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Dietary Polyphenols Alleviate Autoimmune Liver Disease by Mediating the Intestinal Microenvironment: Challenges and Hopes

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    Dietary Polyphenols Alleviate Autoimmune Liver Disease by Mediating the Intestinal Microenvironment: Challenges and Hopes
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    • Zhen Cheng
      Zhen Cheng
      College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110866, China
      Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province, Shenyang, Liaoning 110866, China
      More by Zhen Cheng
      Orcidhttps://orcid.org/0000-0003-3056-5611
    • Yuehua Wang
      Yuehua Wang
      College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110866, China
      Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province, Shenyang, Liaoning 110866, China
      More by Yuehua Wang
      Orcidhttps://orcid.org/0000-0002-1941-4890
    • Bin Li*
      Bin Li
      College of Food Science, Shenyang Agricultural University, Shenyang, Liaoning 110866, China
      Key Laboratory of Healthy Food Nutrition and Innovative Manufacturing of Liaoning Province, Shenyang, Liaoning 110866, China
      *Phone: +86-13998833975. Fax: 02488487161. E-mail: [email protected]
      More by Bin Li
      Orcidhttps://orcid.org/0000-0002-7393-2111
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2022, 70, 35, 10708–10737
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    https://doi.org/10.1021/acs.jafc.2c02654
    Published August 25, 2022
    Copyright © 2022 American Chemical Society
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    Abstract

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    Autoimmune liver disease is a chronic liver disease caused by an overactive immune response in the liver that imposes a significant health and economic cost on society. Due to the side effects of existing medicinal medications, there is a trend toward seeking natural bioactive compounds as dietary supplements. Currently, dietary polyphenols have been proven to have the ability to mediate gut–liver immunity and control autoimmune liver disease through modulating the intestinal microenvironment. Based on the preceding, this Review covers the many forms of autoimmune liver illnesses, their pathophysiology, and the modulatory effects of polyphenols on immune disorders. Finally, we focus on how polyphenols interact with the intestinal milieu to improve autoimmune liver disease. In conclusion, we suggest that dietary polyphenols have the potential as gut-targeted modulators for the prevention and treatment of autoimmune liver disease and highlight new perspectives and critical issues for future pharmacological applications.

    Copyright © 2022 American Chemical Society

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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2022, 70, 35, 10708–10737
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.2c02654
    Published August 25, 2022
    Copyright © 2022 American Chemical Society
    Request reuse permissions

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