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Preparation and Characterization of Ultrarapidly Dissolving Orodispersible Films for Treating and Preventing Iodine Deficiency in the Pediatric Population
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    Preparation and Characterization of Ultrarapidly Dissolving Orodispersible Films for Treating and Preventing Iodine Deficiency in the Pediatric Population
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    School of Pharmacy and School of Chemistry, University of East Anglia, Norwich, Norfolk, United Kingdom NR4 7TJ
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    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2015, 63, 44, 9831–9838
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    https://doi.org/10.1021/acs.jafc.5b03953
    Published October 25, 2015
    Copyright © 2015 American Chemical Society

    Abstract

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    Iodine deficiency is a public health problem that is easily prevented in many countries through having a salt iodization program. However, the World Health Organization (WHO) recommends that particular population groups including infants and young children have a sufficient level of daily iodine intake, while also reducing salt consumption in their diet. While many iodine supplements are available, swallowing tablet supplements is physically difficult for young children; thus, there is a need for the development of novel iodine delivery systems for pediatric patients. In this study a novel, ultrarapidly dissolving, nanofiber-based orodispersible film formulation containing iodine which is constructed from nanofibers was manufactured using an electrospinning technique. The potassium iodate (KIO3)-loaded poly(ethylene oxide) (PEO) fiber orodispersible films dissolve within seconds on wetting (applying on the tongue) without the need for the consumption of water. The electrospinning process and KIO3 loading did not alter the crystallinity and conformation of PEO. With high loading, KIO3 nanocrystals are present in the fibers. This formulation design allows easy administration of iodine for preventing childhood iodine deficiency. We have also described a novel and easy method for producing and harvesting nanocrystals of inorganic salts that can be potentially adopted for use in other relevant fields.

    Copyright © 2015 American Chemical Society

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    Supporting Information

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.5b03953.

    • TEM images of the nanofibers with different KIO3 loading; detailed assignments of all detectable ATR-FTIR peaks of the PEO, electrospun PEO, and KIO3-loaded PEO fibers; detailed assignments of all detectable ATR-FTIR peaks of the KIO3 and KIO3-loaded fibers (PDF)

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    Cited By

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    This article is cited by 18 publications.

    1. Saba Abedin, Oluwatoyin A. Adeleke. State of the art in pediatric nanomedicines. Drug Delivery and Translational Research 2024, 14 (9) , 2299-2324. https://doi.org/10.1007/s13346-024-01532-x
    2. Irma Elisa Cupone, Giuliana Roselli, Fabio Marra, Marika Riva, Silvia Angeletti, Laura Dugo, Silvia Spoto, Marta Fogolari, Andrea Maria Giori. Orodispersible Film Based on Maltodextrin: A Convenient and Suitable Method for Iron Supplementation. Pharmaceutics 2023, 15 (6) , 1575. https://doi.org/10.3390/pharmaceutics15061575
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    11. Hend E. Abdelhakim, Gareth R. Williams, Duncan Q.M. Craig, Mine Orlu, Catherine Tuleu. Human mouthfeel panel investigating the acceptability of electrospun and solvent cast orodispersible films. International Journal of Pharmaceutics 2020, 585 , 119532. https://doi.org/10.1016/j.ijpharm.2020.119532
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    13. Umberto M. Musazzi, Garba M. Khalid, Francesca Selmin, Paola Minghetti, Francesco Cilurzo. Trends in the production methods of orodispersible films. International Journal of Pharmaceutics 2020, 576 , 118963. https://doi.org/10.1016/j.ijpharm.2019.118963
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    16. Il Woo Lee, Jinglei Li, Xiguang Chen, Hyun Jin Park. Fabrication of electrospun antioxidant nanofibers by rutin‐pluronic solid dispersions for enhanced solubility. Journal of Applied Polymer Science 2017, 134 (21) https://doi.org/10.1002/app.44859
    17. Diana A van Riet-Nales, Alfred F A M Schobben, Herman Vromans, Toine C G Egberts, Carin M A Rademaker. Safe and effective pharmacotherapy in infants and preschool children: importance of formulation aspects. Archives of Disease in Childhood 2016, 101 (7) , 662-669. https://doi.org/10.1136/archdischild-2015-308227
    18. Sheng Qi, Duncan Craig. Recent developments in micro- and nanofabrication techniques for the preparation of amorphous pharmaceutical dosage forms. Advanced Drug Delivery Reviews 2016, 100 , 67-84. https://doi.org/10.1016/j.addr.2016.01.003

    Journal of Agricultural and Food Chemistry

    Cite this: J. Agric. Food Chem. 2015, 63, 44, 9831–9838
    Click to copy citationCitation copied!
    https://doi.org/10.1021/acs.jafc.5b03953
    Published October 25, 2015
    Copyright © 2015 American Chemical Society

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