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Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads

  • Mendel Friedman*
    Mendel Friedman
    Healthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, California 94556, United States
    *Phone: 510-559-5615. E-mail: [email protected] (M.F.).
  • Vincent Huang
    Vincent Huang
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
  • Quincel Quiambao
    Quincel Quiambao
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
  • Sabrina Noritake
    Sabrina Noritake
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
  • Jenny Liu
    Jenny Liu
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
    More by Jenny Liu
  • Ohkun Kwon
    Ohkun Kwon
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
    More by Ohkun Kwon
  • Sirisha Chintalapati
    Sirisha Chintalapati
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
  • Joseph Young
    Joseph Young
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
    More by Joseph Young
  • Carol E. Levin
    Carol E. Levin
    Healthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, California 94556, United States
  • Christina Tam
    Christina Tam
    Foodborne Toxins Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, California 94556, United States
  • Luisa W. Cheng
    Luisa W. Cheng
    Foodborne Toxins Detection and Prevention Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, California 94556, United States
  • , and 
  • Kirkwood M. Land*
    Kirkwood M. Land
    Department of Biological Sciences, University of the Pacific, Stockton, California 95211, United States
    *Phone 209-946-7608. E-mail: [email protected] (K.M.L.).
Cite this: J. Agric. Food Chem. 2018, 66, 30, 7942–7947
Publication Date (Web):July 24, 2018
https://doi.org/10.1021/acs.jafc.8b01726
Copyright © 2018 American Chemical Society

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    Abstract

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    Potato peel, a waste product of the potato processing industry, is high in bioactive compounds. We investigated the in vitro antitrichomonad activity of potato peel powders prepared from commercial Russet, red, purple, and fingerling varieties as well as several known potato components, alkaloids and phenolic compounds, against three pathogenic strains of trichomonads. Trichomonas vaginalis is a sexually transmitted protozoan parasite that causes the human disease trichomoniasis. Two distinct strains of the related Tritrichomonas fetus infect cattle and cats. The glycoalkaloids α-chaconine and α-solanine were highly active against all parasite lines, while their common aglycone solanidine was only mildly inhibitory. α-Solanine was several times more active than α-chaconine. The phenolic compounds caffeic and chlorogenic acids and quercetin were mildly active against the parasites. Most of the potato peel samples were at least somewhat active against all three trichomonad species, but their activities were wide-ranging and did not correspond to their glycoalkaloid and phenolic content determined by HPLC. The two Russet samples were the most active against all three parasites. The purple potato peel sample was highly active against bovine and mostly inactive against feline trichomonads. None of the test substances were inhibitory toward several normal microflora species, suggesting the potential use of the peels for targeted therapeutic treatments against trichomonads.

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