Andreas Paul, Martin Sklorz, Hendryk Czech, Bin Xia Yang, Xin Yi Su, Gert Jakobi, Jürgen Orasche, Jürgen Schnelle-Kreis, Seongho Jeong, Thomas Gröger, Michal Pardo, Thorsten Hohaus, Thomas Adam, Astrid Kiendler-Scharr, Yinon Rudich, Ralf Zimmermann, Markus Kalberer. Are reactive oxygen species (ROS) a suitable metric to predict toxicity of carbonaceous aerosol particles?. Atmospheric Chemistry and Physics 2022, 22
(3)
, 1793-1809. https://doi.org/10.5194/acp-22-1793-2022
- Marten in 't Veld, Andres Alastuey, Marco Pandolfi, Fulvio Amato, Noemi Pérez, Cristina Reche, Marta Via, María Cruz Minguillón, Miguel Escudero, Xavier Querol. Compositional changes of PM2.5 in NE Spain during 2009–2018: A trend analysis of the chemical composition and source apportionment. Science of The Total Environment 2021, 795 , 148728. https://doi.org/10.1016/j.scitotenv.2021.148728
- Fobang Liu, Nga Lee Ng, Hang Lu. Emerging applications of microfluidic techniques for
in vitro
toxicity studies of atmospheric particulate matter. Aerosol Science and Technology 2021, 55
(6)
, 623-639. https://doi.org/10.1080/02786826.2021.1879373
- Jinbo Liu, Ning Gao, Xin Wen, Hanzhong Jia, Eric Lichtfouse. Plant and algal toxicity of persistent free radicals and reactive oxygen species generated by heating anthracene-contaminated soils from 100 to 600 °C. Environmental Chemistry Letters 2021, 19
(3)
, 2695-2703. https://doi.org/10.1007/s10311-021-01193-z
- Akihiro Fushimi, Daisuke Nakajima, Akiko Furuyama, Go Suzuki, Tomohiro Ito, Kei Sato, Yuji Fujitani, Yoshinori Kondo, Ayako Yoshino, Sathiyamurthi Ramasamy, James J. Schauer, Pingqing Fu, Yoshiyuki Takahashi, Katsumi Saitoh, Shinji Saito, Akinori Takami. Source contributions to multiple toxic potentials of atmospheric organic aerosols. Science of The Total Environment 2021, 773 , 145614. https://doi.org/10.1016/j.scitotenv.2021.145614
- Christian Gehm, Kevin Schnepel, Hendryk Czech, Toni Miersch, Sven Ehlert, Ralf Zimmermann. Hyper-fast gas chromatography and single-photon ionisation time-of-flight mass spectrometry with integrated electrical modulator-based sampling for headspace and online VOC analyses. The Analyst 2021, 146
(10)
, 3137-3149. https://doi.org/10.1039/D1AN00114K
- Zhiying Zeng, Xiao He, Changying Li, Shan Lin, Hui Chen, Libing Liu, Xuli Feng. Oral delivery of antioxidant enzymes for effective treatment of inflammatory disease. Biomaterials 2021, 271 , 120753. https://doi.org/10.1016/j.biomaterials.2021.120753
- Haijie Tong, Fobang Liu, Alexander Filippi, Jake Wilson, Andrea M. Arangio, Yun Zhang, Siyao Yue, Steven Lelieveld, Fangxia Shen, Helmi-Marja K. Keskinen, Jing Li, Haoxuan Chen, Ting Zhang, Thorsten Hoffmann, Pingqing Fu, William H. Brune, Tuukka Petäjä, Markku Kulmala, Maosheng Yao, Thomas Berkemeier, Manabu Shiraiwa, Ulrich Pöschl. Aqueous-phase reactive species formed by fine particulate matter from remote forests and polluted urban air. Atmospheric Chemistry and Physics 2021, 21
(13)
, 10439-10455. https://doi.org/10.5194/acp-21-10439-2021
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2.5
oxidative potential in Beijing, China. Atmospheric Chemistry and Physics 2021, 21
(7)
, 5549-5573. https://doi.org/10.5194/acp-21-5549-2021
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(41)
, 25386-25395. https://doi.org/10.1073/pnas.2001378117
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