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Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome

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Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Agric. Food Chem. 2024, 72, 50, 27923-27938
    Bioactive Constituents, Metabolites, and Functions

    Neutral Polysaccharide from Platycodonis Radix-Ameliorated PM2.5-Induced Lung Injury by Inhibiting the TLR4/NF-κB p65 Pathway and Regulating the Lung and Gut Microbiome
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    • Yang Sun
      Yang Sun
      College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
      More by Yang Sun
    • Yanchun Wang
      Yanchun Wang
      College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
      More by Yanchun Wang
    • Zaiming Yang
      Zaiming Yang
      College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
      More by Zaiming Yang
    • Xianlei Han
      Xianlei Han
      College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
      More by Xianlei Han
    • Yue Zhang
      Yue Zhang
      College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
      More by Yue Zhang
    • Liyan Chen
      Liyan Chen
      Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150036, China
      More by Liyan Chen
    • Jinhai Huo
      Jinhai Huo
      Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150036, China
      More by Jinhai Huo
    • Rina Wu
      Rina Wu
      College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China
      More by Rina Wu
      Orcidhttps://orcid.org/0000-0002-5846-0013
    • Weiming Wang*
      Weiming Wang
      Institute of Chinese Materia Medica, Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150036, China
      *Email: [email protected]
      More by Weiming Wang
    • Nan Wang*
      Nan Wang
      College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
      *Email: [email protected]
      More by Nan Wang
      Orcidhttps://orcid.org/0000-0002-3604-1432
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2024, 72, 50, 27923–27938
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    https://doi.org/10.1021/acs.jafc.4c07319
    Published December 3, 2024
    Copyright © 2024 American Chemical Society
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    Abstract

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    Platycodonis radix (PR) has been reported to play a protective role in lung injury. However, much less is known about the protective effect and mechanism of its main component PR polysaccharides (PRPs) in particulate matter (PM2.5)-induced lung injury. Here, a neutral polysaccharide (MW: 244.56 kDa) was isolated from PR, mainly composed of Rha, Ara, Gal, Glc, Xyl, and Man. PRPs significantly improved PM2.5-induced pulmonary edema, oxidative damage, and cell apoptosis and downregulated inflammatory factor levels in bronchoalveolar lavage fluid. Mechanistically, PRPs reduced intestinal mucosal barrier damage, thereby lowering serum lipopolysaccharide levels and inhibiting the overactivation of the TLR4/NF-κB signaling pathway in the lung tissue. Notably, PRPs could optimize the composition of pulmonary and intestinal microbiota. Oral administration of PRPs resulted in enrichment of short-chain fatty acid (SCFA)-producing bacteria, thereby upregulating the levels of acetate, butyrate, and isovalerate. Taken together, PRPs have great potential in preventing and repairing the lung injury caused by PM2.5.

    Copyright © 2024 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.jafc.4c07319.

    • Effect of PRP on the composition of lung microbiota and gut microbiota in mice exposed to PM2.5 (PDF)

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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2024, 72, 50, 27923–27938
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.4c07319
    Published December 3, 2024
    Copyright © 2024 American Chemical Society
    Request reuse permissions

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