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Metal−Organic Polyhedron with Four Fe(III) Centers Producing Enhanced T1 Magnetic Resonance Imaging Contrast in Tumors

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    Metal−Organic Polyhedron with Four Fe(III) Centers Producing Enhanced T1 Magnetic Resonance Imaging Contrast in Tumors
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    Inorganic Chemistry

    Cite this: Inorg. Chem. 2022, 61, 5, 2603–2611
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    https://doi.org/10.1021/acs.inorgchem.1c03660
    Published January 24, 2022
    Copyright © 2022 American Chemical Society
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    Abstract

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    A metal−organic polyhedron (MOP) with four paramagnetic Fe(III) centers was studied as a magnetic resonance imaging (MRI) probe. The MOP was characterized in solution by using electron paramagnetic resonance (EPR), UV–visible (UV–vis) spectroscopies, Fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry, and in the solid state with single-crystal X-ray diffraction. Water proton T1 relaxation properties were examined in solution and showed significant enhancement in the presence of human serum albumin (HSA). The r1 relaxivities in the absence and presence of HSA were 8.7 mM–1 s–1 and 21 mM–1 s–1, respectively, per molecule (2.2 mM–1 s–1 and 5.3 mM–1 s–1 per Fe) at 4.7 T, 37 °C. In vivo studies of the iron MOP show strong contrast enhancement of the blood pool even at a low dose of 0.025 mmol/kg with prolonged residence in vasculature and clearance through the intestinal tract of mice. The MOP binds strongly to serum albumin and shows comparable accumulation in a murine tumor model as compared to a covalently linked Gd-HSA contrast agent.

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    • Spectroscopic methods, synthesis and characterization of complexes, studies of kinetic inertness, relaxivity plots and binding isotherms (PDF)

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    CCDC 2108939 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing [email protected], or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033.

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    Inorganic Chemistry

    Cite this: Inorg. Chem. 2022, 61, 5, 2603–2611
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.inorgchem.1c03660
    Published January 24, 2022
    Copyright © 2022 American Chemical Society
    Request reuse permissions

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