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Solubility Measurement and Simulation of Rivaroxaban (Form I) in Solvent Mixtures from 273.15 to 323.15 K

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School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, People’s Republic of China
Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto M5S 3E5, Canada
§ Department of Chemical and Biochemical Engineering, Western University, London, Ontario N6A 5B9, Canada
*E-mail: [email protected]. Fax: +86 21 67791214. Tel.: +86 21 67791216.
Cite this: J. Chem. Eng. Data 2016, 61, 1, 495–503
Publication Date (Web):December 18, 2015
https://doi.org/10.1021/acs.jced.5b00667
Copyright © 2015 American Chemical Society

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    Abstract

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    The solubility of active pharmaceutical ingredients in various solvents is crucial to their industrial production and the development to final formulations. In this work, the solubility of rivaroxaban (form I) in the binary solvent mixtures of 1-methyl-2-pyrrolidinone with water, methanol, ethanol, and isopropanol from 273.15 to 323.15 K has been experimentally measured. Meanwhile, the dependence of the measured solubility on the temperature as well as on the composition of solvent mixtures has been simulated by Jouyban-Acree (JA) and nonrandom two liquid (NRTL) equations, respectively. The results show that as to the solubility simulation of the studied system JA and NRTL give average relative deviations of 0.1081 and 0.1064, respectively, suggesting that both JA and NRTL can act as an efficient simulation tool for the solubility of rivaroxaban (form I) in pure and mixture solvents at various temperatures.

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    Cited By

    This article is cited by 9 publications.

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    6. Afroditi Kapourani, Elisavet Vardaka, Konstantinos Katopodis, Kyriakos Kachrimanis, Panagiotis Barmpalexis. Rivaroxaban polymeric amorphous solid dispersions: Moisture-induced thermodynamic phase behavior and intermolecular interactions. European Journal of Pharmaceutics and Biopharmaceutics 2019, 145 , 98-112. https://doi.org/10.1016/j.ejpb.2019.10.010
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