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Ovomucin Ameliorates Intestinal Barrier and Intestinal Bacteria to Attenuate DSS-Induced Colitis in Mice

  • Aobai Tu
    Aobai Tu
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    More by Aobai Tu
  • Xiu Chao Wang
    Xiu Chao Wang
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
  • Hongwang Chen
    Hongwang Chen
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
  • Xin Jia
    Xin Jia
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    More by Xin Jia
  • Tao Wang
    Tao Wang
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    More by Tao Wang
  • Yanglei Yi
    Yanglei Yi
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    More by Yanglei Yi
  • Bianfang Liu
    Bianfang Liu
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    More by Bianfang Liu
  • Wang Xin
    Wang Xin
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    More by Wang Xin
  • Xin Lü*
    Xin Lü
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    *Email: [email protected]. Tel/Fax: 01186-29-87092940.
    More by Xin Lü
  • , and 
  • Yuanyuan Shan*
    Yuanyuan Shan
    College of Food Science and Engineering, Northwest A&F University, No. 22 Xinong Road, Yangling, Shannxi 712100, P. R. China
    *Email: [email protected]
Cite this: J. Agric. Food Chem. 2021, 69, 21, 5887–5896
Publication Date (Web):May 20, 2021
https://doi.org/10.1021/acs.jafc.1c00865
Copyright © 2021 American Chemical Society

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    Abstract

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    Egg white ovomucin (OVM) is homologically related to MUC2, the key component of colonic mucous layer. This study investigated the effects of orally administered OVM from egg white on the colonic mucosal barrier and the development of colitis using a colitis C57BL/6J mice model. The results showed that daily supplementation of 125 and 250 mg/kg BW of OVM partially relieved the villous destruction and loss of intestinal barrier integrity, and hence decreased the epithelial barrier permeability. The supplementation also reduced the secretion of proinflammatory cytokines TNF-α and IL-6. Besides, OVM administration significantly increased the relative abundance of intestinal beneficial bacteria including Lactobacilli, Faecalibaculum, Ruminococcus, etc. and further upregulated the production of bacterial metabolites such as short-chain fatty acids (SCFAs), which is a direct source of energy for the proliferation of epithelia and goblet cells. In conclusion, OVM from egg white ameliorates colitis by enhancing the intestinal barrier function and abundance of intestinal bacteria, thereby increasing the number of SCFAs.

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jafc.1c00865.

    • Purity information of the ovomucin sample in this study (Figure S1); effect of ovomucin on survival rate of colitis mice (Figure S2); and sample sequencing depth (Figure S3) (PDF)

    • Evaluation standard of DAI index (Table S1) and the primer sequences used in this study (Table S2) (PDF)

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    Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses). Permission may be obtained from ACS for other uses through requests via the RightsLink permission system: http://pubs.acs.org/page/copyright/permissions.html.

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