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Effects of Dietary Selenium Supplementation on Intestinal Barrier and Immune Responses Associated with Its Modulation of Gut Microbiota

  • Qixiao Zhai
    Qixiao Zhai
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China
    U.K.-China Joint Centre on Probiotic Bacteria, Norwich NR4 7UA, United Kingdom
    More by Qixiao Zhai
    Orcidhttp://orcid.org/0000-0003-1415-7247
  • , 
  • Shi Cen
    Shi Cen
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Shi Cen
  • , 
  • Peng Li
    Peng Li
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Peng Li
  • , 
  • Fengwei Tian
    Fengwei Tian
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Fengwei Tian
  • , 
  • Jianxin Zhao
    Jianxin Zhao
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    More by Jianxin Zhao
    Orcidhttp://orcid.org/0000-0002-7414-9030
  • , 
  • Hao Zhang
    Hao Zhang
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    National Engineering Research Centre for Functional Food, Wuxi, Jiangsu 214122, China
    More by Hao Zhang
  • , and 
  • Wei Chen*
    Wei Chen
    State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China
    National Engineering Research Centre for Functional Food, Wuxi, Jiangsu 214122, China
    Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Beijing 100048, China
    *Wei Chen. E-mail: [email protected]. Phone: (86)510-85912155. Fax: (86)510-85912155.
    More by Wei Chen
    Orcidhttp://orcid.org/0000-0003-3348-4710
Cite this: Environ. Sci. Technol. Lett. 2018, 5, 12, 724–730
Publication Date (Web):November 26, 2018
https://doi.org/10.1021/acs.estlett.8b00563
Copyright © 2018 American Chemical Society
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    Abstract

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    Variations in selenium (Se) intake have been reported to affect the barrier function and immune responses in the gut. Previous studies mainly focused on the role of Se itself or its metabolites, while the influences of the Se-intake-related microbiota on gut health were not thoroughly studied. This study compared the effects of different dietary Se supplementation (Se-deficient, Se-adequate, and Se-supranutritional) on the gut microbiota of mice. Fecal microbiota transplantation (FMT) was further conducted to bypass the effect of Se itself and provided direct evidence that the effects of dietary Se supplementation on the intestinal barrier and immune responses are associated with its modulation of the gut microbiota. Deficient Se supplementation can result in a phenotype of gut microbiota that is more susceptible to dextran sulfate sodium (DSS)-induced colitis and Salmonella typhimurium infection. Sufficient or supranutritional Se intake can optimize the gut microbiota for protection against these intestinal dysfunctions.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.estlett.8b00563.

    • Detailed methods for the process of four animal trials and the determination of parameters related to the biological and pathological alterations in mice; some genera of gut microbiota that were significantly altered by different Se treatments (Figure S1); biomarkers that were not significantly altered in normal (Figure S2), DSS-treated (Figure S3), and ST-infected (Figure S4) mice receiving different FMT treatments; concentrations of SCFAs in the colonic contents of mice (Table S1); effects of FMT on colonic oxidative stress status in DSS-treated mice (Table S2) (PDF)

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