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Solubility of Toltrazuril and the Effect of a Cosolvent

  • Yüfang Wu*
    Yüfang Wu
    Department of Biological Sciences, XinZhou Teachers University, Xinzhou, Shanxi 034000, P. R. China
    *Tel.: +86 350 3339210. E-mail: [email protected]
    More by Yüfang Wu
  • Jiaqin Wu
    Jiaqin Wu
    Department of Biological Sciences, XinZhou Teachers University, Xinzhou, Shanxi 034000, P. R. China
    More by Jiaqin Wu
  • Long Cheng
    Long Cheng
    Department of Biological Sciences, XinZhou Teachers University, Xinzhou, Shanxi 034000, P. R. China
    More by Long Cheng
  • , and 
  • Jiachao Wang
    Jiachao Wang
    Department of Biological Sciences, XinZhou Teachers University, Xinzhou, Shanxi 034000, P. R. China
    More by Jiachao Wang
Cite this: J. Chem. Eng. Data 2018, 63, 12, 4468–4474
Publication Date (Web):November 15, 2018
https://doi.org/10.1021/acs.jced.8b00581
Copyright © 2018 American Chemical Society

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    Abstract

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    The purpose of this work is to study the dissolution process of toltrazuril and the influence of the solvent on solubility. In pure solvents, the solubility of toltrazuril increases with the increasing temperature, and the order of solubility data is as follows: ethyl acetate (9.640 × 10–3, 298.15 K) > dichloromethane (6.103 × 10–3, 298.15 K) > toluene (3.132 × 10–3, 298.15 K) > ethanol (1.567 × 10–3, 298.15 K) > isopropyl alcohol (0.9795 × 10–3, 298.15 K) > water (0.01929 × 10–3, 298.15 K), meanwhile in binary mixtures, the solubility increases to a maximum with the increasing temperature and isopropyl alcohol, and then decrease with further increase of cosolvent. However, in the isopropyl alcohol + ethyl acetate mixed solvents, the data increase with the increasing ethyl acetate. Four thermodynamic models are used to discuss the dependence of toltrazuril solubility on temperature and solvent composition. The largest value of relative average deviation and (RAD) and root-mean-square deviation (RMSD) between the calculated and experiment value were no larger than 4.5 × 10–2 and 4.1 × 10–4, respectively. The results indicate that these models were all acceptable to express the dissolution process of toltrazuril in the studied solvents. The method of multiple linear regression analysis (MLRA) involving selected solvent parameters can explain the effect of solvents on solubility of toltrazuril in pure solvents.

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    Cited By

    This article is cited by 2 publications.

    1. Da-Jun Zhang, Quan-Xu Chen, Hong-Wei Lin, Rui-Juan Miao, Shan Li, Lei Zhang. Toltrazuril Polymorphs and the Effect on Hygroscopicity and Dissolution Rate. Crystal Growth & Design 2024, 24 (3) , 1328-1338. https://doi.org/10.1021/acs.cgd.3c01301
    2. Zhenmei Deng, Fangzhao Li, Guomin Zhao, Wenge Yang, Yonghong Hu. Solubility and Dissolution Behavior Analysis of 7-Azaindole in Pure and Binary Mixture Solvents at Temperatures Ranging from 278.15 to 323.15 K. Journal of Chemical & Engineering Data 2020, 65 (7) , 3579-3592. https://doi.org/10.1021/acs.jced.0c00128

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