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Functional Significance of Different Milk Constituents in Modulating the Gut Microbiome and Infant Health

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    Functional Significance of Different Milk Constituents in Modulating the Gut Microbiome and Infant Health
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    • Monica Yadav
      Monica Yadav
      Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
      More by Monica Yadav
    • Ayushi Kapoor
      Ayushi Kapoor
      Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
      More by Ayushi Kapoor
    • Aparna Verma
      Aparna Verma
      Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
      More by Aparna Verma
    • Kiran Ambatipudi*
      Kiran Ambatipudi
      Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee 247667, India
      *Telephone: +91-1332-284786. Fax: +91-1332-273560. E-mail: [email protected]
      More by Kiran Ambatipudi
      Orcidhttps://orcid.org/0000-0003-4157-0678
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2022, 70, 13, 3929–3947
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    https://doi.org/10.1021/acs.jafc.2c00335
    Published March 24, 2022
    Copyright © 2022 American Chemical Society
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    Abstract

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    Human milk, the gold standard for optimal nourishment, controls the microbial composition of infants by either enhancing or limiting bacterial growth. The milk fat globule membrane has gained interest in gut-related functions and cognitive development. The membrane proteins can directly interact with probiotic bacteria, influencing their survival and adhesion through gastrointestinal transit, whereas membrane phospholipids increase the residence time of probiotic bacteria in the gut. The commensal bacteria in milk act as the initial inoculum in building up the gut colonization of an infant, whereas oligosaccharides promote proliferation of beneficial microorganisms. Interestingly, milk extracellular vesicles are also involved in influencing the microbiota composition but are not well-explored. This review highlights the contribution of different milk components in modulating the infant gut microbiota, particularly the fat globule membrane, and the complex interplay between host– and brain–gut microbiota signaling affecting infant and adult health positively.

    Copyright © 2022 American Chemical Society

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    This article is cited by 22 publications.

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    2. C. Raz, N. Tzirkel-Hancock, M. Shemesh, N. Argov-Argaman. The role of structure in the interaction between bacteria, mammary epithelial cells and milk fat globules from raw or “cultured” milk. Food Chemistry 2025, 467 , 142244. https://doi.org/10.1016/j.foodchem.2024.142244
    3. Ye Zhou, Jianxin Zhao, Paul Ross, Catherine Stanton, Wei Chen, Bo Yang. Streptococcus wuxiensis sp. nov., Streptococcus jiangnanensis sp. nov. and Streptococcus fermentans sp. nov.: three novel species of genus Streptococcus isolated from human breast milk. International Journal of Systematic and Evolutionary Microbiology 2025, 75 (2) https://doi.org/10.1099/ijsem.0.006674
    4. Withanage Prasadini Wasana, Mark Waterland, David W. Everett, Caroline Thum. Functional Significance of Probiotic Bacterial Interactions with Milk Fat Globules in a Human Host. Microorganisms 2025, 13 (2) , 223. https://doi.org/10.3390/microorganisms13020223
    5. Monica Yadav, Rashmi Hogarehalli Mallappa, Kiran Ambatipudi. Human milk fat globule delivers entrapped probiotics to the infant's gut and acts synergistically to ameliorate oxidative and pathogenic stress. Food Chemistry 2025, 462 , 141030. https://doi.org/10.1016/j.foodchem.2024.141030
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    15. Ayushi Kapoor, Saurav Datta, Gaurav Gupta, Ajay Vishwakarma, Avinash Singh, Sujay Chattopadhyay, Kiran Ambatipudi. One-step separation of fat globules based on size from bovine milk using a cross-flow microfiltration. Separation and Purification Technology 2024, 330 , 125251. https://doi.org/10.1016/j.seppur.2023.125251
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    20. Sharon M. Donovan, Steven A. Abrams, Meghan B. Azad, Mandy B. Belfort, Lars Bode, Susan E. Carlson, David C. Dallas, Kasper Hettinga, Kirsi Järvinen, Jae H. Kim, Carlito B. Lebrilla, Michelle K. McGuire, David A. Sela, Josef Neu. Summary of the Joint National Institutes of Health and the Food and Drug Administration Workshop Titled “Exploring the Science Surrounding the Safe Use of Bioactive Ingredients in Infant Formula: Considerations for an Assessment Framework”. The Journal of Pediatrics 2023, 255 , 30-41.e1. https://doi.org/10.1016/j.jpeds.2022.11.027
    21. Biswajeet Acharya, Bimalendu Chowdhury, Gurudutta Pattnaik, Amulyaratna Behera, Suchismeeta Behera. Food Safety during Pregnancy: Current Consideration. International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 2023, 16 (1) , 6362-6380. https://doi.org/10.37285/ijpsn.2023.16.1.9
    22. Jiezhong Chen, Luis Vitetta. The Role of the Gut-Lung Axis in COVID-19 Infections and Its Modulation to Improve Clinical Outcomes. Frontiers in Bioscience-Scholar 2022, 14 (3) https://doi.org/10.31083/j.fbs1403023
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2022, 70, 13, 3929–3947
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.2c00335
    Published March 24, 2022
    Copyright © 2022 American Chemical Society
    Request reuse permissions

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