Structure–Activity Relationship Analysis on Antioxidant and Anticancer Actions of Theaflavins on Human Colon Cancer Cells
- Qingyun TanQingyun TanThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Qingyun Tan,
- Lijiao PengLijiao PengAffiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, People’s Republic of ChinaMore by Lijiao Peng,
- Yanyu HuangYanyu HuangThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Yanyu Huang,
- Wei HuangWei HuangThe First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Wei Huang,
- Weibin BaiWeibin BaiInstitute of Food Safety and Nutrition, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Weibin Bai,
- Lei ShiLei ShiInstitute of Food Safety and Nutrition, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Lei Shi,
- Xiaoling Li*Xiaoling Li*Telephone: +86-20-85227082. E-mail: [email protected]Institute of Food Safety and Nutrition, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Xiaoling Li, and
- Tianfeng Chen*Tianfeng Chen*Telephone: +86-20-85225962. Fax: +86-20-85220223. E-mail: [email protected]The First Affiliated Hospital and Department of Chemistry, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of ChinaMore by Tianfeng Chen
Abstract
The roles of natural products as effective cancer prevention and therapeutic agents have been documented by various studies in recent years, but the action mechanisms and structure–activity relationship need more elucidation. The present study showed that theaflavins (theaflavin and its derivatives, TFs) from black tea caused an inhibitory effect on the proliferation of human colon adenocarcinoma cancer SW480 cells and human colon cancer SW620 cells [half maximal inhibitory concentration (IC50) < 32.0 μM] by the induction of cell cycle arrest but exerted lower toxicity against normal cells with a high safety index (1.89–6.26). Moreover, TFs triggered a decrease in reactive oxygen species in SW480 cells as a result of their excellent radical-scavenging ability (e.g., the IC50 value of TF4 to ABTS• + was 1.91 ± 0.21 μM). More importantly, the structure–activity relationship analysis of TFs exhibited that the galloyl group was an important factor to affect these activities. Taken together, we revealed that the TFs could act as substitutes for natural antioxidants and promising anticancer agents with beneficial influence on human health and then anticipated that this study may provide useful information on the development of therapeutic natural products.
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