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    New Synthesis and Biological Evaluation of Benzothiazole Derivates as Antifungal Agents
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    † INFIQC, Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, 5000 Argentina
    ‡ ICTA, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Ciudad Universitaria, Córdoba, 5000 Argentina
    *Phone: +54 351 5353867. Fax: +54 351 4344971. E-mail: [email protected]
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2015, 63, 14, 3681–3686
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    https://doi.org/10.1021/acs.jafc.5b00150
    Published March 21, 2015
    Copyright © 2015 American Chemical Society
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    Abstract

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    In search of new antifungal agrochemicals that could replace commercially available, aryl-2-mercaptobenzothiazoles were synthesized. They were prepared by two methodologies, using both photostimulated reaction and microwave assisted reaction. These reactions took place without the use of metallic catalyst by a one-pot procedure with excellent yields (70–98%). Synthesized compounds were evaluated for fungal growth inhibition against Botrytis cinerea. Most of the compounds have an excellent antifungal activity, and three of these showed a superior inhibitory effect to commercial fungicide Triadimefon. IC50 values observed for 2-(phenylthio)benzothiazole, 2-(2-chlorophenylthio)benzothiazole, and 2-(3-chlorophenyl thio)benzothiazole were 0.75, 0.69, and 0.65 μg mL–1, respectively.

    Copyright © 2015 American Chemical Society

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    General information, optimization of p-bromoiodobenzene with 1, reduction potential, more details about bioassays of fungicidal activities, isolation and spectroscopy data for all compounds. This material is available free of charge via the Internet at http://pubs.acs.org.

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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2015, 63, 14, 3681–3686
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.5b00150
    Published March 21, 2015
    Copyright © 2015 American Chemical Society
    Request reuse permissions

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