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Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota

  • Qixiao Zhai
    Qixiao Zhai
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China
    U.K.-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, United Kingdom
    More by Qixiao Zhai
  • Shi Cen
    Shi Cen
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Shi Cen
  • Peng Li
    Peng Li
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Peng Li
  • Fengwei Tian
    Fengwei Tian
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Fengwei Tian
  • Jianxin Zhao
    Jianxin Zhao
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Jianxin Zhao
  • Hao Zhang
    Hao Zhang
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    National Engineering Research Centre for Functional Food, Wuxi, Jiangsu 214122, China
    More by Hao Zhang
  • , and 
  • Wei Chen*
    Wei Chen
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    National Engineering Research Centre for Functional Food, Wuxi, Jiangsu 214122, China
    Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China
    *Wei Chen. E-mail: [email protected]. Phone: (86)510-85912155. Fax: (86)510-85912155.
    More by Wei Chen
Cite this: Environ. Sci. Technol. Lett. 2018, 5, 12, 724–730
Publication Date (Web):November 26, 2018
Copyright © 2018 American Chemical Society

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    Abstract Image

    Variations in selenium (Se) intake have been reported to affect the barrier function and immune responses in the gut. Previous studies mainly focused on the role of Se itself or its metabolites, while the influences of the Se-intake-related microbiota on gut health were not thoroughly studied. This study compared the effects of different dietary Se supplementation (Se-deficient, Se-adequate, and Se-supranutritional) on the gut microbiota of mice. Fecal microbiota transplantation (FMT) was further conducted to bypass the effect of Se itself and provided direct evidence that the effects of dietary Se supplementation on the intestinal barrier and immune responses are associated with its modulation of the gut microbiota. Deficient Se supplementation can result in a phenotype of gut microbiota that is more susceptible to dextran sulfate sodium (DSS)-induced colitis and Salmonella typhimurium infection. Sufficient or supranutritional Se intake can optimize the gut microbiota for protection against these intestinal dysfunctions.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.estlett.8b00563.

    • Detailed methods for the process of four animal trials and the determination of parameters related to the biological and pathological alterations in mice; some genera of gut microbiota that were significantly altered by different Se treatments (Figure S1); biomarkers that were not significantly altered in normal (Figure S2), DSS-treated (Figure S3), and ST-infected (Figure S4) mice receiving different FMT treatments; concentrations of SCFAs in the colonic contents of mice (Table S1); effects of FMT on colonic oxidative stress status in DSS-treated mice (Table S2) (PDF)

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    13. YiWen HE, Le HUANG, XiHong ZHOU, YuLong YIN, LiuQin HE. Role of selenium and selenoprotein in gut health. SCIENTIA SINICA Vitae 2023, 53 (8) , 1055-1066.
    14. Dearbhla Finnegan, Restituto Tocmo, Christine Loscher. Targeted Application of Functional Foods as Immune Fitness Boosters in the Defense against Viral Infection. Nutrients 2023, 15 (15) , 3371.
    15. Mengge Zhao, Pengkui Xia, Xing Zhang, Hui He, Tao Hou. Selenium-containing soybean peptides ameliorate intestinal inflammation and modulate gut microbiota dysbacteriosis in DSS-induced ulcerative colitis mice. Food & Function 2023, 14 (13) , 6187-6199.
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    52. M. Khajeh Bami, M. Afsharmanesh, M. Salarmoini, H. Ebrahimnejad. Effects of selenium-chitosan on intestinal microflora, intestinal histomorphology, and immune response of broiler chickens. Livestock Science 2022, 255 , 104806.
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    68. Xiaojing Xia, Xiulin Zhang, Mingcheng Liu, Mingyuan Duan, Shanshan Zhang, Xiaobing Wei, Xingyou Liu. Toward improved human health: efficacy of dietary selenium on immunity at the cellular level. Food & Function 2021, 12 (3) , 976-989.
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    72. Ana Margarida Pereira, Carlo Pinna, Giacomo Biagi, Claudio Stefanelli, Margarida R G Maia, Elisabete Matos, Marcela A Segundo, António J M Fonseca, Ana Rita J Cabrita. Supplemental selenium source on gut health: insights on fecal microbiome and fermentation products of growing puppies. FEMS Microbiology Ecology 2020, 96 (11)
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    74. Yang, Liang, Balakrishnan, Belobrajdic, Feng, Zhang. Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review. Nutrients 2020, 12 (2) , 381.
    75. Qixiao Zhai, Xudan Shen, Shi Cen, Chengcheng Zhang, Fengwei Tian, Jianxin Zhao, Hao Zhang, Yuzheng Xue, Wei Chen. Screening of Lactobacillus salivarius strains from the feces of Chinese populations and the evaluation of their effects against intestinal inflammation in mice. Food & Function 2020, 11 (1) , 221-235.
    76. Qixiao Zhai, Dingwu Qu, Saisai Feng, Yaqi Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen. Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice. Frontiers in Microbiology 2020, 10
    77. Sarah E. Sumner, Rachel L. Markley, Girish S. Kirimanjeswara. Role of Selenoproteins in Bacterial Pathogenesis. Biological Trace Element Research 2019, 192 (1) , 69-82.
    78. Jason A. Rothman, Laura Leger, Jay S. Kirkwood, Quinn S. McFrederick, . Cadmium and Selenate Exposure Affects the Honey Bee Microbiome and Metabolome, and Bee-Associated Bacteria Show Potential for Bioaccumulation. Applied and Environmental Microbiology 2019, 85 (21)
    79. Ana Arias-Borrego, Belén Callejón-Leblic, Marta Calatayud, José Luis Gómez-Ariza, Maria Carmen Collado, Tamara García-Barrera. Insights into cancer and neurodegenerative diseases through selenoproteins and the connection with gut microbiota – current analytical methodologies. Expert Review of Proteomics 2019, 16 (10) , 805-814.
    80. Qixiao Zhai, Yue Xiao, Peng Li, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen. Varied doses and chemical forms of selenium supplementation differentially affect mouse intestinal physiology. Food & Function 2019, 10 (9) , 5398-5412.
    81. Qixiao Zhai, Jing Wang, Shi Cen, Jianxin Zhao, Hao Zhang, Fengwei Tian, Wei Chen. Modulation of the gut microbiota by a galactooligosaccharide protects against heavy metal lead accumulation in mice. Food & Function 2019, 10 (6) , 3768-3781.

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