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Biotin–Streptavidin System-Mediated Ratiometric Multiplex Immunochromatographic Assay for Simultaneous and Accurate Quantification of Three Mycotoxins

  • Yanna Shao
    Yanna Shao
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    More by Yanna Shao
  • Hong Duan
    Hong Duan
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    More by Hong Duan
  • Shu Zhou
    Shu Zhou
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    More by Shu Zhou
  • Tongtong Ma
    Tongtong Ma
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    More by Tongtong Ma
  • Liang Guo
    Liang Guo
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    More by Liang Guo
  • Xiaolin Huang*
    Xiaolin Huang
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    School of Food Science and Technology, Nanchang University, Nanchang 330031, P. R. China
    *E-mail: [email protected] or [email protected]
  • , and 
  • Yonghua Xiong*
    Yonghua Xiong
    State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, P. R. China
    Jiangxi-OAI Joint Research Institute, Nanchang University, Nanchang 330047, P. R. China
    School of Food Science and Technology, Nanchang University, Nanchang 330031, P. R. China
    *E-mail: [email protected]
Cite this: J. Agric. Food Chem. 2019, 67, 32, 9022–9031
Publication Date (Web):July 24, 2019
https://doi.org/10.1021/acs.jafc.9b03222
Copyright © 2019 American Chemical Society

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    Abstract

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    The quantitative multiplex immunochromatographic assay (mICA) has received an increasing amount of attention in multitarget detection. However, the quantitative results in the reported mICAs were obtained by recording the signals on the test lines that with which various analyte-independent factors readily interfere, resulting in inaccurate quantitation. The ratiometric strategy using the T/C value (ratios of signals on the test line to those of the control line) for signal correction can effectively circumvent these issues to enable more accurate detection. Herein, we present for the first time a novel ratiometric mICA strip with multiple T lines for the simultaneous quantitative detection of aflatoxin B1 (AFB1), fumonisin B1 (FB1), and ochratoxin A (OTA) using highly luminescent quantum dot nanobeads (QBs) as enhanced signal reporters. To achieve reliable ratiometric signal output, a biotin–streptavidin system was introduced to replace the conventional anti-mouse IgG antibody for reliable reference signals on the control line that are completely independent of the signal probe and analyte. By using stable T/C values as quantitative signals, our proposed QB–mICA method can successfully detect three mycotoxins with concentrations as low as 1.65 pg/mL for AFB1, 1.58 ng/mL for FB1, and 0.059 ng/mL for OTA. The detection performance of the developed QB–mICA strip, including precision, specificity, and reliability, was further evaluated using artificially contaminated cereal samples. The results demonstrate the improved accuracy and reliability of quantitative determination by comparison with the anti-mouse IgG antibody. Thus, this work provides a promising strategy for developing a ratiometric mICA method for accurately quantifying multiple analytes using the biotin–SA system, opening up a new direction in quantitative mICAs.

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    The Supporting Information is available free of charge on the ACS Publications website at DOI: 10.1021/acs.jafc.9b03222.

    • Comparison of FI between CdSe/ZnS QDs and the prepared QBs, confirmation of the saturation concentration of the protein conjugated with QBs, and optimization of the QB strip parameters (PDF)

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