ACS Publications. Most Trusted. Most Cited. Most Read
My Activity
CONTENT TYPES

Figure 1Loading Img

Experiment and Computation of Solubility and Dissolution Properties for Enalapril Maleate and Its Intermediate in Pure Solvents

  • Bin Qiao
    Bin Qiao
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    More by Bin Qiao
  • Cunbin Du
    Cunbin Du
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    More by Cunbin Du
  • Ruimei Dong
    Ruimei Dong
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    More by Ruimei Dong
  • Zhudan Jin
    Zhudan Jin
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    More by Zhudan Jin
  • Ying Zhang
    Ying Zhang
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    More by Ying Zhang
  • Tingting Ye
    Tingting Ye
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    More by Tingting Ye
  • , and 
  • Mingliang Wang*
    Mingliang Wang
    School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P. R. China
    *E-mail: [email protected]
Cite this: J. Chem. Eng. Data 2018, 63, 12, 4306–4313
Publication Date (Web):November 9, 2018
https://doi.org/10.1021/acs.jced.8b00333
Copyright © 2018 American Chemical Society

    Article Views

    369

    Altmetric

    -

    Citations

    -
    LEARN ABOUT THESE METRICS
    Other access options

    Abstract

    Abstract Image

    The object is to research the solid–liquid phase of enalapril maleate and its intermediate enalapril hydride in pure solvent. Within the investigated temperature range, the mole fraction solubility data in the selected solvents increase with the increasing temperature. The solubility of enalapril hydride in different solvents decreases according to the order ethyl acetate > acetone > ethanol > n-octanol > isopropanol > acetonitrile, while enalapril maleate obeys the order ethyl acetate > acetone > ethanol > acetonitrile > n-octanol > isopropanol. The experimental solubility data of enalapril hydride and enalapril maleate in those solvents were correlated by the modified Apelblat equation, Buchowski–Ksiazaczak λh equation, and Wilson equation. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) obtained by the three equations were 1.48 × 10–4, 3.32% (enalapril hydride) and 2.82 × 10–4, 4.36% (enalapril maleate), respectively. It was found from the RMSD value that the modified Apelblat equation is more suitable to describe the solubility behavior of enalapril hydride and enalapril maleate in these solvents.

    Read this article

    To access this article, please review the available access options below.

    Get instant access

    Purchase Access

    Read this article for 48 hours. Check out below using your ACS ID or as a guest.

    Recommended

    Access through Your Institution

    You may have access to this article through your institution.

    Your institution does not have access to this content. You can change your affiliated institution below.

    Cited By

    This article has not yet been cited by other publications.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    Pair your accounts.

    Export articles to Mendeley

    Get article recommendations from ACS based on references in your Mendeley library.

    You’ve supercharged your research process with ACS and Mendeley!

    STEP 1:
    Click to create an ACS ID

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    Please note: If you switch to a different device, you may be asked to login again with only your ACS ID.

    MENDELEY PAIRING EXPIRED
    Your Mendeley pairing has expired. Please reconnect