ACS Publications. Most Trusted. Most Cited. Most Read
Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides

OR SEARCH CITATIONS

My Activity
Publications

Figure 1Loading Img
Download Hi-Res ImageDownload to MS-PowerPointCite This:Inorg. Chem. 2025, 64, 11, 5348-5353
    Communication

    Multinuclear Silver(I)–Selenium Clusters Formation in Selenopeptides
    Click to copy article linkArticle link copied!

    • Tshering Zangmo
      Tshering Zangmo
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      More by Tshering Zangmo
    • Paulina Szczerba
      Paulina Szczerba
      Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
      More by Paulina Szczerba
    • Ioannis Kanavos
      Ioannis Kanavos
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      More by Ioannis Kanavos
    • Alejandro Gutiérrez-Quintanilla
      Alejandro Gutiérrez-Quintanilla
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      More by Alejandro Gutiérrez-Quintanilla
    • Karinne Miqueu
      Karinne Miqueu
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      More by Karinne Miqueu
    • Joanna Szpunar
      Joanna Szpunar
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      More by Joanna Szpunar
    • Panaghiotis Karamanis
      Panaghiotis Karamanis
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      More by Panaghiotis Karamanis
      Orcidhttps://orcid.org/0000-0002-1774-7624
    • Wojciech Bal
      Wojciech Bal
      Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
      More by Wojciech Bal
      Orcidhttps://orcid.org/0000-0003-3780-083X
    • Luisa Ronga*
      Luisa Ronga
      Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, 2 Avenue du Président Pierre Angot, Pau 64053, France
      *Email: [email protected]
      More by Luisa Ronga
      Orcidhttps://orcid.org/0000-0002-8485-6492
    Other Access OptionsSupporting Information (1)

    Inorganic Chemistry

    Cite this: Inorg. Chem. 2025, 64, 11, 5348–5353
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.inorgchem.4c04867
    Published March 12, 2025
    Copyright © 2025 American Chemical Society
    Request reuse permissions

    Abstract

    Click to copy section linkSection link copied!
    Abstract Image

    The reactions of ionic silver (Ag+) with arginine vasopressin (AVP), a nonapeptide hormone cyclized by two cysteine residues, and its diselenium analogue was explored by an integrated LC-MS, UV–vis, and DFT approach. The replacement of Cys by SeCys in AVP increased the reactivity of the peptide toward Ag+ ions under mildly reducing conditions, with the formation of a Se4Ag4 cluster provided by Ag(I)-mediated dimerization of diselenide AVP. Specific electronic absorption bands confirmed the formation of the Ag4peptide2 complex, supported by DFT calculations. These results provide the first ever evidence that Ag(I) ions bind a selenopeptide and prefer SeCys over Cys as binding sites, opening a perspective on the involvement of selenobiomolecules in the emerging cellular toxicity of silver.

    Copyright © 2025 American Chemical Society

    Subjects

    what are subjects

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. Add or change your institution or let them know you’d like them to include access.

    Supporting Information

    Click to copy section linkSection link copied!

    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.inorgchem.4c04867.

    • Experimental procedures, supplementary LC-MS, UV–vis, and DFT analyses (PDF)

    Terms & Conditions

    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

    Cited By

    Click to copy section linkSection link copied!

    This article has not yet been cited by other publications.

    Download PDF
    Go to Inorganic Chemistry
    Get e-Alerts
    Get e-Alerts

    Inorganic Chemistry

    Cite this: Inorg. Chem. 2025, 64, 11, 5348–5353
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.inorgchem.4c04867
    Published March 12, 2025
    Copyright © 2025 American Chemical Society
    Request reuse permissions

    Article Views

    234

    Altmetric

    -

    Citations

    -
    Learn about these metrics

    Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

    Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.

    The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated.